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| 1 | Construction and anti-tumor effects of recombinant fowlpox virus expressing Newcastle disease virus hemagglutinin-neuramidinase gene显示文摘Hemagglutinin-neuramidinase (HN ) ,纽卡斯尔疾病导出病毒的蛋白质,不是仅仅调停受体识别而且拥有 neuraminidase (NA ) 活动,劈开那些受体的一个部件的能力, N-acetylneuraminic 酸(NAcneu, sialic ) 。包括人,在哺乳动物的种类的这蛋白质有有趣的反肿瘤以及有免疫力的刺激性质,这被知道。在癌症基因治疗探索 HN 基因的使用,我们构造了表示 HN 蛋白质(vFV-HN ) 的一个 recombinant 家禽痘病毒并且在 vivo 并且在 vitro 把 recombinant 病毒的 theanti 肿瘤活动与野类型的家禽痘病毒(FPV ) 的作比较。这里,我们发现尽管 B16 房间对野类型的家禽痘病毒的基础细胞毒素的效果有点抵抗,有 vFV-HN 的感染引起了显著细胞毒素的效果并且,与 vFV-HN 使免疫的忍受肿瘤的老鼠的幸存显著地与独自与 FPV 使免疫的老鼠的幸存相比被增加。而且,有 vFV-HNelicited 的老鼠的免疫 B16 肿瘤特定的细胞毒素的 T 淋巴细胞(CTL ) 回答和在 vivo 的 bothCD4+ 和 CD8+ T 房间人口的同种细胞的扩大。另外,从老鼠的淋巴节点的 T 房间种牛痘, Th1 cytokine IL-2 和 IFN-v 高级的 vFV-HN 藏匿了,显示肿瘤房间的回归与 Th1 类型主导的有免疫力的回答有关。这些结果证明有 vFV-HN 的种痘可以是为癌症基因治疗的潜在的策略。 | LI Xiao JIN Ningyi LIAN Hai GUAN Goufang SUN Lili LI Xue mei ZHENG Hongling | 2006 | Chinese Science Bulletin2006，51，22： | 9 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | Effect of minocycline on cerebral ischemia-reperfusion injury显示文摘Minocylcine, a tetracycline derivate, has been shown to cross the blood-brain barrier and enter the central nervous system. In this study, cerebral ischemia-reperfusion injury models were established using the suture method, and minocycline was immediately injected intraperitoneally after cerebral ischemia-reperfusion (22.5 mg/kg, initially 45 mg/kg) at a 12-hour interval. Results showed that after minocycline treatment, the volume of cerebral infarction was significantly reduced, the number of surviving cell in the hippocampal CA1 region increased, the number of apoptotic cells decreased, the expression of caspase-3 and poly(adenosine diphosphate-ribose) polymerase-1 protein was down-regulated, and the escape latency in the water maze test was significantly shortened compared with the ischemia-reperfusion group. Our experimental findings indicate that minocycline can protect against neuronal injury induced by focal ischemia-reperfusion, which may be mediated by the inhibition of caspase-3 and poly(adenosine diphosphate-ribose) polymerase-1 protein expression. | Yuanyin Zheng Lijuan Xu Jinbao Yin Zhichao Zhong Hongling Fan Xi Li Quanzhong Chang | 2013 | Neural Regeneration Research2013，8，10： | 4 |
| 4 | Effects of minocycline on learning and memory of mice following ischemic-hypoxic cerebral injuries显示文摘An ischemic-hypoxic animal model was established using right common carotid artery occlusions and inhalation of low concentrations of oxygen in mice. At 10 days after the ischemic-hypoxic injuries, saline-treated mice exhibited significantly prolonged escape latencies in water-maze tests and significantly shorter memory latencies and more mistakes in step-down tests. In contrast, mice treated with 5 mg/kg minocycline exhibited significant reversals of each of these effects compared with the saline-treated control mice. Moreover, we found that minocycline can relieve brain water content and morphological changes in mice following ischemic-hypoxic cerebral injuries. Accordingly, our findings indicate that minocycline provides some protections against the deleterious effects of these injuries in mice. | Hongling Fan Yuanyin Zheng Lijuan Xu Zhichao Zhong Shining Cai Shuling Zhang Quanzhong Chang | 2012 | Neural Regeneration Research2012，7，2： | 2 |
| 5 | Chloride channel blocker 4,4-diisothiocyanatostilbene-2,2'-disulfonic acid inhibits nitric oxide-induced apoptosis in cultured rat hippocampal neurons显示文摘Apoptosis in cultured rat hippocampal neurons was induced using the nitric oxide donor 3-morpholinosydnonimine, and cells were treated with the chloride channel blocker, 4,4-diisothiocyanatostilbene-2,2'-disulfonic acid. Results showed that the survival rate of neurons was significantly increased after treatment with 4,4-diisothiocyanatostilbene-2,2'-disulfonic acid, and the rate of apoptosis decreased. In addition, the expression of the apoptosis-related proteins poly(adenosine diphosphate-ribose)polymerase-1 and apoptosis-inducing factor were significantly reduced. Our experimental findings indicate that the chloride channel blocker 4,4- diisothiocyanatostilbene-2,2'-disulfonic acid can antagonize apoptotic cell death of hippocampal neurons by inhibiting the expression of the apoptosis-related proteins poly(adenosine diphosphate-ribose)polymerase-1 and apoptosis-inducing factor. | Jinbao Yin Lijuan Xu Shuling Zhang Yuanyin Zheng Zhichao Zhong Hongling Fan XiLi Quanzhong Chang | 2013 | Neural Regeneration Research2013，8，2： | 2 |
| 6 | Treatment design of geological defects in dam foundation of Jinping I hydropower station显示文摘Jinping I hydropower station is one of the most challenging projects in China due to its highest arch dam and complex geological conditions for construction.After geological investigation into the dam foundation,a few large-scale weak discontinuities are observed.The rock masses in the left dam foundation are intensively unloaded,approximately to the depth of 150–300 m.These serious geological defects lead to a geological asymmetry on the left and right banks,and thus some major diffculties of dam construction are encountered.In this paper,the influences of geological defects on the project are analyzed,followed by the concepts and methods of treatment design.Based on the analysis,the treatment methods of the weak rock masses and discontinuities are carefully determined,including the concrete cushion,concrete replacement grids,and consolidation grouting.They work together to enhance the strength and integrity of the dam foundation.Evaluations and calibrations through geo-mechanical model tests in combination with feld monitoring results in early impoundment period show that the arch dam and its foundation are roughly stable,suggesting that the treatment designs are reasonable and effective.The proposed treatment methods and concepts in the context can be helpful for similar complex rock projects. | Shengwu Song Xuemin Feng Hongling Rao Hanhuai Zheng | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，5： | 1 |
| 7 | High-rate lithium-sulfur batteries promoted by reduced graphene oxide coating显示文摘 | LI Nianwu ZHENG Mingbo LU Hongling | 2012 | Chemical Communieations2012，48，34： | 1 |
| 8 | Induction of an effective anti-tumor immune response and tumor regression by combined administration of IL-18 and Apoptin显示文摘 | Hai Lian Ningyi Jin Xiao Li Zhiqiang Mi Jingmin Zhang Lili Sun Xuemei Li Hongling Zheng Ping Li | 2007 | Cancer Immunology Immunotherapy2007，，2： | 1 |
| 9 | Unveiling the impact of residual Li conversion and cation ordering on electrochemical performance of Co-free Ni-rich cathodes显示文摘The residual Li and Li^(+)/Ni_(2)+cation mixing play essential roles in the electrochemical properties of Ni-rich cathodes.However,a general relationship between the residual Li conversion,cation mixing,and their effects on the Li^(+)kinetics and structural stability has yet to be established,due to the presence of cobalt in the cathode.Here,we explore the synergistic impact of the residual Li conversion and cation ordering on a Co-free Ni-rich cathode(i.e.,LiNi0.95Mn0.05O_(2)).It discloses that the rate capability is mainly affected by residual Li contents and operating voltage.Specifically,residual Li can be electrochemically converted to cathode electrolyte interphase(CEI)below 4.3 V,thus inducing high interphase resistance,and decomposes to produce CO_(2)-dominated gas at 4.5 V,causing temporary enhancement of Li^(+)diffusivity but severe surface degradation during cycling.Moreover,the cycling performance of Co-free Ni-rich cathode is not only determined by Li^(+)/Ni_(2)+cation-ordered superlattice,which enhances the structural stability as it functions as the pillar to impede lattice collapse at a highly charged state,but also by the robust CEI layers which protect the bulk from electrolyte attack under 4.3 V.These findings promote an in-depth understanding of residual Li conversion and Li^(+)/Ni_(2)+cation ordering on Co-free Ni-rich cathode. | Chu Wang Lei Tan Hongling Yi Zixiang Zhao Xiaoli Yi Youyuan Zhou Junchao Zheng Jiexi Wang Lingjun Li | 2022 | Nano Research2022，15，10： | 1 |
| 10 | Advancing the pressure sensing performance of conductive CNT/PDMS composite film by constructing a hierarchical-structured surface显示文摘Flexible pressure sensors have attracted wide attention due to their applications to electronic skin,health monitoring,and human-machine interaction.However,the tradeoff between their high sensitivity and wide response range remains a challenge.Inspired by human skin,we select commercial silicon carbide sandpaper as a template to fabricate carbon nanotube(CNT)/polydimethylsiloxane(PDMS)composite film with a hierarchical structured surface(h-CNT/PDMS)through solution blending and blade coating and then assemble the h-CNT/PDMS composite film with interdigitated electrodes and polyurethane(PU)scotch tape to obtain an h-CNT/PDMS-based flexible pressure sensor.Based on in-situ optical images and finite element analysis,the significant compressive contact effect between the hierarchical structured surface of h-CNT/PDMS and the interdigitated electrode leads to enhanced pressure sensitivity and a wider response range(0.1661 kPa^(-1),0.4574 kPa^(-1)and 0.0989 kPa^(-1)in the pressure range of 0–18 kPa,18–133 kPa and 133–300 kPa)compared with planar CNT/PDMS composite film(0.0066 kPa^(-1)in the pressure range of 0–240 kPa).The prepared pressure sensor displays rapid response/recovery time,excellent stability,durability,and stable response to different loading modes(bending and torsion).In addition,our pressure sensor can be utilized to accurately monitor and discriminate various stimuli ranging from human motions to pressure magnitude and spatial distribution.This study supplies important guidance for the fabrication of flexible pressure sensors with superior sensing performance in next-generation wearable electronic devices. | Ye Zhao Taoyu Shen Minyue Zhang Rui Yin Yanjun Zheng Hu Liu Hongling Sun Chuntai Liu Changyu Shen | 2023 | Nano Materials Science2023，5，4： | 1 |
| 11 | analysis of the quality of the yellow riv- er and suggeste to improve the quality of water显示文摘 | ZHENG Hongling WANG Long GENG Yuxiu | 2010 | China rural water and hydropower2010，5，5： | 1 |
| 12 | Versatile and scalable chemical vapor deposition of vertically aligned MoTe2 on reusable Mo foils显示文摘Layered MoTe2 has shown great promises for optoelectronics and energy-storage applications due to its exceptional optical and electrochemical properties.To date,considerable efforts have been devoted to fabricating layered MoTe2 with lateral orientation by means of mechanical/chemical exfoliation and chemical vapor deposition(CVD)methods.As compared to its horizontal counterparts,vertically aligned MoTe2 with higher density of active edge sites is expected to possess unique optoelectronic and electrochemical properties,while which has not been reported yet.In this work,we report a versatile and scalable CVD growth of vertically aligned MoTe2 with length of up to〜7.5 fjm on Mo foil.Remarkably,the dominant phase of the vertically aligned MoTe2 can be tuned from 2H to 1T’by increasing the growth temperature from 630 to 7800C.Owing to the weak interaction between the as-grown MoTe2 and Mo foil,the as-grown MoTe2 can be easily detached from the Mo foil.This in turn enabled economic reuse of the Mo foil for multiple growth.Moreover,the vertical growth of the MoTe2 is proposed to be caused by the internal strain generated during tellurization of Mo foil.Furthermore,the as-grown MoTe2 can also be directly dispersed in solvent to produce high-quality MoTe2 nanosheets.The versatility of this growth strategy was further demonstrated by fabricating other vertically aligned transition metal chalcogenides(TMDs)such as TaTe2 and MoSe2.Hence,this work paves the path towards achieving unique TMDs structures to enable high-performance optoelectronic and electrochemical devices. | Jinjun Lin Hong Wang Roland Yingjie Tay Hongling Li Maziar Shakerzadeh Siu Hon Tsang Zheng Liu Edwin Hang Tong Teo | 2020 | Nano Research2020，13，9： | 0 |
| 13 | Synthesis and Flocculation of Polyacrylamide with Low Water Absorption for Non-dispersible Underwater Concrete显示文摘The polyacrylamide which is directly added into concrete shows strong water absorption property.Thus the construction of underwater constructure would demand high amount of water,resulting in poor workability of concrete and strength shrinkage after hardening.Herein,a kind of anionic polyacrylamide(APAM)grafted with water reducing functional group(-COOH)was synthesized at low temperatures by partial factor design and response surface design.The structure and morphology of APAM were characterized by UV,FTIR and SEM methods.The experimental results show that the molecular weight of the synthesized APAM could reach 11 million,under the condition that the temperature was 35℃,the pH value was 8,the monomer concentration was 27wt%,the initiator dosage was 0.6wt%,and the monomer ratio(n(AM):n(AA))was 3.When the APAM was applied into the underwater slurry,it presented good flocculation and low water demand.When the dosage was 1%of the mass of the cement,the water demand increased by 12%,which could meet the self-leveling and anti-dispersity of the underwater slurry at the same time.This technology provides technical guidance for the large-scale industrial production of polyacrylamide for underwater concrete construction while achieving environmental protection during production. | LI Hongling YAN Na SUN Guowen ZHENG Haorui YANG Xinyu | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，6： | 0 |
| 14 | Influence of Pseudoelasticity on Mechanical Behavior of TiNi Alloy under Dynamic Impact Loading显示文摘The mechanical behavior of TiNi alloy and Cr12MoV alloy under dynamic impact loading was investigated with a self-made impact testing system.The real-time contact force was measured with a piezoelectric force sensor and digital signal processing system during impact.Equations for predicting instantaneous velocity and displacement were presented.The results showed that the TiNi alloy exhibited a plateau of maximum contact force with increasing impact height.At the plateau stage,TiNi alloy in the parent phase can absorb impact energy and keep the maximum contact force nearly identical due to its pseudoelasticity. | Xu Renbo Cui Lishan Zheng Yanjun Chen Hongling | 2007 | Petroleum Science2007，4，1： | 0 |
| 15 | Mechanical Behaviors of TiNi Alloy under Dynamic Impact Loading Conditions显示文摘The mechanical behaviors of Ti-50.7%Ni shape memory alloy under a dynamic impact loading condition were investigated by a home-built impact testing system. Both the contact force and the contact time during the impact process were measured with a piezoelectric force sensor and a digital signal processing system in real time. The predicted instantaneous velocity and the displacement formulae are presented. Results show that the maximum contact force increased, while the contact time decreased with the increase of the temperature when the TiNi alloy was in a martensitic state. When the compressive stress during the impact process was higher than the critical stress of the stress-induced martensitic transformation, the TiNi alloy specimen in the parent phase left no permanent deformation but could dissipate the impact energy. | Xu Renbo Cui Lishan Zheng Yanjun Chen Hongling | 2005 | Petroleum Science2005，2，3： | 0 |
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