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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Carboxymethyl chitosan as a matrix material for platinum 显示文摘 | Michael J Laudenslager Jessica D Schi-ff- man Caroline L Schauer | 2008 | Biomacromolecules2008，9，10： | 1 |
| 3 | Novel Bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | AMANDA C C JESSICA L J LOANNA N | 2002 | J Am Chem Soc2002，124，21： | 1 |
| 4 | The impact of garlic mustard on sandy forest soils 显示文摘 | Sherri J Morris Dustin L Herrmann Jessica McClain | 2012 | Applied Soil Ecology2012，60，： | 1 |
| 5 | Measurement of SO2 solubility in ionic liquids 显示文摘 | Jessica L A Janeille K D Edward J M | 2006 | J Phys Chem B2006，110，15： | 1 |
| 6 | On estimating the exponent of power-law frequency distribution显示文摘 | Ethan P W Brian J E Jessica L G | 2008 | Ecology2008，89，4： | 1 |
| 7 | Measurement of SO2 solubility in ionic liquids显示文摘 | JESSICA L A JANEILLE K D EDWARD J M | 2006 | J Phys Chem B2006，110，15： | 1 |
| 8 | Effects of reproductive hormones on experimental vaginal candidiasis 显示文摘 | Paul L Fidel J Jessica C | 2000 | Infection and Immunity2000，68，2： | 1 |
| 9 | Circulating [alpha]Klotho influences phosphate handling by controlling FGF23 production显示文摘 | Smith Rosamund C O’Bryan Linda M Farrow Emily G Summers Lelia J Clinkenbeard Erica L Roberts Jessica L Cass Taryn A Saha Joy Broderick Carol Ma Y Linda Zeng Qing Qiang Kharitonenkov Alexei Wilson Jonathan M Guo Qianxu Sun Haijun Allen Matt | 2012 | Journal of Clinical Investigation2012，，12： | 1 |
| 10 | Novel Brgnsted acidic ionic liquids and their use as dual solvent-catalysts 显示文摘 | Amanda C C Jessica L J Ioanna N | 2002 | J Am Chem Soc2002，124，21： | 1 |
| 11 | Decabromobiphenyl,Polybrominated Diphenyl Ethers,and Brominated Phenolic Compoundsin Serum of Cats Diagnosed With the Endocrine Disease FelineHyperthyroidism显示文摘 | Jessica N’Bernt J Nils-Gunnar L | 2012 | Arch Environm Contaminat Toxicol2012，63，1： | 1 |
| 12 | Novel Bronsted acidic ionic liquids and their use as dual solvent-catalysts 显示文摘 | AMANDA C C JESSICA L J LOANNA N | 2002 | J Am Chem2002，124，21： | 1 |
| 13 | Is there evidence that proprioception or balance training can prevent anterior cruciate ligament (ACL) injuries in athletes without previous ACL injury?显示文摘 | Jessica L Owen Sara J Falkner Alex T Ward | 2006 | Physical Therapy2006，86，10： | 1 |
| 14 | Microbial biogeography:from taxonomy to Traits显示文摘 | Jessica L G Brendan J M B Rachel J W | 2008 | Science2008，320，： | 1 |
| 15 | Application of capillary electrophoresis to study the enantioselective transformation of five chiral pesticides in aerobic soil slurries显示文摘 | Jessica L Jarman W Jones J | 2005 | J Agric Food Chem2005，53，： | 1 |
| 16 | Improving carbon dioxide solubility in ionic liquids显示文摘 | Mark J Muldoon Sudhir N V K Aki Jessica L Anderson | 2007 | J Phys Chem B2007，111，： | 1 |
| 17 | The JAK2/STAT3 signaling pathway is required for growth of CD44^sup +^CD24^sup -^ stem cell-like breast cancer cells in human tumors显示文摘 | Marotta Lauren L C Almendro Vanessa Marusyk Andriy Shipitsin Michail Schemme Janina Walker Sarah R Bloushtain-Qimron Noga Kim Jessica J Choudhury Sibgat A Maruyama Reo Wu Zhenhua G?nen Mithat Mulvey Laura A Bessarabova Marina O Huh Sung Jin | 2011 | Journal of Clinical Investigation2011，，： | 1 |
| 18 | Cancer Risk Among People With Type 1 and Type 2 Diabetes: Disentangling True Associations, Detection Bias, and Reverse Causation显示文摘 | Harding Jessica L Shaw Jonathan E Peeters Anna Cartensen Bendix Magliano Dianna J | 2015 | Diabetes Care2015，，： | 1 |
| 19 | Three Monte Carlo programs of polarized light transport into scattering media 显示文摘 | Jessica C R R Scott A P Steve L J | 2005 | Optics Express2005，13，12： | 1 |
| 20 | Novel Brnsted acidic ionic liquids and their use as dual solvent-catalysts 显示文摘 | Amanda C C Jessica L J Ioanna N | 2002 | J Am Chem Soc2002，124，21： | 1 |
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