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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Gender and chronic obstructive pulmonary disease: why it matters显示文摘 | Hart MK Postma D Mannino DM | 2007 | Am J Respir Crit Care Med2007，176，12： | 1 |
| 3 | Amblyopia:is visual loss permant显示文摘 | El Mallah MK Chakravarthy U Hart PM | 2000 | Br J Ophtalmol2000，84，9： | 1 |
| 4 | Amblyopia:is visual loss permanent?显示文摘 | El Mallah MK Chakravarthy U Hart PM | | 0，，： | 1 |
| 5 | Evidence for apoptosis in human athemsclemsis and in a rant vascular injury model 显示文摘 | Hart DK Handenschild CC Hong MK | 1995 | Am J Pathol1995，147，2： | 1 |
| 6 | The mode of action ofthe Bacillus thuringiensis vegetative insecticidal protein Vip3Adiffers from that of Cry1Ab-endotoxin显示文摘 | Lee MK Waiters E S Hope Hart | 2003 | Applied and Envi-ronmental Microbiology2003，69，： | 1 |
| 7 | Epidural abscess with spinal cord compression显示文摘 | Hart ES Puttaswamy MK | 2013 | Orthop Nurs2013，32，4： | 1 |
| 8 | Deletion of alphaneurexinⅡresults in autism-related behaviors in mice显示文摘 | Dachtler J Glasper J Cohen RN Ivorra J Jackson AJ Harte MK | 2014 | Transl Psychiatry2014，4，： | 1 |
| 9 | Increased N-acetylaspartate in rat striatum following long-term administration of haloperidol 显示文摘 | Harte MK Bachus SB Reynolds GP | 2005 | Schizophr Res2005，75，23： | 1 |
| 10 | The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes 显示文摘 | Piya MK Harte AL Sivakumar K | 2014 | Am J Physiol Endocrinol Metab2014，306，5： | 1 |
| 11 | The identification of irisin in human cerebrospinal fluid: influence of adiposity, meta- bolic markers, and gestational diabetes 显示文摘 | Piya MK Harte AL Sivakumar K | 2014 | Am J Physiol Endocrinol Metab2014，306，5： | 1 |
| 12 | As- sociation of PAX6 polymorphisms with high myopia in Hart Chi- nese nuclear families 显示文摘 | Hart W- Leung KH Fung WY Mak JY Li YM Yap MK | 2009 | Invest Ophthalmol Vis Sci2009，50，1： | 1 |
| 13 | Amblyopia: is visual loss permanent? 显示文摘 | E1 Mallah MK Chakravarthy U Hart PM | 2000 | Br J Ophthalmol2000，84，9： | 1 |
| 14 | Chronic obstructive pulmonary disease phenotypes:the future of COPD显示文摘 | Hart MK Agusti A Calverley PM | 2010 | Am J Respir Crit Care Med2010，182，5： | 1 |
| 15 | Pulmonary arterial enlargement and acute exacerbations of COPD显示文摘 | Wells JM Washko GR Hart MK | 2012 | N EnglJ Med2012，367，10： | 1 |
| 16 | Protection from Ebola virus mediated by cytotoxic T lymphocytes specific for the viral nucleoprotein显示文摘 | Wilson JA and MK Hart | 2001 | J Virol2001，75，： | 1 |
| 17 | The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study 显示文摘 | Kim V Hart MK Vance GB | 2011 | Chest2011，140，3： | 1 |
| 18 | Overtand relational egression on the playground:Correspondence amongdifferent informants显示文摘 | MCNEILLY-CHOQUE MK HART CH ROBINSON CC | 1996 | J Res Childhood Edu1996，11，1： | 1 |
| 19 | Ebola virus:the search for vaccines and treatments显示文摘 | Wilson JA Bosio CM Hart MK | 2001 | Cell Mol Life Sci2001，58，： | 1 |
| 20 | Fiber tracking by diffustion tensor imaging in corticospinal tract stroke :Topographical cor- relation with clinical symptoms显示文摘 | Lee iS Hart MK Kim SH | 2005 | Neuroimage2005，26，： | 1 |
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