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| 1 | Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases显示文摘AIM To investigate whether immune mediated diseases(IMD) are more frequent in patients with inflammatory bowel disease(IBD).METHODS In this population based registry study,a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16,2013. Controls were randomly selected from the Danish Civil Registration System(CRS) and matched for sex,age,and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis(UC),Crohn's disease(CD) and Both the latter referring to those registered with both diagnoses. Subsequently,odds-ratios(OR) and 95%CI were obtained separately for each group and their respective controls. The use of Bonferoni post-test correction adjusted the significance level to P < 0.00125. P-values were estimated using Fisher's exact test.RESULTS There were significantly more women than men in the registry,and a greater percentage of comorbidity in the IBD groups(P < 0.05). Twenty different IMDs were all significantly more frequent in the IBD group. Sixteen were associated with UC versus twelve with CD. In both UC and CD ORs were significantly increased(P < 0.00125) for primary sclerosing cholangitis(PSC),celiac disease,type 1 diabetes(T1D),sarcoidosis,asthma,iridocyclitis,psoriasis,pyoderma gangrenosum,rheumatoid arthritis,and ankylosing spondylitis. Restricted to UC(P < 0.00125) were autoimmune hepatitis,primary biliary cholangitis,Grave's disease,polymyalgia rheumatica,temporal arteritis,and atrophic gastritis. Restricted to CD(P < 0.00125) were psoriatic arthritis and episcleritis. Restricted to women with UC(P < 0.00125) were atrophic gastritis,rheumatoid arthritis,temporal arteritis,and polymyalgia rheumatica. Restricted to women with CD were episcleritis,rheumatoid arthritis,and psoriatic arthritis. The only disease restricted to men(P < 0.00125) was sarcoidosis. CONCLUSION Immune mediated diseases were significantly more frequent in patients with IBD. Our results strengthen the hypothesis that some IMDs and IBD may have overlapping pathogenic pathways. | Morten L Halling Jens Kjeldsen Torben Knudsen Jan Nielsen Lars Koch Hansen | 2017 | World Journal of Gastroenterology2017，23，33： | 9 |
| 2 | Holocene tephra deposits in the northern Okinawa Trough显示文摘The mineralogical and geochemical characteristics of sediments of Core CSH1, which was collected from the northern Okinawa Trough, indicate that large amounts of volcanic materials have deposited in the northern Okinawa Trough during the Holocene. On the basis of down-core variations in mineral and element contents of sediments, two layers in the uppermost section of Core CSH1 charac- terized by high quartz, Na2O, MnO, K2O, uranium contents and low contents of clay minerals, volatiles, Fe2O3, MgO, CaO and stron- tium, have been identified as the tephra deposits. Systematic grain-size measurements also suggest that sediments from the northern Okinawa Trough are made up of terrigenous materials and volcanic ashes with different proportion during the Holocene. The sedi- ments of tephra layers in Core CSH1 show bi-modal patterns in grain-size distribution with modal grain-sizes of 74.3 and 7.81 μm, respectively. According to the radiocarbon dating on shells of zooplankton foraminifera, two tephra layers in Core CSH1, formed at 7 250 and 10 870 a BP (cal), approximately correspond to the K-Ah tephra [7 300 a BP (cal)] and the eruption of Kuju Volcano (12￣10 ka BP), respectively. | LIU Yanguang OLE BjФrslev Nielsen ZHANG Deyu DU Dewen JAN Heinemeier WU Yonghua | 2006 | Acta Oceanologica Sinica2006，25，1： | 4 |
| 3 | 鸟类对猫捕食敏感性的种间差异研究(英文)显示文摘 | Anders Pape MφLLER Johannes ERRITZφE Jan Tφttrup NIELSEN | 2010 | Chinese Birds2010，，2： | 3 |
| 4 | Mapping the antigenic structure of porcine parvovirus at the level of peptides显示文摘 | S?ren Kamstrup Jan Langeveld Anette B?tner Jens Nielsen Wim M.M Schaaper Ronald S Boshuizen Jose Ignacio Casal Peter H?jrup Carmen Vela Rob Meloen Kristian Dalsgaard | 1998 | Virus Research1998，，2： | 1 |
| 5 | The Proteome of Seed Development in the Model Legume Lotus japonicus1[W]显示文摘 | Dam Svend Laursen Brian S ?rnfelt Jane H Jochimsen Bjarne St?rfeldt Hans Henrik Friis Carsten Nielsen Kasper Goffard Nicolas Besenbacher S?ren Krusell Lene Sato Shusei Tabata Satoshi Th?gersen Ida B Enghild Jan J Stougaard Jens | 2009 | Plant Physiology2009，，3： | 1 |
| 6 | Two-and three- dimensional tetrathiafulvalene macrocycles 显示文摘 | Mogens Brφndsted Nielsen Jan Becher | 1997 | Liebigs Ann1997，，： | 1 |
| 7 | Carsten Tanggaard, Yield curve estimation by kernel smoothing methods 显示文摘 | Oliver Linton Enno Mammen Jans Perch Nielsen | 2001 | Journal of Econometrics2001，105，1： | 1 |
| 8 | Influencing cocoa flavour using Pichia kluyveri and Kluyveromyces marxianus in a defined mixed starter culture for cocoa fermentation显示文摘 | Michael Crafack Morten B. Mikkelsen Sofie Saerens Morten Knudsen Andreas Blennow Samuel Lowor Jemmy Takrama Jan H. Swiegers Gert B. Petersen Hanne Heimdal Dennis S. Nielsen | 2013 | International Journal of Food Microbiology2013，，： | 1 |
| 9 | Combined Intra- articular and intravenous tranexamic acid reduces blood loss in total knee arthro- plasty : a randomized, double - blind, placebo - controlled trial 显示文摘 | Nielsen CS Jans O Orsnes T | 2016 | J Bone Joint Surg Am2016，98，10： | 1 |
| 10 | Tetrathiafulvalenes as building blocks in supramolecular chemistry Ⅱ 显示文摘 | Mogens Brondsted Nielsen Christian Lomhoh Jan Becher | 2000 | Chem Soc Rev2000，29，： | 1 |
| 11 | 关节腔和静脉联合应用氨甲环酸显著降低人工膝关节出血量:一项随机双盲对照试验显示文摘关节腔或者静脉应用氨甲环酸显著降低人工膝关节出血量,两种方式同时应用还没有文献报道。作者将60例患者随机分为两组,一组为关节腔和静脉联合应用氨甲环酸(实验组,30例),术前静脉应用1g氨甲环酸,手术切口缝合后将3 g氨甲环酸溶于100 ml生理盐水注入关节腔;另一组为对照组(30例),术前静脉应用1 g氨甲环酸,手术切口缝合后将100 ml生理盐水注入关节腔。24 h失血量:实验组为466 ml ±313 ml,对照组为743 ml ±358 ml;第2天失血量:实验组为644 ml ±382 ml,对照组为1017±519 ml。两组术后90 d 内均未见血栓形成。因此作者认为,关节腔和静脉联合应用氨甲环酸比单纯静脉应用氨甲环酸可以减少大约37%失血量。 | Nielsen C S Jans φ φrsnes T 胡孔足 | 2016 | 临床骨科杂志2016，19，3： | 1 |
| 12 | 东格陵兰盆地晚二叠世缺氧事件:对北欧和北极潜在烃源岩的意义显示文摘在东格陵兰盆地,晚二叠Ravnefjeld组(FoldvikCreek群)海相沉积物属Wuchiapingian期(Stemmerik等,2001),遍布整个东格陵兰盆地的Ravnefjeld组由三套生物扰动粉砂岩夹两套薄层状泥页岩组成(Piasecki和Stemmerik,1991)。这些富含有机质的薄层沉积是易于生油的烃源岩,其平均总有机碳含量为4wt%,HI值为300~400mg/g TOC,属于Ⅱ型于酪根(Christiansen等,1993)。黄铁矿莓球的含量表明这种薄层的沉积条件为含硫底水,生物扰动单元代表半氧化-氧化条件(Nielsen和Shen2004),氧化还原敏感元素也指示了沉积环境。 | Jesper Kresten Nielsen Yanan She Jan Kresten Nielsen Nils - Martin Hanken Sten- Andreas Grundvag 吴峧歧(译) 邱燕(校对) | 2008 | 海洋地质2008，24，3： | 1 |
| 13 | 大型太阳能供热系统——发展与前景显示文摘由于当前国际和欧洲发展形势和目标的要求,以及供热(制冷)领域使用可再生能源的需要,使用大型太阳能供热技术成为欧洲未来区域供热的一种选择方案。研究显示,随着政策的改变,太阳能供热技术在区域供热领域的潜在需求正在不断增长。 | Jan Michael Runager Jan Erik Nielsen 马景涛 张明明 钳锋 | 2008 | 区域供热2008，，4： | 1 |
| 14 | Heat exchanger network modelling framework for optimal design and retrofitting显示文摘 | Jan Sandvig Nielsen Mogens Weel Hansen Sten bay Joergensen | 1996 | Computers and Chemical Engineering1996，，： | 1 |
| 15 | Prey vulnerability in relation to sexual coloration of prey显示文摘 | Anders Pape M?ller Jan T?ttrup Nielsen | 2006 | Behavioral Ecology and Sociobiology2006，，2： | 1 |
| 16 | Physiologic Effects of Bowel Preparation显示文摘 | Kathrine Holte M.D. Kristine Grubbe Nielsen M.S. Jan Lysg?rd Madsen M.D. Ph.D. Henrik Kehlet M.D. Ph.D | 2004 | Diseases of the Colon & Rectum2004，，8： | 1 |
| 17 | Intellectual capital statementson their way to the stock exchange:Ananlyzingnew reporting systems显示文摘 | Christian Nielsen Per Nikolaj Bukh Jan Mourtsen Mette Rosenkrands Johanse | 2006 | Journal of Intellectual Capital2006，，7： | 1 |
| 18 | 卡尔斯港文化中心显示文摘本案位于瑞典卡尔斯港一处面向大海的东部码头。3XN建筑事务所在此开发设计了个新文化中心和图书馆。弯曲有机形态的设计沉浸于俏皮的光的表达之中,体现出该建筑的有机形态与逻辑性。建筑分为上下两大体块,彼此之间形成位移,创建出一个面朝西北方向的低入口、一个位于东北角的露天剧场和一处可用作庇荫的阳光充足的休闲区。 | Kim Herforth Nielsen Jan Ammundsen Morten Breinholt Rasmus Mφller Maria Tcacova Filip Lipinski 姜敏华 | 2014 | 现代装饰2014，，6： | 0 |
| 19 | Enhanced Free Radical Scavenging and Inhibition of DPP-4 and ACE Activities by Compounds from Salmon Tissues Digested in Vitro with Gastrointestinal Proteases显示文摘 | Susan Skanderup Falkenberg Jan Stagsted Henrik Hauch Nielsen | 2014 | Journal of Agricultural Science and Technology(B)2014，4，5： | 0 |
| 20 | 4显示文摘 | Margit Andreasen Lis Alban Jan Dahl Anette Cleveland Nielsen | 2012 | Journal of Agricultural Science and Technology(A)2012，2，3： | 0 |
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