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| 1 | Role of the Arabidopsis thafiana NAC transcription factors ANAC019 and ANAC055 in regulating jasmonic acid-signaled defense responses显示文摘Jasmonic 酸(JA ) 是对草食动物攻击,病原体感染并且机械伤害调整植物防卫回答的重要植物激素。在这份报告,我们提供了生物化学、基因的证据证明 Arabidopsis thaliana NAC 家庭蛋白质 ANAC019 和 ANAC055 可能作为抄写使活跃之物工作调整辩护基因的导致 JA 的表示。在 JA 发信号的二 NAC 基因的角色与 anac019 anac055 被检验两倍异种并且与转基因的植物 overexpressing ANAC019 或 ANAC055。两倍变异的植物显示出的 anac019 anac055 稀释了导致 JA 的植物的存储 PROTEIN1 (VSP1 ) 和 LIPOXYGENASE2 (LOX2 ) 表示,而二 NAC 基因显示出的转基因的植物 overexpressing 提高了导致 JA 的 VSP1 和 LOX2 表示。二 NAC 基因的 导致JA 的表示取决于 COI1 和 AtMYC2 的功能和发现 ANAC019 的那 overexpression 部分救了 atmyc2-2 异种的JA相关的显型,带了我们到二 NAC 蛋白质 AtMYC2 下游地扮演调整 发信号JA 的防卫回答的一个假设。证实这个想法的进一步的证据来自观察到 necrotrophic 真菌的两倍异种高显示出的 anac019 anac055 的反应类似到 atmyc2-2 异种的。 | Qingyun Bu Hongling Jiang Chang-Bao Li Qingzhe Zhai Jie Zhang Xiaoyan Wu Jiaqiang Sun Qi Xie Chuanyou Li | 2008 | Cell Research2008，18，7： | 60 |
| 2 | A Transcriptional Network Promotes Anthocyanin Biosynthesis in Tomato Flesh显示文摘Dietary anthocyanins are important health-promoting antioxidants that make a major contribution to the quality of fruits. It is intriguing that most tomato cultivars do not produce anthocyanins in fruit. However, the purple tomato variety Indigo Rose, which has the dominant Aft locus combined with the recessive atv locus from wild tomato species, exhibits light-dependent anthocyanin accumulation in the fruit skin. Here, we report that Aft encodes a functional anthocyanin activator named SlAN2-like, while atv encodes a nonfunctional version of the anthocyanin repressor SlMYBATV. The expression of SlAN2-like is responsive to light, and the functional SlAN2-like can activate the expression of both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator in the activation of anthocyanin biosynthesis. We further showed that cultivated tomatoes contain nonfunctional alleles of SlAN2-like and therefore fail to produce anthocyanins. Consistently, expression of a functional SlAN2-like gene driven by the fruit-specific promoter in a tomato cultivar led to the activation of the entire anthocyanin biosynthesis pathway and high-level accumulation of anthocyanins in both the peel and flesh. Taken together, our study exemplifies that efficient engineering of complex metabolic pathways could be achieved through tissue-specific expression of master transcriptional regulators. | Chuanlong Sun Lei Deng Minmin Du Jiuhai Zhao Qian Chen Tingting Huang Hongling Jiang Chang-Bao Li Chuanyou Li | 2020 | Molecular Plant2020，13，1： | 17 |
| 3 | IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis显示文摘Macrophages acquire distinct phenotypes during tissue stress and inflammatory responses.Macrophages are roughly categorized into two different subsets named inflammatory M1 and anti-inflammatory M2 macrophages.We herein identified a unique pathogenic macrophage subpopulation driven by IL-23 with a distinct gene expression profile including defined types of cytokines.The freshly isolated resting mouse peritoneal macrophages were stimulated with different cytokines in vitro,the expression of cytokines and chemokines were detected by microarray,real-time PCR,ELISA and multiple colors flow cytometry.Adoptive transfer of macrophages and imiquimod-induced psoriasis mice were used.In contrast to M1-and M2-polarized macrophages,IL-23-treated macrophages produce large amounts of IL-17A,IL-22and IFN-γ.Biochemical and molecular studies showed that IL-23 induces IL-17A expression in macrophages through the signal transducer and activator of transcription 3(STAT3)-retinoid related orphan receptor-γ T (RORyT)pathway.T-bet mediates the IFN-γ production in IL-23-treated macrophages.Importantly,IL-23-treated macrophages signifi- cantly promote the dermatitis pathogenesis in a psoriasis-like mouse model.IL-23-treated resting macrophages express a distinctive gene expression prolife compared with M1 and M2 macrophages.The identification of IL-23-induced macrophage polarization may help us to understand the contribution of macrophage subpopulation in Th17-cytokines-related pathogenesis. | Yuzhu Hou Linnan Zhu Hongling Tian Hai-Xi Sun Ruoyu Wang Lianfeng Zhang Yong Zhao | 2018 | Protein & Cell2018，9，12： | 16 |
| 4 | Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions显示文摘在 Arabidopsis, nodulin 26-like 内在的蛋白质(捏) aquaporin 蛋白质的亚科由九个成员,组成哪个中的五个(NIP1; 1, NIP1; 2, NIP5; 1, NIP6; 1,并且 NIP7; 1 ) 以前被识别对亚砷酸盐可渗透。然而,角色在植物在亚砷酸盐的 root-to-shoot translocation 捏仍然保持糟糕理解。在这研究,用反向的基因策略, Arabidopsis NIP3; 1 被识别在亚砷酸盐压力条件下面在砷举起和 root-to-shoot 分发起一个重要作用。nip3; 1 loss-of-function 异种在亚砷酸盐忍耐显示了明显的改进为未葬生长和积累的更少砷在野类型的植物比那些射击,而 nip3; 1 nip1; 1 两倍异种显示出强壮的亚砷酸盐忍耐并且在亚砷酸盐压力条件下面改进了根和射击的生长。一个倡导者 -- glucuronidase 分析揭示了那 NIP3; 1 几乎专门在根被表示(与根尖端的异常) ,并且在酵母 Saccharomyces cerevisiae 的 heterologous 表示表明了那 NIP3; 1 能调停亚砷酸盐运输。一起拿,我们的结果建议那 NIP3; 1 在 Arabidopsis 涉及亚砷酸盐举起和 root-to-shoot translocation,可能作为被动、双向的亚砷酸盐 transporter。 | WenzhongXu Wentao Dai Huili Yan Sheng Li Hongling Shen Yanshan Chen Hua Xu Yangyang Sun Zhenyan He Mi Ma | 2015 | Molecular Plant2015，8，5： | 13 |
| 5 | Efficient generation of pink-fruited tomatoes using CRISPR/Cas9 system显示文摘Tomato(Solanum lycopersicum)is the leading vegetable crop worldwide and an essential component of a healthy diet(Lin et al.,2014;Du et al.,2017).Fruit color is regarded as one of the most important commercial traits in tomato(The Tomato Genome Consortium,2012).Consumers in different regions have different color preferences.For example,European and | Lei Deng Hang Wang Chuanlong Sun Qian Li Hongling Jiang Minmin Du Chang-Bao Li Chuanyou Li | 2018 | Journal of Genetics and Genomics2018，45，1： | 13 |
| 6 | The Arabidopsis P450 protein CYP82C2 modulates jasmonateinduced root growth inhibition, defense gene expression and indole glucosinolate biosynthesis显示文摘Jasmonic 酸(JA ) 是对草食动物和一些微生物引起的病原体调整大量植物防卫回答的一个丰满的导出酸的发信号分子。分子的基因研究证实了 JA 也在植物开发的几个方面执行一个关键角色。这里,我们描述 Arabidopsis 变异的 jasmonic acid-hypersensitive1-1 (jah1-1 ) 的描述,它在 JA 回答的几个方面是有缺点的。尽管异种在根生长抑制展出增加的敏感到 JA,它显示出 JA 可诱导的防卫基因和减少的抵抗的减少的表示到 necrotrophic 真菌 Botrytis cinerea。基因克隆研究显示这些缺点被一个变化在细胞色素 P450 蛋白质 CYP82C2 引起。我们提供证明的证据到 B 的 jah1-1 异种的损害抵抗。cinerea 被导致 JA 的防卫基因的减少的表示伴随并且减少了导致 JA 的吲哚 glucosinolates (IG ) 的累积。相反地,提高的抵抗到 B。在 CYP82C2-overexpressing 植物的 cinerea 被导致 JA 的防卫基因的增加的表示伴随并且提高了导致 JA 的 IG 的层次。我们证明 CYP82C2 影响 IG biosynthetic 先锋的导致 JA 的累积色氨酸(Trp ) ,然而并非导致 JA 的 IAA 或导致病原体的 camalexin。一起,我们 CYP82C2 可以在导出 Trp 的第二等的代谢物的新陈代谢扮演在下面的一个假设在 JA 在哪个铺平调节的结果支持被提高。jah1-1 异种应该因此在向理解位于调停 JA 的微分回答的复杂性下面的机制的未来研究是重要的,它是重要的让植物使他们的生长适应千变万化环境。 | Fang Liu Hongling Jiang Songqing Ye Wen-Ping Chen Wenxing Liang Yingxiu Xu Bo Sun Jiaqiang Sun Qiaomei Wang Jerry D Cohen Chuanyou Li | 2010 | Cell Research2010，20，5： | 10 |
| 7 | Construction and anti-tumor effects of recombinant fowlpox virus expressing Newcastle disease virus hemagglutinin-neuramidinase gene显示文摘Hemagglutinin-neuramidinase (HN ) ,纽卡斯尔疾病导出病毒的蛋白质,不是仅仅调停受体识别而且拥有 neuraminidase (NA ) 活动,劈开那些受体的一个部件的能力, N-acetylneuraminic 酸(NAcneu, sialic ) 。包括人,在哺乳动物的种类的这蛋白质有有趣的反肿瘤以及有免疫力的刺激性质,这被知道。在癌症基因治疗探索 HN 基因的使用,我们构造了表示 HN 蛋白质(vFV-HN ) 的一个 recombinant 家禽痘病毒并且在 vivo 并且在 vitro 把 recombinant 病毒的 theanti 肿瘤活动与野类型的家禽痘病毒(FPV ) 的作比较。这里,我们发现尽管 B16 房间对野类型的家禽痘病毒的基础细胞毒素的效果有点抵抗,有 vFV-HN 的感染引起了显著细胞毒素的效果并且,与 vFV-HN 使免疫的忍受肿瘤的老鼠的幸存显著地与独自与 FPV 使免疫的老鼠的幸存相比被增加。而且,有 vFV-HNelicited 的老鼠的免疫 B16 肿瘤特定的细胞毒素的 T 淋巴细胞(CTL ) 回答和在 vivo 的 bothCD4+ 和 CD8+ T 房间人口的同种细胞的扩大。另外,从老鼠的淋巴节点的 T 房间种牛痘, Th1 cytokine IL-2 和 IFN-v 高级的 vFV-HN 藏匿了,显示肿瘤房间的回归与 Th1 类型主导的有免疫力的回答有关。这些结果证明有 vFV-HN 的种痘可以是为癌症基因治疗的潜在的策略。 | LI Xiao JIN Ningyi LIAN Hai GUAN Goufang SUN Lili LI Xue mei ZHENG Hongling | 2006 | Chinese Science Bulletin2006，51，22： | 9 |
| 8 | The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses显示文摘在真核细胞的房间的送信人 RNA (mRNA ) 周转以弄短开始 poly 在 3 鈥 ? 结束的(A) 尾巴,一个过程叫了 deadenylation。在酵母, deadenylation 反应被 CCR4 和联系 CCR4 的因素主要调停 1 (CAF1 ) ,描述得好的蛋白质建筑群的二个部件 CCR4 不说出。我们这里报导那 AtCAF1a 和 AtCAF1b,酵母 CAF1 基因的通常认为的 Arabidopsis 相当或相同的事物,部分面对咖啡因或在高温度补充酵母 caf1 异种的生长缺点。AtCAF1a 和 AtCAF1b 的表示被多重压力相关的荷尔蒙和刺激导致。在 vitro 的 AtCAF1a 和在预言的活跃地点的点变化破坏这项活动。破坏 AtCAF1a 或 AtCAF1b 的表示的 T-DNA 插入异种在压力相关的 mRNAs 的 deadenylation 是有缺点的,显示二 AtCAF1 蛋白质涉及在 vivo 的调整 mRNA deadenylation。有趣地, AtCAF1a 和 AtCAF1b 表演的单个、双的异种减少了表示致病相关( PR )基因 PR1 和 PR2 并且更产生 Pseudomonas syringae pv 西红柿 DC3000 ( Pst DC3000 )感染,而转基因的植物过去表示的 AtCAF1a 表演提高了 PR1 和 PR2 的表示并且增加了抵抗到一样的病原体。我们的结果在到病原体感染的调整 mRNA deadenylation 和防卫回答建议 AtCAF1 蛋白质的角色。 | Wenxing Liang Changbao Li Fang Liu Hongling Jiang Shuyu Li Jiaqiang Sun Xiaoyan Wu Chuanyou Li | 2009 | Cell Research2009，19，3： | 8 |
| 9 | Comparison of thermal and light performance in two typical Chinese solar greenhouses in Beijing显示文摘Solar greenhouses have been used for producing vegetables in northern China during early spring,late autumn or over-winter.To improve the thermal performance of solar greenhouses,a traditional type and a retrofitted design were comparatively evaluated.In the retrofitted design,three adjustments were incorporated:the material and structure of the walls,south-facing roof angle,and structure of the north-facing back-roof.The results indicated that the thermal and light performance of the retrofitted greenhouse was much better than that of the traditional greenhouse.Specifically,the daily mean temperature,minimum air temperature,and soil temperature inside the greenhouses after retrofit ting were increased by 1.3,2.4,and 1.9℃,respectively,meanwhile,the daily total solar radiation and PAR were increased by 28.2%and 9.2%,respectively.The wall temperature and its daily variation range were reduced with increasing depth and height.The characteristic analysis of heat storage and release indicated that higher locations have longer heat storage,and shorter heat release time in vertical direction,as well as a lower ratio of heat release to storage.In horizontal direction,the western wall has the shortest heat storage time but the highest heat release flux density.Altogether,the heat storage time of the wall is 1.5 h less than that of the soil.The heat storage flux density of the wall is 1.5 times of that of the soil,but the heat release flux is only 61%of the soil’s value.The total wall heat storage is half of that of the soil in the greenhouse;the total wall heat release amount is only a quarter of that of the soil.Therefore,the thermal environment of solar greenhouses can be further improved by improving the thermal insulation properties of the wall. | Fan Xu Chao Shang Hongling Li Xuzhang Xue Weituo Sun Hong Chen Yinkun Li Zhenhe Zhang Xinxu Li Wenzhong Guo | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 4 |
| 10 | Realization of an integrated seeding and compensating potato planter based on one-way clutch显示文摘The yield reduction caused by miss-seeding in potato mechanized sowing is astonishing.The existing research always needs to install a spare compensator on the original seed-metering device.Therefore,problems of complex planter structure and compensated potato seed poor landing accuracy need to be solved urgently.Consequently,a scheme of integrated seeding and compensating potato planter based on one-way clutch is proposed in this paper.Based on a basic‘improved one raw potato planter’and the working principle of one-way clutch,power of seed-metering system is provided through main power transmission one-way clutch by land wheels when the system works properly.However,when miss-seeding detection system with infrared radiation deciding that a miss-seeding incident has happened,the seed-metering power will be replaced by a compensatory motor through compensating one-way clutch at a higher speed.Thus,the idea of catching-up compensation can be realized.After compensation is completed,the system controller disconnects the compensatory motor,and the seed-metering power will naturally switch to the land wheels again.A prototype based on this idea was built.Field tests showed that the accuracy of seed monitoring system is more than 99.9%;the adoption of catching-up compensation scheme does not bring about empty spoon rate rise significantly.Within the range of 0.2-0.8 m/s of the seed-metering chain speed,although the average success compensation rate decreases evidently with the increase of the chain speed,the success compensation rate is still near 70%even at 0.8 m/s,the vast majority of missed seeds can be compensated effectively. | Guanping Wang Wei Sun Lea-Der Chen Hua Zhang Xiaolong Liu Hongling Li Xiaoping Yang Hao Yang | 2020 | International Journal of Agricultural and Biological Engineering2020，13，3： | 3 |
| 11 | Na-doping-induced modification of the Cu_(2)ZnSn(S,Se)_(4)/CdS heterojunction towards efficient solar cells显示文摘It is very important to understand why a small amount of alkali metal doping in Cu_(2)ZnSn(S,Se)_(4)(CZTSSe)solar cells can improve the conversion efficiency.In this work,Na-doped CZTSSe is prepared by a simple solution method,and then the effects on the surface properties of the absorber layer,the buffer layer growth,and the modifications of the solar cell performance induced by the Na doping are studied.The surface of the absorber layer is more Cu-depletion and less roughness due to the Na doping.In addition,the contact angle of the surface increases because of Na doping.As a consequence,the thickness of the CdS buffer layer is significantly reduced and the optical losses in the CdS buffer layer are decreased.The difference of quasi-Fermi levels(EFn-EFp) increases with a small amount of Na doping in the CZTSSe solar cell,so that open circuit voltage(VOC) increased significantly.This work offers new insights into the effects of Na doping on CZTSSe via a solution-based approach and provides a deeper understanding of the origin of the efficiency improvement of Na-doped CZTSSe thin film solar cells. | Yali Sun Hongling Guo Pengfei Qiu Shengli Zhang Siyu Wang Li Wu Jianping Ao Yi Zhang | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 12 | Probiotic applica- tion of two dominant gut Bacillus strains with antagonistic activity improved the growth performance and immune response of grouper Epinephelus coioides显示文摘 | SUN Yunzhang YANG Hongling MA Rulong | 2010 | Fish & Shellfish Immunology2010，29，： | 1 |
| 13 | The performances of TiB 2 -contained iron-based coatings at high temperature显示文摘 | Xibao Wang Hongling Shun Chunguo Li Xiaofeng Wang Dong Sun | 2006 | Surface & Coatings Technology2006，，6： | 1 |
| 14 | The bHLH-type transcription factor AtAIB positively regulates ABA response in Arabidopsis显示文摘 | Hongmei Li Jiaqiang Sun Yingxiu Xu Hongling Jiang Xiaoyan Wu Chuanyou Li | 2007 | Plant Molecular Biology2007，，5： | 1 |
| 15 | The role of prolactin/vasoinhibins in cardiovascular diseases显示文摘Prolactin(PRL)is a polypeptide hormone that is mainly synthesized and secreted by the lactotroph cells of the pituitary.There are two main isoforms of PRL:23-kDa PRL(named full-l ength PRL)and vasoinhibins(including 5.6–18 kDa fragments).Both act as circulating hormones and cytokines to stimulate or inhibit vascular formation at different stages and neovascularization,including endothelial cell proliferation and migration,protease production,and apoptosis.However,their effects on vascular function and cardiovascular diseases are different or even contrary.In addition to the structure,secretion regulation,and signal transduction of PRL/vasoinhibins,this review focuses on the pathological mechanism and clinical significance of PRL/vasoinhibins in cardiovascular diseases. | Hui Zhao Sugang Gong Yongcong Shi Cijun Luo Hongling Qiu Jing He Yuanyuan Sun Yuxia Huang Shang Wang Yuqing Miao Wenhui Wu | 2023 | Animal Models and Experimental Medicine2023，6，2： | 1 |
| 16 | Journal of Otorhinolaryngology,combined with allergic rhinitis and allergic rhinitis patients quality of life than children of a comparative s t u d y显示文摘 | Wu Hongling Lu Jihong Sun Rongrong | 2013 | C h i n a i n t e g r a t e d t r a d i t i o n a l C h i n e s e a n d We s t e r n medicine2013，2，5： | 1 |
| 17 | An Improved S-Random Interleaver Design for Turbo Code Based on Chaos Model显示文摘A new method to design interleaver based on Henon chaos model is presented. The designed interleaver is with rather random behavior. Experimental results show that the proposed S-henon interleaver make a magnitude of improvement in bit error rate (BER) performance by 0.4 dB compared with the S-random interleaver for AWGN channel respectively. The S-henon interleaver may be adapted to 3G mobile communication systems. | XIAO Dongliang SHI Hongling SUN Hong JIAO Bingli | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 1 |
| 18 | Li_(2)S doping into CZTSe drives the large improvement of V_(OC) of solar cell显示文摘Alkali metal doping or sulfurization are commonly applied in Cu_(2)ZnSnSe_(4) (CZTSe) solar cell to improve the open-circuit voltage (VOC). However, alkali metal sulfide affording both alkali metal and sulfur is seldom to be studied, which restrains the development of kesterite solar cells. In this study, we evaporate Li_(2)S during selenization process and hope to provide both alkali metal and sulfur to CZTSe film. The result indicates that Li shows a gradient distribution near the surface of CZTSe film and the content of S is slight. The film quality is improved and the recombination at grain boundaries is decreased after Li_(2)S treatment. Besides, the bandgap of the absorber gets wider. Under the synergy of sulfur and lithium (mainly from lithium), the work function of the treated absorber gets higher and the conduction band offset (CBO) is in the ideal range. Combined with these contributions, the V_(OC) of the champion device treated by Li_(2)S dramatically increase by 120 mV. This study discloses that alkali metal brings the main effect on the performance of the kesterite solar cell even an alkali metal sulfide is evaporated, which deepens the understanding of sulfurization of CZTSe and also promote the progress of kesterite solar cells. | Zhan Shen Siyu Wang Yue Liu Yali Sun Jianyu Wu Hongling Guo Kaizhi Zhang Shengli Zhang Fangfang Liu Yi Zhang | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 19 | Induction of an effective anti-tumor immune response and tumor regression by combined administration of IL-18 and Apoptin显示文摘 | Hai Lian Ningyi Jin Xiao Li Zhiqiang Mi Jingmin Zhang Lili Sun Xuemei Li Hongling Zheng Ping Li | 2007 | Cancer Immunology Immunotherapy2007，，2： | 1 |
| 20 | Adaptive active control of periodic vibration using maglev actuators显示文摘 | Fengyan An Hongling Sun Xiaodong Li | 2012 | Journal of Sound and Vibration2012，，331： | 1 |
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