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| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | Research progress on ecological protection technology of highway slope: status and challenges显示文摘Slope protection has always been a major concern in highway construction and later operation.Ecological protection technology is widely used in highway slope,which takes into account functions of protection,ecology,and landscape.Ecological protection technology is mainly to improve the stability of the slope through the combination of supporting structure and plants,and vegetation restoration can reduce the negative impact of highway construction.In this paper,the latest research progress of ecological protection technology was first reviewed to identify the main construction process and types,which revealed the protection mechanism of ecological protection technology.The comprehensive benefits of ecological slope protection technology were analysed from the aspects of air,water circulation,landscape and biodiversity.It has found that ecological protection technology of highway slope mainly forms the atmosphere-plant-soil system.Ecological protection technology of highway slope improved the stability of the slope through the supporting structure and the anchoring effect of plant roots.And the restoration of the surface vegetation on the slope promoted the photosynthesis and transpiration of plants and purifies the air quality along the highway.Ecological protection technology of highway slope could quickly restore the ecological balance,overall landscape and biodiversity of the region. | Hongyuan Fu Huanyi Zha Ling Zeng Caiying Chen Chuankun Jia Hanbing Bian | 2020 | Transportation Safety and Environment2020，2，1： | 6 |
| 3 | Review on biomass metallurgy:Pretreatment technology,metallurgical mechanism and process design显示文摘The metallurgy industry consumes a considerable amount of coal and fossil fuels,and its carbon dioxide emissions are increasing every year.Replacing coal with renewable,carbon-neutral biomass for metallurgical production is of great significance in reducing global carbon consumption.This study describes the current state of research in biomass metallurgy in recent years and analyzes the concept and scientific principles of biomass metallurgy.The fundamentals of biomass pretreatment technology and biomass metallurgy technology were discussed,and the industrial application framework of biomass metallurgy was proposed.Furthermore,the economic and social advantages of biomass metallurgy were analyzed to serve as a reference for the advancement of fundamental theory and industrial application of biomass metallurgy. | Jianliang Zhang Hongyuan Fu Yanxiang Liu Han Dang Lian Ye Alberto N.Conejio Runsheng Xu | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，6： | 4 |
| 4 | Stability analysis of Runge-Kutta methols for non-linear delay differential equations显示文摘 | Huang chengming Fu Hongyuan Li Shoufu Chen Guangnan | 1999 | B1T1999，39，： | 1 |
| 5 | Nonlinear hyperbolic systems of higher order of generalized Sine-Gordon type 显示文摘 | Zhou Yulin Fu Hongyuan | 1983 | Aeta Mathematiea Siniea1983，，26： | 1 |
| 6 | The BZR1-EDS1 module regulates plant growth-defense coordination显示文摘Plants have developed sophisticated strategies to coordinate growth and immunity,but our understanding of the underlying mechanism remains limited.In this study,we identified a novel molecular module that reg-ulates plant growth and defense in both compatible and incompatible infections.This module consisted of BZR1,a key transcription factor in brassinosteroid(BR)signaling,and EDS1,an essential positive regulator of plant innate immunity.We found that EDS1 interacts with BZR1 and suppresses its transcriptional activ-ities.Consistently,upregulation of EDS1 function by a virulent Pseudomonas syringae strain or salicylic acid treatment inhibited BZR1-regulated expression of BR-responsive genes and BR-promoted growth.Furthermore,we showed that the cytoplasmic fraction of BZR1 positively regulates effector-triggered im-munity(ETI)controlled by the TIR-NB-LRR protein RPS4,which is attenuated by BZR1's nuclear transloca-tion.Mechanistically,cytoplasmic BZR1 facilitated AvrRps4-triggered dissociation of EDS1 and RPS4 by binding to EDS1,thus leading to efficient activation of RPS4-controlled ETI.Notably,transgenic expression of a mutant BZR1 that accumulates exclusively in the cytoplasm improved pathogen resistance without compromising plant growth.Collectively,these results shed new light on plant growth-defense coordina-tion and reveal a previously unknown function for the cytoplasmic fraction of BZR1.The BZR1-EDS1 mod-ule may be harnessed for the simultaneous improvement of crop productivity and pathogen resistance. | Guang Qi Huan Chen Dian Wang Hongyuan Zheng Xianfeng Tang Zhengzheng Guo Jiayu Cheng Jian Chen Yiping Wang Ming-yi Bai Fengquan Liu Daowen Wang Zheng Qing Fu | 2021 | Molecular Plant2021，14，12： | 1 |
| 7 | Stability analysis of Runge-Kutta methols for non-linear delay differential equations显示文摘 | HUANG CHENG MING FU HONGYUAN LI SHOUFU | 1999 | BIT1999，39，： | 1 |
| 8 | Stability Analysis of Runge-Kutta Methods for Non-Linear Delay Differential Equations显示文摘 | Huang Chengming Fu Hongyuan Li Shoufu Chen Guangnan | 1999 | Bit Numerical Mathematics1999，，2： | 1 |
| 9 | Regime Map of Dry Neutralization Agglomeration Process Containing Non-Reactive Ingredient on a Laboratory Scale显示文摘This study described a regime map for dry neutralization agglomeration. Based on the map, the effects of selected key parameters, such as ingredient composition, operation temperature, agitation speed, and size of Na_2CO_3 particles, were investigated using a laboratory-scale mixer, and properties of the agglomeration product were analyzed, including particle size distribution, Hunter color, and flowability. Torque curves evolving during the process were correlated with the system flowability. Three distinguishable regimes were indicated, dry, wet, and transitional, and the agitation speed was found to have a different influence on the agglomeration process for the three regimes. Furthermore, the influence of temperature on reactive agglomeration significantly differed from that in agglomeration processes in which the binder was non-reactive. | Leping Dang Xu Li Jinsheng Fu Xiaojun Lang Hongyuan Wei | 2019 | Transactions of Tianjin University2019，25，1： | 1 |
| 10 | Stability Analysis of Runge-Kutta Methods for Non-Linear Delay Differential Equations显示文摘 | Huang Chengming Fu Hongyuan Li Shoufu Chen Guangnan | 1999 | Bit Numerical Mathematics1999，，2： | 1 |
| 11 | Effects of Soil Hydraulic Properties on Soil Moisture Estimation显示文摘Accurate quantification of soil moisture is essential to understand the land surface processes.Soil hydraulic properties influence water transport in soil and thus affect the estimation of soil moisture.However,some soil hydraulic properties are only observable at a few field sites.In this study,the effects of soil hydraulic properties on soil moisture estimation are investigated by using the one-dimensional(1-D)Richards equation at ELBARA,which is part of the Maqu monitoring network over the Tibetan Plateau(TP),China.Soil moisture assimilation experiments are then conducted with the unscented weighted ensemble Kalman filter(UWEnKF).The results show that the soil hydraulic properties significantly affect soil moisture simulation.Saturated soil hydraulic conductivity(Ksat)is optimized based on its observations in each soil layer with a genetic algorithm(GA,a widely used optimization method in hydrology),and the 1-D Richards equation performs well using the optimized values.If the range of Ksat for a complete soil profile is known for a particular soil texture(rather than for arbitrary layers within the horizon),optimized Ksat for each soil layer can be obtained by increasing the number of generations in GA,although this increases the computational cost of optimization.UWEnKF performs well with optimized Ksat,and improves the accuracy of soil moisture simulation more than that with calculated Ksat.Sometimes,better soil moisture estimation can be obtained by using optimized saturated volumetric soil moisture content Ksat.In summary,an accurate soil profile can be obtained by using soil moisture assimilation with optimized soil hydraulic properties. | Xiaolei FU Haishen LYU Zhongbo YU Xiaolei JIANG Yongjian DING Donghai ZHENG Jinbai HUANG Hongyuan FANG | 2023 | Journal of Meteorological Research2023，37，1： | 1 |
| 12 | Difference graphs of a class of alternating block Crank-Nicolson methods显示文摘By using the concept of multigraphs, the difference graphs of a class of alternating block Crank-Nicolson methods are defined and described, which extends the results on difference graphs of parallel computing for the finite difference method. | Baolin Zhang Hongyuan Fu | 1999 | Chinese Science Bulletin1999，44，19： | 0 |
| 13 | Introduction to special issue on life-cycle assessment of infrastructure显示文摘Life-cycle assessment(LCA)is a methodological framework for assessing the environmental performance of products or services at all life-cycle stages,including raw materials extraction,materials processing,manufacture,use,maintenance and end-of-life.In recent years,LCA has been increasingly employed to evaluate the sustainability of subgrades,pavements and side slopes in highway engineering.This would necessarily lead to the advance of design and construction technologies of highways and the improvement of the durability of road infrastructure. | Jianlong Zheng Hongyuan Fu Ling Zeng Junhui Zhang Qianfeng Gao | 2020 | Transportation Safety and Environment2020，2，1： | 0 |
| 14 | Application of Mathematial-Simulated Model Setup for Eudcational Planning | FU Hongyuan (Chongqing Institute of Architecture and Engineering ) | 1994 | Systems Science and Systems Engineering1994，4，2： | 0 |
| 15 | Coupling boron-modulated bimetallic oxyhydroxide with photosensitive polymer enable highly-active and ultra-stable seawater splitting显示文摘Seawater photoelectrolysis is showing huge potential in green energy conversion field,yet it is still a formidable challenge to develop one catalyst that can drive the electrolysis reaction stably,economically and efficiently.Motivated by this point,the inorganic–organic hybridization strategy is proposed to insitu construct one hierarchical electrode via concurrent electroless plating and polymerization,which assures the growth of boron-modulated nickel–cobalt oxyhydroxide nanoballs and photosensitive polyaniline nanochains on the self-supporting Ti-based foil(B-Co Ni OOH/PANI@TiO_(2)/Ti).Upon inducing photoelectric effect(PEE),the designed target electrode delivers overpotentials as low as 196 and 398 mV at 100 mA cm^(-2)for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER),respectively,corresponding to an activity enhancement by about 15%as compared to those without PEE.Inspiringly,when served as bifunctional electrocatalysts for overall seawater electrolysis,it can stably maintain at 200 mA cm^(-2)with negligible decay over 72 h.Further analysis reveals that the exceptional catalytic performance can be credit to the B-CoNiOOH,polyaniline(PANI)and TiO_(2)subunit coupling-induced physically and chemically synergistic catalysis effect such as admirable composition stability,photoelectric function and adhesion capability.The finding in this contribution may trigger much more broad interest to the novel hybrid catalysts consisting of photosensitive polymer and transition metal-based electrocatalysts. | Weiju Hao Chengyu Fu Yingming Wang Kui Yin Hongyuan Yang Ruotao Yang Ziliang Chen | 2022 | Journal of Energy Chemistry2022，，12： | 0 |
| 16 | Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients显示文摘Elderly people and patients with comorbidities are at higher risk of COVID-19 infection,resulting in severe complications and high mortality.However,the underlying mechanisms are unclear.In this study,we investigate whether miRNAs in serum exosomes can exert antiviral functions and affect the response to COVID-19 in the elderly and people with diabetes. | Yanbo Wang Xiaoju Zhu Xia-Ming Jiang Jingwei Guo Zheng Fu Zhen Zhou Ping Yang Hongyuan Guo Xu Guo Gaoli Liang Ping Zeng Gengfu Xiao Jizheng Ma Xin Yin Lei-Ke Zhang Chao Yan Chen-Yu Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 0 |
| 17 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 18 | Rising from the dead: the power of genome editing显示文摘To protect themselves against diverse pathogens, plants have developed sophisticated defense mechanisms. Hypersensitive response or the rapid localized death of plant cells is a major defense strategy deployed by plants to kill the invading pathogens(Wu et al., 2014). | Hongyuan Zheng Junyao Zhao Daowen Wang Zheng Qing Fu | 2023 | Science China(Life Sciences)2023，66，12： | 0 |
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