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| 1 | Dexamethasone-loaded ROS-responsive poly(thioketal)nanoparticles suppress inflammation and oxidative stress of acute lung injury显示文摘Acute lung injury(ALI)is associated with excessive inflammatory response,leading to acute respiratory distress syndrome(ARDS)without timely treatment.A fewer effective drugs are available currently to treat the ALI/ARDS.Herein,a therapeutic nanoplatform with reactive oxygen species(ROS)-responsiveness was developed for the regulation of inflammation.Dexamethasone acetate(Dex)was encapsulated into poly(thioketal)polymers to form polymeric nanoparticles(NPs)(PTKNPs@Dex).The NPs were composed of poly(1,4-phenyleneacetonedimethylene thioketal)(PPADT)and polythioketal urethane(PTKU),in which the thioketal bonds could be cleaved by the high level of ROS at the ALI site.The PTKNPs@Dex could accumulate in the pulmonary inflammatory sites and release the encapsulated payloads rapidly,leading to the decreased ROS level,less generation of pro-inflammatory cytokines,and reduced lung injury and mortality of mice.RNA sequencing(RNA-seq)analysis showed that the therapeutic efficacy of the NPs was associated with the modulation of many immune and inflammation-linked pathways.These findings provide a newly developed nanoplatform for the efficient treatment of ALI/ARDS. | Zihe Zhai Wei Ouyang Yuejun Yao Yuqi Zhang Haolan Zhang Feng Xu Changyou Gao | 2022 | Bioactive Materials2022，7，8： | 5 |
| 2 | Recent strategies for constructing efficient interfacial solar evaporation systems显示文摘Interfacial solar evaporation(ISE)is a promising technology to relieve worldwide freshwater shortages owing to its high energy conversion efficiency and environmentally sustainable potential.So far,many innovative materials and evaporators have been proposed and applied in ISE to enable highly controllable and efficient solar-to-thermal energy conversion.With rational design,solar evaporators can achieve excellent energy management for lowering energy loss,harvesting extra energy,and efficiently utilizing energy in the system to improve freshwater production.Beyond that,a strategy of reducing water vaporization enthalpy by introducing molecular engineering for water-state regulation has also been demonstrated as an effective approach to boost ISE.Based on these,this article discusses the energy nexus in two-dimensional(2D)and three-dimensional(3D)evaporators separately and reviews the strategies for design and fabrication of highly efficient ISE systems.The summarized work offers significant perspectives for guiding the future design of ISE systems with efficient energy management,which pave pathways for practical applications. | Yida Wang Junqing Hu Li Yu Xuan Wu Yingying Zhang Haolan Xu | 2023 | Nano Research Energy2023，2，2： | 1 |
| 3 | Spheroids of Endothelial Cells and Vascular Smooth Muscle Cells Promote Cell Migration in Hyaluronic Acid and Fibrinogen Composite Hydrogels显示文摘Cell migration plays a pivotal role in many pathological and physiological processes.So far,most of the studies have been focused on 2-dimensional cell adhesion and migration.Herein,the migration behaviors of cell spheroids in 3D hydrogels obtained by polymerization of methacrylated hyaluronic acid(HA-MA)and fibrinogen(Fg)with different ratios were studied.The Fg could be released to the medium gradually along with time prolongation,achieving the dynamic change of hydrogel structures and properties.Three types of cell spheroids,i.e.,endothelial cell(EC),smooth muscle cell(SMC),and EC-SMC spheroids,were prepared with 10,000 cells in each,whose diameters were about 343,108,and 224μm,respectively.The composite hydrogels with an intermediate ratio of Fg allowed the fastest 3D migration of cell spheroids.The ECs-SMCs migrated longest up to 3200μm at day 14,whereas the SMC spheroids migrated slowest with a distance of only~400μm at the same period of time.The addition of free RGD or anti-CD44 could significantly reduce the migration distance,revealing that the cell-substrate interactions take the major roles and the migration is mesenchymal dependent.Moreover,addition of anti-N-cadherin and MMP inhibitors also slowed down the migration rate,demonstrating that the degradation of hydrogels and cell-cell interactions are also largely involved in the cell migration.RT-PCR measurement showed that expression of genes related to cell adhesion and antiapoptosis,and angiogenesis was all upregulated in the EC-SMC spheroids than single EC or SMC spheroids,suggesting that the use of composite cell spheroids is more promising to promote cell-substrate interactions and maintenance of cell functions. | Xingang Zuo Haolan Zhang Tong Zhou Yiyuan Duan Hao Shou Shan Yu Changyou Gao | 2020 | Research2020，，1： | 1 |
| 4 | Relationship between charac- teristics of virtual brand community and brand attach- ment for Nokia BBS users 显示文摘 | Libing Shu Haolan Zhang | 2013 | Journal of Computers2013，8，12： | 1 |
| 5 | Emission and capture characteristics of deep hole trap in n-GaN by optical deep level transient spectroscopy显示文摘Emission and capture characteristics of a deep hole trap(H1)in n-GaN Schottky barrier diodes(SBDs)have been investigated by optical deep level transient spectroscopy(ODLTS).Activation energy(Eemi)and capture cross-section(σ_(p))of H1 are determined to be 0.75 eV and 4.67×10^(−15)cm^(2),respectively.Distribution of apparent trap concentration in space charge region is demonstrated.Temperature-enhanced emission process is revealed by decrease of emission time constant.Electricfield-boosted trap emission kinetics are analyzed by the Poole−Frenkel emission(PFE)model.In addition,H1 shows point defect capture properties and temperature-enhanced capture kinetics.Taking both hole capture and emission processes into account during laser beam incidence,H1 features a trap concentration of 2.67×10^(15)cm^(−3).The method and obtained results may facilitate understanding of minority carrier trap properties in wide bandgap semiconductor material and can be applied for device reliability assessment. | Jin Sui Jiaxiang Chen Haolan Qu Yu Zhang Xing Lu Xinbo Zou | 2024 | Journal of Semiconductors2024，45，3： | 0 |
| 6 | Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion显示文摘Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer(LbL) self-assembly are much attractive due to their advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate(PA) was synthesized, and was copolymerized with acrylic acid(AA) to obtain the amphiphilic and photodegradable P(PA-co-AA)polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride(PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549, HepG2 and endothelial cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected significantly until 5 d. | Haolan Zhang Danyu Wang Xue Lin Nikolaos Politakos Jimena S. Tuninetti Sergio Enrique Moya Changyou Gao | 2018 | Science China Chemistry2018，61，1： | 0 |
| 7 | Reactive oxygen species-scavenging nanoparticles coated with chondroitin sulfate protect cartilage against osteoarthritis in vivo显示文摘Osteoarthritis(OA)is a prevalent chronic inflammatory disease in joints.Current interventions confront systemic toxicity and insufficient bioavailability.The unbalanced microenvironment of OA joints mainly fosters over-expressed reactive oxygen species(ROS),extracellular matrix disintegration,and apoptosis of chondrocytes.In this study,a kind of ROS-scavenging,biodegradable and drug-free nanoparticles(PP NPs)were constructed by the crosslinking of poly(propylene fumarate)(PPF)and ROS-scavenging poly(thioketal)(PTK).The high content of PTK and high crosslinking density of PPF and PTK innovatively endowed the NPs with slow degradation and prolonged ROS-elimination ability.The NPs were further surface-modified with chondroitin sulfate(CS),one of the dietary supplements for osteoarthritis.The intrinsic properties of resultant PP-CS NPs were excavated in vitro and in vivo.The PP-CS NPs could desirably consume 1,10-diphenyl-2-picrylhydrazyl(DPPH)radicals without toxicity to RAW264.7 cells in vitro.With an average diameter of~300 nm,the PP-CS NPs could be intra-articular administrated in OA rats and showed prolonged joint retention time,allowing only one injection per month.Moreover,the PP-CS NPs possessed a prolonged ROS depletion and M2 macrophage induction effect,down-regulated inflammatory cytokines,and reduced glycosaminoglycans loss.Consequently,the PP-CS NPs protected articular surface erosion,inhibited uneven cartilage matrix,and attenuated OA progression. | Zhaoyi Wang Hao Xiong Zihe Zhai Yuejun Yao Tong Zhou Haolan Zhang Cunyi Fan Changyou Gao | 2023 | Nano Research2023，16，2： | 0 |
| 8 | Mechanism and preventive measures of slurry leakage at shield tail brushes under abnormal shutdown condition—A case study显示文摘Based on an underwater shield tunnel project,this study introduces the phenomenon of abnormal shutdown and the measures designed to mitigate problems in construction.On the strength of the analysis of the slurry leakage causes during re-tunneling,the mech-anism of slurry leakage induced by jack retraction was studied,and treatment measures of leakage at shield tail brushes were elaborated upon.The results show that the sudden change of stratum leads to an abnormal shutdown,and a sharp increase in the slurry pressure at the shield cut location leads to the slurry penetrating the gap between the outer wall of the shield shell and the soil,increasing the risk of instantaneous breakdown at shield tail brushes.The radial displacement of the outer wall of the segments caused by retractions of three jacks and a single jack along the circumferential direction distinctly shows three regions and four regions,respectively.The radial shrink-age of the outer wall of the segments at the jack retraction position decreases the tightness between the shield tail brushes and the outer wall of the segments.The expansion of the outer wall of the segments at the surrounding position,especially at the lower position,increases the slurry level to the radial shrinkage position of the segments,which increases the risk of slurry leakage.Furthermore,when the shield machine faces an abnormal shutdown,re-tunneling,and assembly of segments,the jack can be gradually retracted from top to bottom.The slurry leakage degree can be observed when retracting,and the corresponding measures can be taken for timely plugging.According to the leakage degree,it can be determined whether to replace the shield tail brushes to reduce the risk of large-scale leakage accidents. | Fei Ye Haolan Feng Xingbo Han Xiaoming Liang Haidong Sun Wenjun Zhang Xiaoyong Cao | 2023 | Underground Space2023，，1： | 0 |
| 9 | Gain of function screen of PATs reveals an essential role of Hip14 in Drosophila host defense显示文摘The innate immune system is the first line of host defense against the invading pathogens in multicellular organisms,which is the key to eliminating pathogen infections,mitigating pathogen-induced inflammation,and activating adaptive immunity(Buchon et al.,2014;Liu and Cao 2016). | Zhu Deng Hui Chen Lingling Xiao Haolan Jin Qinhao Zhang Renjie Jiao Chuanxian Wei | 2023 | Journal of Genetics and Genomics2023，50，12： | 0 |
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