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| 1 | Identification of an HLA-A~* 0201-restricted CD8^+ T-cell epitope SSp-1 of SARS-CoV spike protein显示文摘A novel coronavirus, severe acute respiratory syndrome (SA RS)-associated coronavirus (SARS-CoV), has been identified as the causal agent of SARS. Spike (S) protein is a major structural glycoprotein of the SARS virus and a potential target for SARS-specific cell-mediated immune responses. A pa nel of S protein-derived peptides was tested for their binding affinity to HLA -A *0201 molecules. Peptides with high affinity for HLA-A *0201 were then as se ssed for their capacity to elicit specific immune responses mediated by cytotoxi c T lymphocytes (CTLs) both in vivo, in HLA-A2.1/K b transgenic mice, a nd in vitro, from peripheral blood lymphocytes (PBLs) harvested from healthy HLA-A 2.1 + donors. SARS-CoV protein-derived peptide-1 (SSp-1 RLNEVAKNL), induced pepti de-specific CTLs both in vivo (transgenic mice) and in vitro (human PBL s), which specifically released interferon-gamma (IFN-gamma) upon stimulation with SSp-1-pulsed autologous dendritic cells (DCs) or T2 cells. SSp-1-specif ic CTLs also lysed major histocompatibility complex (MHC)-matched tumor cell lines engineered to express S proteins. HLA-A *0201-SSp-1 tetramer staining re vealed the presence of significant populations of SSp-1-specific CTLs in SSp- 1-induced CD8 + T cells. We propose that the newly identified epitope SSp-1 w ill help in the characterization of virus control mechanisms and immunopathology in SARS-CoV infection, and may be relevant to the development of immunotherape utic approaches for SARS. | WangB ChenH JiangX ZhangM WanT LiN ZhouX WuY YangF YuY WangX YangR CaoX | 2004 | 第二军医大学学报2004，25，9： | 21 |
| 2 | Providing personalized converged services based on flexible network reconfiguration显示文摘Recent developments show a progressing convergence of networks, services, and applications, which results in the necessity for new approaches to provide a ubiquitous experience on converged networks for specialized high data-rate services. A fundamental diversifying attribute for the future physical network convergence paradigm is pressing. In this paper, we make researches on converged resource reconfiguration model of substrate physical network based on hardware virtualization and provide a service oriented network architecture as a network convergence primitive. Based on the idea of hardware virtualization which is performed by platform deformation and component processing with reconfiguration (here, they are realized as reconfigurable routers (RR)), the substrate converged network, which inter-connects various access networks by reconfigurable routers, could be mapped into multiplex service oriented logical networks, supports dynamic reconfiguration due to diversified quality of services under heterogeneous environment, and therefore provides more flexible and high- speed multiple services. In addition, to demonstrate the generality of our model, we provide a prototype of reconfigurable router. The design, implementation and task scheduling as well as both hardware and software reconfiguration process of reconfigurable router are discussed in detail. Our evaluation shows that reconfigurable router is transparent for upper service-providing networks and results in little performance impact on the service delivery when both hardware and software reconfiguration are used. | HU YuXiang LAN JuLong WU JiangXing | 2011 | Science China(Information Sciences)2011，54，2： | 15 |
| 3 | Survivable Virtual Network Mapping Using Optimal Backup Topology in Virtualized SDN显示文摘Software-Defined Network architecture offers network virtualization through a hypervisor plane to share the same physical substrate among multiple virtual networks.However,for this hypervisor plane,how to map a virtual network to the physical substrate while guaranteeing the survivability in the event of failures,is extremely important.In this paper,we present an efficient virtual network mapping approach using optimal backup topology to survive a single link failure with less resource consumption.Firstly,according to whether the path splitting is supported by virtual networks,we propose the OBT-Ⅰ and OBT-Ⅱ algorithms respectively to generate an optimal backup topology which minimizes the total amount of bandwidth constraints.Secondly,we propose a Virtual Network Mapping algorithm with coordinated Primary and Backup Topology(VNM-PBT)to make the best of the substrate network resource.The simulation experiments show that our proposed approach can reduce the average resource consumption and execution time cost,while improving the request acceptance ratio of VNs. | WANG Zhiming WU Jiangxing WANG Yu QI Ning LAN Julong | 2014 | China Communications2014，11，2： | 14 |
| 4 | Overview of 5G security technology显示文摘The 5 th-generation mobile communication system(5 G) has higher security requirements than previous systems. Accordingly, international standard organizations, operators, and equipment manufacturers are focusing extensively on 5 G security technology. This paper analyzes the security requirements of 5 G business applications, network architecture, the air interface, and user privacy. The development trends of5 G security architecture are summarized, with a focus on endogenous defense architecture, which represents a new trend in 5 G security development. Several incremental 5 G security technologies are reviewed, including physical layer security, lightweight encryption, network slice security, user privacy protection, and block chain technology applied to 5 G. | Xinsheng JI Kaizhi HUANG Liang JIN Hongbo TANG Caixia LIU Zhou ZHONG Wei YOU Xiaoming XU Hua ZHAO Jiangxing WU Ming YI | 2018 | Science China(Information Sciences)2018，61，8： | 14 |
| 5 | Thoughts on the development of novel network technology显示文摘In this paper, we explore potential innovations that could lead to breakthrough developments in Internet technologies. The deep integration of the Internet and economic society brings professionalized service capacity demand, while existing Internet infrastructure with its current technological systems still face a number of challenges, such as intelligence, diversification, personalization, robustness, and efficiency.First, we analyze the actual foundation of innovation and specify the basic technical features of a novel network. Then, we propose a fully dimensionally definable open architecture as the primary direction, and consider reshaping baseline technologies as a starting point and discuss the core operational mechanisms of the novel network based on such reshaped baseline technologies. | Jiangxing WU | 2018 | Science China(Information Sciences)2018，61，10： | 13 |
| 6 | Introduction to Wireless Endogenous Security and Safety:Problems, Attributes, Structures and Functions显示文摘The information security and functional safety are fundamental issues of wireless communications sytems.The endogenous security principle based on Dynamic Heterogeneous Redundancy provides a direction for the development of wireless communication security and safety technology.This paper introduces the concept of wireless endogenous security from the following four aspects.First,we sorts out the endogenous security problems faced by the current wireless communications system,and then analyzes the endogenous security and safety attributes of the wireless channel.After that,the endogenous security and safety structure of the wireless communications system is given,and finally the applications of the existing wireless communication endogenous security and safety functions are listed. | Liang Jin Xiaoyan Hu Yangming Lou Zhou Zhong Xiaoli Sun Huiming Wang Jiangxing Wu | 2021 | China Communications2021，18，9： | 10 |
| 7 | Dynamic changes in soil chemical properties and microbial community structure in response to different nitrogen fertilizers in an acidified celery soil显示文摘To determine the effects of different kinds of nitrogen fertilizer,especially high-efficiency slowrelease fertilizers,on soil pH,nitrogen(N)and microbial community structures in an acidic celery soil,four treatments(CK,no N fertilizer;NR,urea;PE,calcium cyanamide fertilizer;and SK,controlled-release N fertilizer)were applied,and soil pH,total soil N,inorganic N,and soil microbial biomass C were analyzed.Phospholipid fatty acids(PLFAs)were extracted and detected using the MIDI Sherlock microbial identification system.The PE treatment significantly improved soil pH,from 4.80 to>6.00,during the whole growth period of the celery,and resulted in the highest celery yield among the four treatments.After 14 d application of calcium cyanamide,the soil nitrate content significantly decreased,but the ammonium content significantly increased.The PE treatment also significantly increased soil microbial biomass C during the whole celery growth period.Canonical variate analysis of the PLFA data indicated that the soil microbial community structure in the CK treatment was significantly different from those in the N applied treatments after 49 d fertilization.However,there was a significant difference(P<0.05)in soil microbial community structure between the PE treatment and the other three treatments at the end of the experiment.Calcium cyanamide is a good choice for farmers to use on acidic celery land because it supplies sufficient N,and increases soil pH,microbial biomass and the yield of celery. | Yuping Wu Jiangxing Wu Yongjun Ma Ying Lian Hui Sun Danchao Xie Yaying Li Philip C.Brookes Huaiying Yao | 2019 | Soil Ecology Letters2019，1，3： | 7 |
| 8 | Problems and solutions regarding generalized functional safety in cyberspace显示文摘The common endogenous security problems in cyberspace and related attack threats have posed subversive challenges to conventional theories and methods of functional safety.In the current design of the cyber physical system(CPS),functional safety and cyber security are increasingly intertwined and inseparable,which evolve into the generalized functional safety(S&S)problem.The conventional reliability and cybersecurity technologies are unable to provide security assurance with quanti able design and veri cation metrics in response to the cyberattacks in hardware and software with common endogenous security problems,and the functional safety of CPS facilities or device has become a frightening ghost.The dynamic heterogeneity redundancy(DHR)architecture and coding channel theory(CCT)proposed by the cyberspace endogenous security paradigm could handle random failures and uncertain network attacks in an integrated manner,and its generalized robust control mechanism can solve the universal problem of quantitative design for functional safety under probability or improbability perturbation.As a generalized functional safety enabling structure,DHR opens up a new direction to solve the common endogenous security problems in the cross-disciplinary elds of cyberspace. | JiangXing Wu | 2022 | Security and Safety2022，1，1： | 5 |
| 9 | EARS: Intelligence-Driven Experiential Network Architecture for Automatic Routing in Software-Defined Networking显示文摘Software-Defined Networking(SDN)adapts logically-centralized control by decoupling control plane from data plane and provides the efficient use of network resources.However,due to the limitation of traditional routing strategies relying on manual configuration,SDN may suffer from link congestion and inefficient bandwidth allocation among flows,which could degrade network performance significantly.In this paper,we propose EARS,an intelligence-driven experiential network architecture for automatic routing.EARS adapts deep reinforcement learning(DRL)to simulate the human methods of learning experiential knowledge,employs the closed-loop network control mechanism incorporating with network monitoring technologies to realize the interaction with network environment.The proposed EARS can learn to make better control decision from its own experience by interacting with network environment and optimize the network intelligently by adjusting services and resources offered based on network requirements and environmental conditions.Under the network architecture,we design the network utility function with throughput and delay awareness,differentiate flows based on their size characteristics,and design a DDPGbased automatic routing algorithm as DRL decision brain to find the near-optimal paths for mice and elephant flows.To validate the network architecture,we implement it on a real network environment.Extensive simulation results show that EARS significantly improve the network throughput and reduces the average packet delay in comparison with baseline schemes(e.g.OSPF,ECMP). | Yuxiang Hu Ziyong Li Julong Lan Jiangxing Wu Lan Yao | 2020 | China Communications2020，17，2： | 4 |
| 10 | An Aware-Scheduling Security Architecture with Priority-Equal Multi-Controller for SDN显示文摘Current SDN controllers suffer from a series of potential attacks. For example, malicious flow rules may lead to system disorder by introducing unexpected flow entries. In this paper, we propose Mcad-SA, an aware decision-making security architecture with multiple controllers, which could coordinate heterogeneous controllers internally as a 'big' controller. This architecture includes an additional plane, the scheduling plane, which consists of transponder, sensor, decider and scheduler. Meanwhile it achieves the functions of communicating, supervising and scheduling between data and control plane. In this framework, we adopt the vote results from the majority of controllers to determine valid flow rules distributed to switches. Besides, an aware dynamic scheduling(ADS) mechanism is devised in scheduler to intensify security of Mcad-SA further. Combined with perception, ADS takes advantage of heterogeneity and redundancy of controllers to enable the control plane operate in a dynamic, reliable and unsteady state, which results in significant difficulty of probing systems and executing attacks. Simulation results demonstrate the proposed methods indicate better security resilience over traditional architectures as they have lower failure probability when facing attacks. | Chao Qi Jiangxing Wu Guozhen Cheng Jianjian Ai Shuo Zhao | 2017 | China Communications2017，14，9： | 4 |
| 11 | Performance Modeling Based on GSPN for Cyberspace Mimic DNS显示文摘Cyberspace mimic domain name system(CMDNS)adopts dynamic heterogeneous redundant architecture with strategic decision mechanism to control the effectiveness of uncertain disturbance.There is lack of methods to evaluate the availability and awareness security of CMDNS.To further describe and analyze the characteristics of CMDNS accurately,the Generalized stochastic Petri net(GSPN)is used to model the attack disturbance and defense of mimic Domain name system(DNS),and the availability and awareness security of Dissimilar redundancy system(DRS)and mimic DNS under different disturbance intensities are compared.We compared the different effect of local service query and real network query on the average response delay.The results show that the introduction of mimic architecture will inevitably pay the corresponding delay cost which increase 9.3% compared with traditional local DNS,but it has little effect on the service which only increases by 1.9% compared with the DNS transmission delay at the network communication level. | REN Quan WU Jiangxing HE Lei | 2020 | Chinese Journal of Electronics2020，29，4： | 3 |
| 12 | MimicCloudSim:An Environment for Modeling and Simulation of Mimic Cloud Service显示文摘In recent years,an increasing number of application services are deployed in the cloud.However,the cloud platform faces unknown security threats brought by its unknown vulnerabilities and backdoors.Many researchers have studied the Cyber Mimic Defense(CMD)technologies of the cloud services.However,there is a shortage of tools that enable researchers to evaluate their newly proposed cloud service CMD mechanisms,such as scheduling and decision mechanisms.To fill this gap,we propose MimicCloudSim as a mimic cloud service simulation system based on the basic functionalities of CloudSim.MimicCloudSim supports the simulation of dynamic heterogeneous redundancy(DHR)structure which is the core architecture of CMD technology,and provides an extensible interface to help researchers implement new scheduling and decision mechanisms.In this paper,we firstly describes the architecture and implementation of MimicCloudSim,and then discusses the simulation process.Finally,we demonstrate the capabilities of MimicCloudSim by using a decision mechanism.In addition,we tested the performance of MimicCloudSim,the conclusion shows that MimicCloudSim is highly scalable. | Liming Pu Jiangxing Wu Hailong Ma Yuhang Zhu Yingle Li | 2021 | China Communications2021，18，1： | 2 |
| 13 | Cyberspace Endogenous Safety and Security显示文摘Uncertain security threats caused by vulnerabilities and backdoors are the most serious and difficult problem in cyberspace.This paper analyzes the philosophical and technical causes of the existence of so-called'dark functions'such as system vulnerabilities and backdoors,and points out that endogenous security problems cannot be completely eliminated at the theoretical and engineering levels;rather,it is necessary to develop or utilize the endogenous security functions of the system architecture itself.In addition,this paper gives a definition for and lists the main technical characteristics of endogenous safety and security in cyberspace,introduces endogenous safety and security mechanisms and characteristics based on dynamic heterogeneous redundancy(DHR)architecture,and describes the theoretical implications of a coding channel based on DHR. | Jiangxing Wu | 2022 | Engineering2022，8，8： | 2 |
| 14 | Secure Cloud Architecture for 5G Core Network显示文摘Service-based architecture(SBA)is a profound advancement in the novel 5G Core network(5GC).Existing studies show that SBA can benefit from cloud computing to achieve extensibility,modularity,reusability,and openness.It also brings security problems(e.g.,hypervisor hijacking,and malware injection).To provide secure 5G services,we propose a service-based cloud architecture called Mimicloud for 5GC based on dynamic and heterogeneous techniques.Mimicloud provides flexible reconfiguration mechanisms to protect containers and eliminate all attack knowledge obtained from adversaries.We use multiple containers to execute crucial services and ensure security with crosscheck.Mimicloud employs heterogeneous components to prevent multiple containers from being breached through the same vulnerabilities.Experimental results show that Mimicloud can effectively strengthen the security of the 5GC.The performance overhead is analyzed in order to demonstrate its scalability. | LI Lingshu WU Jiangxing HU Hongchao LIU Wenyan GUO Zehua | 2021 | Chinese Journal of Electronics2021，30，3： | 2 |
| 15 | Roleof X - lin kedinhibitor of apoptosis protein in chemoresistance in ovarian cancer: possible involvement of the phosphoinositide - 3 kinase / Akt pathway 显示文摘 | ChengJQ JiangX FraserM | 2002 | Drug Resist Updat2002，5，34： | 1 |
| 16 | Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plaxticity and survival from genes to phenotype显示文摘 | Marini AM JiangX WuX | | 0，，02： | 1 |
| 17 | Anti-Attacking Modeling and Analysis of Cyberspace Mimic DNS显示文摘With the rapid development of information technology,the cyberspace security problem is increasingly serious.Kinds of dynamic defense technology have emerged such as moving target defense and mimic defense.This paper aims to describe the architecture and analyze the performance of Cyberspace Mimic DNS based on generalized stochastic Petri net.We propose a general method of anti-attacking analysis.For general attack and special attack model,the available probability,escaped probability and nonspecial awareness probability are adopted to quantitatively analyze the system performance.And we expand the GSPN model to adjust to engineering practice by specifying randomness of different output vectors.The result shows that the proposed method is effective,and Mimic system has high anti-attacking performance.To deal with the special attack,we can integrate the traditional defense mechanism in engineering practice.Besides,we analyze the performance of mimic DNSframework based on multi-ruling proxy and input-output desperation,the results represent we can use multi ruling or high-speed cache servers to achieve the consistent cost of delay,throughput compared with single authorized DNS,it can effectively solve 10%to 20%performance loss caused by general ruling proxy. | Lei He Quan Ren Bolin Ma Weili Zhang Jiangxing Wu | 2022 | China Communications2022，19，5： | 1 |
| 18 | Therole of ^18F-FDGPET/CT in the evaluation of ascites of undetermined origin显示文摘 | Zhang M JiangX ZhangM etal | 2009 | J Nucl Med2009，50，： | 1 |
| 19 | Defining honeybee subspecies in an evolutionary context warrants strategized conservation显示文摘Despite the urgent need for conservation consideration,strategic action plans for the preservation of the Asian honeybee,Apis cerana Fabricius,1793,remain lacking.Both the convergent and divergent adaptations of this widespread insect have led to confusing phenotypical traits and inconsistent infraspecific taxonomy.Unclear subspecies boundaries pose a significant challenge to honeybee conservation efforts,as it is difficult to effectively prioritize conservation targets without a clear understanding of subspecies identities.Here,we investigated genome variations in 362 worker bees representing almost all populations of mainland A.cerana to understand how evolution has shaped its population structure.Whole-genome single nucleotide polymorphisms(SNPs)based on nuclear sequences revealed eight putative subspecies,with all seven peripheral subspecies exhibiting mutually exclusive monophyly and distinct genetic divergence from the widespread central subspecies.Our results demonstrated that most classic morphological traits,including body size,were related to the climatic variables of the local habitats and did not reflect the true evolutionary history of the organism.Thus,such morphological traits were not suitable for subspecific delineation.Conversely,wing vein characters showed relative independence to the environment and supported the subspecies boundaries inferred from nuclear genomes.Mitochondrial phylogeny further indicated that the present subspecies structure was a result of multiple waves of population divergence from a common ancestor.Based on our findings,we propose that criteria for subspecies delineation should be based on evolutionary independence,trait distinction,and geographic isolation.We formally defined and described eight subspecies of mainland A.cerana.Elucidation of the evolutionary history and subspecies boundaries enables a customized conservation strategy for both widespread and endemic honeybee conservation units,guiding colony introduction and breeding. | Lifei Qiu Jiangxing Dong Xingan Li Sajad HParey Ken Tan Michael Orr Aquib Majeed Xue Zhang Shiqi Luo Xuguo Zhou Chaodong Zhu Ting Ji Qingsheng Niu Shanlin Liu Xin Zhou | 2023 | Zoological Research2023，44，3： | 1 |
| 20 | The effect of rubrene as a dopant on the efficiency and stability of organic thin film electroluminescent devices 显示文摘 | Zhang Z L JiangX Y XuSH | 1998 | J Phys D: Appl Phys1998，31，： | 1 |
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