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| 1 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 2 | SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis显示文摘Dear Editor,Takotsubo syndrome(TS)is a stress-induced non-ischaemic cardiomyopathy that is more common in women,but is associated with higher morbidity and mortality in males.Also known as broken-heart syndrome,TS is characterised by transient left ventricular(LV)dysfunction independent of obstructive coronary artery disease.TS is a polygenic condition and nowhere is this more evident than the use of positive inotropes,such as isoprenaline(ISO)in pre-clinical models.1 There is no standard therapy for broken-heart syndrome because the mechanisms underlying the condition remain unknown.Furthermore,there is no consensus on predisposition for Takotsubo2 and our goal was to better understand the regulatory mechanism as a first step towards improved treatment plans.Suberanilohydroxamic acid or SAHA,a drug approved for cancer treatment by the US Food and Drug Administration has previously been shown to improve cardiopulmonary function.3 We tested the hypothesis that the cardioprotective benefit of SAHA in a pre-clinical model of Takotsubo is conferred by an epigenetic acetylation/deacetylation(Ac/Dc)axis. | Ishant Khurana Scott Maxwell Simon Royce Prabhu Mathiyalagan Tom Karagiannis Nadia Mazarakis Jitraporn Vongsvivut Harikrishnan K.N. Jun Okabe Keith Al-Hasani Chrishan Samuel Assam El-Osta | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 3 | Observational results of lightning current on transmission towers显示文摘 | Jun Takami Shigemitsu Okabe | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 4 | Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma显示文摘 | Jun Osugi Yuka Kimura Yuki Owada Takuya Inoue Yuzuru Watanabe Takumi Yamaura Mitsuro Fukuhara Satoshi Muto Naoyuki Okabe Yuki Matsumura Takeo Hasegawa Athushi Yonechi Mika Hoshino Mitsunori Higuchi Yutaka Shio Hiroyuki Suzuki Mitsukazu Gotoh James L. Muls | 2015 | Journal of Oncology2015，，： | 1 |
| 5 | Characteristics of Direct Lightning Strokes to Phase Conductors of UHV Transmission Lines显示文摘 | TAKAMI Jun OKABE Shigemitsu | | 0，，01： | 1 |
| 6 | Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice显示文摘 | Tomoko Masuda Katsuhiko Itoh Hiroaki Higashitsuji Hisako Higashitsuji Noa Nakazawa Toshiharu Sakurai Yu Liu Hiromu Tokuchi Takanori Fujita Yan Zhao Hiroyuki Nishiyama Takashi Tanaka Manabu Fukumoto Masahito Ikawa Masaru Okabe Jun Fujita | 2012 | Proceedings of the National Academy of Sciences2012，，27： | 1 |
| 7 | Early magnetic resonance detection of cortical necrosis and acute network injury associated with neonatal and infantile cerebral infarction显示文摘 | Tetsuhiko Okabe Noriko Aida Tetsu Niwa Kumiko Nozawa Jun Shibasaki Hitoshi Osaka | 2014 | Pediatric Radiology2014，，5： | 1 |
| 8 | Observational results of lightning current on transmission towers显示文摘 | Jun Takami Shigemitsu Okabe | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 9 | Observational results of lightning current on transmission towers 显示文摘 | Jun Takami Shigemitsu Okabe | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 10 | Characteristics of direct lightning strokes to phase conductors of UHV transmission lines显示文摘 | Jun Takami Shigemitsu Okabe | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 11 | Characteristics of Direct Lightning Strokes to Phase Conductors of UHV Transmission Lines显示文摘 | Jun Takami Shigemistu Okabe | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 12 | Observational results of lighting current on transmission towers显示文摘 | Jun Takami Shigemitsu Okabe | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 13 | Lightning sur-ge overvoltages at substations due to backlnashover with assumed lightning current waveforms based on observa-tions显示文摘 | Jun Takami Shigemitsu Okabe Eiichi Zaima | | 0，，04： | 1 |
| 14 | Lightning surge overvoltages at substations due to backflashover with assumed lightning current waveforms based on observations显示文摘 | Jun Takami Shigemitsu Okabe Eiichi Zaima | | 0，，04： | 1 |
| 15 | Characteristics of direct lightning strokes to phase conductors of UHV transmission lines显示文摘 | Jun Takami Shigemitsu Okabe | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 16 | Characteristics of direct lightning strokes to phase conductors of UHV transmission lines显示文摘 | Jun Takami Shigemitsu Okabe | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 17 | Observational results of light ning current on transmission towers显示文摘 | Jun Takami Shigemitsu Okabe | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 18 | Characteristics of direct lightning strokes to phase conductors of UHV transmission lines 显示文摘 | Jun Takami Shigemitsu Okabe | 2007 | IEEE Trans on Power Delivery2007，22，1： | 1 |
| 19 | Occurrence probability of lightning failure rates at substations in consideration of light- niug stroke current waveforms显示文摘 | Shigemitsu Okabe Jun Takami | 2011 | IEEE Transactions on Die lectricsand Electrical Insulation2011，18，22： | 1 |
| 20 | Enhancement of ε-polylysine production by Streptomyces albulus strain 410 using pH control显示文摘 | Prihardi Kahar Toshiharu Iwata Jun Hiraki Enoch Y. Park Mitsuyasu Okabe | 2001 | Journal of Bioscience and Bioengineering2001，，2： | 1 |
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