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| 1 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet . 2005 (9472)2005，，9472： | 6 |
| 2 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 4 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | 2005 (9472)2005，，9472： | 2 |
| 5 | 英国私营企业的可持续供应链管理显示文摘目前,私营企业越来越关注购买和供应产品和服务时的可持续性,也即称为'可持续供应链管理',利用采购活动来减少对环境、经济和社会的负面影响。但是言辞和现实之间经常会有差距,企业经常因标榜绿色耍嘴皮子而受到指责。该研究将探讨可持续供应链在7个处于各自行业领先地位的企业的实施情况,并探究影响可持续供应链的因素及将来会有哪些变化。 | Helen Walker Neil Jones 李玉荣 | 2015 | 世界农业2015，，1： | 2 |
| 6 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 2 |
| 7 | Risk in supply networks显示文摘 | Christine Harland Richard Brenchley Helen Walker | 2003 | Journal of Purchasing and Supply Management2003，，2： | 1 |
| 8 | A study of the dispersion and transport of reactive pollutants in and above street canyons a large eddy simulation 显示文摘 | Jacob Baker Helen L Walker Xiaoming Cai | 2004 | Atmosheric Environment2004，38，12： | 1 |
| 9 | Elements affecting wound healing time: An evidence based analysis显示文摘 | Hanan Khalil Marianne Cullen Helen Chambers Matthew Carroll Judi Walker | 2015 | Wound Rep and Reg2015，，4： | 1 |
| 10 | A study of the dispersion and transport of reactive pollutants in and above street canyons-a large eddy simulation显示文摘 | Jacob Baker Helen L Walker Xiaoming Cai | 2004 | Atmospheric Environment2004，38，12： | 1 |
| 11 | Outsourcing: assessing the risks and benefits for organisations, sectors and nations显示文摘 | Christine Harland Louise Knight Richard Lamming Helen Walker | 2005 | International Journal of Operations & Production Management2005，，9： | 1 |
| 12 | A study of the dispersion and transport of reactive pollutants in and above street canyons-a large eddy simulation 显示文摘 | Jacob Baker Helen L Walker Xiaoming Cai | 2004 | Atmospheric Environment2004，38，12： | 1 |
| 13 | Risk in supply networks, 显示文摘 | Christine Harland Richard Brenchley Helen Walker | 2003 | Journal of Purchasing & Supply Management2003，9，： | 1 |
| 14 | The Importance of Diagnostic Cytogenetics on Outcome in AML:Analysis of 1,612 Patients Entered Into the MRC AML 10 Tr-ial显示文摘 | David Grimwade Helen Walker Fiona Oliver | 1998 | Blood1998，92，7： | 1 |
| 15 | Self-organization, evolutionary and rev-olutionary change in organizations显示文摘 | DOY SUNDARASARADULA HELEN HASAN DAVID S WALKER | 2005 | Strategic Change2005，14，7： | 1 |
| 16 | Risk in supply networks显示文摘 | Christine Harland Richard Brenchley and Helen Walker | 2003 | Journal of Purchasing and Supply Management2003，9，2： | 1 |
| 17 | A study of the dispersion and transport of reactive pollutants in and above street canyons-a large eddy simulation 显示文摘 | Jacob Baker Helen L Walker Xiaoming Cai | 2004 | Atmospheric Environment2004，38，39： | 1 |
| 18 | Abnormal cytokine levels in non-pregnant women with a history of recurrent miscarriage显示文摘 | Rhoda Wilson Carol Jenkins Helen Miller Iain B McInnes Judith Moore Marjorie A McLean James J Walker | 2004 | European Journal of Obstetrics and Gynecology2004，，1： | 1 |
| 19 | Risk in supply networks 显示文摘 | Christine Harland Richard Brenchley Helen Walker | 2003 | Journal of Purchasing and Supply Management2003，9，2： | 1 |
| 20 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 1 |
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