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19篇 您的检索式:作者名="Hang Mi"
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1Numerical and experimental research on different inlet configurations of high speed centrifugal compressor显示文摘Three different inlet configurations,including a original straight pipe and two bend pipes with different axial length,for a high speed low mass flow centrifugal compressor were modeled with whole blade passages and simulated unsteadily by 3D viscous Navier-Stokes equations.The performance disparities of compressor stage were tested and verified by experiments in which dynamic pressure data acquisition of internal flow field was performed.As the result shows,the choke point decreases to lower mass flow rate due to the distortion caused by bend-pipe inlet and is aggravated as the rotation speed increases.The distortion effect spreads circumferentially in impeller and makes the flow structure varied.The longer axial distance bent inlet leads to larger radial distortion and heavy blockage at mid-span under large mass flow mainly causes compressor choke margin nar-rowed.Bend pipe distortion brings an impact up to diffuser on unsteady pressure pulsation caused by blades sweep and the impact appears more powerful when it is closer to volute tongue.LI Du YANG Ce ZHOU Mi ZHU ZhiFu WANG Hang 2012Science China(Technological Sciences)2012,55,1:9
2A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga-Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong 2017Virologica Sinica2017,32,2:4
3Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant显示文摘A moderate inflammatory response at the early stages of fracture healing is necessary for callus formation.Over-active and continuous inflammation,however,impairs fracture healing and leads to excessive tissue damage.Adequate fracture healing could be promoted through suppression of local over-active immune cells in the fracture site.In the present study,we achieved an enriched concentration of PD-L1 from exosomes(Exos)of a genetically engineered Human Umbilical Vein Endothelial Cell(HUVECs),and demonstrated that exosomes overexpressing PD-L1 specifically bind to PD-1 on the T cell surface,suppressing the activation of T cells.Furthermore,exosomal PD-L1 induced Mesenchymal Stem Cells(MSCs)towards osteogenic differentiation when pre-cultured with T cells.Moreover,embedding of Exos into an injectable hydrogel allowed Exos delivery to the surrounding microenvironment in a time-released manner.Additionally,exosomal PD-L1,embedded in a hydrogel,markedly promoted callus formation and fracture healing in a murine model at the early over-active inflammation phase.Importantly,our results suggested that activation of T cells in the peripheral lymphatic tissues was inhibited after local administration of PD-L1-enriched Exos to the fracture sites,while T cells in distant immune organs such as the spleen were not affected.In summary,this study provides the first example of using PD-L1-enriched Exos for bone fracture repair,and highlights the potential of Hydrogel@Exos systems for bone fracture therapy through immune inhibitory effects.Ze Lin Yuan Xiong Weilin Meng Yiqiang Hu Lili Chen Lang Chen Hang Xue Adriana CPanayi Wu Zhou Yun Sun Faqi Cao Guodong Liu Liangcong Hu Chenchen Yan Xudong Xie Chuanchuan Lin Kaiyong Cai Qian Feng Bobin Mi Guohui Liu 2022Bioactive Materials2022,7,7:4
4Advances and perspective on animal models and hydrogel biomaterials for diabetic wound healing显示文摘Diabetic wounds are a common complication in diabetes patients.Due to peripheral nerve damage and vascular dysfunction,diabetic wounds are prone to progress to local ulcers,wound gangrene and even to require amputation,bringing huge psychological and economic burdens to patients.However,the current treatment methods for diabetic wounds mainly include wound accessories,negative pressure drainage,skin grafting and surgery;there is still no ideal treatment to promote diabetic wound healing at present.Appropriate animal models can simulate the physiological mechanism of diabetic wounds,providing a basis for translational research in treating diabetic wound healing.Although there are no animal models that can fully mimic the pathophysiological mechanisms of diabetic wounds in humans,it is vital to explore animal simulation models used in basic research and preclinical studies of diabetic wounds.In addition,hydrogel materials are regarded as a promising treatment for diabetic wounds because of their good antimicrobial activity,biocompatibility,biodegradation and appropriate mechanical properties.Herein,we review and discuss the different animal models used to investigate the pathological mechanisms of diabetic wounds.We further discuss the promising future application of hydrogel biomaterials in diabetic wound healing.Yiqiang Hu Yuan Xiong Ranyang Tao Hang Xue Lang Chen Ze Lin Adriana C.Panayi Bobin Mi Guohui Liu 2022Biomaterials Translational2022,3,3:2
5Multi-Scenario Millimeter Wave Wireless Channel Measurements and Sparsity Analysis显示文摘Wireless channel characteristics have significant impacts on channel modeling,estimation,and communication performance.While the channel sparsity is an important characteristic of wireless channels.Utilizing the sparse nature of wireless channels can reduce the complexity of channel modeling and estimation,and improve system design and performance analysis.Compared with the traditional sub6 GHz channel,millimeter wave(mmWave)channel has been considered to be more sparse in existing researches.However,most research only assume that the mmWave channel is sparse,without providing quantitative analysis and evaluation.Therefore,this paper evaluates the sparsity of mmWave channels based on mmWave channel measurements.A vector network analyzer(VNA)-based mmWave channel sounder is developed to measure the channel at 28 GHz,and multi-scenario channel measurements are conducted.The Gini index,Rician��factor and rootmean-square(RMS)delay spread are used to measure channel sparsity.Then,the key factors affecting mmWave channel sparsity are explored.It is found that antenna steering direction and scattering environment will affect the sparsity of mmWave channel.In addition,the impact of channel sparsity on channel eigenvalue and capacity is evaluated and analyzed.Hang Mi Bo Ai Ruisi He Xin Zhou Zhangfeng Ma Mi Yang Zhangdui Zhong Ning Wang 2022China Communications2022,19,11:2
6Polymerization of Norbornene via an Iron-Based Complex/MAO Catalytic System显示文摘Polynorbornenes were synthesized in the presence of an iron based catalyst, 2,6-bis[1-(2,6-diisopropyl-phenylimino)ethyl]pyridine iron(Ⅱ) dichloride. The FTIR, 1H NMR and 13C NMR analysis results revealed that the structure of the obtained polynorbornenes consisted of vinyl addition polymer substructures without any ring-opening structures. The polymers were amorphous with a short-range order, displayed in the WAXD(wide angle X-ray diffraction) diagrams. The glass transition temperatures ranged from 200 to 400 ℃. The effects of the polymerization reaction conditions, such as Al/Fe molar ratio and toluene/CH2Cl2 volume ratio, on the activity, intrinsic viscosity and Tg were also studied.MI Xia 1,2, MA Zhi 1,2, YAN Wei-dong 3, LIU Yuan-xia 1,2, WANG Hang 1,2, KE Yu-cai 1 and HU You-liang 1**1. State Key Lab of Engineering Plastics, Center for Molecular Science, Beijing Laboratory of Catalysis, CNPC Key Laboratory of Catalysis,Institute of Chemistry, Chinese Academy of Sciences,Beijing 100080, P. R. China 2. Graduate School of Chinese Academy of Sciences, Beijing 1000803. Institute of Polymer Science and Engineering, Hebei University of Technology,Tianjin 300130, P. R. China 2002Chemical Research in Chinese Universities2002,18,4:1
7Molecular analysis of rice plants harboring an Ac/Ds transposable element‐mediated gene trapping system显示文摘Hang GyeongChin Mi SookChoe Sung‐HoLee Sung HanPark Su HyunPark Ja ChoonKoo No YoulKim Jeung JooLee Byeong GeunOh Gi HwanYi Soon ChulKim Hae ChuneChoi Moo JeCho Chang‐deokHan 2002The Plant Journal2002,,5:1
8Intra-host Ebola viral adaption during human infection显示文摘The onsite next generation sequencing(NGS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this virus.Herein,we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015,during the late phase of the outbreak.The surviving EBOV patients had a recovery process characterized by decreasing viremia,fever,and biochemical parameters.EBOV genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection,including the previously described short stretches of 13 serial TNC mutations.Remarkably,within individual patients,samples collected during the early phase of infection possessed Ts at these nucleotide sites,whereas they were replaced by Cs in samples collected in the later phase,suggesting that these short stretches of TNC mutations could emerge independently.In addition,up to a total of 35 nucleotide sites spanning the EBOV genome were mutated coincidently.Our study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions.William JLiu Weifeng Shi Wuyang Zhu Cong Jin Shumei Zou Ji Wang Yuehua Ke Xiaofeng Li Mi Liu Tao Hu Hang Fan Yigang Tong Xiang Zhao Wenbin Chen Yuhui Zhao Di Liu Gary Wong Chengchao Chen Chunyu Geng Weiwei Xie Hui Jiang Idrissa Laybor Kamara Abdul Kamara Matt Lebby Brima Kargbo Xiangguo Qiu Yu Wang Xiaofeng Liang Mifang Liang Xiaoping Dong Guizhen Wu George F.Gao Yuelong Shu 2019Biosafety and Health2019,1,1:1
93D-Printed Bio-inspired Multi-channel Cathodes for Zinc–air Battery Applications显示文摘It is of great significance to enhance mass transfer and improve active surface area in cathodes for zinc–air batteries(ZABs),which promote oxygen reduction reaction(ORR)efficiency and power outputs.Nature has endowed some tissues with special structures to have efficient mass transfer properties and high active surface area.As an important mass transfer part of trees,xylem contains massive long and partially aligned channels,which provides numerous“passageway”and high active surface area for plants to facilitate the efficient transport of oxygen and inorganic salts.The multi-channel structures give an important insight to develop high efficient air cathode.Herein,3D-printed bio-inspired multi-channel cathodes(BMCs),inspired by xylem structures,have been developed for high-performance ZABs via 3D printing.Channels of bionic cathode contribute to forming a continuous supply of oxygen from air.As a result,massive tri-phase boundary regions,where ORR happens,are formed inside of cathode.Moreover,the 3D-printed metal-based framework can facilitate electron transfer during ORR process.Benefiting from the multi-channel framework,the assembled ZABs with BMC-600 show excellent electrochemical performances in terms of the high power density of 170.1 mW cm^(−2) and a high open-circuit voltage of 1.51 V.Therefore,BMCs provide a potential alternative as promising cathode for metal-air batteries.Xin Men Zhiyuan Li Wei Yang Mi Wang Song Liang Hang Sun Zhenning Liu Guolong Lu 2022Journal of Bionic Engineering2022,19,4:1
10Enhanced tissue regeneration through immunomodulation of angiogenesis and osteogenesis with a multifaceted nanohybrid modified bioactive scaffold显示文摘Major traumatic tissue defects are common clinical problems often complicated by infection and local vascular dysfunction, processes which hinder the healing process. Although local application of growth factors or stem cells through various tissue engineering techniques are promising methods for the repair of tissue defects, limitations in their clinical application exist. Herein, we synthesized multifaceted nanohybrids composed of Quaternized chitosan (QCS), Graphene oxide (GO), and Polydopamine (PDA;QCS-GO-PDA). Covalent grafting of QCS and GO at a mass ratio of 5:1 (5QCS-1GO) displayed excellent biocompatibility and enhanced osteogenic ability, while addition of PDA (5QCS-1GO-PDA) reduced the level of reactive oxygen species (ROS). 5QCS-1GO-PDA was able to achieve wound tissue regeneration by reducing the inflammatory response and enhancing angiogenesis. Furthermore, Polylactic acid/hydroxyapatite (PLA/HA) composite scaffolds were printed using Selective Laser Sintering (SLS) and the hybrid nanomaterial (5QCS-1GO-PDA) was used to coat the PLA/HA scaffold (5QCS-1GO-PDA@PLA/HA) to be used for rapid bone regeneration. 5QCS-1GO-PDA not only improved angiogenesis and osteogenic differentiation, but also induced M2-type polarization of macrophages and promoted bone regeneration via the BMP2/BMPRs/Smads/Runx2 signaling pathway. The bidirectional enhanced healing ability of the multifaceted nanohybrids 5QCS-1GO-PDA provides a promising method of effectively treating tissue defects.Hang Xue Zhenhe Zhang Ze Lin Jin Su Adriana CPanayi Yuan Xiong Liangcong Hu Yiqiang Hu Lang Chen Chenchen Yan Xudong Xie Yusheng Shi Wu Zhou Bobin Mi Guohui Liu 2022Bioactive Materials2022,7,12:1
11White light-emitting diodes of GaN-based Sr2SiO4:Eu and the luminescent properties显示文摘Joung Kyu Park Mi Ae Lim hang Hae Kim 2003Applied Physics Letters2003,82,5:1
12Microstructure evolution of ultra-high-strength twinning-induced plasticity(TWIP)steel under dynamic loading显示文摘To prepare ultra-high-yield strength twinning-induced plasticity(TWIP)steel and reveal its work hardening mechanism at different strain rates from the microcosmic range,the microstructure evolution mechanism of Fe–20Mn–0.6C TWIP steel was investigated at strain rates of 10^(-4)–10^(3)s^(-1)using a high-speed tensile testing machine and a transmission electron microscope.The results show that the strain rate and deformation had a significant effect on the twin morphology of TWIP steels.At a strain rate of 10^(2)s^(-1),secondary deformation twins were developed,which intersected with the initial deformation twins and increased the resistance of dislocation movement,as well as the plasticity.TWIP steel at a strain rate of 10^(2)s^(-1)had a higher twin formation speed than that at 10^(0)s^(-1).At the same amount of deformation,the twin boundary fraction was higher and increased linearly at a strain rate of 10^(2)s^(-1),while the rule of twin growth at 10^(0)s^(-1)was conformed to S-curve change of DoseResp model.Qi‑hang Pang Mei Xu Zhen‑li Mi Juan Cui Jing Guo 2021Journal of Iron and Steel Research(International)2021,28,1:0
13Optimal Gestational Weight Gain for Women with Gestational Diabetes Mellitus—China,2011–2021显示文摘Summary What is already known about this topic?Joint effects of gestational weight gain(GWG)and hyperglycemia on adverse pregnancy outcomes suggest that lower optimal GWG is optimal for women with gestational diabetes mellitus(GDM).However,there is still a lack of guidelines.What is added by this report?Optimal weekly GWG range after diagnosis of GDM for underweight,normal-weight,overweight,and obese women was 0.37–0.56 kg/week,0.26–0.48 kg/week,0.19–0.32 kg/week,and 0.12–0.23 kg/week,respectively.What are the implications for public health practice?The findings may be used to inform prenatal counseling regarding optimal gestational weight gain for women with gestational diabetes mellitus,and suggest the need for weight gain management.Jinlang Lyu Yin Sun Yuelong Ji Nana Liu Suhan Zhang Hang Lin Yaxin Wang Xuanjin Yang Shuai Ma Na Han Yang Mi Dan Zheng Zhifen Yang Hongping Zhang Yan Jiang Liangkun Ma Haijun Wang 2023China CDC weekly2023,5,9:0
14Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss显示文摘The clinical role and underlying mechanisms of valproic acid(VPA)on bone homeostasis remain controversial.Herein,we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density(BMD)in both patients and mice.This effect was attributed to VPA-induced elevation in osteoclast formation and activity.Through RNA-sequencing,we observed a significant rise in precursor miR-6359 expression in VPA-treated osteoclast precursors in vitro,and further,a marked upregulation of mature miR-6359(miR-6359)in vivo was demonstrated using quantitative real-time PCR(qRT-PCR)and miR-6359 fluorescent in situ hybridization(miR-6359-FISH).Specifically,the miR-6359 was predominantly increased in osteoclast precursors and macrophages but not in neutrophils,T lymphocytes,monocytes and bone marrow-derived mesenchymal stem cells(BMSCs)following VPA stimulation,which influenced osteoclast differentiation and bone-resorptive activity.Additionally,VPA-induced miR-6359 enrichment in osteoclast precursors enhanced reactive oxygen species(ROS)production by silencing the SIRT3 protein expression,followed by activation of the MAPK signaling pathway,which enhanced osteoclast formation and activity,thereby accelerating bone loss.Currently,there are no medications that can effectively treat VPA-induced bone loss.Therefore,we constructed engineered small extracellular vesicles(E-sEVs)targeting osteoclast precursors in bone and naturally carrying anti-miR-6359 by introducing of EXOmotif(CGGGAGC)in the 3’-end of the anti-miR-6359 sequence.We confirmed that the E-sEVs exhibited decent bone/osteoclast precursor targeting and exerted protective therapeutic effects on VPA-induced bone loss,but not on ovariectomy(OVX)and glucocorticoid-induced osteoporotic models,deepening our understanding of the underlying mechanism and treatment strategies for VPA-induced bone loss.Xudong Xie Peng Cheng Liangcong Hu Wu Zhou Detai Zhang Samuel Knoedler Guodong Liu Yuan Xiong Hang Xue Yiqiang Hu Barbara Kern Doha Obed Adriana CPanayi Lang Chen Chenchen Yan Ze Lin Guandong Dai Bobin Mi Yingze Zhang Guohui Liu 2024Signal Transduction and Targeted Therapy2024,9,2:0
15Radio Communication Scenarios in 5G-Railways显示文摘With the rapid development of railways,especially high-speed railways,there is an increasingly urgent demand for new wireless communication system for railways.Taking the mature 5G technology as an opportunity,5G-railways(5G-R)have been widely regarded as a solution to meet the diversified demands of railway wireless communications.For the design,deployment and improvement of 5GR networks,radio communication scenario classification plays an important role,affecting channel modeling and system performance evaluation.In this paper,a standardized radio communication scenario classification,including 18 scenarios,is proposed for 5GR.This paper analyzes the differences of 5G-R scenarios compared with the traditional cellular networks and GSM-railways,according to 5G-R requirements and the unique physical environment and propagation characteristics.The proposed standardized scenario classification helps deepen the research of 5G-R and promote the development and application of the existing advanced technologies in railways.Ruisi He Bo Ai Zhangdui Zhong Mi Yang Chen Huang Ruifeng Chen Jianwen Ding Hang Mi Zhangfeng Ma Guiqi Sun Changzhu Liu 2023China Communications2023,20,9:0
16Weekly Weight Gain in Women with Gestational Diabetes Mellitus and Neonatal Birth Weight - China, 2011–2021显示文摘What is already known about this topic?Elevated gestational weight gain(GWG)during pregnancy among women diagnosed with gestational diabetes mellitus(GDM)is correlated with an increased instance of large for gestational age(LGA)and macrosomia.However,it remains uncertain whether managing weekly GWG following a GDM diagnosis positively impacts fetal birth weight.What is added by this report?Our study found that GWG following GDM diagnosis correlates positively with the risk of LGA and macrosomia among all body mass index(BMI)subgroups,especially for overweight and obese women.What are the implications for public health practice?The results of this research highlight the importance of enforcing a more stringent regulation on GWG on a weekly basis for overweight and obese women diagnosed with GDM,particularly when considering neonatal growth.Nana Liu Jinlang Lyu Haijun Wang Yin Sun Suhan Zhang Hang Lin Yaxin Wang Xuanjin Yang Shuai Ma Na Han Yang Mi Dan Zheng Zhifen Yang Hongping Zhang Yan Jiang Yuelong Ji Liangkun Ma 2023China CDC weekly2023,5,32:0
17In silico assessment of the impact of 2019 novel coronavirus genomic variation on the efficiency of published real-time quantitative polymerase chain reaction detection assays显示文摘To the Editor:In December 2019,coronavirus disease 2019 outbreak caused by the 2019 novel coronavirus(2019-nCoV)happened in Wuhan,China.Now,it has posed a worldwide public health threat.Real-time quanti-tative polymerase chain reaction(RT-qPCR)was recom-mended as an effective pathogen detection method and has played an important role in prevention and control of the current outbreak.Many research institutions have released their primer sets for RT-qPCR.If the variant sites were located in the primer regions,the efficiency of RT-qPCR would be reduced,thus possibly causing false negative results,and leading to unpredictable impact on the diagnosis of patients and the control of this outbreak.Therefore,a comprehensive investigation on 2019-nCoV genome variation is necessary to evaluate the effectiveness of current released RT-qPCR methods.Hang Fan Xiang-Li-Lan Zhang Ya-Wei Zhang Yong Huang Yue Teng Yan Guo Zhi-Qiang Mi Rui-Fu Yang Ya-Jun Song Yu-Jun Cui 2020Chinese Medical Journal2020,,13:0
18Dielectric and ferroelectric characteristics of Ba(Ti_(0.25)Zr_(0.25)Hf_(0.25)Sn_(0.25))O_(3)high-entropy ceramics显示文摘Ba(Ti_(0.25)Zr_(0.25)Hf_(0.25)Sn_(0.25))O_(3)high-entropy ceramics were prepared by a standard solid state reaction process,and the dielectric and ferroelectric characteristics were investigated together with the structures.Both X-ray diffraction(XRD)and energy dispersive spectroscopy(EDS)analysis demonstrated a single-phase perovskite structure in the present ceramics.A broad dielectric peak with strong frequency dispersion feature was determined,which indicated the typical relaxor nature originating from the nanoscale ferroelectric domain structures.These resulted from the structural distortion and chemical disorder due to high-entropy,where the long-range order of ferroelectric domains was destroyed.The homogeneous microstructure led to the reduced leakage current density and significantly improved dielectric strength,which was desired for the practical applications.Compared with the similar systems of Ba(Ti_(1-x)Zr_(x))O_(3)&Ba(Ti_(1-x)Sn_(x))O_(3),the present high-entropy ceramics indicated better relaxor ferroelectric characteristics.Rui Hu Mi Bu Hang Chen Xiao Li Zhu Xiang Ming Chen 2023Journal of Materiomics2023,9,4:0
19SAPT:a synchrotron-based proton therapy facility in Shanghai显示文摘Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in Shanghai.The synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected performances.After a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products Administration.The characteristics of the accelerator and treatment systems are described in this article.Man-Zhou Zhang De-Ming Li Li-Ren Shen Hai-Rong Zhang Zhi-Ling Chen Han-Wen Du Ming Gu Rui Li De-Kang Liu Yue-Hu Pu Jun-Feng Yu Jian-Feng Chen Chu Chen Chun-Long Guo Hao Guo Ge-Yang Jiang Zhi-Qiang Jiang Lin Jin Wen-Jing Li Xiu-Fang Li Ye Lin Ming Liu Yong-Hao Liu Ya-Juan Liu Ming Lv Qing-Ru Mi Lian-Hua Ouyang Wei-Guo Shi Hang Shu Qi-Sheng Tang Kun Wang Zhi-Shan Wang Jun Wu Xiao-Bing Wu Jia-Qiang Xu Wen-Zhen Xu Chong-Xian Yin Cheng Yu Ren-Xian Yuan Qi-Bing Yuan Hai-Qun Zhang Miao Zhang Wen-Zhi Zhang Li-Ying Zhao Wei-Min Zhou Shou-Xian Fang Xi-Dong Sun Zhen-Tang Zhao 2023Nuclear Science and Techniques2023,34,10:0
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