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| 1 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 2 | Marine Carbon-Sulfur Biogeochemical Cycles during the Steptoean Positive Carbon Isotope Excursion(SPICE) in the Jiangnan Basin, South China显示文摘Global occurrences of Steptoean Positive Carbon Isotope Excursion(SPICE) during Late Cambrian recorded a significant perturbation in marine carbon cycle, and might have had profound impacts on the biological evolution. In previous studies, SPICE has been reported from the Jiangnan slope belt in South China. To evaluate the bathymetric extent of SPICE, we investigate the limestone samples from the upper Qingxi Formation in the Shaijiang Section in the Jiangnan Basin. Our results show the positive excursions for both carbonate carbon(δ^(13)C) and organic carbon(δ^(13)C_(org)) isotopes, as well as the concurrent positive shifts in sulfur isotopes of carbonate associated sulfate(CAS, δ^(34)S_(CAS)) and pyrite(δ^(34)S_(pyrite)), unequivocally indicating the presence of SPICE in the Jiangnan Basin. A 4‰ increase in δ^(13)C_(carb) of the Qingxi limestone implies the increase of the relative flux of organic carbon burial by a factor of two. Concurrent positive excursions in δ^(34)S_(CAS) and δ^(34)S_(pyrite) have been attributed to the enhanced pyrite burial in oceans with extremely low concentration and spatially heterogeneous isotopic composition of seawater sulfate. Here, we propose that the seawater sulfur isotopic heterogeneity can be generated by volatile organic sulfur compound(VOSC, such as methanethiol and dimethyl sulfide) formation in sulfidic continental margins that were widespread during SPICE. Emission of 32S-enriched VOSC in atmosphere, followed by lateral transportation and aerobic oxidation in atmosphere, and precipitation in open oceans result in a net flux of ^(32)S from continental margins to open oceans, elevating δ^(34)S of seawater sulfate in continental margins. A simple box model indicates that about 35% to 75% of seawater sulfate in continental margins needs to be transported to open oceans via VOSC formation. | Yang Peng Yongbo Peng Xianguo Lang Haoran Ma Kangjun Huang Fangbing Li Bing Shen | 2016 | Journal of Earth Science2016，27，2： | 5 |
| 3 | Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing,membrane fusion,and viral infectivity显示文摘Dear Editor,By the end of June 2020,the pandemic of coronavirus diseases 2019(COVID-19)had resulted in more than 10 million individuals,all over the world,being infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).1 The high contagiousness of SARS-CoV-2 virus was largely attributed to the relatively unique sequence composition in its spike(S)glycoprotein,which is in charge of the host entry by interacting with its cellular receptor angiotensin-converting enzyme 2(ACE2).2,3 The S glycoprotein can be processed into an N terminal S1 fragment that is responsible for receptor binding,and a C terminal S2 fragment that functions to promote membrane fusion.4 SARS-CoV-2 is a type of single-stranded positive-sense ribonucleic acid(RNA)virus,and an increasing number of mutations were identified across the SARS-CoV-2 genome,including the region encoding S glycoprotein.Nevertheless,the functional implications of these mutations remain largely unknown,we here reported the mutation analysis of S gene and a functional exploration of the dominant D614G mutation. | Xiaoyi Jiang Zhengrong Zhang Chenxi Wang Hongguang Ren Lihua Gao Haoran Peng Zubiao Niu He Ren Hongyan Huang Qiang Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 4 | Three Tiaobu Feishen therapies protect human alveolar epithelial cells against cigarette smoking and tumor necrosis factor-mlear factor-kappa B pathwayα-induced inflamation by nuc显示文摘OBJECTIVE: To investigate the efficacy of Tiaobu Feishen formulae(TBFS), including Bufei Jianpi formula(BJF), Bufei Yishen formula(BYF), and Yiqi Zishen formula(YZF), on inflammatory response, protease-anti-protease imbalance and collagen deposition in rats.METHODS: In present work, we used an in vitro model of cigarette smoking extract(CSE)-and tumor necrosis factor-α(TNF-α)-induced A549 cellsto examine the efficacy of BJF, BYF and YZF on the production of inflammatory cytokines, including TNF-α and interleukin(IL)-8, IL-6, matrix metalloproteinases(MMP)-9, and IL-10 in CSE or TNF-ls. And their related transcripα-induced A549 celtion factors and signaling pathway were also analyzed.RESULTS: The results showed that BJF, BYF and YZF could significantly decrease the expression levels of the pro-inflammatory cytokines induced by CSE or TNF-α. Furthermore, BJF, BYF and YZF could suppress CSE-or TNF-α-induced activation of nuclear factor-kappa B(NF-κB) transcription factors and its corresponding pathways. Taken together, these data implied that BJF, BYF and YZF effectively inhibited CSE-or TNF-α-induced inflammatory response in alveolar epithelial cell, which was due to their inhibition effect on NF-κB pathways.CONCLUSION: Our findings suggest that the Tiaobu Feishen therapies may protect human alveolar epithelial cells against cigarette smoking and TNF-α-induced inflammation. NF-κB pathway may involve in the actions. | Chen Yulong Wu Yaosong Li Jiansheng Feng Suxiang Hao Lili Liu Xuefang Zheng Wanchun Dong Haoran Qin Yanqin Yin Sugai Zhao Peng | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 5 | Heterogeneous Mg isotopic composition of the early Carboniferous limestone: implications for carbonate as a seawater archive显示文摘Carbonate precipitation and hydrothermal reaction are the two major processes that remove Mg from seawater.Mg isotopes are significantly(up to 5%)fractionated during carbonate precipitation by preferential incorporation of ^(24)Mg,while hydrothermal reactions are associated with negligible Mg isotope fractionation by preferential sequestration of^( 26)Mg.Thus,the marine Mg cycle could be reflected by seawater Mg isotopic composition(δ^(26)Mg_(sw)),which might be recorded in marine carbonate.However,carbonates are both texturally and compositionally heterogeneous,and it is unclear which carbonate component is the most reliable for reconstructing δ^(26)Mg_(sw).In this study,we measured Mg isotopic compositions of limestone samples collected from the early Carboniferous Huangjin Formation in South China.Based on petrographic studies,four carbonate components were recognized:micrite,marine cement,brachiopod shell,and mixture.The four components had distinct δ^(26)Mg:(1)micrite samples ranged from -2.86% to -2.97%;(2)pure marine cements varied from -3.40% to -3.54%,while impure cement samples containing small amount of Rugosa coral skeletons showed a wider range(-3.27% to-3.75%);(3)values for the mixture component were-3.17% and -3.49%;and (4)brachiopod shells ranged from -2.20% to -3.07%,with the thickened hinge area enriched in ^( 24)Mg.Due to having multiple carbonate sources,neither the micrite nor the mixture component could be used to reconstruct δ^(26)Mg_(sw).In addition,the marine cement was homogenous in Mg isotopes,but lacking the fractionation by inorganic carbonate precipitation that is prerequisite for the accurate determination of δ^(26)Mg_(sw).Furthermore,brachiopod shells had heterogeneous C and Mg isotopes,suggesting a significant vital effect during growth.Overall,the heterogeneous δ^(26)Mg of the Huangjin limestone makes it difficult to reconstruct δ^(26)Mg_(sw)using bulk carbonate/calcareous sediments.Finally,δ^(26)Mg_(sw)was only slightly affected by the faunal composition of carbonate-secreting organisms,even though biogenic carbonate accounts for more than 90% of marine carbonate production in Phanerozoic oceans and there is a wide range(0.2%–4.8%)of fractionation during biogenic carbonate formation. | Haoran Ma Yihe Xu Kangjun Huang Yuanlin Sun Shan Ke Yang Peng Xianguo Lang Zhen Yan Bing Shen | 2018 | Acta Geochimica2018，37，1： | 3 |
| 6 | Genome-wide analysis of NDR1/HIN1-like genes in pepper(Capsicum annuum L.)and functional characterization of CaNHL4 under biotic and abiotic stresses显示文摘Plant NDR1/HIN1-like(NHL)genes play an important role in triggering plant defenses in response to biotic stresses.In this study,we performed a genome-wide identification of the NHL genes in pepper(Capsicum annuum L.)and characterized the functional roles of these CaNHL genes in response to abiotic stresses and infection by different pathogens.Phylogenetic analysis revealed that CaNHLs can be classified into five distinct subgroups,with each group containing generic and specific motifs.Regulatory element analysis showed that the majority of the promoter regions of the identified CaNHLs contain jasmonic acid(JA)-responsive and salicylic acid(SA)-responsive elements,and transcriptomic analysis revealed that CaNHL genes are expressed in all the examined tissues of pepper.The CaNHL1,CaNHL4,CaNHL6,CaNHL10,CaNHL11,and CaNHL12 genes were significantly upregulated under abiotic stress as well as in response to different pathogens,such as TMV,Phytophthora capsici and Pseudomonas syringae.In addition,we found that CaNHL4 localizes to the plasma membrane.CaNHL4-silenced pepper plants display significantly increased susceptibility to TMV,Phytophthora capsici and Pseudomonas syringae,exhibiting reduced expression of JA-related and SA-related genes and reduced ROS production.However,transient overexpression of CaNHL4 in pepper increases the expression of JArelated and SA-related genes,enhances the accumulation of ROS,and inhibits the infection of these three pathogens.Collectively,for the first time,we identified the NHL genes in pepper and demonstrated that CaNHL4 is involved in the production of ROS and that it also regulates the expression of JA-related and SA-related genes in response to different pathogens,suggesting that members of the CaNHL family play an essential role in the disease resistance of pepper. | Changyun Liu Haoran Peng Xinyu Li Chaolong Liu Xing Lv Xuefeng Wei Aihong Zou Jian Zhang Guangjin Fan Guanhua Ma Lisong Ma Xianchao Sun | 2020 | Horticulture Research2020，7，1： | 2 |
| 7 | Analysis on the development status of intelligent and connected vehicle test site显示文摘With the development of automobile intelligence and connectivity,Intelligent and Connected Vehicle(ICV)is an inevitable trend in the transformation and upgrading of the automotive industry.The maturity of any advanced technology is inseparable from a large number of test verifications,especially the research and application of automotive technology require a large number of reliable tests for evaluation and confirmation.Therefore,the ICV Test Site(ICVTS)will become a key deployment area.In this paper,we analyze the development status of ICVTS outside and within China,summarize the shortcomings of the existing test sites,and put forward some targeted suggestions,in an effort to guide the development and construction of ICVTS towards the path that seems to be most promising. | Peng Zhi Rui Zhao Haoran Zhou Yanwu Zhou Nam Ling Qingguo Zhou | 2021 | Intelligent and Converged Networks2021，2，4： | 2 |
| 8 | A Great late Ediacaran ice age显示文摘The emergence of the Ediacara biota soon after the Gaskiers glaciation ca.580 million years ago(Ma)implies a possible glacial fuse for the evolution of animals.However,the timing of Ediacaran glaciation remains controversial because of poor age constraints on the∼30 Ediacaran glacial deposits known worldwide.In addition,paleomagnetic constraints and a lack of convincing Snowball-like cap carbonates indicate that Ediacaran glaciations likely did not occur at low latitudes.Thus,reconciling the global occurrences without global glaciation remains a paradox.Here,we report that the large amplitude,globally synchronous ca.571–562 Ma Shuram carbon isotope excursion occurs below the Ediacaran Hankalchough glacial deposit in Tarim,confirming a post-Shuram glaciation.Leveraging paleomagnetic evidence for a∼90°reorientation of all continents due to true polar wander,and a non-Snowball condition that rules out low-latitude glaciations,we use paleogeographic reconstructions to further constrain glacial ages.Our results depict a‘Great Ediacaran Glaciation’occurring diachronously but continuously from ca.580–560 Ma as different continents migrated through polar–temperate latitudes.The succession of radiation,turnover and extinction of the Ediacara biota strongly reflects glacial–deglacial dynamics. | Ruimin Wang Bing Shen Xianguo Lang Bin Wen Ross N.Mitchell Haoran Ma Zongjun Yin Yongbo Peng Yonggang Liu Chuanming Zhou | 2023 | National Science Review2023，10，8： | 2 |
| 9 | PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study显示文摘Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular risks.In addition,an association between PM_(2.5) and gut microbiota and metabolites was established.The above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence. | Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang Fuchang Deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi | 2022 | The Innovation2022，3，2： | 2 |
| 10 | Cracking the superheavy pyrite enigma:possible roles of volatile organosulfur compound emission显示文摘The global deposition of superheavy pyrite(pyrite isotopically heavier than coeval seawater sulfate in the Neoproterozoic Era and particularly in the Cryogenian Period)defies explanation using the canonical marine sulfur cycle system.Here we report petrographic and sulfur isotopic data(δ^(34)Spy)of superheavy pyrite from the Cryogenian Datangpo Formation(660–650 Ma)in South China.Our data indicate a syndepositional/early diagenetic origin of the Datangpo superheavy pyrite,with ^(34)S-enriched H_(2)S supplied from sulfidic(H_(2)S rich)seawater.Instructed by a novel sulfur-cycling model,we propose that the emission of ^(34)S-depleted volatile organosulfur compounds(VOSC)that were generated via sulfide methylation may have contributed to the formation of ^(34)S-enriched sulfidic seawater and superheavy pyrite.The global emission of VOSC may be attributed to enhanced organic matter production after the Sturtian glaciation in the context of widespread sulfidic conditions.These findings demonstrate that VOSC cycling is an important component of the sulfur cycle in Proterozoic oceans. | Xianguo Lang Zhouqiao Zhao Haoran Ma Kangjun Huang Songzhuo Li Chuanming Zhou Shuhai Xiao Yongbo Peng Yonggang Liu Wenbo Tang Bing Shen | 2021 | National Science Review2021，8，10： | 2 |
| 11 | A study of phase constitution near the interface of Mg/Al vacuum diffusion bonding 显示文摘 | Liu Peng Li Yajiang Geng Haoran | 2005 | Materials Letters2005，59，16： | 1 |
| 12 | A study of phase constitution near the interface of Mg/Al vacuum diffusion bonding显示文摘 | Liu Peng Li Yajiang Geng Haoran | 2005 | Materials Letters2005，59，2： | 1 |
| 13 | Investigation of interfacial structure of Mg/Al vacuum diffusion-bonded joint显示文摘 | Liu Peng Li Yajiang Geng Haoran | 2006 | Vacuum2006，80，5： | 1 |
| 14 | In situ grown TiN/N-TiO_(2)composite for enhanced photocatalytic H_(2)evolution activity显示文摘Titanium nitride(TiN)decorated N-doped titania(N-TiO_(2))composite(TiN/N-TiO_(2))is fabricated via an in situ nitridation using a hydrothermally synthesized TiO_(2)and melamine(MA)as raw materials.After the optimization of the reaction condition,the resultant TiN/NTiO_(2)composite delivers a hydrogen evolution activity of up to 703μmol/h under the full spectrum irradiation of Xelamp,which is approximately 2.6 and 32.0 times more than that of TiO_(2)and TiN alone,respectively.To explore the underlying photocatalytic mechanism,the crystal phase,morphology,light absorption,energy band structure,element composition,and electrochemical behavior of the composite material are characterized and analyzed.The results indicate that the superior activity is mainly caused by the in situ formation of plasmonic TiN and N-TiO_(2)with intimate interface contact,which not only extends the spectral response range,but also accelerates the transfer and separation of the photoexcited hot charge carrier of TiN.The present study provides a fascinating approach to in situ forming nonmetallic plasmonic material/N-doped TiO_(2)composite photocatalysts for high-efficiency water splitting. | Dong LIU Zhuqing YAN Peng ZENG Haoran LIU Tianyou PENG Renjie LI | 2021 | Frontiers in Energy2021，15，3： | 1 |
| 15 | Calcined polyani- line-iron composite as a high efficient cathodic catalyst in microbial fuel cells显示文摘 | Lai Bin Wang Peng Li Haoran | 2013 | Bioresource Technology2013，131，0： | 1 |
| 16 | A Novel Millimeter-Wave Channel Measurement Platform for 6G Intelligent Railway Scenarios显示文摘This paper presented a novel millimeterwave channel measurement platform for the 6G intelligent railway.This platform used phased array antenna with 64 elements and can support instant bandwidth up to 1 GHz.Combined with improved multi-tone sounding signals,the platform can enhance dynamic measurement capability in high-speed railway scenarios.We performed calibration works about frequency flatness,frequency offset and proved platform reliability with channel emulator based closed-loop verification.We also carried out field trials in high-speed railway carriage scenarios.Based on measurement results,we extracted channel characteristic parameters of path loss,power delay profile and delay spread to further verify the field measurement performance of the platform. | Dan Fei Chen Chen Peng Zheng Dongsheng Zhang Jingya Yang Haoran Chen Bo Ai | 2022 | China Communications2022，19，11： | 1 |
| 17 | Low-bandgap conjugated polymers based on benzodipyrrolidone with reliable unipolar electron mobility exceeding 1 cm^(2) V^(-1)s^(-1)显示文摘The employment of an intrinsic quinoidal building block,benzodipyrrolidone(BDP),on constructing conjugated polymers(PBDP-2F and PBDP-2CN)with high electron mobility and unipolar transport characteristic in polyethylenimine ethoxylated(PEIE)modified organic field-effect transistors(OFETs)is reported.The intrinsic quinoidal characteristic and excellent coplanarity of BDP can lower the lowest unoccupied molecular orbital(LUMO)levels and improve ordered interchain packing of the resulting polymers in solid states,which are favorable for electron-injection and transport.By using PEIE as the interlayer to block the hole injection,unipolar n-type transport characteristics with high electron mobility of 0.58 and 1.01 cm^(2) V^(-1)s^(-1)were achieved by the OFETs based on PBDP-2F and PBDP-2CN,respectively.More importantly,the extracted mobilities are highly reliable with the reliability factor of above 80%.To the best of our knowledge,PBDP-2CN is the very first quinoid-based conjugated polymer with reliable electron mobility exceeding 1 cm^(2) V^(-1)s^(-1).This work represents a significant step in exploring intrinsic quinoidal CPs for application in n-channel OFETs and logic complementary circuits. | Mingqun Yang Tian Du Xuxia Zhao Xuelong Huang Langheng Pan Shuting Pang Haoran Tang Zhongxiang Peng Long Ye Yunfeng Deng Mingliang Sun Chunhui Duan Fei Huang Yong Cao | 2021 | Science China Chemistry2021，64，7： | 1 |
| 18 | DualFace:Two-stage drawing guidance for freehand portrait sketching显示文摘Special skills are required in portrait painting, such as imagining geometric structures and facial detail for final portrait designs. This makes it a difficult task for users, especially novices without prior artistic training, to draw freehand portraits with high-quality details. In this paper, we propose dualFace, a portrait drawing interface to assist users with different levels of drawing skills to complete recognizable and authentic face sketches. Inspired by traditional artist workflows for portrait drawing, dualFace gives two-stages of drawing assistance to provide global and local visual guidance. The former helps users draw contour lines for portraits (i.e., geometric structure), and the latter helps users draw details of facial parts, which conform to the user-drawn contour lines. In the global guidance stage, the user draws several contour lines, and dualFace then searches for several relevant images from an internal database and displays the suggested face contour lines on the background of the canvas. In the local guidance stage, we synthesize detailed portrait images with a deep generative model from user-drawn contour lines, and then use the synthesized results as detailed drawing guidance. We conducted a user study to verify the effectiveness of dualFace, which confirms that dualFace significantly helps users to produce a detailed portrait sketch. | Zhengyu Huang Yichen Peng Tomohiro Hibino Chunqi Zhao Haoran Xie Tsukasa Fukusato Kazunori Miyata | 2022 | Computational Visual Media2022，8，1： | 1 |
| 19 | A study of phase constitution near the interface of Mg/A1 vacuum diffusion bonding显示文摘 | LIU Peng LI Yajiang GENG Haoran | 2005 | Materials Letters2005，59，16： | 1 |
| 20 | Microstructure characteristics in TIG welded joint of Mg/A1 dissimilar materials 显示文摘 | Liu Peng Li Yajang Geng Haoran | 2007 | Materials Letters2007，61，： | 1 |
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