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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Moisture level and movement effects on methane production rates in landfill samples显示文摘 | Hartz K E Ham R K | 1983 | Waste management and research1983，，1： | 1 |
| 3 | Managing fruit solu- ble solids with late-seasan deficitirrigation in drip-irrigated processing tomato production 显示文摘 | Johnstone P R Hartz T K LeStrange M | 2005 | Hortscience2005，40，6： | 1 |
| 4 | Coordinated nuclear receptor regulation of the efflux transporter,Mrp2,and the phaseII metabolizing enzyme,GSTpi,at the blood-brain barrier显示文摘 | Bauer B Hartz A M Lucking J R | 2008 | J Cereb Blood Flow Metab2008，28，： | 1 |
| 5 | Temperature effects:methane generation from landfill samples显示文摘 | HARTZ K E KLINK R E HAM R K | 1982 | Journal of the Environmental Engineering Division1982，108，4： | 1 |
| 6 | 显示文摘 | Hartz A J Noyes R Bentler SE | 2000 | Gen Hosp Psycheatry2000，22，3： | 1 |
| 7 | 'Ready to roll up their sleeves' : Creating scenarios of unity in employee magazines显示文摘 | Hartz R Habscheid S | 2006 | Intervention Research2006，，2： | 1 |
| 8 | On-farm assessment of soil quality in California's central valley显示文摘 | Andrews SS Mitchell JP Mancinelli R Karlen DL Hartz TH Horwath WR Pettygrove GS Scow KM Munk DS | | 0，，： | 1 |
| 9 | Coronary embolism following atrial septal defect repair显示文摘 | Backer C L Hartz R S Meyers S N | 1988 | Ann Thorac Surg1988，45，5： | 1 |
| 10 | The association of waist hip ratio and angiographically determined coronary artery disease显示文摘 | Grubb B Wild R | 1990 | International Journal of Obesity1990，14，： | 1 |
| 11 | Unexplained symptoms in primary care:perspectives of doctors and patients显示文摘 | Hartz AJ Noyes R Bentler SE | | 0，，03： | 1 |
| 12 | Relationship of body fat distribution to blood pressure, carbohydrate tolerance,and plasma lipids in healthy obese women显示文摘 | KALKHOFF R K HARTZ A H RUPLEY D | 1983 | J Lab Clin Med1983，102，： | 1 |
| 13 | Relationship between soil phosphorus availability and phosphorus loss potential in runoff and drainage显示文摘 | HARTZ T K and JOHMSTONE P R | 2006 | Communications in Soil Science and Plant Analysis2006，37，1112： | 1 |
| 14 | Potassium requirements for maximun yield and fruit quality of processing tomato显示文摘 | Hartz H K Miyao G Mullen R J | 1999 | Journal of the American Society for Horticultural Science1999，124，： | 1 |
| 15 | Managing fruit soluble solids with late-season deficit irrigation in drip-irrigated processing tomato production显示文摘 | Johnstone P R Hartz T K LeStrange M | 2005 | Hortscience2005，40，6： | 1 |
| 16 | Predictors of mortality in pul- monary thromboendarterectomy 显示文摘 | Hartz R Byrne J Levitsky S | 1996 | Ann Thorac Surg1996，62，： | 1 |
| 17 | Unexplained symptoms in primary care : perspectives of doctors and patients 显示文摘 | Hartz AJ Noyes R Bentler SE | 2000 | Gen Hosp Psychiatry2000，22，3： | 1 |
| 18 | Use of soil solarization to control fu sarium wilt of watermelon显示文摘 | Martyn R D Hartz T K | 1986 | Plant Disease1986，70，8： | 1 |
| 19 | Temperature effects: Methane generation from landfill samples显示文摘 | HARTZ K E KLINK R E HAM R K | 1982 | Journal of the Environment Engineering Divison- ASCE1982，108，4： | 1 |
| 20 | Mesenterictumefac tions 显示文摘 | Hartz R StrykerS SparbergM | 1980 | Am Surg1980，46，5： | 1 |
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