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| 1 | Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment显示文摘AIM:To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth(SIBO) in patients with inactive Crohn's disease(CD).METHODS:This was a prospective study in patients with CD in remission and without corticosteroid treatment,included consecutively from 2004 to 2010.SIBO was investigated using the hydrogen glucose breath test.RESULTS:One hundred and seven patients with CD in remission were included.Almost 58%of patients used maintenance immunosuppressant therapy and 19.6%used biological therapy.The prevalence of SIBO was16.8%.No association was observed between SIBO and the use of thiopurine Immunosuppressant(12/62patients),administration of biological drugs(2/21 patients),or with double treatment with an anti-tumor necrosis factor drugs plus thiopurine(1/13 patients).Half of the patients had symptoms that were suggestive of SIBO,though meteorism was the only symptom that was significantly associated with the presence of SIBO on univariate analysis(P<0.05).Multivariate analysis revealed that the presence of meteorism and a fistulizing pattern were associated with the presence of SIBO(P<0.05).CONCLUSION:Immunosuppressants and/or biological drugs do not induce SIBO in inactive CD.Fistulizing disease pattern and meteorism are associated with SIBO. | Cristina Sánchez-Montes Vicente Ortiz Guillermo Bastida Ester Rodríguez María Yago Belén Beltrán Mariam Aguas Marisa Iborra Vicente Garrigues Julio Ponce Pilar Nos | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 2 | Constipation during pregnancy: a longitudinal survey based on self-reported symptoms and the Rome II criteria显示文摘 | Julio Ponce Beatriz Martínez Alberto Fernández Marta Ponce Guillermo Bastida Encarna Plá Vicente Garrigues Vicente Ortiz | 2008 | European Journal of Gastroenterology & Hepatology2008，，1： | 1 |
| 3 | Clinical usefulness of adherence to gastro-esophageal reflux disease guideline by Spanish gastroenterologists显示文摘AIM:To investigate usefulness of adherence to gastroesophageal reflux disease(GERD) guideline established by the Spanish Association of Gastroenterology.METHODS:Prospective,observational and multicentre study of 301 patients with typical symptoms of GERD who should be managed in accordance with guidelines and were attended by gastroenterologists in daily practice.Patients(aged > 18 years) were eligible for inclusion if they had typical symptoms of GERD(heartburn and/or acid regurgitation) as the major complaint in the presence or absence of accompanying atypical symptoms,such as dyspeptic symptoms and/or supraesophageal symptoms.Diagnostic and therapeutic decisions should be made based on specific recommendations of the Spanish clinical practice guideline for GERD which is a widely disseminated and well known instrument among Spanish in digestive disease specialists.RESULTS:Endoscopy was indicated in 123(41%) patients:50 with alarm symptoms,32 with age > 50 years without alarm symptom.Seventy-two patients(58.5%) had esophagitis(grade A,23,grade B,28,grade C,18,grade D,3).In the presence of alarm symptoms,endoscopy was indicated consistently with recommendations in 98% of cases.However,in the absence of alarm symptoms,endoscopy was indicated in 33% of patients > 50 years(not recommended by the guideline).Adherence for proton pump inhibitors(PPIs) therapy was 80%,but doses prescribed were lower(half) in 5% of cases and higher(double) in 15%.Adherence regarding duration of PPI therapy was 69%;duration was shorter than recommended in 1%(4 wk in esophagitis grades C-D) or longer in 30%(8 wk in esophagitis grades A-B or in patients without endoscopy).Treatment response was higher when PPI doses were consistent with guidelines,although differences were not significant(95% vs 85%).CONCLUSION:GERD guideline compliance was quite good although endoscopy was over indicated in patients > 50 years without alarm symptoms;PPIs were prescribed at higher doses and longer duration. | Fermín Mearin Julio Ponce Marta Ponce Agustín Balboa Miguel A González Javier Zapardiel | 2012 | World Journal of Gastroenterology2012，18，35： | 1 |
| 4 | The appropriateness of colonoscopies at a teaching hospital: magnitude, associated factors, and comparison of EPAGE and EPAGE-II criteria显示文摘 | Lidia Argüello Virginia Pertejo Marta Ponce Salvador Peiró Vicente Garrigues Julio Ponce | 2012 | Gastrointestinal Endoscopy2012，，1： | 1 |
| 5 | One year intermittent rifaximin plus fibre supplementation vs. fibre supplementation alone to prevent diverticulitis recurrence: A proof-of-concept study显示文摘 | Angel Lanas Julio Ponce Angelo Bignamini Fermín Mearin | 2012 | Digestive and Liver Disease2012，，： | 1 |
| 6 | Frequency and clinical implications of supraesophageal and dyspeptic symptoms in gastroesophageal reflux disease显示文摘 | Fermín Mearin Julio Ponce Marta Ponce Agustín Balboa Miguel A. Gónzalez Javier Zapardiel | 2012 | European Journal of Gastroenterology & Hepatology2012，，6： | 1 |
| 7 | Clinical patterns and outcomes of ischaemic colitis: Results of the Working Group for the Study of Ischaemic Colitis in Spain (CIE study)显示文摘 | Miguel A. Montoro Lawrence J. Brandt Santos Santolaria Fernando Gomollon Belén Sánchez Puértolas Jesús Vera Luis. Bujanda Angel Cosme José Luis Cabriada Margarita Durán Laura Mata Ana Santamaría Gloria Ce?a Jose Manuel Blas Julio Ponce Marta Ponce Luis Ro | 2011 | Scandinavian Journal of Gastroenterology2011，，2： | 1 |
| 8 | Quantitative cholescintigraphy and bile abnormalities in patients with acalculous biliary pain显示文摘 | Julio Ponce Vicente Pons Ramón Sopena Vicente Garrigues Marta Ponce Vicente Ortiz Virginia Pertejo | 2004 | European Journal of Nuclear Medicine and Molecular Imaging2004，，8： | 1 |
| 9 | Influence of Cholecystitis State on Pharmacological Response to Cholecystokinin of Isolated Human Gallbladder with Gallstones显示文摘 | María A. Martínez-Cuesta Lucrecia Moreno Julia Morillas Julio Ponce Juan V. Esplugues | 2003 | Digestive Diseases and Sciences2003，，5： | 1 |
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