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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Particle Size Effect on Heat Transfer Performance in an Oscillating Heat Pipe 显示文摘 | JI YL MA HB SU FM | 2011 | Ex- perimental Thermal and Fluid Science2011，35，72： | 1 |
| 3 | A new biomechanical model for evaluation of fixation systems of maxillofacial fractures 显示文摘 | Ji BH Chun W Song FM | 2012 | J Cranio Maxillofac Surg2012，40，5： | 1 |
| 4 | Normative apparent diffusion coefficient values in the developing fetal brain 显示文摘 | Schneider MM Berman JI Baumer FM | 2009 | AJNR Am J Neuroradiol2009，30，9： | 1 |
| 5 | Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes 显示文摘 | Elliott JI Surprenant A Marelli-Berg FM | 2005 | Nat Cell Biol2005，7，8： | 1 |
| 6 | Management of carotid 'blowout'with endovascular stent grafts 显示文摘 | Warren FM Cohen JI Nesbit GM | 2002 | Laryngoscope2002，112，： | 1 |
| 7 | Statistical correlation of nucleotides in a DNA sequence显示文摘 | Lee WJ Jia LJ Ji FM Tsai L | 1998 | Phys Rev E1998，58，： | 1 |
| 8 | Prediction for Target Sites of Small Interfering RNA Duplexes in SARS Coronavirus显示文摘 | Ji FM Luo LF | 2005 | Genome Biology2005，5，： | 1 |
| 9 | Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat 显示文摘 | Zurvarra FM Salvetti NR Mason JI | 2009 | Reprod Fertil Dev2009，21，7： | 1 |
| 10 | Epidemiological survey on mental disability And intellectual 7 areas of China显示文摘 | FM LM Ji LP Shen YC | 1999 | Zhonghua Jingshenke Zazhi1999，31，2： | 1 |
| 11 | Guidelines on genet- ic evaluation and management of lynch syndrome: a consensus statement by the US multi-society task force on eolorectal cancer 显示文摘 | Giardiello FM Alien JI Axilbund JE | 2014 | Gastroenterology2014，147，： | 1 |
| 12 | Radioactivity in bottled waters sold in Mexico显示文摘 | Dávila R JI López del RH García FM | 2002 | Appl Radiat Isotopes2002，56，6： | 1 |
| 13 | Epidemiological survey on mental disability And intellectual 7 areas of China显示文摘 | FM LM Ji LP Shen YC | 1999 | Zhonghua Jingshenke Zazhi1999，31，2： | 1 |
| 14 | The preferential mode analysis of DNA sequence显示文摘 | Luo LF Ji FM | 1997 | J Theor Biol1997，188，： | 1 |
| 15 | Synaptic plasticity and nicotine addiction显示文摘 | Dani JA Ji D Zhou FM | 2001 | Neuron2001，31，： | 1 |
| 16 | Synaptic plasticity and nicotine addiction显示文摘 | Dani JA Ji D Zhou FM | 2001 | Neuron2001，31，3： | 1 |
| 17 | Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat 显示文摘 | Zurvarra FM Salvetti NR Mason JI | 2009 | Reprod Fertil Dev2009，21，7： | 1 |
| 18 | Factors associated with mortality in patients with bloodstream infection and pneumonia due to Stenotrophomonas maltophilia显示文摘 | Paez JI Tengan FM Barone AA | 2008 | Eur J Clin Microbiol Infect Dis2008，27，10： | 1 |
| 19 | Differential micro RNA expression by solexa sequencing in the sera of ovarian cancer patients显示文摘 | Ji T Zheng GZ Wang FM | 2014 | Asian Pac J Cancer Prev2014，15，4： | 1 |
| 20 | Early psychosocial intervention following traumatic events 显示文摘 | Bisson JI Brayne M Ochberg FM | 2007 | Am J Psychiatry2007，164，7： | 1 |
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