|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 2 | Converting an Esterase into an Epoxide Hydrolase 显示文摘 | Jochens H Stiba K Savile C | 2009 | Angew Chem Int Ed Engl2009，48，19： | 1 |
| 3 | Functional impairment, disability, and quality of life outcome after decompressive emicraniectomy in malignant middle cerebral artery infarction 显示文摘 | Foerch CH Lang JM Jochen K | 2004 | Neurosurg2004，101，： | 1 |
| 4 | Wnt inducible protein is a key regulator of alveolar epithelial cell hyperplasia in pulmonary fibrosis显示文摘 | Melanie K Jochen W Andreas J | 2006 | Eur Respir Rev2006，15，101： | 1 |
| 5 | Cocon: From NMR Correlation Data to Molecular Constitutions显示文摘 | Thomas Lindel Jochen Junker Matthias K?ck | 1997 | Journal of Molecular Modeling1997，，8： | 1 |
| 6 | Relevance of drug uptake and efflux for cisplatin sensitivity of tumor cells显示文摘 | JOCHEN Z SUSANNE K STEFAN L | 2007 | Biochem Pharmacol2007，73，2： | 1 |
| 7 | Protein engineering of α/β-hydrolase fold enzymes显示文摘 | Jochens H Hesseler M Stiba K | 2011 | Chembiochem2011，12，10： | 1 |
| 8 | The proline 12 alanine substitution in the peroxisome proliferator - activated receptor gamma gene is associated with lipoprotein lipase activity in vivo 显示文摘 | Jochen S Joerg K | 2002 | Didbetes2002，51，： | 1 |
| 9 | Importance of conversion for results obtained with laparoscopic colorectal surgery显示文摘 | Dr. Frank Marusch M.D. Ingo Gastinger M.D. Claus Schneider M.D. Hubert Scheidbach M.D. Jochen Konradt M.D. Hans-Peter Bruch M.D. Lothar K?hler M.D. Eckhard B?rlehner M.D. Ferdinand K?ckerling M.D | 2001 | Diseases of the Colon & Rectum2001，，2： | 1 |
| 10 | Are NMDA or AMPA/kainite receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury?显示文摘 | Jochen HM Prehn KL Josef K | 1995 | Eur J Pharmacol1995，292，2： | 1 |
| 11 | The proline 12 alanine substitution in the peroxisome proliferator-activated receptor gamma gene is associated with lower lipoprotein lipase activity in vivo显示文摘 | Jochen S Joerg K Andreas H | 2002 | Diabetes2002，51，： | 1 |
| 12 | Real-Time fluorescence PCR assays for detection and characterization of Shiga toxin, intimin, and enterohemolysin genes from Shiga toxin-producing Escherichia coil 显示文摘 | Udo Reischl Mohammad T Y Jochen K | 2004 | J Clin Microbiology2004，42，9： | 1 |
| 13 | Associations between calcium and vitamin D supplement use as well as their serum concentrations and subclinical cardiovascular disease phenotypes显示文摘 | Inke Thiele Jakob Linseisen Christa Meisinger Sigrid Schwab Cornelia Huth Annette Peters Siegfried Perz Thomas Meitinger Florian Kronenberg Claudia Lamina Joachim Thiery Wolfgang Koenig Wolfgang Rathmann Stefan K??b Cornelia Then Jochen Seissler Barbara T | 2015 | Atherosclerosis2015，，2： | 1 |
| 14 | Post-traumatic syndrome after minor head injury cannot be predicted by neurological investigations显示文摘 | RUDOLF K JOCHEN S JURGEN W | 2004 | Brain & Development2004，26，： | 1 |
| 15 | The proline 12 alanine substitution in the peroxisome proliferator-activated receptor gamma gene is associated with lipoprotein lipase activity in vivo显示文摘 | JOCHEN S JOERG K ANDREAS H | 2002 | Diabetes2002，51，： | 1 |
| 16 | Fuel-Air mixing under simulated high pressure and high temperature conditions显示文摘 | Gotz Jochen Gupta Ashwani K | 1997 | American Institute of Aeronautics and Astronautics1997，，： | 1 |
| 17 | The influence of fiber-surface treatment on the mechanical properties of jute-polypropylene composites显示文摘 | GASSAN Jochen BLEDZKI Andrzej K | 1997 | Composites Part A1997，28，： | 1 |
| 18 | Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma 显示文摘 | Andrey K Jochen M David C | 2009 | Acta Neuropatho12009，118，： | 1 |
| 19 | Lean blowout limit and NOx production of a premixed sub-ppm NOx burner with periodic recirculation of combustion products显示文摘 | R K Jochen S Thomas | 2006 | Journal of Engineering for Gas Turbines and Power(Transactions of the ASME)2006，128，2： | 1 |
| 20 | Development of fluid eonduits in the auriferous shear zone of the Hutti Gold Mine,India: evidence for spatially and temporally heterogeneous fluid flow显示文摘 | JOCHEN K AMANDA R MICHAEL M F | 2004 | Tectonophysics2004，378，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员