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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling显示文摘 | Bauer B Hartz AM Pekcec A ei al | 2008 | Mol Pharmacol2008，73，： | 1 |
| 3 | Seizure-Induced Upregulation of P-glycoprotein at the Blood-Brain Barrier through Glutamate and COX-2 Signaling显示文摘 | Hartz AM Pekeec A | 2007 | Mol Pharmacol2007，，： | 1 |
| 4 | The naturalhistory of primary dysmen orrhea:a longitudinal study显示文摘 | Weismann A M Hartz A J Hansen M D | 2004 | Br J Obstet Gynaecol2004，111，4： | 1 |
| 5 | Novel glimepiride derivatives with potential as double-edged swords against type II diabetes显示文摘 | Müller G Schulz A Hartz D | 2010 | Arch Physiol Biochem2010，116，1： | 1 |
| 6 | Clinical signs of androgen excess as risk factors for coronary artery disease显示文摘 | Wild RA Grubb B Hartz A | | 0，，： | 1 |
| 7 | Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier显示文摘 | Bauer B Hartz A M Miller D S | | 0，，03： | 1 |
| 8 | Coordinated nuclear receptor regulation of the efflux transporter,Mrp2,and the phaseII metabolizing enzyme,GSTpi,at the blood-brain barrier显示文摘 | Bauer B Hartz A M Lucking J R | 2008 | J Cereb Blood Flow Metab2008，28，： | 1 |
| 9 | Rapid regulation of p-glycoprotein at the blood-brain barrier by endothelin-1显示文摘 | HARTZ A M BAUER B FRICKER G | 2004 | Mol Pharmacol2004，10，： | 1 |
| 10 | Factors that influence improvement for patients with poorly controlled type 2 diabetes显示文摘 | Hartz A Kent S James P | 2006 | Diabetes Res Clin Pract2006，74，3： | 1 |
| 11 | Factors that influence improvement for patients with poorly controlled type 2 diabetes显示文摘 | Hartz A Kent S James P | 2006 | Diabetes Res Clin Pract2006，74，3： | 1 |
| 12 | 显示文摘 | Hartz A J Noyes R Bentler SE | 2000 | Gen Hosp Psycheatry2000，22，3： | 1 |
| 13 | Curcumin inhibits the activity of ABCG2/BCRP 1, a multidrug resistance-linked ABC drug transporter in mice 显示文摘 | Shukla S Iaher H Hartz A | 2009 | Pharm Res2009，26，2： | 1 |
| 14 | The association of obesity with infertility and related menstural abnormalities in women显示文摘 | Hartz AJ Barboriak PN Wong A | 1978 | Intern J Obesity1978，3，1： | 1 |
| 15 | Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier显示文摘 | Bauer B Hartz A M S Fricker G Miller D S | 2004 | Mol Pharmacol2004，66，： | 1 |
| 16 | The association of waist hip ratio and angiographically determined coronary artery disease显示文摘 | Grubb B Wild R | 1990 | International Journal of Obesity1990，14，： | 1 |
| 17 | Seizure-Induced Up-Regulation of P-Olycoprotein at the Blood- Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling显示文摘 | Bjorn Bauer Hartz AM Pekcec A | 2008 | Molecular Pharmacology Fast Forward2008，2，1： | 1 |
| 18 | Relationship of body fat distribution to blood pressure, carbohydrate tolerance,and plasma lipids in healthy obese women显示文摘 | KALKHOFF R K HARTZ A H RUPLEY D | 1983 | J Lab Clin Med1983，102，： | 1 |
| 19 | Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants 显示文摘 | Weissman A M Levy B T Hartz A J | 2004 | Am J Psychiatry2004，161，6： | 1 |
| 20 | Improvement in resource utilization after development of a clinical pathway for patients with pressure ulcers 显示文摘 | Dzwierzynski WW Spitz K Hartz A | 1998 | Plast Reeonstr Surg1998，102，6： | 1 |
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