| 1 | Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment显示文摘The Hedgehog(HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment(TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance.The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6(IL-6) and interferon-g(IFN-g), macrophages, and T cell-dependent immune responses, play a vital role in tumor growth by affecting the HH signaling pathway. Moreover, inhibition of proliferating cancer-associated fibroblasts(CAFs) and inflammatory factors can normalize the TME by suppressing HH signaling. Furthermore, aberrant HH signaling activation is favorable to both the proliferation of cancer stem cells(CSCs) and the drug resistance of gastrointestinal tumors. This review discusses the current understanding of the role and mechanism of aberrant HH signaling activation in gastrointestinal carcinogenesis, the gastrointestinal TME,tumor immune tolerance and drug resistance and highlights the underlying therapeutic opportunities. | Jinghui Zhang Jiajun Fan Xian Zeng Mingming Nie Jingyun Luan Yichen Wang Dianwen Ju Kai Yin | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 2 | MoS_2 decorated lignin-derived hierarchical mesoporous carbon hybrid nanospheres with exceptional Li-ion battery cycle stability显示文摘Lignin is the most abundant and important macromolecule in organic matter and its yield is second only to cellulose. Lignin is abundant in source, low in price, and has a large number of active groups such as methoxy group and carboxyl group, so it has great utilization value. We used lignin as a carbon source to prepare porous carbon nanosphere(PCN) materials, and in-situ synthesized the MoS_ 2 on its surface. The high specific surface area(462.8 m^2/g), large pore volume and good electron conductivity of the porous carbon scaffold facilitated the reversible electro-chemical reaction of S towards metallic Li, and thus the nano-hybrid showed a high specific energy and excellent cycle stability which still remained 520m Ah/g after 50 cycles. | Feng Chen Long Wu Zeping Zhou Jiajun Ju Zhengping Zhao Mingqiang Zhong Tairong Kuang | 2019 | Chinese Chemical Letters2019，30，1： | 3 |
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