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| 1 | Genome-wide Expansion and Expression Divergence of the Basic Leucine Zipper Transcription Factors in Higher Plants with an Emphasis on Sorghum显示文摘Plant bZIP transcription factors play crucial roles in multiple biological processes.However,little is known about the sorghum bZIP gene family although the sorghum genome has been completely sequenced.In this study,we have carried out a genome-wide identification and characterization of this gene family in sorghum.Our data show that the genome encodes at least 92 bZIP transcription factors.These bZIP genes have been expanded mainly by segmental duplication.Such an expansion mechanism has also been observed in rice,arabidopsis and many other plant organisms,suggesting a common expansion mode of this gene family in plants.Further investigation shows that most of the bZIP members have been present in the most recent common ancestor of sorghum and rice and the major expansion would occur before the sorghum-rice split era.Although these bZIP genes have been duplicated with a long history,they exhibited limited functional divergence as shown by nonsynonymous substitutions (Ka)/synonymous substitutions (Ks) analyses.Their retention was mainly due to the high percentages of expression divergence.Our data also showed that this gene family might play a role in multiple developmental stages and tissues and might be regarded as important regulators of various abiotic stresses and sugar signaling. | Jizhou Wang Junxia Zhou Baolan Zhang Jeevanandam Vanitha Srinivasan Ramachandran Shu-Ye Jiang | 2011 | Journal of Integrative Plant Biology2011，53，3： | 41 |
| 2 | Carbon Isotope Gradient of the Ediacaran Cap Carbonate in the Shennongjia Area and Its Implications for Ocean Stratification and Palaeogeography显示文摘The geochemistry and paleogeography of the Doushantuo succession in the Shennongjia area have been insufficiently studied. Here, we report on the carbon and oxygen isotope compositions of Ediacaran Doushantuo cap carbonates from four sections(Longxi, Muyu, Yazikou and Songluo) in the Shennongjia area. A large C-isotopic gradient(~5‰) between the Longxi and Songluo sections, here identified for the first time, is inferred to have been dynamically maintained by photosynthesis in surface waters and anaerobic oxidation of dissolved organic carbon(DOC) in deep waters. Spatial variation in C-isotope chemostratigraphy among the four sections was related to Marinoan post-glacial sea-level elevation changes. At Longxi, a positive δ^(13)C_(carb) shift below the horizon containing tepee-like structure resulted from intense photosynthesis during early regression. A negative δ^(13)C_(carb) shift within the tepee-horizon was triggered by sulfate reduction and freshwater mixing with ^(13)C-depleted dissolved inorganic carbon(DIC) during late regression. A positive δ^(13)C_(carb) excursion in the uppermost part of the cap carbonate was related to enhance primary productivity and organic matter burial during early transgression. At Muyu, the carbon isotopic variation tendency, which is similar to that at Longxi, may have been mildly influenced by the surface water environment. At Songluo, the positive δ^(13)C_(carb) excursion, up to-4‰ in the lower part of the cap carbonate, was probably associated with methanogenesis in deep waters during late transgression to early regression and subsequently disappeared due to decomposition of methane hydrate during late regression. At Yazikou, the consistently stable δ^(13)C_(carb) values around-4‰ indicate that the cap carbonate may have deposited at intermediate water depths. As evidenced by diagnostic sedimentary characteristics of the study sections, the palaeogeographic framework of the Shennongjia area exhibited deepening from SE to NW during the Early Ediacaran Period in the aftermath of Snowball Earth. | Guangzhe Wang Jiasheng Wang Zhou Wang Can Chen Junxia Yang | 2017 | Journal of Earth Science2017，28，2： | 5 |
| 3 | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis显示文摘Dear Editor,Ferroptosis is an iron-dependent,non-apoptotic form of regulated cell death characterized by an accumulation of lipid.derived reactive oxygen species(ROS).The small-molecule compo und erastin in duces ferroptosis via in hibiti ng the cystineglutamate antiporter system x_(c).which consists of two subunits,namely the light chain xCT and the heavy chain 4F2hc(encoded by the SLC7A11 and SLC3A2 genes,respectively).^(1-4) | Renhong Yan Enjun Xie Yaning Li Jin Li Yuanyuan Zhang Ximin Chi Xueping Hu Lei xu Tingjun Hou Brent R.Stockwell Junxia Min Qiang Zhou Fudi Wang | 2022 | Cell Research2022，32，7： | 4 |
| 4 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 5 | Preparation of porous spherical α-Ni(OH) 2 and enhancement of high-temperature electrochemical performances through yttrium addition 显示文摘 | Ren Junxia Zhou Zhen Gao Xueping | 2006 | Electrochim Acta2006，52，3： | 1 |
| 6 | Deposition of Pt on the stable nanotubular TiO2 and its photocatalytic performance显示文摘 | An Huiqin Zhou Jian Li Junxia | 2009 | Catal Commun2009，11，3： | 1 |
| 7 | Long-term declining in carbon monoxide(CO)at a rural site of Beijing during 2006-2018 implies the improved combustion efficiency and effective emission control显示文摘Carbon monoxide(CO)is primarily the result of incomplete combustion,which has impor-tant impacts on the atmospheric chemical cycle and climate.Improved quantitative char-acterization of long-term CO trends is important for both atmospheric modeling and the design and implementation of policies to efficiently control multiple pollutants.Due to the limitations of high time-resolution and high-quality long-term observational data,studies on long-term trends in the CO concentration in China are quite limited.In this study,the observational data of the concentration of CO in a rural site of Beijing during 2006-2018 was used to analyze the long-term trend in CO concentration in Beijing.The Theil-Sen method and the generalized additive model(GAM)-based method,were used to conduct the trend estimation analysis.We found that the concentration of CO at the Shangdianzi site showed a significant downward trend during 2006-2018,with a decline rate of 22.8±5.1 ppbV per year.The declining trend in CO also showed phasic characteristics,with a fast decreasing rate during the period of 2006-2008,stable variations during the period of 2009-2013 and a continuous downward trend after 2013.The declining trend in the CO concentration in the south to west(S-W)sectors where the polluted air masses come from is more rapid than that in the sectors where the clean air masses come from.The declining trend in the CO concentration implies the improved combustion efficiency and the successful air pollution control policies in Beijing and the surrounding area. | Yingruo Li Zhiqiang Ma Tingting Han Weijun Quan Junxia Wang Huaigang Zhou Di He Fan Dong | 2022 | Journal of Environmental Sciences2022，34，5： | 1 |
| 8 | Labile and Recalcitrant Organic Matter and Microbial Communities in Soil After Conversion of Abandoned Lands in the Loess Plateau, China显示文摘 | Junjian Li Hongjian Li Xiaomei Zhou Xi Zhao Junxia Yan | 2011 | Soil Science2011，，6： | 1 |
| 9 | A comparative study of alteration in retinal layer segmentation alteration by SD-OCT in neuromyelitis optica spectrum disorders: A systematic review and meta-analysis显示文摘Background:To evaluate the feature of different retinal layer segmentation in neuromyelitis optica spectrum disorders(NMOSD)with spectral-domain optical coherence tomography(SD-OCT)and to compare it with that in multiple sclerosis(MS),healthy controls(HC),and idiopathic optic neuritis(ION).Methods:We retrieved four electronic databases,including Pubmed,Embase,Cochrane Library,and Web of Science from inception to September 1st,2021.A meta-analysis was performed to compare different retinal layer segmentation thicknesses between patients with or without a history of optic neuritis(ON)in NMOSD and the control group,including patients with MS,HC,and ION.Results:Forty-two studies were included and the interval between the last ON onset and examination was greater than 3 months.Compared with that in HC eyes,the loss of retinal nerve fiber layer(RNFL)and macular ganglion cell and inner plexiform layer(GC-IPL)was serious in NMOSD eye especially after ON.Moreover,compared with that in ION eyes or MS-related-ON eyes,the injury to the peripapillary retinal nerve fiber layer(pRNFL)was severe in NMOSD-related-ON eyes.In addition,the correlation coefficient between pRNFL and prognostic visual acuity was 0.43.However,the one-arm study revealed the inner nuclear layer(INL)was thickened in NMOSDrelated-ON eyes compared with HC eyes.Conclusions:Inclusion of the RNFL and macular GC-IPL is recommended for monitoring disease progression and attention should be paid to changes in the INL. | Junxia Fu Shaoying Tan Chunxia Peng Huanfen Zhou Shihui Wei | 2021 | Advances in Ophthalmology Practice and Research2021，1，1： | 1 |
| 10 | The clinical application of critical flicker fusion frequency in demyelinating optic neuritis显示文摘Purpose:To investigate the application of critical flicker fusion frequency(CFF)in demyelinating optic neuritis(DON).Methods:A cross-sectional study.A total of 127 eyes in 69 DON patients and 63 eyes in 33 healthy control(HC)groups were included between January 2021 to September 2021 from Department of Ophthalmology,PLA General Hospital.Patients underwent best-corrected visual acuity(BCVA),visual field,optical coherence tomography(OCT),flash visual evoked potential(F-VEP),and CFF examinations.The affected eyes were divided into aquaporins 4(AQP4-),myelin oligodendrocyte glycoprotein(MOG-),and double negative DON according to serum antibody;mild,moderate,severe degree visual impairment according to BCVA0.5,0.1-0.5,<0.1;and 4 groups:<1,1~<3,3~<6 and>6 months according to time interval from onset to CFF examination.One-way ANOVA was used to perform above subgroup analysis.The correlations between CFF and F-VEP peak time,peak value,BCVA and mean visual filed defect(MD)were analyzed in order via Pearson correlation analysis.Results:he trichromatic values of red,green,and yellow in DON affected eyes were 21.83±9.03,23.66±10.21,24.09±10.77 Hz,respectively,which was significantly reduced compared with the HC group(t=-14.82,-14.22,-14.00;P<0.001).The subgroup analysis showed no significant difference between different antibody subtypes(P=0.914<0.848<0.604),whereas,a significant decrease of CFF trichromatic value was found in severe visual acuity impairment group(P<0.001).There was a significant difference in CFF-trichromatic values at different time points(P<0.001),to be specific,CFF fluctuated under 20Hz within 3 months after onset and tended to be stable around 24-28Hz.Correlation analysis showed that the peak time of F-VEP(r=-0.486,-0.515,-0.526;P<0.001),BVCA(r=-0.640,-0.659,-0.642;P<0.001),were negatively correlated with CFF trichromatic values,MD and CFF were positively correlated(r=0.486,0.453,0.476;P=0.003,0.006,0.004).Conclusions:A significant decrease of CFF value was found in DON-affected eyes,and it has a good correlation with BCVA,MD and latency of F-VEP,and can better reflect the impairment of visual function. | Junxia Fu Yongping Wang Shaoying Tan Guangcan Xu Huanfen Zhou Quangang Xu Shihui Wei | 2021 | Advances in Ophthalmology Practice and Research2021，1，2： | 0 |
| 11 | Differences in the involved sites among different types of demyelinating optic neuritis in traditional MRI examination:A systematic review and meta-analysis显示文摘Background:Magnetic resonance imaging(MRI)plays a significant role in assessing optic neuropathy and providing more detailed information about the lesion of the visual pathway to help differentiate optic neuritis from other visual disorders.This study aims to systematically review the literature and verify if there is a real difference in lesion location among different demyelinating optic neuritis(DON)subtypes.Methods:A systematic search was conducted including 8 electronic databases and related resources from the establishment of the database to August 25th,2020.We classified DON into 5 subtypes and divided the visual pathways into five segments mainly comparing the differences in the involved visual pathway sites of different subtypes.Results:Fifty-five studies were included in the analysis,and the abnormal rate was as high as 92%during the acute phase(within 4 weeks of symptom onset).With respect to lesion location,the orbital segment of the optic nerve was the most frequently involved(87%),whereas optic tract involvement was very rare.Involvement of the orbital segment was more common in myelin oligodendrocyte glycoprotein antibody-related optic neuritis(MOGON)(78%)and chronic relapsing inflammatory optic neuropathy(CRION)(81%),while the lesion was found to be located more posteriorly in neuromyelitis optica spectrum disorder-related optic neuritis(NMOSD-ON).With respect to lesion length,approximately 77%of MOG-ON patients had lesions involving more than half of the optic nerve length.Conclusions:MRI examination is recommended for DON patients in the acute phase.In MOG-ON,anterior involvement is more common and the involved length is mostly more than 1/2 of the optic nerve length,whereas posterior involvement,intracranial segment,optic chiasm,or optic tract,is more common in NMOSD-ON. | Yongping Wang Junxia Fu Honglu Song Quangang Xu Huanfen Zhou Shihui Wei | 2021 | Advances in Ophthalmology Practice and Research2021，1，2： | 0 |
| 12 | Fbxl4作为节律输出分子通过周期性降解GABAA受体调控睡眠行为显示文摘文章简介睡眠是一种保守、可逆的行为状态,该过程受到生物节律和睡醒稳态的调控。然而生物节律到底是以何种输出形式调控睡眠的一直不清楚。 | Qian Li Yi Li Xiao Wang Junxia Qi Xi Jin Huawei Tong Zikai Zhou Zi Chao Zhang 韩俊海 | 2018 | 科学新闻2018，0，4： | 0 |
| 13 | Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody显示文摘Induction of broadly neutralizing monoclonal antibodies(bNAbs)that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus(HCV)vaccine research.The study of bNAbs arising in natural infection is essential in this endeavor.We generated a human antibody,8D6,recognizing the E2 protein of HCV isolated from a chronic hepatitis C patient.This antibody shows broadly neutralizing activity,which covers a pan-genotypic panel of cell culture-derived HCV virions(HCVcc).Functional and epitope analyses demonstrated that 8D6 can block the interaction between E2 and CD81 by targeting a highly conserved epitope on E2.We describe how the 8D6 lineage evolved via somatic hypermutation to achieve broad neutralization.We found that the V(D)J recombination-generated junctional and somatic hypermutation-induced disulfide bridge(C-C)motif in the CDRH3 is critical for the broad neutralization and binding activity of 8D6.This motif is conserved among a series of broadly neutralizing HCV antibodies,indicating a common binding model.Next,the 8D6 inferred germline(iGL)was reconstructed and tested for its binding affinity and neutralization activity.Interestingly,8D6 iGL-mediated relatively strong inhibition of the 1b genotype PR79L9 strain,suggesting that PR79L9 may serve as a potential natural viral strain that provides E2 sequences that induce bNAbs.Overall,our detailed epitope mapping and genetic studies of the HCV E2-specific mAb 8D6 have allowed for further refinement of antigenic sites on E2 and reveal a new mechanism to generate a functional CDRH3,while its iGL can serve as a probe to identify potential HCV vaccine strains. | Chunyan Yi Jing Xia Lan He Zhiyang Ling Xuesong Wang Yu Yan Jiangjun Wang Xinhao Zhao Weiguo Fan Xiaoyu Sun Ronghua Zhang Sheng Ye Rongguang Zhang Yongfen Xu Liyan Ma Yaguang Zhang Honglin Zhou Zhong Huang Junqi Niu Gang Long Junxia Lu Jin Zhong Bing Sun | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 14 | Analysis of Boundary Layer Structure,Turbulence,and Flux Variations before and after the Passage of a Sea Breeze Front Using Meteorological Tower Data显示文摘A detailed analysis of a sea breeze front(SBF)that penetrated inland in the Beijing–Tianjin–Hebei urban agglomeration of China was conducted.We focused on the boundary layer structure,turbulence intensity,and fluxes before and after the SBF passed through two meteorological towers in the urban areas of Tianjin and Beijing,respectively.Significant changes in temperature,humidity,winds,CO_(2),and aerosol concentrations were observed as the SBF passed.Differences in these changes at the two towers mainly resulted from their distances from the ocean,boundary layer conditions,and background turbulences.As the SBF approached,a strong updraft appeared in the boundary layer,carrying near-surface aerosols aloft and forming the SBF head.This was followed by a broad downdraft,which destroyed the near-surface inversion layer and temporarily increased the surface air temperature at night.The feeder flow after the thermodynamic front was characterized by low-level jets horizontally,and downdrafts and occasional updrafts vertically.Turbulence increased significantly during the SBF’s passage,causing an increase in the standard deviation of wind components in speed.The increase in turbulence was more pronounced in a stable boundary layer compared to that in a convective boundary layer.The passage of the SBF generated more mechanical turbulences,as indicated by increased friction velocity and turbulent kinetic energy(TKE).The shear term in the TKE budget equation increased more significantly than the buoyancy term.The atmosphere shifted to a forced convective state after the SBF’s passage,with near isotropic turbulences and uniform mixing and diffusion of aerosols.Sensible heat fluxes(latent heat and CO_(2)fluxes)showed positive(negative)peaks after the SBF’s passage,primarily caused by horizontal and vertical transport of heat(water vapor and CO_(2))during its passage.This study enhances understanding of boundary layer changes,turbulences,and fluxes during the passage of SBFs over urban areas. | Ju LI Junxia DOU Donald H. LENSCHOW Mingyu ZHOU Lihong MENG Xiaobin QIU Yubing PAN Jingjiang ZHANG | 2023 | Journal of Meteorological Research2023，37，6： | 0 |
| 15 | Trends in the Beijing cesarean section rate and reasons for the fluctuations显示文摘To the Editor:Cesarean section(CS)resolves dystocia and serious pregnancy-related complications but also has adverse outcomes such as long recovery time,uterine rupture,and dangerous placenta previa in future pregnancies.The increase in cesarean section rates(CsRs)worldwide has drawn the attention of international scholars. | Ruifen Zhao Li Zhou Weiyuan Zhang Moning Guo Xiaohong Deng Chenghong Yin Jianxia Wei Junxia Shi Xueying Wang Yi Feng | 2022 | Chinese Medical Journal2022，，12： | 0 |
| 16 | A Stable Luminescent Covalent Organic Framework Nanosheet for Sensitive Molecular Recognition显示文摘Despite rapid advances in fluorescence detectors over the past decade,the development of a highly stable,sensitive,and selective fluorescence platform for molecular recognition remains a considerable challenge.Here we report a stable carbazole-based sp2 carbon fluorescence covalent organic framework(COF)nanosheet,termed a JUC-557 nanosheet.Owing to the synergistic effect of aggregation-induced emission-and aggregation-caused quenching-based chromophores,the architecture of the JUC-577 shows high absolute quantum yields(up to 23.0%)in the solid state and when dispersed in various solvents as well as excellent sensing performance toward specific analytes,such as iodine(Ka:2.10×10^(5)M−1 and LOD:302 ppb),2,4,6-trinitrotoluene(Ka:4.38×10^(5)M−1 and LOD:129 ppb),and especially nitrobenzene(Ka:6.18×10^(6)M−1 and LOD:5 ppb)that is superior to that of fluorescence detection materials reported so far.Furthermore,the JUC-557 nanosheet preserves strong luminescence and sensitive recognition,even under harsh conditions,and allows trace detection of various analytes via a handheld UV lamp.These findings pave the way for developing stable ultrathin COF nanomaterials for highly sensitive and selective molecular detection. | Yaozu Liu Junxia Ren Yujie Wang Xin Zhu Xinyu Guan Zisheng Wang Yida Zhou Liangkui Zhu Shilun Qiu Shengxiong Xiao Qianrong Fang | 2023 | CCS Chemistry2023，5，9： | 0 |
| 17 | Zooming in and out of ferroptosis in human disease显示文摘Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation.In the past decade,it has been implicated in the pathogenesis of various diseases that together involve almost every organ of the body,including various cancers,neurodegenerative diseases,cardiovascular diseases,lung diseases,liver diseases,kidney diseases,endocrine metabolic diseases,iron-overload-related diseases,orthopedic diseases and autoimmune diseases.Understanding the underlying molecular mechanisms of ferroptosis and its regulatory pathways could provide additional strategies for the management of these disease conditions.Indeed,there are an expanding number of studies suggesting that ferroptosis serves as a bona-fide target for the prevention and treatment of these diseases in relevant pre-clinical models.In this review,we summarize the progress in the research into ferroptosis and its regulatory mechanisms in human disease,while providing evidence in support of ferroptosis as a target for the treatment of these diseases.We also discuss our perspectives on the future directions in the targeting of ferroptosis in human disease. | Xue Wang Ye Zhou Junxia Min Fudi Wang | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 18 | Novel Ag-bridged dual Z-scheme g-C_(3)N_(4)/BiOI/AgI plasmonic heterojunction: Exceptional photocatalytic activity towards tetracycline and the mechanism insight显示文摘Rational design and synthesis of highly efficient and robust photocatalysts with positive exciton splitting and interfacial charge transfer for environmental applications is critical.Herein,aiming at overcoming the common shortcomings of traditional photocatalysts such as weak photoresponsivity,rapid combination of photo-generated carriers and unstable structure,a novel Ag-bridged dual Z-scheme g-C_(3)N_(4)/BiOI/AgI plasmonic heterojunction was successfully synthesized using a facile method.Results showed that Ag-AgI nanoparticles and three-dimensional(3D)BiOI microspheres were decorated highly uniformly on the 3D porous g-C_(3)N_(4) nanosheet,resulting in a higher specific surface area and abundant active sites.The optimized 3D porous dual Z-scheme g-C_(3)N_(4)/BiOI/Ag-AgI manifested exceptional photocatalytic degradation efficiency of tetracycline(TC)in water with approximately 91.8%degradation efficiency within 165 min,outperforming majority of the reported g-C_(3)N_(4)-based photocatalysts.Moreover,g-C_(3)N_(4)/BiOI/Ag-AgI exhibited good stability in terms of activity and structure.In-depth radical scavenging and electron paramagnetic resonance(EPR)analyses confirmed the relative contributions of various scavengers.Mechanism analysis indicated that the improved photocatalytic performance and stability were ascribed to the highly ordered 3D porous framework,fast electron transfer of dual Z-scheme heterojunction,desirable photocatalytic performance of BiOI/AgI and synergistic effect of Ag plasmas.Therefore,the 3D porous Z-scheme g-C_(3)N_(4)/BiOI/Ag-AgI heterojunction had a good prospect for applications in water remediation.The current work provides new insight and useful guidance for designing novel structural photocatalysts for environment-related applications. | Wenxia Wang Zhen Li Kailin Wu Guodong Dai Qingping Chen Lihua Zhou Junxia Zheng Liang Ma Guiying Li Wanjun Wang Taicheng An | 2023 | Journal of Environmental Sciences2023，，9： | 0 |
| 19 | Periostin promotes EMT via inhibition of RIN1-mediated endocytosis of EGFR in gliomas显示文摘Purpose:Approximately 1/3 of brain tumors are gliomas.Previous glioma-related studies have reported increased expression of periostin(POSTN)in these cancerous tissues,but the role and mechanism of POSTN in glioma development remain unclear.Methods:Nanoscale liquid chromatography coupled with tandem mass spectrometry(nano LC-MS/MS)and RNA sequencing were used to identify diferential protein and mRNA expression in clinical glioma samples.Quantitative real-time PCR(qRT-PCR)was used to measure the expression of POSTN in tissues and cells.The efects of POSTN on glioma cell migration and invasion were examined using wound healing,Transwell,and three-dimensional spheroid assays in vitro and a nude mouse xenograft model in vivo.The efects of POSTN on the stability,endocytosis,and degradation of EGFR were examined by immunoblotting and immunofuorescence staining.Truncation mutation analysis was performed to investigate direct interactions between POSTN and EGFR.Immunohistochemical staining was carried out to confrm the clinical signifcance of POSTN.Results:Overexpression of POSTN induced epithelial-to-mesenchymal transition(EMT)in glioma cells in vivo and in vitro.Mechanistically,POSTN downregulation inhibited EGFR signaling by promoting EGFR endocytosis and degradation.In addition,POSTN was found to bind to EGFR and RIN1,inhibiting EGFR endocytosis and degradation and thus activating the PI3K-Akt signaling pathway.Conclusion:These fndings indicate the mechanism by which the POSTN/EGFR/RIN1 axis inhibits EGFR endocytosis and degradation,resulting in glioma cell EMT through the PI3K-AKT signaling pathway.Targeting POSTN/EGFR/RIN1 interactions may guarantee benefcial outcomes of glioma treatment. | Fengqi Zhou Tianfu Yu Fan Xiao Binbin Wang Wei Tian Ran Xu Xiaochun Zhao Ailiang Zeng Ning Liu Yingyi Wang Yongping You Junxia Zhang | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 20 | Cache Pollution Prevention Mechanism Based on Deep Reinforcement Learning in NDN显示文摘As a representative architecture of contentcentric paradigms for the future Internet,named data networking(NDN)enables consumers to retrieve content duplicates from either the original server or intermediate routers.Each node of NDN is equipped with cache that buffers but not validates the data,making it vulnerable to various attacks.Cache pollution,one of the specific attacks in NDN,fraudulently alters the cached contents by excessively requesting worthless information,squeezing the space of real popular contents and thus degrading the experience of normal users.In order to address the issue,this paper proposes a defense scheme based on deep reinforcement learning(DRL)against cache pollution attack,in which whether a data packet is to be cached is decided by a trained intelligent agent,that is adaptive to dynamic network states and following long term rewards,the accumulative data-requesting delays.Finally,the DRL-based scheme is evaluated and compared to two other existing schemes.Experimental results show that the proposed defense mechanism outperforms the others significantly,and is proved to be effective against cache pollution attacks. | Jie Zhou Jiangtao Luo Junxia Wang Lianglang Deng | 2021 | Journal of Communications and Information Networks2021，6，1： | 0 |
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