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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors显示文摘Programmed cell death protein-1(PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T(CAR-T)cells in solid tumors.We generated PD-1 and T cell receptor(TCR)deficient mesothelin-specific CAR-T(MPTK-CAR-T)cells using CRISPR-Cas9 technology and evaluated them in a dose-escalation study.A total of 15 patients received one or more infusions of MPTK-CAR-T cells without prior lymphodepletion.No dose-limiting toxicity or unexpected adverse events were observed in any of the 15 patients.The best overall response was stable disease(2/15 patients).Circulating MPTK-CAR-T cells peaked at days 7–14 and became undetectable beyond 1 month.TCR-positive CAR-T cells rather than TCR-negative CAR-T cells were predominantly detected in effusion or peripheral blood from three patients after infusion.We further confirmed the reduced persistence of TCR-deficient CAR-T cells in animal models.Our results establish the preliminary feasibility and safety of CRISPR-engineered CAR-T cells with PD-1 disruption and suggest that the natural TCR plays an important role in the persistence of CAR-T cells when treating solid tumors. | Zhenguang Wang Na Li Kaichao Feng Meixia Chen Yan Zhang Yang Liu Qingming Yang Jing Nie Na Tang Xingying Zhang Chen Cheng Lianjun Shen Jiaping He Xun Ye Wei Cao Haoyi Wang Weidong Han | 2021 | Cellular & Molecular Immunology2021，18，9： | 7 |
| 3 | Spatiotemporal Mapping of Salt Marshes in the Intertidal Zone of China during 1985-2019显示文摘This study mapped the areal extent,identified the species composition,and analyzed the changes of salt marshes in the intertidal zone of China during the period 1985–2019.With the aid of the cloud platform of the Google Earth Engine,we selected Landsat 5/8 and Sentinel-2 images and used the support vector machine classification method to extract salt marsh information for the years of 1985,1990,1995,2000,2005,2010,2015,and 2019.Seven major species of salt marshes:Phragmites australis,Suaeda spp.,Spartina alterniflora,Scirpus mariqueter,Tamarix chinensis,Cyperus malaccensis,and Sesuvium portulacastrum were identified.Our results showed that salt marshes are mainly distributed in Liaoning,Shandong,Jiangsu,Shanghai,and Zhejiang,with varying patterns of shrinking,expansion,or wavering in different places.The distribution of salt marshes has declined considerably from 151,324 ha in 1985 to 115,397 ha in 2019,a drop of 23.7%.During the same period,the area of native species has dropped 95.4%from 77,741 ha to 3,563 ha for Suaeda spp.and 45.1%from 60,511 ha to 33,193 ha for P.australis;on the contrary,the area of exotic species,S.alterniflora,has exhibited a sharp rise from just 99 ha to 67,527 ha.For the past 35 years,the driving factors causing salt marsh changes are mainly land reclamation,variations in water and sand fluxes,and interspecific competition and succession of salt marsh vegetation.These results provide fundamental reference information and could form the scientific basis for formulating policies for the conservation and utilization of salt marsh resources in China. | Guangwei Chen Runjie Jin Zhanjiang Ye Qi Li Jiali Gu Min Luo Yongming Luo George Christakos James Morris Junyu He Dan Li Hengwei Wang Li Song Qiuxuan Wang Jiaping Wu | 2022 | Journal of Remote Sensing2022，，1： | 2 |
| 4 | Metal-film-assisted ultra-clean transfer of single-walled carbon nanotubes显示文摘 | Yujun He Dongqi Li Tianyi Li Xiaoyang Lin Jin Zhang Yang Wei Peng Liu Lina Zhang Jiaping Wang Qunqing Li Shoushan Fan Kaili Jiang | 2014 | Nano Research2014，7，7： | 1 |
| 5 | Freestanding macroscopic metal-oxide nanotube films derived from carbon nanotube film templates显示文摘与非结晶的碳涂的排列的碳 nanotube 电影被原子层免职开发进新奇模板。独立宏观的金属氧化物 nanotube 电影然后被使用这些模板成功地综合。反应的非结晶的碳层极大地改进了原子核密度,它保证了这些电影的高质量并且允许 nanotubes 的墙厚度的精确控制。用综合模板的氧化铝 nanotube 电影,我们以高反应速度,一个传播电子显微镜学(TEM ) 格子,和催化剂支持表明一个湿度传感器。跨 stacked 汇编, ultrathin 厚度,化学不活泼,和氧化铝 nanotube 电影的高热的稳定性贡献了这些设备的优秀性能。另外,金属氧化物 nanotube 电影将由于他们的材料丰富,宏观的外观,灵活性,与半导体的技术的相容性,和大量生产的可行性有重要潜力,这被期望。 | He Ma Yang Wei Jiangtao Wang Xiaoyang Lin WenyunWu Yang Wu Ling Zhang Peng Liu Jiaping Wang Qunqing Li Shoushan Fan Kaili Jiang | 2015 | Nano Research2015，8，6： | 1 |
| 6 | Adjuvant tran- scatheter arterial chemocmbo|ization improves efficacy of hepatectomy for patients with hepatocellular carcinoma and portal vein tumor thrombus 显示文摘 | BaoGang Peng Qiang He JiaPing Li | 2009 | The American Journal of Surgery2009，198，3： | 1 |
| 7 | True-color real-time imaging and spectroscopy of carbon nanotubes on substrates using enhanced Rayleigh scattering显示文摘白光照亮的围单人赛的碳 nanotubes (SWCNT ) 应该由于散布的回声瑞利显得有颜色。然而,底层上的 SWCNT 的真彩成像没被报导,因为 SWCNT 和散布的强壮的底层的极其低的散布紧张。这里,我们证明散布的瑞利能被接口偶极子改进效果极大地提高。底层上的因而丰富多彩的 SWCNT 能被宽地 supercontinuum 激光照明直接在一台光显微镜下面想象,它便于单个 SWCNT 的高产量 chirality 赋值。这条途径,称为的瑞利成像显微镜学,没被限制为 SWCNT,但是对许多 nanomaterials 广泛地适用,它使丰富多彩的 nanoworld 能在光显微镜下面被探索。 | Wenyun Wu Jingying Yue Xiaoyang Lin Dongqi Li Fangqiang Zhu Xue Yin Jun Zhu Jiangtao Wang Jin Zhang Yuan Chen Xinhe Wang Tianyi Li Yujun He Xingcan Dai Peng Liu Yang wei Jiaping Wang Wei Zhang Yidong Huang Li Fan Lina Zhang Qunqing Li Shoushan Fan Kaili Jiang | 2015 | Nano Research2015，8，8： | 1 |
| 8 | Fabrication and ethanol-sensing properties of micro gas sensor based on electrospun SnO2 nanofibers显示文摘 | ZHANG Yang HE Xiuli LI Jiaping | 2008 | Sensors and Actuators B2008，32，1： | 1 |
| 9 | Microscale comprehensive evaluation of continental shale oil recoverability显示文摘This paper targets the shale oil reservoirs of middle to high maturity in four major basins of China,including the Permian Lucaogou Formation of the Jimsar Sag in the Junggar Basin,the Chang 73 Member of the Triassic Yanchang Formation in the Longdong area of the Ordos Basin,the Kong 2 Member of the Paleogene Kongdian Formation in Cangdong Sag of the Bohai Bay Basin,and the Qing 1 Member of the Cretaceous Qingshankou Formation in Changling Sag of the Songliao Basin.The key parameters of the shale oil reservoirs in the four basins,such as reservoirs effectiveness,oil content,crude oil movability,and fracability,have been revealed under identical experimental conditions using the same evaluation technical system,on the basis of technique development and integrated application of multi-scale spatial distribution depiction,effective connectivity calculation,movable oil assessment based on the charging effect,and simulation of fracture propagation during reservoir stimulation.This research overcomes insufficient resolutions of conventional analysis approaches and difficulties in quantitative evaluation,develops the evaluation method for resource recoverability of different types of shale oil,and gains insights into different types of shale oil via comparison.The results of experiments and comparative analysis show that there are significant differences in the endowment of continental shale oil resources in the four major basins in China.Among them,the Lucaogou Formation in the Junggar Basin has more effective shale reservoirs,the Chang 73 sub-member of the Ordos Basin has a comparatively good proportion of movable oil and the Kong 2 Member of the Bohai Bay Basin has the best fracability.These results can provide references and basis for choosing development plans and engineering techniques. | JIN Xu LI Guoxin MENG Siwei WANG Xiaoqi LIU Chang TAO Jiaping LIU He | 2021 | Petroleum Exploration and Development2021，48，1： | 0 |
| 10 | Organization and evolution of climate responsive strategies,used in Turpan vernacular buildings in arid region of China显示文摘Under the global crisis of energy shortage and environmental pollution,the climate responsive strategies used in vernacular buildings have attracted much attention for their potential to reduce energy consumption and carbon emissions.However,the relationships between these traditional climatic strategies were not precisely perceived,which may cause the inapplicability of these strategies for contemporary rural houses.In this paper,taking the Turpan vernacular buildings in arid region of China,the climate responsive strategies of buildings in the most significant periods such as the Gaochang period(before 1318),the Khanate and Republican period(1318–1949),the Modern period(1949–2010),and the Contemporary period(2011–present)were summarized.In addition,two different types of climatic strategies organizations,namely multilayer spaces and integrated building envelopes,were identified based on the temperature difference measurement and comparative analysis.The assessment of thermal performance of the organizations was conducted by the methodology of software simulation.Furthermore,the applicability of the organizations in rural areas was discussed,and a new combined organization was proposed.Consequently,this study can contribute to provide the main approaches for climatically responsive rural houses. | Wenfang He Zhenying Wu Ran Jin Jiaping Liu | 2023 | Frontiers of Architectural Research2023，12，3： | 0 |
| 11 | Practice and development suggestions of hydraulic fracturing technology in the Gulong shale oil reservoirs of Songliao Basin, NE China显示文摘This paper reviews the multiple rounds of upgrades of the hydraulic fracturing technology used in the Gulong shale oil reservoirs and gives suggestions about stimulation technology development in relation to the production performance of Gulong shale oil wells.Under the control of high-density bedding fractures,fracturing in the Gulong shale results in a complex fracture morphology,yet with highly suppressed fracture height and length.Hydraulic fracturing fails to generate artificial fractures with sufficient lengths and heights,which is a main restraint on the effective stimulation in the Gulong shale oil reservoirs.In this regard,the fracturing design shall follow the strategy of'controlling near-wellbore complex fractures and maximizing the extension of main fractures'Increasing the proportions of guar gum fracturing fluids,reducing perforation clusters within one fracturing stage,raising pump rates and appropriately exploiting stress interference are conducive to fracture propagation and lead to a considerably expanded stimulated reservoir volume(SRV).The upgraded main hydraulic fracturing technology is much more applicable to the Gulong shale oil reservoirs.It accelerates the oil production with a low flowback rate and lifts oil cut during the initial production of well groups,which both help to improve well production.It is suggested to optimize the hydraulic fracturing technology in six aspects,namely,suppressing propagation of near-wellbore microfractures,improving the pumping scheme of CO_(2),managing the perforating density,enhancing multi-proppant combination,reviewing well pattern/spacing,and discreetly applying fiber-assisted injection,so as to improve the SRv,the distal fracture complexity and the long-term fracture conductivity. | LIU He HUANG Youquan CAI Meng MENG Siwei TAO Jiaping | 2023 | Petroleum Exploration and Development2023，50，3： | 0 |
| 12 | Scanning electron microscopy imaging of single-walled carbon nanotubes on substrates显示文摘因为它的高效率和高空间的分辨率,扫描电子显微镜学(SEM ) 在描绘 nanomaterials 在 nanoscience 和纳米技术起一个不可缺少的作用。如果围单人赛的碳 nanotubes (SWCNT ) 被放在底层上,最近的进步显示从不同传导性或 bandgaps 产生的对比能在 SEM 图象被观察。在这研究,我们在不同底层上把 SWCNT 用作模型系统执行 nanomaterials 的 SEM 成像。实质的 SEM 观察在高、低的加速电压被进行,导致材料和表面费用上的成像参数和底层的效果的全面理解信号,以及 SEM 成像。SEM 成像的这幅统一图画不仅在许多底层上推进我们 SWCNT 的 SEM 图象的理解而且为为在 nanoelectronics 和 nanophotonics 使用的另外的重要 nanomaterials 开发新成像配方提供一个基础。 | Dongqi Li Jin Zhang Yujun He Yan Qin Yang Wei Peng Liu Lina Zhang Jiaping Wang Qunqing Li Shoushan Fan Kaili Jiang | 2017 | Nano Research2017，10，5： | 0 |
| 13 | The histone H3K27 demethylase REF6/JMJ12 promotes thermomorphogenesis in Arabidopsis显示文摘Dynamic trimethylation of histone H3 at Lys27(H3 K27 me3)affects gene expression and controls plant development and environmental responses.In Arabidopsis thaliana,RELATIVE OF EARLY FLOWERING 6(REF6)/JUMONJI DOMAIN-CONTAINING PROTEIN 12 demethylates H3 K27 me3 by recognizing a specific DNA motif.However,little is known about how REF6 activates target gene expression after recognition,especially in environmental responses.In response to warm ambient temperature,plants undergo thermomorphogenesis,which involves accelerated growth,early flowering and changes in morphology.Here we show that REF6 regulates thermomorphogenesis and cooperates with the transcription factor PHYTOCHROME INTERACTING FACTOR 4 to synergistically activate thermoresponsive genes under warm ambient temperature.The ref6 loss-of-function mutants exhibited attenuated hypocotyl elongation at warm temperature,partially due to downregulation of GIBBERELLIN20-OXIDASE 2 and BASIC HELIX-LOOP-HELIX 87.REF6 enzymatic activity is necessary for warm ambient temperature responses.Together,our results provide direct evidence of an epigenetic modifier and a transcription factor working together to respond to the environment. | Kaixuan He Hailiang Mei Jiaping Zhu Qi Qiu Xiaofeng Cao Xian Deng | 2022 | National Science Review2022，9，5： | 0 |
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