|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 2 | Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo显示文摘Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer. | Guangyao Lv Dengjun Sun Jingwen Zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 6 |
| 3 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 4 | An application of the differential spread-spectrum technique in mobile underwater acoustic communication显示文摘A direct sequence/binary differential phase-shift keying underwater acoustic communication technique based on differential coherent demodulation is proposed.Differential coherent demodulation is adopted at the receiving terminal to overcome the difficulty of estimating the carrier in underwater acoustic communication and overcoming the frequency and phase error resulting from carrier frequency drift.Anti-multipath,antiDoppler,low-error-rate,effective and robust features for a complex underwater acoustic channel were verified in a lake experiment. | YIN JingWei ZHANG Xiao SUN LiQiang MEI JiDan | 2011 | Science China(Information Sciences)2011，54，10： | 5 |
| 5 | Design and baseline data of a populationbased metabonomics study of eye diseases in eastern China: the Yueqing Ocular Diseases Investigation显示文摘Background:China is undergoing a massive transition toward an urban and industrial economy.These changes will restructure the demographics and economy which will eventually influence the future patterns of disease.The risk factors of vision-impairing eye diseases remain ambiguous and poorly understood.Metabolomics is an ideal tool to understand and shed light on the ocular disease mechanisms for earlier treatment.This article aims to describe the design,methodology and baseline data of the Yueqing Ocular Diseases Investigation(YODI),a developed county population-based study to determine the prevalence and primary causes of visual impairment;also with metabonomics analysis we aimed to identify,predict and suggest some preventive biomarkers that cause blindness.Methods:A population-based,cross-sectional study.Randomized clustering sampling was used to identify adults aged 50 years and older in Xiangyang Town,Yueqing county-level City.The interviews covered demographic,behavioral,ocular risk factors and mental health state.The ocular examination included visual acuity,autorefraction,intraocular pressure,anterior and posterior segment examinations,fundus photography,retinal tomography and angiography,and visual field testing.Anthropometric measurements included height and weight,waist and hip circumference,blood pressure,pulse rate,electrocardiogram,and abdominal ultrasound scan.A venous blood sample was collected for laboratory tests and metabonomics studies.Results:Of the 5319 individuals recruited for the YODI,4769(89.7%)subjects were enrolled for analyses.The median age was 62.0 years,and 45.6%were male.The educational level of illiteracy or semi-illiteracy,primary,middle and high school or above was 29.8%,45.5%,20.1%,and 3.3%,respectively.Majority of the participants were female,younger,and less educated when compared with nonparticipants.The average body mass index and waist-hip ratios were 24.4±3.4 kg/m^(2) and 0.9±0.1 respectively.Blood sample collection reached a sample size of 1909(479 from subjects with selfreported diabetes and 1430 from one-third of the 4290 subjects without self-reported diabetes).Conclusions:The YODI provides population-based data with a high response rate(89.7%)on the prevalence and primary causes of major vision-impairing eye diseases in developed county areas in eastern China.Metabonomics analysis from YODI will provide further association of metabolic characteristics with the visual impairment eye diseases.The risk prediction model could be created and has the potential to be generalized to developed eastern areas in China for prevention. | Yuxuan Deng Yuanbo Liang Sigeng Lin Liang Wen Jin Li Yue Zhou Meixiao Shen Jingwei Zheng Kemi Feng Yanting Sun Kwapong Willaim Robert Jia Qu Fan Lu | 2020 | Eye and Vision2020，7，1： | 4 |
| 6 | Fair exchange signature schemes显示文摘In this paper a new class of fair exchange signature scheme (FESS) is proposed that allows two players to exchange digital signatures in a fair way. The new signature scheme is a general model and has various implementations based on most of the existing signature schemes; thus it may also be considered as an interesting extension of concurrent signature presented in EUROCRYPT 2004 that is constructed from ring signatures. In FESS, two unwakened signatures signed respectively by two participants can be verified easily by each player, but it would not go into effect until an extra piece of commitment keystone is released by one of the players. Once the keystone is revealed, two signatures are both aroused and become valid. A key feature of FESS is that two players can exchange digital signatures simultaneously through a secret commitment keystone without involvement of any trusted third party (TTP). Moreover, the efficiency of the new scheme is higher than that of concurrent signatures. | LIU JingWei SUN Rong KWAK KyungSup | 2010 | Science China(Information Sciences)2010，53，5： | 3 |
| 7 | Effect of potential HONO sources on peroxyacetyl nitrate(PAN)formation in eastern China in winter显示文摘As an important secondary photochemical pollutant,peroxyacetyl nitrate(PAN)has been studied over decades,yet its simulations usually underestimate the corresponding observations,especially in polluted areas.Recent observations in north China found unusually high concentrations of PAN during wintertime heavy haze events,but the current model still cannot reproduce the observations,and researchers speculated that nitrous acid(HONO)played a key role in PAN formation.For the first time we systematically assessed the impact of potential HONO sources on PAN formation mechanisms in eastern China using the Weather Research and Forecasting/Chemistry(WRF-Chem)model in February of 2017.The results showed that the potential HONO sources significantly improved the PAN simulations,remarkably accelerated the RO x(sum of hydroxyl,hydroperoxyl,and organic peroxy radicals)cycles,and resulted in 80%–150%enhancements of PAN near the ground in the coastal areas of eastern China and 10%–50%enhancements in the areas around 35–40°N within 3 km during a heavy haze period.The direct precursors of PAN were aldehyde and methylglyoxal,and the primary precursors of PAN were alkenes with C>3,xylenes,propene and toluene.The above results suggest that the potential HONO sources should be considered in regional and global chemical transport models when conducting PAN studies. | Jingwei Zhang Yitian Guo Yu Qu Yong Chen Ruipeng Yu Chaoyang Xue Rui Yang Qiang Zhang Xingang Liu Yujing Mu Jing Wang Can Ye Haihan Zhao Qiangqiang Sun Ziwen Wang Junling An | 2020 | Journal of Environmental Sciences2020，32，8： | 3 |
| 8 | Development of a PVDF sensor for potted seedling clamping force of vegetable transplanting显示文摘Aiming at the problems of loose bowl,nutritive bowl damage and planting leakage caused by lack of perception and detection of seedling clamping force in vegetable transplanting,a semi-micro-column structure sensor for measuring potted seedling clamping force was developed based on polyvinylidene fluoride(PVDF)piezoelectric film.The diameter of the semi-micro-column is 4 mm.The size of the force probe is 14 mm×30 mm,the encapsulation position of the force probe is 25 mm away from the tip of the seedling claw.The hardware circuit for sensor signal acquisition including pre-amplification module,power frequency notch module,low-pass filter module,processor module and power module was designed.The circuit completes charge-voltage conversion,clamping force signal amplification,power frequency signal elimination,vibration and noise elimination,and ensures the accurate acquisition of clamping force signal.In order to verify the sensor performance,sensor calibration tests and indoor experiments were carried out respectively.The calibration tests showed that the sensitivity of the clamping force sensor was 0.5264 V/N,the linearity was 4.74%,the accuracy was 6.51%,the hysteresis was 3.63%,and the range was 8 N under the impact of different waveforms and frequencies,which fully meet the accuracy requirements of the clamping force detection during transplanting.Indoor experiments showed that the clamping force sensor had good stability and adaptability under different seedling frequencies.The sensor can provide useful reference for the perception and detection of seedling clamping force and the feedback regulation of seedling clamping force. | Jiangtao Ji Jingwei Sun Xin Jin Mingyong Li Xinwu Du | 2019 | International Journal of Agricultural and Biological Engineering2019，12，5： | 3 |
| 9 | Bioavailability of heavy metals in soil of the Tieguanyin tea garden, southeastern China显示文摘The bioavailability of 22 heavy metals was investigated at 19 sampling sites in Tieguanyin tea garden in Anxi County,Fujian Province,southeastern China.Heavy metal concentrations were determined by inductively coupled plasma-mass spectrometry(ICP-MS)and evaluated by geo-accumulation index(I_(geo)).Dilute nitric acid extraction was used to evaluate biological activity.Cu,Pb,and Cd were highly bioavailable and most easily absorbed by tea trees.Heavy metal bioavailability in the surface soil was as the ratio of the effective state to the total amount.Cd had the highest I_(geo)values,and the respective samples and sites were classified as moderately/strongly contaminated.Cd element is considered the main factor of heavy metal pollution in the tea garden in Anxi.The other heavy metals studied were present in lower concentrations;thus,the samples were classified as uncontaminated or slightly contaminated. | Jingwei Sun Ruilian Yu Gongren Hu Songhe Jiang Yunfeng Zhang Xiaoming Wang | 2017 | Acta Geochimica2017，36，3： | 2 |
| 10 | Nocturnal Low-levelWinds and Their Impacts on Particulate Matter over the Beijing Area显示文摘Three-month wind profiles, 260 m PM_1 concentrations [i.e., particulate matter(PM) with an aerodynamic diameter ≤1μm], and carrier-to-noise ratio data at two Beijing sites 55 km apart(urban and suburban) were collected to analyze the characteristics of low-level nocturnal wind and PM in autumn and winter. Three mountain-plain wind events with wind shear were selected for analysis. The measurements indicated that the maximum wind speeds of the northerly weak low-level jet(LLJ) below 320 m at the suburban site were weaker than those at the urban site, and the LLJ heights and depths at the suburban site were lower than those at the urban site. The nocturnal 140 m mean vertical velocities and the variations in vertical velocity at the urban site were larger than those at the suburban site. A nocturnal breeze with a weak LLJ of ~3 m s^(-1) noticeably offset nocturnal PM transport due to southerly flow and convergence within the northern urban area of Beijing. Characteristics of the nocturnal LLJ, such as start-up time, structure, intensity, and duration, were important factors in determining the decrease in the nocturnal horizontal range and site-based low-level variations in PM. | Yong CHEN Junling AN Yele SUN Xiquan WANG Yu QU Jingwei ZHANG Zifa WANG Jing DUAN | 2018 | Advances in Atmospheric Sciences2018，35，12： | 2 |
| 11 | Ultrasmall AU10 clusters anchored on pyramid-capped rectangular TiO2 for olefin oxidation显示文摘Ultrasmall Au 10 簇作为一座充电水库有唯一的电子结构和罐头行为捐赠电子或接受费用。这为催化作用是特别地重要的,自从它越过在金种类和氧化物底层之间的接口导致灵巧的费用转移。在催化氧化上决定 Au 10 的电子、结构的效果,一个 TiO 2 费用搬运人为石蜡氧化被选择为底层到锚 Au 10 。在 TiO 2-RP 上支持的 Au 10(RP = 盖住金字塔的圆柱的结构) 展出优异催化活动到 Au 10/TiO2 nanotubes 和 Au 10/P25。另外,支持的 Au 10 簇比支持的 Au 20, Au 144 簇,和 5 nm Au 产生了更高的活动 nanocrystals。Au 10/TiO2-RP 的优异催化能力从 Au 10/TiO2-RP 接口的控告 / 解除效果产生,它有效地在 Au 10, 的终端位置在充满电子的金原子上改进活跃的氧种类的形成并且在 Au 10 的电子缺乏的金原子上支持石蜡 C=C 契约的激活。 | Lixiong Li Shuangshuang Huang Jianjun Song Nating Yang Jingwei Liu Yuyun Chen Yuhan Sun Rongchao Jin Yan Zhu | 2016 | Nano Research2016，9，4： | 2 |
| 12 | ABO blood type and ABO gene with susceptibility to deep vein thrombosis following orthopedic surgery: a casecontrol study in Chinese Han population显示文摘The ABO gene encodes a glycosyltransferase with three main alleles(A,B,and O).The ABO blood group molecules are expressed in varieties of human tissues.Individuals with type O blood group have about 25%lower plasma FVIII and VWF levels[1].Increased plasma FVIII and VWF levels are associated with an increased risk for VTE, | SUN Ye MAO Ping LU JingWei DAI Jin TENG HuaJian JIANG Qing | 2015 | Science China(Life Sciences)2015，58，4： | 2 |
| 13 | Copolymer of lactide and ε-caprolactone catalyzed by bimetallic Schiff base aluminum complexes显示文摘A series of copolymers of lactide(LA) and e-caprolactone(ε-CL) with different monomer feed ratios were achieved using three kinds of bimetallic Schiff aluminum complexes as catalysts. The ratios of LA and ε-CL units in different copolymers and the average segments length were determined by NMR analysis. The comparative kinetic study of L-LA/ε-CL and rac-LA/ε-CL copolymerization systems showed that the polymerization rate of LA was faster than ε-CL, and L-LA showed polymerization rate slightly faster than rac-LA. It was inferred that the copolymers achieved by these complexes were gradient copolymers with gradual change in distribution of LA and e-CL units. The thermal properties of these copolymers were characterized by DSC analysis, which showed that the glass transition temperature(Tg) of these copolymers changed regularly according to the pro-portion change of two structural units. | Jingwei Yang Zhiqiang Sun Ranlong Duan Lili Li Xuan Pang Xuesi Chen | 2016 | Science China Chemistry2016，59，11： | 2 |
| 14 | Synthesis ofdual-mesoporous silica using non-ionic diblock copolymerand cationic surfactant as Co-templates显示文摘 | Wei Jingwei Yue Qin Sun Zhenkun | 2012 | AngewandteChemie International Edition2012，51，： | 1 |
| 15 | Calculation of three-dimensional acoustic scattering from Gaussian rough under-ice surface using the Kirchhoff approximation method with modified reflection coefficient显示文摘The Kirchhoff approximation with a modified reflection coefficient is used to calculate the three-dimensional acoustic scattering of a Gaussian rough under-ice surface.The concept of a local statistical average reflection coefficient of an under-ice surface is proposed in the calculation model.The scattered sound field of a two-dimensional Gaussian rough under-ice surface is divided into coherent scattering and incoherent scattering.A formula is derived for the scattering coefficient of each scattering component,and the three-dimensional scattering intensity is obtained.The relationships between the scattering intensity and(ⅰ)the root-meansquare height of the Gaussian rough under-ice surface,(ⅱ)the angle of incidence,and(ⅲ)the sound frequency are analyzed.The scattering intensity of a Gaussian rough under-ice surface is measured in a laboratory water tank,and the calculation results of the theoretical model are verified.The experimental results are compared with those of the theoretical model using(ⅰ)the present local statistical average reflection coefficient of an under-ice surface and(ⅱ)the mirror reflection coefficient of an under-ice surface from the literature.The calculation results of the model using the local statistical average reflection coefficient agree well with the experimental results. | CHEN Wenjian LANG Pengyuan HU Siwei YIN Jingwei SUN Hui ZHANG Yuxiang | 2020 | Chinese Journal of Acoustics2020，39，3： | 1 |
| 16 | Parametric array differential Pattern time delay shift coding underwater acoustic communication in the under-ice environment显示文摘In order to meet the demands of underwater acoustic communication in under ice environment,a differential Pattern time delay shift coding underwater acoustic communication method based on parametric array is introduced in this paper.The under ice underwater acoustic channel is characterized by heavy multipath transmission.Under this model,a parametric array emission method of Pattern signal is derived and the system performance is analyzed.A broadband low frequency sound waves with narrow beam-pattern,which will reduce the interface reflections and suppress the effects of multipath transmission,can be obtained by the emission method.The Songhua River under ice trial results show that there is an anti-multipath property and a higher data rate in the under-ice acoustic channel in proposed approach. | YIN Jingwei ZHANG Xiao ZHU Guangping TANG Shengyu SUN Hui | 2016 | Chinese Journal of Acoustics2016，35，4： | 1 |
| 17 | Degradation of diuron in aqueous solution by dielectric barrier discharge 显示文摘 | FENG Jingwei ZHENG Zheng SUN Yabing | 2008 | J Hazard Mater2008，154，： | 1 |
| 18 | Seroepidemiology and genetic characterization of hepatitis E virus in the northeast of china显示文摘 | Yuanhua Yu Jingwei Sun Meixiang Liu Liliang Xia Chenyan Zhao Tim J Harrison Youchun Wang | 2009 | Infection Genetics and Evolution2009，，4： | 1 |
| 19 | Cardiolipin Remodeling by ALCAT1 Links Oxidative Stress and Mitochondrial Dysfunction to Obesity显示文摘 | Jia Li Caroline Romestaing Xianlin Han Yuan Li Xinbao Hao Yinyuan Wu Chao Sun Xiaolei Liu Leonard S. Jefferson Jingwei Xiong Kathryn F. LaNoue Zhijie Chang Christopher J. Lynch Huayan Wang Yuguang Shi | 2010 | Cell Metabolism2010，，2： | 1 |
| 20 | Life Cycle Assessment Analysis and Comparison of 1000 MW S-CO_(2)Coal Fired Power Plant and 1000 MW USC Water-Steam Coal-Fired Power Plant显示文摘The objective of this paper is to understand the benefits that one can achieve for large-scale supercritical CO_(2)(S-CO_(2))coal-fired power plants.The aspects of energy environment and economy of 1000 MW S-CO_(2)coal-fired power generation system and 1000 MW ultra-supercritical(USC)water-steam Rankine cycle coal-fired power generation system are analyzed and compared at the similar main vapor parameters,by adopting the neural network genetic algorithm and life cycle assessment(LCA)methodology.Multi-objective optimization of the 1000 MW S-CO_(2)coal-fired power generation system is further carried out.The power generation efficiency,environmental impact load,and investment recovery period are adopted as the objective functions.The main vapor parameters of temperature and pressure are set as the decision variables.The results are concluded as follows.First,the total energy consumption of the S-CO_(2)coal-fired power generation system is 10.48 MJ/k Wh and the energy payback ratio is 34.37%.The performance is superior to the USC coal-fired power generation system.Second,the resource depletion index of the S-CO_(2)coal-fired power generation system is 4.38μPRchina,90,which is lower than that of the USC coal-fired power generation system,and the resource consumption is less.Third,the environmental impact load of the S-CO_(2)coal-fired power generation system is 0.742 m PEchina,90,which is less than that of the USC coal-fired power generation system,0.783 m PEchina,90.Among all environmental impact types,human toxicity potential HTP and global warming potential GWP account for the most environmental impact.Finally,the investment cost of the S-CO_(2)coal-fired power generation system is generally less than that of the USC coal-fired power generation system because the cost of the S-CO_(2)turbine is only half of the cost of the steam turbine.The optimal turbine inlet temperature T_(5)becomes smaller,and the optimal turbine inlet pressure is unchanged at 622.082°C/30 MPa. | LI Mingjia WANG Ge XU Jinliang NI Jingwei SUN Enhui | 2022 | Journal of Thermal Science2022，31，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员