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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Seasonal variations of acute appendicitis and nonspecific abdominal pain in Finland显示文摘AIM:To investigate whether seasonal changes had an effect on the incidence of acute appendicitis(AA)or nonspecific abdominal pain(NSAP).METHODS:We carried out a national register study of all patients with a hospital discharge diagnosis of AA and acute NSAP in Finland.Data were analyzed for the whole country and correlated to seasonal and weather parameters(temperature,humidity).Moreover,additional sub-analyses were performed for five geographically different area of Finland.RESULTS:The observation period spanned 21 years,with 186558 appendectomies,of which 137528(74%)cases were reported as AA.The incidence of AA declined for 32%over the study period.The average incidence of the NSAP was 34/10000 per year.The mean annual temperature,but not relative humidity,showed clear geographical variations.The incidence of AA decreased significantly during the cold months of the year.No correlation was detected between temperature and incidence of NSAP.Humidity had a statistically significant impact on NSAP.CONCLUSION:The incidence of acute appendicitis is declining in Finland.We detected a clear seasonality in the incidence of AA and NSAP. | Imre Ilves Anne Fagerstrm Karl-Heinz Herzig Petri Juvonen Pekka Miettinen Hannu Paajanen | 2014 | World Journal of Gastroenterology2014，20，14： | 6 |
| 3 | Emulsifi cation of Partially Miscible Liquids Using Colloidal Parti cles: Nonspherical and Extended Domain Structures显示文摘 | Clegg P S Herzig E M Sehofield A B | 2007 | Langmuir2007，23，： | 1 |
| 4 | Hydrothermal silica chimney field in the Galapagos Spreading Center at 86°W 显示文摘 | Herzig P M Beckor K P Stoffers P | 1988 | Earth and Planetary Science Letters1988，89，： | 1 |
| 5 | Long-term follow up of factual knowledge after a single,randomised problem-based learning course显示文摘 | HERZIG S LINKE R M MARXEN B | 2003 | BMC Medical Education2003，，3： | 1 |
| 6 | Beam shaping for high power laser diode array by holographic optical elements in holographic systems显示文摘 | Herzig H P D(a)ndliker R Teijido J M | 1989 | Components and Applications1989，311，： | 1 |
| 7 | Passive bio - monitoring with lichens as a part of an integrated biological measuring system for monitoring air pollution in Switzerland 显示文摘 | Herzig R Liebendo rfer L Urech M | 1989 | International Journal of Environmental Analytical Chemistry1989，35，： | 1 |
| 8 | Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction显示文摘AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modif ication of dietary protein source and calcium. METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomicanalyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform. RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites. CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied. | Taru K Pilvi Tuulikki Seppnen-Laakso Helena Simolin Piet Finckenberg Anne Huotari Karl-Heinz Herzig Riitta Korpela Matej Orei Eero M Mervaala | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 9 | Is atrial fibrillation associated with poor outcome after thrombolysis?显示文摘 | Sanak D Herzig R Kral M | 2010 | J Neurol2010，257，6： | 1 |
| 10 | Flow of suspensions through porous media: Application to deep filtration 显示文摘 | Herzig J P Lecler D M LeGoff P | 1970 | Industrial and Engineering Chemistry1970，62，： | 1 |
| 11 | Tumor progression induced by the loss of E - cadherin independent of beta - catenin/ Tcf- mediated Wnt signaling 显示文摘 | Herzig M Savarese F Novatehkova M | 2007 | Oncogene2007，26，16： | 1 |
| 12 | Economic potential of sea-floor massive sulphidedeposits: Ancient and modern 显示文摘 | HERZIG P M | 1999 | Phil Trans R Soc Lond A1999，357，： | 1 |
| 13 | Tumor progression in- duced by the loss of E-cadherin independent of B-catenin/Tcfmedi- ated Wnt signaling 显示文摘 | Herzig M Savarese F Novatchkova M | 2007 | Oncogene2007，26，4： | 1 |
| 14 | Geology and volcanic facies architecture of the Lower Ordovician Waterloo massive sufide deposit,Australia显示文摘 | Monecke T Gemmell J B Herzig P M | 2006 | Economic Geology2006，101，： | 1 |
| 15 | Cardlovas- cular eeets of ghrelin antagonist in eomcfious mrs显示文摘 | VLASOVA M A JARVINEN K HERZIG K H | 2009 | Regtd Pept2009，156，： | 1 |
| 16 | Oxaliplatin - induced damage of cellular DNA 显示文摘 | Woynarowski J M Faivre S Herzig M C S | 2000 | Molecular pharmacology2000，58，5： | 1 |
| 17 | Hydrothermal mineralization from the Valu Fa Ridge, Lau back-arc basin(SW Pacific)显示文摘 | Herzig P M Von Stackelberg U and Petersen S | 1990 | Marine Mining1990，9，： | 1 |
| 18 | Potassic igneous rocks from the vicinity of epithermal gold mineralization,Lihir Island,Papua New Guinea显示文摘 | Muller D Franz L Herzig P M | 2001 | Lithos2001，57，： | 1 |
| 19 | TAG hydrothermal system显示文摘 | Herzig P M Humphnis S and Stokking L | 1994 | Joides Journal1994，20，： | 1 |
| 20 | Extra- cellular amyloid formation and associated pathology in neural grafts显示文摘 | Meyer Luehmann M Stalde M Herzig M C | 2003 | Nat Neurosci2003，6，： | 1 |
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