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| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | 851 resected cystic tumors of the pancreas: A 33-year experience at the Massachusetts General Hospital显示文摘 | Nakul P. Valsangkar Vicente Morales-Oyarvide Sarah P. Thayer Cristina R. Ferrone Jennifer A. Wargo Andrew L. Warshaw Carlos Fernández-del Castillo | 2012 | Surgery2012，，3： | 3 |
| 3 | Pancreatic Ductal Adenocarcinoma: Is There a Survival Difference for R1 Resections Versus Locally Advanced Unresectable Tumors? What Is a “True” R0 Resection?显示文摘 | Ioannis T. Konstantinidis Andrew L. Warshaw Jill N. Allen Lawrence S. Blaszkowsky Carlos Fernandez-del Castillo Vikram Deshpande Theodore S. Hong Eunice L. Kwak Gregory Y. Lauwers David P. Ryan Jennifer A. Wargo Keith D. Lillemoe Cristina R. Ferrone | 2013 | Annals of Surgery2013，，4： | 3 |
| 4 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 5 | Pancreatic ductal adenocarcinoma: Long-term survival does not equal cure显示文摘 | Cristina R. Ferrone Rafael Pieretti-Vanmarcke Jordan P. Bloom Hui Zheng Jackye Szymonifka Jennifer A. Wargo Sarah P. Thayer Gregory Y. Lauwers Vikram Deshpande Mari Mino-Kenudson Carlos Fernández-del Castillo Keith D. Lillemoe Andrew L. Warshaw | 2012 | Surgery2012，，： | 2 |
| 6 | Metastatic Tumors in the Pancreas in the Modern Era显示文摘 | Ioannis T. Konstantinidis Abdulmetin Dursun Hui Zheng Jennifer A. Wargo Sarah P. Thayer Carlos Fernandez-del Castillo Andrew L. Warshaw Cristina R. Ferrone | 2010 | Journal of the American College of Surgeons2010，，6： | 1 |
| 7 | Ocular melanoma metastatic to the pancreas after a 28-year disease-free interval显示文摘 | Parsia A. Vagefi Lars Stangenberg Gregor Krings David G. Forcione Jennifer A. Wargo | 2010 | Surgery2010，，1： | 1 |
| 8 | N0/N1, PNL, or LNR? The Effect of Lymph Node Number on Accurate Survival Prediction in Pancreatic Ductal Adenocarcinoma显示文摘 | Nakul P. Valsangkar Devon M. Bush James S. Michaelson Cristina R. Ferrone Jennifer A. Wargo Keith D. Lillemoe Carlos Fernández-del Castillo Andrew L. Warshaw Sarah P. Thayer | 2013 | Journal of Gastrointestinal Surgery2013，，2： | 1 |
| 9 | Potential role of 5- aza-2’-deoxycytidine induced MAGE-A4 expression in immunotherapy for anaplastic thyroid cancer显示文摘 | Viswanath Gunda Alexandria P. Cogdill Maria J. Bernasconi Jennifer A. Wargo Sareh Parangi | 2013 | Surgery2013，，： | 1 |
| 10 | Surgery for Small and Asymptomatic Branch-Duct IPMNs显示文摘 | Carlos F. Fernandez-del Castillo Sarah P. Thayer Cristina R. Ferrone Jennifer Wargo | 2014 | Annals of Surgery2014，，3： | 1 |
| 11 | Potential role of 5-Aza-2′-deoxycytidine induced MAGE-A4 expression in immunotherapy for anaplastic thyroid cancer显示文摘 | Viswanath Gunda Alexandria P. Cogdill Maria J. Bernasconi Jennifer A. Wargo Sareh Parangi | 2013 | Surgery2013，，： | 1 |
| 12 | Pancreatic Ductal Adenocarcinoma: Is There a Survival Difference for R1 Resections Versus Locally Advanced Unresectable Tumors? What Is a “True” R0 Resection?显示文摘 | Ioannis T. Konstantinidis Andrew L. Warshaw Jill N. Allen Lawrence S. Blaszkowsky Carlos Fernandez-del Castillo Vikram Deshpande Theodore S. Hong Eunice L. Kwak Gregory Y. Lauwers David P. Ryan Jennifer A. Wargo Keith D. Lillemoe Cristina R. Ferrone | 2013 | Annals of Surgery2013，，4： | 1 |
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