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| 1 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 2 | Effects of precipitation and landuse on runoff during the past 50 years in a typical watershed in the Loess Plateau, China显示文摘In the past century, great progress has been made worldwide in our understanding of forest-water relationship. The successful forestation programs implemented in China-which have improved the ecological environmental conditions-have gained the attention of many researchers and highlighted the relationship between forestation and water yields. The arid and semi-arid Loess Plateau has received attention from water engineers and eco-hydrological researchers in China because of a shortage in water resources. We selected one of the oldest stations conducting soil and water conservation experiments, the Xifeng soil and water conservation station, and chose the Nanxiaohe catchment and its paired catchments (Yangjiagou catchment and Dongzhuanggou catchment) as our research areas. Trends in precipitation, air temperature, streamflow over the past 50 years, and the effect of changing land use on streamflow were analyzed. The Mann-Kendall test showed that precipitation had a negative trend (downward trend), whereas air temperature showed a positive trend (upward trend) from the past to present in the Nanxiaohe catchment. However, the trends seen in precipitation, air temperature did not contain any 'jumping points.' The paired catchment approach is used to detect the effects of land cover change on hydrology in the Yangjiagou and the contrast catchment, i.e., Dongzhuanggou catchment in our study. The results showed a large change in land use in the Yangjiagou catchment from 1954 to 2008. An increase in forested land (from 0% to 40.08% from 1954 to 2008) and a reduction of bare land (from 51.26% to 5.50% from 1954 to 2008) accounted for a large part of the change in land use. However, the land use changed little in the contrast catchment. The comparison of streamflow in the paired catchments showed that forestation reduced streamflow by 49.63% (or 6.5 mm) each year. | Huaxing BI Bin LIU Jie WU Lei YUN Zhihan CHEN Zhewei CUI | 2009 | International Journal of Sediment Research2009，24，3： | 21 |
| 3 | Interactive effects of water and nitrogen addition on soil microbial communities in a semiarid steppe显示文摘Aims Better understanding of microbial compositional and physiological acclimation mechanisms is critical for predicting terrestrial ecosystem responses to global change.The aim is to assess variations in soil microbial communities under future scenarios of changing precipitation and N deposition in a semiarid grassland of northern China.Methods In order to explicitly estimate microbial responses,a field experiment with water and N addition was established in April 2005 and continuously conducted for 4 years.Specifically,soil microbial community composition and microbial C utilization potential were determined by phospholipid fatty acid(PLFA)and community-level physiological profiles,respectively.Important Findings Water addition had no effects on the PLFA concentrations of grampositive(GP)and negative bacteria(GN),total bacteria and fungi.However,N addition caused significant reductions in the PLFA concentrations of GP,GN,total bacteria and fungi and thus decreased total PLFA of microbial communities.Moreover,there were interactive effects of water and N addition on GN/GPand the ratio of fungal to bacterial PLFA(F/B).In addition,synergistic effects were found between water and nitrogen in affecting microbial C utilization potentials,which implies that microbial C utilization potentials tend to be enhanced when both N and water availability are sufficient.Overall,the microbial responses to water and N addition support our hypothesis that water and N addition may be combined together to affect microbial communities in the semiarid grassland. | Jie Bi Naili Zhang Yu Liang Haijun Yang Keping Ma | 2012 | Journal of Plant Ecology2012，5，3： | 21 |
| 4 | Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes显示文摘Objective To examine the association between serum uric acid levels and cardiovascular disease risk among individuals without diabetes. Methods We investigated the association between serum uric acid levels and the risk of prevalent cardiometabolic diseases, 10-year Framingham risk for coronary heart disease, and 10-year risk for atherosclerotic cardiovascular diseases(ASCVD) among 8,252 participants aged ≥ 40 years without diabetes from Jiading district, Shanghai, China. Results Body mass index, waist circumference, blood glucose, glycated hemoglobin, blood pressure, and serum lipids increased progressively across the sex-specific quartiles of uric acid(all P trend < 0.05). Compared with individuals in the lowest quartile, those in the higher quartiles had a significantly higher prevalence of obesity, hypertension, and dyslipidemia(all P trend < 0.05). A fully adjusted logistic regression analysis revealed that individuals in the highest quartile had an increased risk of predicted cardiovascular disease compared with those in the lowest quartile of uric acid. The multivariate adjusted odds ratios(ORs) [95% confidence intervals(CIs)] for the highest quartiles for high Framingham risk were 3.00(2.00-4.50) in men and 2.95(1.08-8.43) in women. The multivariate adjusted ORs(95% CIs) for the highest quartile for high ASCVD risk were 1.93(1.17-3.17) in men and 4.53(2.57-7.98) in women. Conclusion Serum uric acid level is associated with an increased risk of prevalent obesity, hypertension, dyslipidemia, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD among Chinese adults without diabetes. | CHENG Di DU Rui WU Xue Yan LIN Lin PENG Kui MA Li Na XU Yu XU Min CHEN Yu Hong BI Yu Fang WANG Wei Qing DAI Meng LU Jie Li | 2018 | Biomedical and Environmental Sciences2018，31，2： | 13 |
| 5 | Relative apparent diffusion coefficient: a promising tool to differentiate metastatic from benign lymph nodes in animal models显示文摘背景散开加权的成像广泛地被用来区分 lymphadenopathy 的特性。但是优先的研究之间有重要差别。学习的目的是在二个观察员独立地测量了的兔子 model.Methods 在变形、良性的淋巴节点的区别比较明显的散开系数(模数转换器) 和 rADC 的利益在有兴趣(ROI ) 的区域的不同尺寸的散开加权的图象上的每只兔子的四头肌的模数转换器。为 rADC 的适当 ROI 用 interobserver 系数被决定。rADC 被 ADClesion/ADCreference 地点计算。接收装置操作特征(巨鸟) 分析被执行在区分比较 ADC 值的诊断的值和 rADC 值从良性的淋巴 nodes.Results 变形当 ROI 包括了五个象素时, ICC 是 0.816,显示一个好 interobserver 协议。在变形、良性的淋巴节点之间的模数转换器和 rADC 价值的差别两个都是统计上重要的。在 ROC 曲线下面的区域比为 ADC 为 rADC 是更大的。与 0.640 的 rADC 标准,为区分的敏感和特性从良性的淋巴节点变形是 93 和 90,是的 respectively.Conclusion 一个参考地点,肌肉用小 ROI 揭示好重覆性, rADC 可以为在动物模型检测变形节点改进诊断精确性。 | XING Wei SHENG Jing CHEN Jie TIAN Jian-ming BI Heng-liang | 2011 | Chinese Medical Journal2011，，18： | 11 |
| 6 | Atmospheric Deposition-Carried Pb, Zn, and Cd from a Zinc Smelter and Their Effect on Soil Microorganisms显示文摘Dust emissions from smelters, as a major contributor to heavy metal contamination in soils, could severely influence soil quality. Downwind surface soils within 1.5 km of a zinc smelter, which was active for 10 years but ceased in 2000, in Magu Town, Guizhou Province, China were selected to examine Pb, Zn, and Cd concentrations and their fractionation along a distance gradient from a zinc smelter, and to study the possible e?ects of Pb, Zn, and Cd accumulation on soil microorganisms by comparing with a reference soil located at a downwind distance of 10 km from the zinc smelter. Soils within 1.5 km of the zinc smelter accumulated high levels of heavy metals Zn (508 mg kg-1), Pb (95.6 mg kg-1), and Cd (5.98 mg kg-1) with low ratios of Zn/Cd (59.1-115) and Pb/Cd (12.4-23.4). Composite pollution indices (CPIs) of surface soils (2.52-15.2) were 3 to 13 times higher than the reference soils. In metal accumulated soils, exchangeable plus carbonate-bound fractions accounted for more than 10% of the total Zn, Pb, and Cd. The saturation degree of metals (SDM) in soils within 1.5 km of the smelter (averaging 1.25) was six times higher than that of the reference soils (0.209). A smaller soil microbial biomass was found more frequently in metal accumulated soils (85.1-438 μg C g-1) than in reference soils (497 μg C g-1), and a negative correlation (P < 0.01) of soil microbial biomass carbon to organic carbon ratio (Cmic/Corg) with SDM was observed. Microbial consumption of carbon sources was more rapid in contaminated soils than in reference soils, and a shift in the substrate utilization pattern was apparent and was negatively correlated with SDM (R = -0.773, P < 0.01). Consequently, dust deposited Pb, Zn, and Cd in soils from zinc smelting were readily mobilized, and were detrimental to soil quality mainly in respect of microbial biomass. | YANG Yuan-Gen2, JIN Zhi-Sheng, BI Xiang-Yang, LI Fei-Li, SUN Li, LIU Jie and FU Zhi-You Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002 (China) | 2009 | Pedosphere2009，19，4： | 11 |
| 7 | Early constraint-induced movement therapy affects behavior and neuronal plasticity in ischemia-injured rat brains显示文摘Constraint-induced movement therapy is an effective rehabilitative training technique used to improve the restoration of impaired upper extremity movement after stroke. However, whether constraint-induced movement therapy is more effective than conventional rehabilitation in acute or sub-acute stroke remains controversial. The aim of the present study was to identify the optimal time to start constraint-induced movement therapy after ischemic stroke and to explore the mechanisms by which constraint-induced movement therapy leads to post-stroke recovery. Sixty-four adult male Sprague-Dawley rats were randomly divided into four groups: sham-surgery group, cerebral ischemia/reperfusion group, early constraint-induced movement therapy group, and late constraint-induced movement therapy group. Rat models of left middle cerebral artery occlusion were established according to the Zea Longa line embolism method. Constraint-induced movement therapy was conducted starting on day 1 or day 14 in the early constraint-induced movement therapy and late constraint-induced movement therapy groups, respectively. To explore the effect of each intervention time on neuromotor function, behavioral function was assessed using a balance beam walking test before surgery and at 8 and 21 days after surgery. The expression levels of brain-derived neurotrophic factor, nerve growth factor and Nogo receptor were evaluated using real time-polymerase chain reaction and western blot assay to assess the effect of each intervention time. The results showed that the behavioral score was significantly lower in the early constraint-induced movement therapy group than in the cerebral ischemia/reperfusion and late constraint-induced movement therapy groups at 8 days. At 21 days, the scores had significantly decreased in the early constraint-induced movement therapy and late constraint-induced movement therapy groups. At 8 days, only mild pyknosis appeared in neurons of the ischemic penumbra in the early constraint-induced movement therapy group, which was distinctly better than in the cerebral ischemia/reperfusion group. At 21 days, only a few vacuolated cells were observed and no obvious inflammatory cells were visible in late constraint-induced movement therapy group, which was much better than at 8 days. The mRNA and protein expression levels of brain-derived neurotrophic factor and nerve growth factor were significantly higher, but expression levels of Nogo receptor were significantly lower in the early constraint-induced movement therapy group compared with the cerebral ischemia/reperfusion and late constraint-induced movement therapy groups at 8 days. The changes in expression levels at 21 days were larger but similar in both the early constraint-induced movement therapy and late constraint-induced movement therapy groups. Besides, the protein nerve growth factor level was higher in the late constraint-induced movement therapy group than in the early constraint-induced movement therapy group at 21 days. These results suggest that both early(1 day) and late(14 days) constraint-induced movement therapy induces molecular plasticity and facilitates functional recovery after ischemic stroke, as illustrated by the histology. The mechanism may be associated with downregulation of Nogo receptor expression and upregulation of brain-derived neurotrophic factor and nerve growth factor expression. | Xi-Hua Liu Hong-Yan Bi Jie Cao Shuo Ren Shou-Wei Yue | 2019 | Neural Regeneration Research2019，14，5： | 11 |
| 8 | Investigation of free amino acid, total phenolics,antioxidant activity and purine alkaloids to assess the health properties of non-Camellia tea显示文摘To find novel functional beverages from folk teas, 33 species of frequently used non-Camellia tea(plants other than Camellia) were collected and compared with Camellia tea(green tea, pu-erh tea and black tea) for the first time. Data are reported here on the quantities of 20 free amino acids(FAAs) and three purine alkaloids(measured by UHPLC), total polyphenols(measured by Folin-Ciocalteu assay), and antioxidant activity(DPPH). The total amounts of FAAs in non-Camellia tea(0.62–18.99 mg/g) are generally less than that of Camellia tea(16.55–24.99 mg/g). However, for certain FAAs, the quantities were much higher in some non-Camellia teas, such as γ-aminobutyric acid in teas from Ampelopsis grossedentata, Isodon serra and Hibiscus sabdariffa. Interestingly, theanine was detected in tea from Potentilla fruticosa(1.16±0.81 mg/g). Furthermore, the content of polyphenols in teas from A. grossedentata, Acer tataricum subsp. ginnala are significantly higher than those from Camellia tea;teas from I. serra, Pistacia chinensis and A. tataricum subsp. ginnala have remarkable antioxidant activities similar to the activities from green tea(44.23 μg/m L). Purine alkaloids(caffeine, theobromine and theophylline) were not detected in non-Camellia teas. The investigation suggest some non-Camellia teas may be great functional natural products with potential for prevention of chronic diseases and aging,by providing with abundant polyphenols, antioxidants and specific FAAs. | Wu Bi Chunnian He Yunyun Ma Jie Shen Linghua Harris Zhang Yong Peng Peigen Xiao | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 11 |
| 9 | SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer显示文摘SIRT7,a sirtuin family member implicated in aging and disease,is a regulator of metabolism and stress responses.It remains elusive how human somatic stem cell populations might be impacted by SIRT7.Here,we found that SIRT7 expression declines during human mesenchymal stem cell(hMSC)aging and that SIRT7 deficiency accelerates senescence.Mechanistically,SIRT7 forms a complex with nuclear lamina proteins and heterochromatin proteins,thus maintaining the repressive state of heterochromatin at nuclear periphery.Accordingly,deficiency of SIRT7 results in loss of heterochromatin,derepression of the LINE1 retrotransposon(LINE1),and activation of innate immune signaling via the cGAS-STING pathway.These agingassociated cellular defects were reversed by overexpression of heterochromatin proteins or treatment with a LINE1 targeted reverse-transcriptase inhibitor.Together,these findings highlight how SIRT7 safeguards chromatin architecture to control innate immune regulation and ensure geroprotection during stem cell aging. | Shijia Bi Zunpeng Liu Zeming Wu Zehua Wang Xiaoqian Liu Si Wang Jie Ren Yan Yao Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu | 2020 | Protein & Cell2020，11，7： | 10 |
| 10 | A 2-way cross-over,open-labeled trial to compare efficacy and safety of insulin Aspart and Novolin R delivered with CSII in 21 Chinese diabetic patients显示文摘背景下的吸收被胰岛素 Aspart 的 monomeric 符合构造加速,它向好 glycemic 控制提供低血糖症和更少的身体重量增加的更低的风险。在我们调查了的现在的学习,快速行动的人的胰岛素类似物(胰岛素 Aspart )的功效和安全与类型 1 或类型 2 糖尿病与连续下的胰岛素注入( CSII )交付了进 21 个病人的中国糖尿病的 patients.Methods Atotal 为2方法转线路被招募,开标签的试用,然后使随机化组织 A ( n=10 ,与胰岛素 Aspart 对待)或组 B ( n=11 ,与 Novolin 对待 R )。胰岛素 Aspart 和 Novolin R 被 CSII 管理。毛状的葡萄糖集中在 8 个次点被测量,餐前、饭后,上床时间(10 下午) ,午夜(2 是) 每天,在 treatment.Results 期间,平均毛状的葡萄糖介绍因为日子更好比在组 B (P0.01 ) 在组 A 被控制。血葡萄糖层次更好特别地在早餐前比在组 B 在组 A 被控制((6. | BI Yu-fang ZHAO Lie-bin LI Xiao-ying WANG Wei-qing SUN Shou-yue CHEN Yu-hong HONG Jie SU Ting-wei LIU Jian-min NING Guang | 2007 | Chinese Medical Journal2007，，19： | 9 |
| 11 | Subtyping Animal Influenza Virus with General Multiplex RT-PCR and Liquichip High Throughput (GMPLex)显示文摘This study developed a multiplex RT-PCR integrated with luminex technology to rapidly subtype simultaneously multiple influenza viruses. Primers and probes were designed to amplify NS and M genes of influenza A viruses HA gene of H1, H3, H5, H7, H9 subtypes, and NA gene of the N1 and N2 subtypes. Universal super primers were introduced to establish a multiplex RT-PCR (GM RT-PCR). It included three stages of RT-PCR amplification, and then the RT-PCR products were further tested by LiquiChip probe, combined to give an influenza virus (IV) rapid high throughput subtyping test, designated as GMPLex. The IV GMPLex rapid high throughput subtyping test presents the following features: high throughput, able to determine the subtypes of 9 target genes in H1, H3, H5, H7, H9, N1, and N2 subtypes of the influenza A virus at one time; rapid, completing the influenza subtyping within 6 hours; high specificity, ensured the specificity of the different subtypes by using two nested degenerate primers and one probe, no cross reaction occurring between the subtypes, no non-specific reactions with other pathogens and high sensitivity. When used separately to detect the product of single GM RT-PCR for single H5 or N1 gene, the GMPLex test showed a sensitivity of 10-5(= 280ELD50) forboth tests and the Luminex qualitative ratio results were 3.08 and 3.12, respectively. When used to detect the product of GM RT-PCR for H5N1 strain at the same time, both showed a sensitivity of 10-4(=2800 ELD50). The GMPLex rapid high throughput subtyping test can satisfy the needs of influenza rapid testing. | Zhi-feng Qin Jie Sun Ti-kang Lu Shao-ling Zeng Qun-yi Hua Qing-yan Ling Shu-kun Chen Jian-qiang Lv Cai-hong Zhang Bing Cheng Zhou-xi Ruan Ying-zuo Bi Joseph J Giambrone Hong-zhuan Wu | 2012 | Virologica Sinica2012，27，2： | 8 |
| 12 | The effect of the endosymbiont Wolbachia on the behavior of insect hosts显示文摘As one of the most successful intracellular symbiotic bacteria,Wolbachia can infect many arthropods and nematodes.Wolbachia infection usually affects the reproduction of their hosts to promote their own proliferation and transmission.Currently,most of the studies focus on the mechanisms of Wolbachia interactions with host reproduction.However,in addition to distribution in the reproductive tissues,Wolbachia also infect various somatic tissues of their hosts,including the brain.This raises the potential that Wolbachia may influence some somatic processes,such as behaviors in their hosts.Sofar,information about the effects of Wolbachia infection on host behavior is still very limited.The present review presents the current literature on different aspects of the influence of Wolbachia on various behaviors,including sleep,learning and memory,mating,feeding and aggression in their insect hosts.We then highlight ongoing scientific efforts in the field that need addressing to advance this field,which can have significant implications for further developing Wolbachia as environmentally friendly biocontrol agents to control insect-borne diseases and agricultural pests. | Jie Bi Yu-Feng Wang | 2020 | Insect Science2020，27，5： | 7 |
| 13 | OpenKG Chain:A Blockchain Infrastructure for Open Knowledge Graphs显示文摘The early concept of knowledge graph originates from the idea of the semantic Web,which aims at using structured graphs to model the knowledge of the world and record the relationships that exist between things.Currently publishing knowledge bases as open data on the Web has gained significant attention.In China,Chinese Information Processing Society of China(CIPS)launched the OpenKG in 2015 to foster the development of Chinese Open Knowledge Graphs.Unlike existing open knowledge-based programs,OpenKG chain is envisioned as a blockchain-based open knowledge infrastructure.This article introduces the first attempt at the implementation of sharing knowledge graphs on OpenKG chain,a blockchain-based trust network.We have completed the test of the underlying blockchain platform,and the on-chain test of OpenKG’s data set and tool set sharing as well as fine-grained knowledge crowdsourcing at the triple level.We have also proposed novel definitions:K-Point and OpenKG Token,which can be considered to be a measurement of knowledge value and user value.1,033 knowledge contributors have been involved in two months of testing on the blockchain,and the cumulative number of on-chain recordings triggered by real knowledge consumers has reached 550,000 with an average daily peak value of more than 10,000.For the first time,we have tested and realized on-chain sharing of knowledge at entity/triple granularity level.At present,all operations on the data sets and tool sets at OpenKG.CN,as well as the triplets at OpenBase,are recorded on the chain,and corresponding value will also be generated and assigned in a trusted mode.Via this effort,OpenKG chain looks forward to providing a more credible and traceable knowledge-sharing platform for the knowledge graph community. | Huajun Chen Ning Hu Guilin Qi Haofen Wang Zhen Bi Jie Li Fan Yang | 2021 | Data Intelligence2021，3，2： | 7 |
| 14 | A new strategy for obtaining highly concentrated phosphorus recovery solution in biofilm phosphorus recovery process显示文摘Recovery of phosphorus(P)from wastewater is of great significance for alleviating the shortage of P resources.At present,the P recovery process is faced with the problem of excessive organic carbon consumption when obtaining a P-concentrated recovery solution.This study proposed a new strategy to obtain a more highly concentrated P recovery solution with minimal carbon consumption by strengthening the P storage capacity of the biofilm.A biofilm sequencing batch reactor(BSBR)process was modified to treat synthetic wastewater.The effect of the dissolved oxygen(DO)concentration on the P storage capacity of the biofilm was investigated at DO concentrations of DO 3.5 mg/L(P_(L))and DO 6.5 mg/L(P_(H)).The results showed a maximum P storage of 101.2 and 149.6 mg-P/g-mixed liquid suspended solids under the two conditions.Strengthening the P storage capacity of the biofilm resulted in a net increase in the P recovery rate,which was as high as 66.96%in a harvesting cycle,and total soluble P>220 mg/L in the P recovery solution was successfully achieved.Meanwhile,the carbon cost of P recovery in the BSBR was reduced to 41.57 g-chemical oxygen demand/gP,and the carbon utilization efficiency was enhanced.To highlight the new strategy,the P recovery performance of the BSBR was given and the relationship between P content and anaerobic P release was discussed.In addition,the changes in the microbial communities under P_(L) and P_(H) conditions were analyzed. | Wanjing Yang Jie Shan Yang Pan Zhen Bi Yong Huang Hao Zhang Min Ni | 2022 | Journal of Environmental Sciences2022，34，2： | 6 |
| 15 | Latitudinal diversity gradients in bryophytes and woody plants: Roles of temperature and water availability显示文摘微生物和宏有机体的纬度的差异坡度是否被一样的宏环境的变量驾驶,仍然保持不清楚。我们在中国使用了最新完成的种类目录和藓苔类的植物的分发信息探索他们的空间种类丰富模式,并且在塑造这些模式调查精力可获得性,气候的 seasonality,和环境异质的内在的角色。我们然后把这些模式比作作出对有利的裁决的那些木质的植物。我们发现苔藓和地钱不同于木质的植物,在种类丰富显示出仅仅弱否定的纬度的趋势。地钱丰富和苔藓丰富的空间模式被当代的环境变量压倒性地解释,尽管解释变化为木质的植物是比那低的。类似于假设作为解释变量统治,但是在塑造藓苔类的植物的分发显示出高冗余性的木质的植物,精力和气候的 seasonality。水变量,也就是说在降水的年度可获得性, intra 年度的可变性和空间异质,在解释藓苔类的植物的种类丰富的空间变化起了一个占优势的作用特别为地钱,而木质的植物丰富被温度变量最影响。我们建议关于藓苔类的植物的空间模式的进一步的研究应该在他们的生态生理学和进化上合并知识。 | Sheng-Bin Chen J. W. Ferry Slik Jie Gao Ling-Feng Mao Meng-Jie Bi Meng-Wei Shen Ke-Xin Zhou | 2015 | Journal of Systematics and Evolution2015，53，6： | 6 |
| 16 | Elevated Resting Heart Rate is Associated with Dyslipidemia in Middle-aged and Elderly Chinese显示文摘Objective To study the relationship between resting heart rate and blood lipid level.Methods A total of 9 415 subjects aged≥40 years were included in the present study.Their resting heart rate was monitored and their serum levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)were measured to define dyslipidemia according to the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults.Results The subjects were divided into group A with their resting heart rate<70 beats/min,group B with their resting heart rate=70-79 beats/min,group C with their resting heart rate=80-89 beats/min,and group D with their resting heart rate≥90 beats/min.High TG,TC,and LDL-C were presented across the resting heart rate(Ptrend<0.01).Multiple logistic regression analysis revealed that the risk of high TG and TC was higher in subjects with their resting heart rate≥90 beats/min than in those with their resting heart rate<70 beats/min(OR=1.42;95%CI:1.16-1.74 and OR=1.33;95%CI:1.09-1.64,respectively).Conclusion Elevated resting heart rate is associated with high TG and TC in middle-aged and elderly Chinese subjects. | SUN Ji Chao HUANG Xiao Lin DENG Xin Ru LV Xiao Fei LU Jie Li CHEN Yu Hong BI Yu Fang WANG Wei Qing XU Min NING Guang | 2014 | Biomedical and Environmental Sciences2014，27，8： | 5 |
| 17 | Association between Free Triiodothyronine Levels and Peripheral Arterial Disease in Euthyroid Participants显示文摘这当前的代表性的研究 40 年并且在上面在 euthyroid 汉语人口之中调查在甲状腺荷尔蒙和外部动脉疾病(垫) 之间的关系。浆液免费 triiodothyronine (FT3 ) ,免费甲状腺素(FT4 ) ,刺激甲状腺的荷尔蒙(TSH ) ,和甲状腺抗体被测量。垫被定义为脚关节臂的索引(ABI )< 0.9。有 91 (2.9%) 在 3,148 euthyroid 之中的垫案例学习参加者。参加者在有的 FT3 和 free-triiodothyronine-to-free-thyroxin (FT3/FT4 比率) 最高方照流行的垫的减少的风险(调整 multivariate 的机会比率, 95% 信心间隔:0.32, 0.15-0.62,为趋势 = 的 P 0.01 和 0.31, 0.13-0.66,为趋势 = 的 P 0.004,分别地) 与那些相比在里面最低方照。得出结论, FT3 层次和 FT3/FT4 比率相反地 40 年并且在上面在 euthyroid 汉语人口与流行的垫被联系。 | WANG Po DU Rui LIN Lin DING Lin PENG Kui XU Yu XU Min BI Yu Fang WANG Wei Qing NING Guang LU Jie Li | 2017 | Biomedical and Environmental Sciences2017，30，2： | 5 |
| 18 | Hypoxia training attenuates left ventricular remodeling in rabbit with myocardial infarction显示文摘ObjectivePrevious 研究证明组织缺氧 preconditioning 能保护心脏的功能免于随后的心肌的梗塞损害。然而,在在心肌的梗塞以后室的左的组织缺氧的效果仍然是不清楚的。这研究因此试图调查在在兔子柱子的左室的改变上训练的组织缺氧的效果心肌的 infarction.MethodsAdult 男性兔子随机被划分成三个组:那么组织(假冒操作) ,组 MI (心肌的梗塞仅仅) 并且组 MI-HT (加组织缺氧训练的心肌的梗塞) 。心肌的梗塞被左室的分支结扎导致。训练的组织缺氧在一个比重低於脑脊髓液的房间被执行(在 4000 m 的高度有相等的状况, F i 为 1 h/day 的 O 214.9%) ,为四个星期的 5 天 / 星期。在端点,在血浆的脉管的 endothelial 生长因素(VEGF ) 被测量。梗塞尺寸和毛状的密度被组织学检测。左室的改变和功能被 echocardiography.ResultsAfter 估计 4 星期的实验,与这个组相比那么,在组 MI 的血浆 VEGF 层次(130.27 ±18.58 pg/mL, P <0.01 ) 并且 MI-HT (181.93 ±20.29 pg/mL, P <0.01 ) 显著地被增加。在组 MI-HT 的梗塞尺寸(29.67%±7.73%) 显著地被死亡,当时它的毛状的密度(816.0 ±122.2/mm 2) 显著地被增加。为组 MI 和 MI-HT,而左室的喷射部分被减少,左室的结束心脏舒张、结束收缩的尺寸被增加。与组 MI 相比,然而,组 MI-HT 减少了留给室结束心脏舒张(15.86 ±1.09 公里, P <0.05 ) 并且结束收缩的尺寸(12.10 ±1.20 公里, P <0.01 ) 显著地并且改进左室的喷射部分(54.39 ±12.74 公里, P <0.05 ) 训练可以改进的 .ConclusionHypoxia 让室的功能和还原剂与 MI 在兔子经由 angiogenesis 改变。 | Chun-Xiao WAN Yun-Feng LAN Hui JIANG Jie HUANG Rui-Sheng LI Sheng BI Jian-An LI | 2014 | Journal of Geriatric Cardiology2014，11，3： | 5 |
| 19 | Smoking and Its Relation to Metabolic Status among Chinese Adults: Analysis of a Nationwide Survey显示文摘Objective To update the estimated prevalence rates of smoking and examine major metabolic diseases associated with smoking status in Chinese adults. Methods Using a complex, multistage, probability sampling design, we recruited a nationally representative sample of 98,658 Chinese adults aged ≥18 years in 2010. Information on current, former, never, and passive smoking status was obtained using a standard questionnaire. All estimates were weighted to represent the overall Chinese adult population. Results The estimated proportion of current smokers was 28.3% for Chinese adults aged ≥18 years. The corresponding values of former and passive smokers were 5.1% and 21.4%, respectively. Additionally, former smokers were found to have a less favorable metabolic risk profile among all categories of smoking status in both men and women. The prevalence of metabolic diseases such as diabetes and hypertension also increased with a greater number of smoking pack-years in men. Conclusion The prevalences of current smoking and passive smoking remain high in Chinese adults. | DING Lin XU Yu WANG Li Min JIANG Yong ZHANG Mei LI Yi Chong LU Jie Li XU Min WANG Tian Ge LI Mian ZHAO Zhi Yun DAI Meng WANG Wei Qing ZHAO Wen Hua WANG Lin Hong BI Yu Fang NING Guang 无 | 2016 | Biomedical and Environmental Sciences2016，29，9： | 5 |
| 20 | Association between Lipoprotein(a) Levels and Metabolic Syndrome in a Middle-aged and Elderly Chinese Cohort显示文摘Objective The association between lipoprotein(a)[Lp(a)] levels and metabolic syndrome(MetS) remains uncertain, especially in the Asian population. The purpose of this study was to demonstrate the association between Lp(a) levels and MetS in a middle-aged and elderly Chinese cohort. Methods A cross-sectional study of 10,336 Chinese adults aged 40 years or older was conducted in Jiading District, Shanghai, China. Logistic regression analysis was used to evaluate the association between serum Lp(a) levels and MetS. Results In the overall population, 37.5% of participants had MetS. Compared with individuals in the lowest quartile of serum Lp(a) levels, those in the highest quartile had a lower prevalence of MetS(30.9% vs. 46.9%, P for trend < 0.0001). Multivariate logistic regression analyses showed that compared with participants in the bottom quartile of serum Lp(a) levels, those in the top quartile had decreased odds ratio(OR) for prevalent MetS [multivariate-adjusted OR 0.45(95% confidence interval 0.39-0.51);P < 0.0001]. Additionally, Lp(a) level was conversely associated with the risk of central obesity, high fasting glucose, high triglycerides, and low HDL cholesterol, but not with hypertension. Stratified analyses suggested that increasing levels of Lp(a) was associated with decreased risk of MetS in all the subgroups. Conclusion Serum Lp(a) level was inversely associated with the risk of prevalent MetS in a middle-aged and elderly Chinese cohort. | WU Xue Yan LIN Lin Qi Hong Yan DU Rui HU Chun Yan MA Li Na PENG Kui LI Mian XU Yu XU Min CHEN Yu Hong LU Jie Li BI Yu Fang WANG Wei Qing NING Guang | 2019 | Biomedical and Environmental Sciences2019，32，7： | 5 |
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