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| 1 | Influence of genes,sex,age and environment on the onset of autoimmune hepatitis显示文摘The pathogenesis of autoimmune hepatitis (AIH) is complex. However,it is believed that a susceptible individual,owing to his genetic background,sex and age,can develop the disease following exposure to an environmental trigger. Autoimmune hepatitis does not follow a Mendelian pattern of inheritance; hence no single causative genetic locus has been identified. However,several genes,inside and outside the HLA locus,have been linked to an increased susceptibility to AIH. Epidemiological evidence also suggests that the sex and age of the patient plays a role in AIH pathogenesis as the disease onset occurs mainly in the two first decades of life and a higher disease incidence is observed in females. No environmental trigger has been identified,but several have been proposed,mainly viruses and xenobiotics. This article aims at reviewing the current knowledge on susceptibility factors leading to AIH and putative triggers,emphasizing fundamental mechanisms responsible for the break of liver immunological tolerance. | Kathie Béland Pascal Lapierre Fernando Alvarez | 2009 | World Journal of Gastroenterology2009，15，9： | 8 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | Infection with virulent strains of helicobacter pylori is not associated with ischaemic heart disease:evidence from a population-based case-control study of myocardial infarction显示文摘 | Liam J Kathy B Bamford F K | 2000 | Atherosclerosis2000，149，： | 2 |
| 4 | Thermogravimetric analytical procedures for characterizing New Zealand and Eastern coals 显示文摘 | Kathy E Benfell B Basil Bcanish | 1996 | Thermochim Acta1996，，286： | 1 |
| 5 | Functional expression of the multimodal extracellular calcium-sensing receptor in pulmonary neuro- endocrine cells显示文摘 | Robrecht LB Inge B Kathy S | 2013 | J Cell Sci2013，126，19： | 1 |
| 6 | Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial显示文摘 | Stephen J Allen Kathie Wareham Duolao Wang Caroline Bradley Hayley Hutchings Wyn Harris Anjan Dhar Helga Brown Alwyn Foden Michael B Gravenor Dietrich Mack | 2013 | The Lancet . 2013 (9900)2013，，9900： | 1 |
| 7 | Toxicity of selenium and other elements in food organisms to razorback sucker larvae显示文摘 | Steven J H Kathy M H Kevin J B | 2002 | Aquatic Toxicology2002，59，34： | 1 |
| 8 | Balanced scorecard:Twoperspectives显示文摘 | Shih-Jen Kathy Ho Ruth B McKay | 2002 | The CPA Journal New York Mar 20022002，2023，： | 1 |
| 9 | Primary care residents self assessment skills in dementia 显示文摘 | Kathy B Deborah S Edmend D | 2003 | Advances in Health Sciences Education2003，，8： | 1 |
| 10 | Thermogravimetric analytical procedures for characterizing New Zealand and Eastern Australian coals 显示文摘 | Kathy E Benfell B Basil Bcamish k | 1996 | Thermochimica Acta1996，286，2： | 1 |
| 11 | Sleeppromotion in hospitalized elder 显示文摘 | Corey L Nagel Megan B Markie Kathy C Richards | 2003 | Mcd Surg Nursing2003，，12： | 1 |
| 12 | Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4显示文摘 | Ruth B?hni Juan Riesgo-Escovar Sean Oldham Walter Brogiolo Hugo Stocker Bernard F Andruss Kathy Beckingham Ernst Hafen | 1999 | Cell1999，，7： | 1 |
| 13 | Sleep promotion in hospitalized elder显示文摘 | Corey L Nagel Megan B Markie Kathy C Richards | 2003 | Med Surg Nursing2003，，12： | 1 |
| 14 | Uranium depositional controls at the Prairie Flats surficial uranium deposit, Summerland,British Columbia 显示文摘 | Kathy T Roger B | 2002 | Environmental Geology2002，40，： | 1 |
| 15 | Intelligent fusion processing in BMD applications显示文摘 | Kathy B Charles B | 1997 | SPIE1997，3067，： | 1 |
| 16 | The specific role of isoflavones on estrogen metabolism in premenopausal women 显示文摘 | Kumar Nagi B Cantor A Kathy A | 2002 | Cancer2002，94，4： | 1 |
| 17 | Primary care residents self assessment skill in dementia显示文摘 | Kathy B Deborah S Edmend D | 2003 | Advances in Health Sciences Education2003，8，： | 1 |
| 18 | Unintentional Hypothermia: Implications for Perianesthesia Nurses显示文摘 | Shari M B Mary W Kathy P | 2015 | Journal of PeriAnesthesia Nursing2015，1，4： | 1 |
| 19 | The specific role o isoflavones on estrogen metabolism in premenopausal women显示文摘 | B Kumar Nagi Cantor Alan Al len Kathy | 2002 | Cancer2002，94，4： | 1 |
| 20 | Faculty and student perceptions of effective clinlcalteachers:n extension study显示文摘 | Kathy B TerriG | | 0，，01： | 1 |
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