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| 1 | Cationic conjugated polymers for homogeneous and sensitive fluorescence detection of hyaluronidase显示文摘The cationic charged water-soluble polyfluorenes containing 2,1,3-benzothiadiazole (BT) units (P1-3) have been synthesized and characterized. These polymers demonstrate intramolecular energy transfer from the fluorene units to the BT sites when oppositely charged hyaluronan is added due to the formation of electrostatic complexes, followed by a shift in emission color from blue to green or brown. Upon adding hyaluronidase, the hyaluronan is cleaved into fragments. The relatively weak electrostatic interactions of hyaluronan fragments with polyfluorenes keep their main chains separated and energy transfer from the fluorene units to the BT sites is inefficient, and the polyfluorenes recover their blue emissions. The complexes of conjugated polymers/hyaluronan can be utilized as probes for sensitive and facile fluorescence assays for hyaluronidase. The new assay method interfaces with the aggregation and light harvesting properties of conjugated polymers. | AN LingLing LIU LiBing WANG Shu | 2009 | Science China Chemistry2009，52，6： | 5 |
| 2 | Living Bacteria-Mediated Aerobic Photoinduced Radical Polymerization for in Situ Bacterial Encapsulation and Differentiation显示文摘Conventional polymerizations mediated by living cells typically require synthetic transition-metal complexes or photoredox catalysts.Herein,we report an alternative photoinduced polymerization strategy for preparing functional polymer hydrogels through bacteria-initiated radical polymerization of acrylamides in ordinary culture media.Upon light irradiation under ambient conditions,polyacrylamides were obtained with molecular weights of over 150 kDa using various bacteria. | Huan Lu Yiming Huang Fengting Lv Libing Liu Yuguo Ma Shu Wang | 2021 | CCS Chemistry2021，3，7： | 2 |
| 3 | Conjugated Polymer Nanomaterials for Phototherapy of Cancer显示文摘Due to the excellent properties including high specificity,low side-effect and good biocompatibility,conjugated polymer nanomaterials have been served as efficient anticancer reagents in die past decades.According to the developed anticancer systems based on conjugated polymer nanomaterials,it could be summarized into three main cancer therapy strategies:photodynamic therapy(PDT),photothermal therapy(PTT)and combination therapy.In this mini review,we provide a brief introduction to three different cancer therapy modes,their mechanisms and potential biological applications.Furthermore,some perspectives on the further development of conjugated polymer nanomaterials are proposed in the territory of anticancer precision medicine. | FU Xuancheng BAI Haotian LYU Fengting LIU Libing WANG Shu | 2020 | Chemical Research in Chinese Universities2020，36，2： | 2 |
| 4 | Oligo(p-phenylenevinylene)-rhodium complex as intracellular catalyst for enhancing biosynthesis of polyhydroxybutyrate biomaterials显示文摘Microbial synthesis utilizes sustainable resources to produce valuable chemicals,as a potential alternative to petroleum-based chemical industry.Although metabolic engineering is an efficient method to enhance the biosynthesis efficacy of microorganisms,it requires complicated biological procedures.Herein,we report a facile intracellular catalysis system for augmenting the production of bio-based material in microorganism.Covalent linking of oligo(p-phenylenevinylene)(OPV)and cyclopentadienyl rhodium(Ⅲ)bipyridine offers intracellular metal catalyst(OPV-Rh).The OPV-Rh complex displayed certain resistance to toxic biomolecules,which guaranteed its catalytic activity in complicated biological systems.With uptake by Gramnegative bacterium Ralstonia eutropha H16(R.eutropha H16),the OPV-Rh complex promotes the transformation of intracellular NADP+to NADPH,which further enhances the biosynthesis of polyhydroxybutyrate(PHB)by this microorganism.This work demonstrates that synthetic metal catalyst can be employed for regulating microbial biosynthesis intracellularly. | Nan Dai Hao Zhao Wen Yu Fengting Lv Libing Liu Shu Wang | 2021 | Science China Chemistry2021，64，1： | 2 |
| 5 | Cationic conjugated polymers for detection and inactivation of pathogens显示文摘Conjugated polymers(CPs) are referred to a kind of fluorescent polymer materials with delocalized π-conjugated backbones.For the last decades, cationic CPs(CCPs) have been widely used in biosensor, imaging and biomedical fields due to their good photophysical properties and solubility in water medium resulting from side chain modification with ionized moieties. In this mini-review, we mainly introduced the applications of CCPs in detection and inactivation of pathogen with typical examples, and also briefly discussed the relevant mechanisms. We hold the expectation that this mini-review can offer researchers a general reference and inspire them to construct new systems with high performances of pathogen detection and antimicrobial activity. | Ping He Fengting Lv Libing Liu Shu Wang | 2017 | Science China Chemistry2017，60，12： | 1 |
| 6 | Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability显示文摘Increasing multidrug-resistant(MDR) superbugs emerge worldwide causing a public health crisis. Consequently, it is urgent to find new antibiotics with efficient broad-spectrum antimicrobial activity. By virtue of versatility in molecular design, a new peptide-like cell membrane-broken molecule, oligo-(7,7′-bifluoren-benzo[c][1,2,5]thiadiazole)(OFBT) possessing a conjugated backbone and eight pendant guanidyl moieties was designed and synthesized. OFBT exhibits favorable broad-spectrum of antimicrobial activity to pathogens including Gram-negative and Gram-positive bacteria, and fungi with the minimum inhibitory concentration(MIC)below 3.0 μM. Moreover, OFBT exhibits high selectivity for pathogens over human cells to make it a promising broad spectrum antimicrobial agent. | Hui Chen Meng Li Zhang Liu Rong Hu Shengliang Li Yuan Guo Fengting Lv Libing Liu Yilin Wang Yuanping Yi Shu Wang | 2018 | Science China Chemistry2018，61，1： | 1 |
| 7 | Water-soluble fluorescent conjugated polymers and their interactions with biomacromolecules for sensitive biosensors 显示文摘 | Feng Xuli Liu Libing Wang Shu | 2010 | Chem Soc Rev2010，39，7： | 1 |
| 8 | Multiplex detection of KRAS and BRAF mutations using cationic conjugated polymers显示文摘The mutation detections of KRAS and BRAF genes are of significant importance to predict the responses to anti-cancer therapy and develop new drugs. In this paper, we developed a multi-step fluorescence resonance energy transfer (FRET) assay for multiplex detection of KRAS and BRAF mutations using cationic conjugated polymers (CCP). The newly established detection system could detect as low as 2% mutant DNAs in DNA admixtures. By triggering the emission intensity change of CCP and the dyes labeled in the DNA, four possible statuses (three mutations and one wildtype) can be differentiated in one extension reaction. The detection efficiency of this new method in clinical molecular diagnosis was validated by determining KRAS and BRAF mutations of 51 formalin-fixed paraffin-embedded (FFPE) ovary tissue samples. Furthermore, the result of the CCP-based multi-step FRET assay can be directly visualized under UV light so that no expensive instruments and technical expertise are needed. Thus, the assay provides a sensitive, reliable, cost-effective and simple method for the detection of disease-related gene mutations. | XING BaoLing SONG JinZhao GE SuMei TANG ZhengHua LIU MengLu YANG Qiong Lü FengTing LIU LiBing WANG Shu | 2013 | Chinese Science Bulletin2013，58，8： | 1 |
| 9 | In Situ-Induced Multivalent Anticancer Drug Clusters in Cancer Cells for Enhancing Drug Efficacy显示文摘Increasing intracellular drug concentration is an effec-tive way for cancer chemotherapeutics to enhance efficacy and combat drug resistance.In this work,a series of anticancer drug conjugates were prepared by linking thiol-modified oligo(p-phenylene viny-lene)with paclitaxel,vincristine,teniposide,tamoxi-fen,doxorubicin,or podophyllotoxin(OPV-S-Drugs)through a Michael addition reaction. | Lingyun Zhou Fengting Lv Libing Liu Shu Wang | 2019 | CCS Chemistry2019，1，1： | 1 |
| 10 | Nucleic acids analysis显示文摘Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic analysis.During the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological breakthroughs.In this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided. | Yongxi Zhao Xiaolei Zuo Qian Li Feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian Huang Yanyi Huang Guoliang Ke Hua Kuang Fan Li Jiang Li Min Li Na Li Zhenyu Lin Dingbin Liu Juewen Liu Libing Liu Xiaoguo Liu Chunhua Lu Fang Luo Xiuhai Mao Jiashu Sun Bo Tang Fei Wang Jianbin Wang Lihua Wang Shu Wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-Feng Yuan Quan Yuan Chao Zhang Zhi Zhu Chaoyong Yang Xiao-Bing Zhang Huanghao Yang Weihong Tan Chunhai Fan | 2021 | Science China Chemistry2021，64，2： | 1 |
| 11 | Relationship between charac- teristics of virtual brand community and brand attach- ment for Nokia BBS users 显示文摘 | Libing Shu Haolan Zhang | 2013 | Journal of Computers2013，8，12： | 1 |
| 12 | Protein-assisted conjugated polymer microarray: Fabrication and sensing applications显示文摘A new strategy is performed to fabricate conjugated polymer microarray with the assistance of protein in this work.The water-soluble cationic conjugated polymer employed in the present work is capable of absorbing light at 510 nm,which makes it compatible with a variety of commercial microarray scanners.It is demonstrated that the protein-assisted conjugated polymer microarray exhibits higher fluorescence signal and better stability in comparison with the case without protein.The conjugated polymer microarray can be used for sensitive detection of picric acid(PA).A major advantage of our approach is its simplicity and chemical linking is not required between the conjugated polymer and microarray substrate.Considering the simplicity of the preparation of the conjugated polymer microarray,it is anticipated that novel sensing platforms will be constructed by employing this versatile method. | Lü FengTing FENG XuLi LIU LiBing WANG Shu | 2013 | Chinese Science Bulletin2013，58，33： | 0 |
| 13 | Conjugated polymer nanoparticles as fluorescence switch for selective cell imaging显示文摘Fluorescence switch plays a vital role in bioelectronics and bioimaging.Herein,we presented a new kind of facile electrostatic complex nanoparticles(ECNs)for fluorescence switching in cells and marking of individual cell.The ECNs were prepared by mixing positively charged poly(6-(2-(thiophen-3-yl)ethoxy)hexyl trimethylammonium bromide)(PT)and negatively charged diarylethene sodium salt(DAECOONa).DAE-COONa is a photoswitchable molecule which can be transformed between the ring-closed fo rm and ring-open form under the irradiation of UV or visible light.The closed-form of DAE-COONa can efficie ntly quench the fluorescence of PT through intermolecular energy transfer,while the open form of DAE-COONa does not influence the emission of PT.Thus,the fluorescence of ECNs can be modulated by light irradiation,and the ECNs with good fluorescence switching performance have been employed for fluorescence imaging and individual cell lighting up process successfully.We demonstrate that the electrostatic complex strategy provides a facile method to construct fluorescence switch fo r selective cell marking and imaging applications. | Ke Peng Fengting Lv Huan Lu Jianwu Wang Hao Zhao Libing Liu Shu Wang | 2020 | Chinese Chemical Letters2020，31，3： | 0 |
| 14 | Effects of Microbial Fertilizers in Improving Acidic Tobacco-planting Soil and Tobacco Leaf Quality显示文摘[Objectives]This study was conducted to improve acidic soil and enhance the quality of tobacco leaves.[Methods]The effects of different microbial fertilizers on improving acidic tobacco-planting soil and tobacco leaf quality were investigated through plot experiments.[Results]The application of microbial fertilizers could improve the pH value of acidic soil,and composite microbial agent A showed the best application effect.The application of bio-organic fertilizer was beneficial to improving the contents of available phosphorus and available boron in acidic soil.The application of composite microbial agent A was beneficial to improving the contents of available phosphorus and available potassium in acidic soil,and could promote the growth of tobacco plants and improve the economic traits of flue-cured tobacco and the coordination of chemical components in tobacco leaves.The application of composite microbial agent B led to a downward trend in the content of available boron in acidic soil.The application of composite microbial agent B could promote the absorption of nutrients by tobacco plants,and improve their disease resistance and the quality of tobacco leaves.Due to the differences in functional microorganisms contained,the application effects of different microbial fertilizers in improving acidic tobacco-planting soil and improving tobacco leaf quality varied.Overall,the application of microbial fertilizers could increase soil pH,activate soil nutrients,promote tobacco growth,enhance disease resistance,increase tobacco output value,and improve tobacco quality.Microbial fertilizers have good application prospects in improving acidic soil and improving tobacco quality.[Conclusions]The application of microbial fertilizers to improve acidic tobacco-planting soil can ensure the normal growth and development of tobacco plants and the improvement of tobacco leaf quality,achieving high-quality and sustainable development of Zhaotong tobacco. | Xia NI Shungang SHEN Xianyi ZENG Dewen LI Yeming FU Min CHEN Chaokai YU Libing QI Ying-guo RUAN Changchong ZI Haohan GONG Guangjun HU Mengsheng ZHANG Xu ZHANG Shu PENG Hongbing LI | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
| 15 | Electrochemical Regulation of Antibacterial Activity Using Ferrocene-Containing Antibiotics显示文摘The widespread use of antibiotics causes the accumulation of a large amount of antibiotics in the environment.Excessively active antibiotics in the environment results in the emergence of bacterial resistance.Building smart antibiotics capable of reversible regulation between active and inactive states on demand is a promising approach to address this issue.Herein,a ferrocene-containing quaternary ammonium compound has been developed for electrochemical redox-controlled bacterial inhibition.The reversible switch of the reduced and oxidized ferrocene groups between hydrophobic and hydrophilic states triggers the assembly and disassembly of the micelles while modulating the interactions of antibiotic molecules with the bacteria membrane,providing a new way to regulate antibacterial activity.In addition,the alternate use of reduced and oxidized antibiotics exhibits a favorable effect in preventing bacterial resistance.Thus,an unconventional strategy is offered to prevent the build-up of active bactericide in the environment and decrease bacterial resistance. | Song Shen Yiming Huang Anran Yuan Fengting Lv Libing Liu Shu Wang | 2021 | CCS Chemistry2021，3，11： | 0 |
| 16 | Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)显示文摘The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system. | Xuming Mo Wei Cai Jirong Qi Zhuoming Xu Ying Wang Weihui Yan Shoujun Li Nianguo Dong Xinxin Chen Jinfen Liu Qiang Shu Jimei Chen Haibo Zhang Hao Zhang Quansheng Xing Qi An Xiaofeng Li Xu Wang Yan He Junwu Su Taibing Fan Teng Ming Weibing Tang Li Hong Jinghao Zheng Ming Ye Guocheng Sun Yiqun Ding Liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang Libing Zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui Chen Chun Wu Zhiyu Feng Caixia Liu Yaping Mi Rufang Zhang Ke Lin Xin Li Mingan Pi Xiangming Fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei Chen Shuguang Tao Yaqin Shu Huifeng Zhang Lan Jiang Min Da Nishant Patel Liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association | 2023 | Congenital Heart Disease2023，18，6： | 0 |
| 17 | Synthesis of amphiphilic poly(fluorene) derivatives for selective imaging of Staphylococcus aureus显示文摘Three amphiphilic poly(fluorene-co-phenylene) derivatives with different side chains(PFP-1, PFP-2, PFP-3) were designed and synthesized for exploring their detection and imaging of pathogens. Upon incubation with six kinds of different pathogens, it was found the three polymers could selectively interact with Staphylococcus aureus(S. aureus). Their selective imaging towards S. aureus were thus realized. The selective imaging towards S. aureus was also confirmed even under the blend of microbes. PFP-3 shows stronger fluorescence imaging signal than PFP-1 and PFP-2. Zeta potential and isothermal titration microcalorimetry(ITC) tests demonstrated that both electrostatic interactions and hydrophobic interactions played important roles in the binding between PFPs and pathogens. Thus, amphiphilic PFP-3 exhibits great potential for specific imaging of S. aureus in a simple and rapid manner. | Ping He Fengting Lv Libing Liu Shu Wang | 2018 | Science Bulletin2018，63，14： | 0 |
| 18 | MDR1-targeted siRNA delivery with cationic dendritic conjugated polymers显示文摘A cationic dendritic polyfluorene (PFP) is examined as a siRNA delivery vector. This material was designed to facilitate the nucleic acid binding, encapsulation and efficient cellular uptake. PFP can effectively protect siRNA against nuclease degradation, which is necessary for gene carriers. PFP can be used for multidrug resistance gene-targeted siRNA delivery in doxorubicin (Dox)-resistant human breast cancer cells (MCF7) cells. As a siRNA transfection agent, PFP can efficiently achieve the reversal of drug resistance and enhance the drug sensitivity. These new features and capabilities represent a major step toward conjugated polymers that can function for therapeutic application. | FENG XuLi Lü FengTing LIU LiBing WANG Shu | 2013 | Chinese Science Bulletin2013，58，22： | 0 |
| 19 | Selective biocompatibility and responsive imaging property of cationic conjugated polyelectrolyte to cancer cells显示文摘Optical imaging, as an important molecular imaging modality, has emerged many attractions in studying the biological or molecular events both in cell level and living subject because of its high resolution and sensitivity, noninvasive manner and low cost. Herein, we bring novel insights into a water-soluble conjugated polyelectlyte by deeply studying its properties in cells. Poly(9, 9-bis(6'-N,N,N-trimethylammonium hexyl)fluorene phenylene)(PFP), a good biosensing material, was studied in this paper. The biocompatibility of PFP was investigated in different cells, and cell cycle analysis was carried out to explore the reasons of different biocompatibility of PFP to cells. After irradiation, fluorescence enhancement of blue emission and turn-on of long-wavelength emission of PFP in HepG2 cells was observed, which was first reported as far as we know. The differentiated biocompatibility of PFP and its particular imaging properties in cancer cells can help to guide the application of conjugated polymers in cells and provide a new dimension in designing sensitive and responsive imaging materials. | Bing Wang Chenyao Nie Libing Liu Fengting Lv Shu Wang | 2017 | Chinese Chemical Letters2017，28，10： | 0 |
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