|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Magnifying colonoscopy as a non-biopsy technique for differential diagnosis of non-neoplastic and neoplastic lesions显示文摘瞄准:为了澄清与放大结肠镜检查观察的粘膜地窟模式是否对可行,把非肿瘤的息肉与肿瘤的息肉区分开来。方法:从通过 2000 年 3 月的 1999 年 6 月,有 210 损害的 180 个连续病人与放大结肠镜诊断了(CF-200Z,天堂光有限公司,东京,日本) 被注册。有 0.2% 靛青洋红染料的放大和多彩石印版内视镜检查法为粘膜地窟观察被用于每损害。损害出现打字我和 II 地窟模式被活体检视组织学地认为非肿瘤、检验,而损害证明到 V 地窟模式的类型 III 被移开内视镜的联盟者或通过手术。内视镜的诊断和 histologic 诊断的关联然后被调查。结果:在内视镜检查法, 24 损害证明我或 II 坑模式,和 186 损害显示出的一种类型打 III 到 V 坑模式。与 histologic 检查, 26 损害作为非肿瘤的息肉被诊断,并且 184 损害作为肿瘤的息肉被诊断。全面诊断精确性是 99.1%(208/210 ) 。敏感和特性是 92.3%(24/26 ) 并且 99.8%(184/186 ) 分别地。结论:放大结肠镜检查能作为一种非活体检视技术被使用区分肿瘤、非肿瘤的息肉。 | Shigeharu Kato Kuang I Fu Yasushi Sano Takahiro Fujii Yutaka Saito Takahisa Matsuda Ikuro Koba Shigeaki Yoshida Takahiro Fujimori | 2006 | World Journal of Gastroenterology2006，12，9： | 31 |
| 2 | Induced biosyntheses of a novel butyrophenone and two aromatic polyketides in the plant pathogen Stagonospora nodorum显示文摘Fungal aromatic compounds comprise an important and structurally diverse group of secondary metabolites.Several genome sequencing projects revealed many putative biosynthetic gene clusters of fungal aromatic compounds,but many of these genes seem to be silent under typical laboratory culture conditions.To gain access to this untapped reservoir of natural products,we utilized chemical epigenetic modifiers to induce the expression of dormant biosynthetic genes.As a result,the concomitant supplementation of the histone deacetylase inhibitors suberoylanilide hydroxamic acid(500mM)and nicotinamide(50mM)to the culture medium of a fungal pathogen,Stagonospora nodorum,resulted in the isolation of three aromatic compounds(1-3),including a novel natural butyrophenone,(+)-4'-methoxy-(2S)-methylbutyrophenone(1),and two known polyketides,alternariol(2)and(-)-(3R)-mellein methyl ether(3). | Xiao-Long YANG Takayoshi AWAKAWA Toshiyuki WAKIMOTO Ikuro ABE | 2013 | Natural Products and Bioprospecting2013，3，4： | 9 |
| 3 | Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreaticcancer显示文摘 | Makoto Abue Misa Yokoyama Rie Shibuya Keiichi Tamai Kazunori Yamaguchi Ikuro Sato Nobuyuki Tanaka Shin Hamada Tooru Shimosegawa Kazuo Sugamura Kennichi Satoh | 2015 | International Journal of Oncology2015，，2： | 3 |
| 4 | Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity显示文摘Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However,biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible gene cluster for fusidic acid(fus cluster). This gene cluster consists of eight genes, among which six are conserved in the helvolic acid gene cluster except fusC1 and fusB1. Introduction of the two genes into the Aspergillus oryzae NSAR1 expressing the conserved six genes led to the production of fusidic acid. A stepwise introduction of fusC1 and fusB1 revealed that the two genes worked independently without a strict reaction order. Notably, we identified two short-chain dehydrogenase/reductase genes fusC1 and fusC2 in the fus cluster, which showed converse stereoselectivity in 3-ketoreduction. This is the first report on the biosynthesis and heterologous expression of fusidic acid. | Zhiqin Cao Shaoyang Li Jianming Lv Hao Gao Guodong Chen Takayoshi Awakawa Ikuro Abe Xinsheng Yao Dan Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 5 | A Novel Function of the Receptor for Advanced Glycation End-Products (RAGE) in Association with Tumorigenesis and Tumor Differentiation of HCC显示文摘 | Kiyokazu Hiwatashi MD Shinichi Ueno MD PhD Kazuhiro Abeyama MD PhD Fumitake Kubo MD PhD Masahiko Sakoda MD PhD Ikuro Maruyama MD PhD Masahiro Hamanoue MD PhD Shoji Natsugoe MD PhD Takashi Aikou MD PhD | 2008 | Annals of Surgical Oncology2008，，3： | 2 |
| 6 | Epigenetic modifier-induced biosynthesis of novel fusaric acid derivatives in endophytic fungi from Datura stramonium L.显示文摘The treatment of fungi with DNA methyltransferase(DNMT)and/or histone deacetylase(HDAC)inhibitors is a promising way to activate secondary metabolite biosynthetic pathways that are dormant under normal conditions.In this study,we included an HDAC inhibitor,suberoylanilide hydroxamic acid(SBHA),in the culture medium of endophytic fungi isolated from the medicinal plant Datura stramonium L.The production of two compounds was induced in the culture supplemented with SBHA,and their structures were determined to be the fusaric acid derivatives 5-butyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid and 5-(but-9-enyl)-6-oxo-1,6-dihydropyridine-2-carboxylic acid.The result confirmed that the use of chemical epigenetic modifiers is an effective technique for promoting the expression of silent biosynthetic pathways to produce unique secondary metabolites. | Han-Jing CHEN Takayoshi AWAKAWA Jie-Yin SUN Toshiyuki WAKIMOTO Ikuro ABE | 2013 | Natural Products and Bioprospecting2013，3，1： | 2 |
| 7 | Efficacy of MK615 for the treatment of patients with liver disorders显示文摘AIM:To investigate the hepatoprotective effect of MK615,a Japanese apricot extract,in an animal model,and its clinical therapeutic effect.METHODS:Wistar rats were administered physiological saline(4 mL/kg) or MK615 solution(4 mL/kg) for 7 d.On the sixth d,acute hepatic injury was induced by administering a single intraperitoneal injection(ip) of D-galactosamine hydrochloride(D-GalN)(600 mg/kg).Plasma levels of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) were determined,and liver tissues were used for histopathological analysis.Fifty-eight patients with liver disorders [hepatitis C(n = 40),non-alcoholic fatty liver disease(n = 15),and autoimmune liver disease(n = 3)] were orally administered commercially available Misatol ME-containing MK615(13 g/d) daily for 12 wk.Blood and urine were sampled immediately before and 6 wk,12 wk,and 16 wk after the start of intake to measure various biochemical parameters.The percentage change in ALT and AST levels after 12 wk from the pre-intake baseline served as a primary endpoint.RESULTS:D-GalN effectively induced acute hepatic injury in the rats.At 48 h after the ip injection of D-GalN,the plasma levels of ALT(475.6 ± 191.5 IU/L vs 225.3 ± 194.2 IU/L,P < 0.05) and AST(1253.9 ± 223.4 IU/L vs 621.9 ± 478.2 IU/L,P < 0.05) in the MK615 group were significantly lower than the control group.Scattered single cell necrosis,loss of hepatocytes,and extensive inflammatory cell infiltration were observed in hepatic tissue samples collected from the control group.However,these findings were less pronounced in the group receiving MK615.At the end of the clinical study,serum ALT and AST levels were significantly decreased compared with pre-intake baseline levels from 103.5 ± 58.8 IU/L to 71.8 ± 39.3 IU/L(P < 0.05) and from 93.5 ± 55.6 IU/L to 65.5 ± 34.8 IU/L(P < 0.05),respectively.A reduction of ≥ 30% from the pre-study baseline ALT level was observed in 26(45%) of the 58 patients,while 25(43%) patients exhibited similar AST level reductions.The chronic hepatitis C group exhibited significant ALT and AST level reductions from 93.4 ± 51.1 IU/L to 64.6 ± 35.1 IU/L(P < 0.05) and from 94.2 ± 55.5 IU/L to 67.2 ± 35.6 IU/L(P < 0.05),respectively.A reduction of ≥ 30% from the pre-study baseline ALT level was observed in 20(50%) of the 40 patients.ALT levels in both the combined ursodeoxycholic acid(UDCA) treatment and the UDCA uncombined groups were significantly lower after Misatol ME administration.MK615 protected hepatocytes from D-GalN-induced cytotoxicity in rats.Misatol ME decreased elevated ALT and AST levels in patients with liver disorders.CONCLUSION:These results suggest that MK615 and Misatol ME are promising hepatoprotective agents for patients with liver disorders. | Atsushi Hokari Tomohisa Ishikawa Hisao Tajiri Takahide Matsuda Osamu Ishii Nobuyuki Matsumoto Chiaki Okuse Hideaki Takahashi Takeshi Kurihara Ko-ichi Kawahara Ikuro Maruyama Mikio Zeniya | 2012 | World Journal of Gastroenterology2012，18，31： | 2 |
| 8 | Effects of surface oxidesof the phosphatability of the high strengh (’old rolled steels 显示文摘 | Masahiro N Ikuro H Shinji K | 2006 | Testsu to Humane2006，92，6： | 1 |
| 9 | Perspective on BiCMOS VLSI's显示文摘 | Masaharu Kubo Ikuro Masuda Kenji Miyata | 1988 | IEEE J of Solid- State Circuits1988，23，1： | 1 |
| 10 | THROMBOMODULIN ALFA IN THE TREATMENT OF INFECTIOUS PATIENTS COMPLICATED BY DISSEMINATED INTRAVASCULAR COAGULATION: SUBANALYSIS FROM THE PHASE 3 TRIAL显示文摘 | Naoki Aikawa Shuji Shimazaki Yasuhiro Yamamoto Hidehiko Saito Ikuro Maruyama Ryuzo Ohno Akio Hirayama Yoshikazu Aoki Nobuo Aoki | 2011 | Shock2011，，4： | 1 |
| 11 | Expert consensus for the treatment of disseminated intravascular coagulation in Japan显示文摘 | Hideo Wada Hidesaku Asakura Kohji Okamoto Toshiaki Iba Toshimasa Uchiyama Kazuo Kawasugi Shin Koga Toshihiko Mayumi Kaoru Koike Satoshi Gando Shigeki Kushimoto Yoshinobu Seki Seiji Madoiwa Ikuro Maruyama Akira Yoshioka | 2009 | Thrombosis Research2009，，1： | 1 |
| 12 | Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin–Thrombomodulin Complexes显示文摘 | Takashi Ito Ko-ichi Kawahara Kohji Okamoto Shingo Yamada Minetsugu Yasuda Hitoshi Imaizumi Yuko Nawa Xiaojie Meng Binita Shrestha Teruto Hashiguchi Ikuro Maruyama | 2008 | Arteriosclerosis, Thrombosis, and Vascular Biology2008，，10： | 1 |
| 13 | Anti-High-Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Sepsis显示文摘 | Koichi Suda Yuko Kitagawa Soji Ozawa Yoshiro Saikawa Masakazu Ueda Masahito Ebina Shingo Yamada Satoru Hashimoto Shinji Fukata Edward Abraham Ikuro Maruyama Masaki Kitajima Akitoshi Ishizaka | 2006 | World Journal of Surgery2006，，9： | 1 |
| 14 | Bacillus Calmette-Guerin Tokyo172 substrain for superficial bladder cancer:characterization and antitumor effect显示文摘 | Noriko I Ikuro H Ikura Y | 2005 | J Urol2005，173，5： | 1 |
| 15 | Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy显示文摘Fusidane-type antibiotics,represented by helvolic acid,fusidic acid and cephalosporin P1,are fungi-derived antimicrobials with little cross-resistance to commonly used antibiotics.Generation of new fusidane-type derivatives is therefore of great value,but this is hindered by available approaches.Here,we developed a stochastic combinational strategy by random assembly of all the post-tailoring genes derived from helvolic acid,fusidic acid,and cephalosporin P1 biosynthetic pathways in a strain that produces their common intermediate.Among a total of 27 gene combinations,24 combinations produce expected products and afford 58 fusidane-type analogues,of which 54 are new compounds.Moreover,random gene combination can induce unexpected activity of some post-tailoring enzymes,leading to a further increase in chemical diversity.These newly generated derivatives provide new insights into the structure-activity relationship of fusidane-type antibiotics.The stochastic combinational strategy established in this study proves to be a powerful approach for expanding structural diversity of natural products. | Xiaojun Song Jianming Lv Zhiqin Cao Huiyun Huang Guodong Chen Takayoshi Awakawa Dan Hu Hao Gao Ikuro Abe Xinsheng Yao | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 1 |
| 16 | Benzophenone synthase from Garcinia mangostana L. pericarps显示文摘 | Natsajee Nualkaew Hiroyuki Morita Yoshihiko Shimokawa Keishi Kinjo Tetsuo Kushiro Wanchai De-Eknamkul Yutaka Ebizuka Ikuro Abe | 2012 | Phytochemistry2012，，： | 1 |
| 17 | Alcoholic brain damage dementia viewed by MRI, with special consideration on frontal atrophy and white matter damage in dyslipidemic patients 显示文摘 | Ikuro Namura | 2006 | Psycho geriatrics2006，6，： | 1 |
| 18 | Whole genome sequence analysis ofMycobacterium bovis bacillus almette-Gu6rin (BCG) Tokyo 172: A comparative study of BCG vaccine substrains显示文摘 | Masaaki Seki Ikuro Honda | 2009 | Vaccine2009，27，： | 1 |
| 19 | Evaluation of microbial regrowth potential by assimilable organic carbon in various reclaimed water and distribution systems显示文摘 | Parinda T Futoshi K Ikuro K | 2013 | Water Research2013，47，1： | 1 |
| 20 | Analysis of the phylogenetic diversity of estrone - degrading bacteria in activated sewage sludge using microautoradiography -fluorescence in situ hybridization 显示文摘 | Kaisai Zang Futoshi Kurisu Ikuro Kasuga | 2008 | Syst Appl Microbiol2008，31，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员