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| 1 | Molecular therapy for hepatic injury and fibrosis:Where are we?显示文摘肝的纤维变性是弯屈的愈合的回答,包含发炎和纤维发生的小径。响应各种各样的侮辱,例如酒精,局部缺血,病毒的代理人,和药或肝毒素, hepatocyte 损坏将在肝由 Kupffer 房间和另外的房间类型引起 cytokines 和另外的可溶的因素的版本。这些因素导致肝的星形细胞的激活,它综合大量细胞外的矩阵部件。与长期的损害和纤维变性,肝建筑学和新陈代谢被破坏,最后作为肝硬化和它的复杂并发症表明。除了消除病原学,例如抗病毒的治疗和药理学干预,新奇策略正在被开发直接在细胞的潜水艇和分子的层次探讨肝的损害和纤维变性,这令人鼓舞。与在理解这些机制和小径的改进,在损害给步调音,发信号,激活,和基因表示被分子的形式和分子的其它或基因治疗途径正在指向。这篇文章打算为肝的损害和纤维变性以分子的治疗的当前的地位提供更改并且我们多远从这些新治疗学的形式的临床的利用。 | Colette C Prosser Roy D Yen Jan Wu | 2006 | World Journal of Gastroenterology2006，12，4： | 41 |
| 2 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 3 | Biotransformation of linalool to furanoid and pyranoid linalool oxides by Aspergillus niger 显示文摘 | Jan C R D Hendra W | 1993 | Phytochemistry1993，47，6： | 2 |
| 4 | Effect of systemic herbicides on N2-fixing and phosphate solubilizing microorganisms in relation to availability of nitrogen and phosphorus in paddy soils of West Bengal显示文摘 | DAS A C AN JAN D | 2006 | Chemosphere2006，65，6： | 1 |
| 5 | Absorption of a mutagenic metabolite released from protein-bound residues of furazolidone显示文摘 | Laurentius A.P Hoogenboom Gerard D van Bruchem Kim Sonne Ilona C Enninga Johannes A van Rhijn Henri Heskamp Margot B.M Huveneers-Oorsprong Jan C.M van der Hoeven Harry A Kuiper | 2002 | Environmental Toxicology and Pharmacology2002，，3： | 1 |
| 6 | Modeling ofgeneric slung load system 显示文摘 | MORTEN B JAN D B ANDERS C | 2009 | Journal of Guidance Control and Dynamics2009，32，2： | 1 |
| 7 | A Study of Innovation Design on Taiwan Culture Creative Product: A Case Study of the Facial Mask of Ba Ja Jang显示文摘 | CHEN C H CHEN B C JAN C D | 2009 | Lecture Notes in Computer Science2009，，： | 1 |
| 8 | Complete nucleotide sequence and genetic organization of papaya ringspot virus RNA显示文摘 | Yeh S D Jan F J Chiang C H | 1992 | J Gen Virol1992，73，10： | 1 |
| 9 | Application of artificial neural networks in typhoon surge forecasting显示文摘 | Tseng C M Jan C D Wang J S | 2007 | Ocean Engineering2007，34，1112： | 1 |
| 10 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 11 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 12 | Complete nucleotide sequence and genetic organization of Papaya fingspot virus RNA显示文摘 | Yeh S D Jan F J Chiang C H | 1992 | J Gen Virol1992，73，： | 1 |
| 13 | Analysis of rainfall-induced quick groundwater-level response by using a Kernel funetion显示文摘 | JAN C D CHEN T H HUANG H M | 2013 | Paddy Water Environment2013，，11： | 1 |
| 14 | Intronic microRNA precursors that bypass Drosha processing显示文摘 | Ruby J G Jan C H Bartel D P | 2007 | Nature2007，448，7149： | 1 |
| 15 | Hemophagocytic lymphohistiocytosis secondary to T-cell/ histiocyte rich large B-cell lymphoma显示文摘 | Katherine D Jan C Bradley S | 2014 | Leuk Res Rep2014，3，2： | 1 |
| 16 | Intronie microR- NA precursors that bypass Drosha processing显示文摘 | Ruby J G Jan C H Bartel D P | 2007 | Nature2007，448，7149： | 1 |
| 17 | Influence of lightweight aggregate on the microstructure and durability of mortar显示文摘 | AMIR E MENASHI D C JAN O | 2005 | Cement and Concrete Research2005，35，7： | 1 |
| 18 | Nuclear targeting signal recognition:a key control point in nuclear transport?显示文摘 | Jans D A Xiao C Y and Lam M H | 2000 | Bioessays2000，22，6： | 1 |
| 19 | Calibration of Businger-Arya type of eddy viscosity model's parameters显示文摘 | Hsu T W Jan C D | 1998 | Journal of Waterway Port Coastal and Ocean Engineering-Asce1998，124，5： | 1 |
| 20 | Passively mode-locked diode laser with optimized dispersion man- agement 显示文摘 | Jan C B Rouven O H P Benjamin D | 2015 | IEEE Journal of Selected Topics in Quan- tum Electronics2015，21，11： | 1 |
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