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| 1 | Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis显示文摘Background:Nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease diagnosis.Methods:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect models.We searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and anxiety.Eligible studies were publications in English with original data on one or more of these symptoms.Results:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD diagnosis.For all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the patients.Hyposmia was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this.However,the prevalence estimates were fairly robust in several sensitivity analyses.Only 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in controls.Conclusion:These symptoms are common among PD patients both before and after diagnosis.Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. | Honglei Chen Edward J Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna J Ciesielski-Jones Michele A Justice Deborah S Cousins Shyamal Peddada | 2015 | Translational Neurodegeneration2015，4，1： | 18 |
| 2 | 经肛全直肠系膜切除术治疗直肠癌的优点和局限显示文摘在美国,结直肠癌的发病率和死亡率分别位于恶性肿瘤的第4位和第2位,其中直肠癌约占结直肠癌的1/3。对于可切除直肠癌而言,全直肠系膜切除术(total mesorectal excision,TME)仍然是手术的金标准。但骨盆狭窄、新辅助治疗后肿瘤触摸不清、照明及术野显露困难、远切缘确定困难及吻合器无法放置等解剖、技术和患者方面的因素,会使开腹及腹腔镜TME手术困难。在此环境下,"自下而上"的TME手术——经肛全直肠系膜切除手术(taTME)应运而生。taTME手术结合了腹腔镜及机器人手术的微创化、高清内镜平台的可视化及功能化以及经肛经腹直肠癌TME手术的优势。2010—2013年期间,Lacy等研究者陆续系列报道了taTME手术的实施情况,将该术式推向了高潮。
taTME手术采取改良截石位。手术分为腹部手术和会阴手术两个部分。腹部手术具体步骤可由术者偏好调整,但总体包括游离左侧结肠和脾曲、高位结扎肠系膜下血管和标准的TME手术。会阴部手术先在肿瘤远端采用荷包缝合封闭肠腔,在进行直肠冲洗后,放入操作平台,环形切开肠壁,"自下而上"沿直肠系膜无血管层面进行游离,直至与腹部组会合。标本可以经肛或经造口部位取出。可采取手工缝合或吻合器吻合完成消化道重建。taTME手术的优点和局限如下。
1. taTME手术优点:taTME手术采用经肛进入盆腔的入路方式,即使在低位局部进展期直肠癌、肥胖、骨盆狭窄等操作难度大的手术中,依然可以获得满意的视野显露。同时,由于在肿瘤远端荷包缝合肠壁,故对肿瘤远端切缘的判断更加准确。taTME手术相对简便地完成远端直肠系膜的游离切除,可能更有利于确保手术标本切缘的安全性和淋巴清扫的彻底性,并能得到更高质量的TME手术切除标本,使直肠癌患者的生存获益。国际登记机构的结果显示,taTME术后系膜完整率为96%,环周切缘和远端切缘阳性率分别为2.4%和0.3%。与腹腔镜手术相比,taTME手术时间更短,术后并发症发生率更低。taTME术后吻合口漏发生率和病死率分别为6.7%和2.6%。
2. taTME手术局限:尽管taTME手术有上述优点,现有研究也提示,taTME术后短期肿瘤学安全性满意,但这毕竟是一种新术式,尚缺乏长期随访结果,需要更大样本的对照试验来探究其临床、肿瘤学和功能学结果。此外,对于一个新术式,在实践中会遇见一些新的并发症。特别是"自下而上"的路径,要求外科医生从不同的视角重新认识原来的解剖结构,如直肠后间隙的游离、血管神经束的保护等。此外,也需要重视和预防术中输尿管损伤、盆壁自主神经损伤、骶前静脉损伤和术后盆腔脓肿的发生。上述损伤尤其容易发生在系膜或前列腺层面上,因此,对于有肿瘤史、盆腔放疗史、前列腺切除史或前列腺肥大的患者尤其需要谨慎。必须指出的是,梗阻性直肠肿瘤、急诊手术和T4期肿瘤是taTME的禁忌证。
综上所述,taTME有利于骨盆狭窄的"高难度"低位直肠癌患者的手术切除和标本质量,但作为一种全新的术式,还需要进一步研究其临床、肿瘤学和功能学结果。 | Deborah S Keller Scott R Steele 楼征 张卫 | 2018 | 中华胃肠外科杂志2018，21，3： | 16 |
| 3 | Review of 500 single incision laparoscopic colorectalsurgery cases-Lessons learned显示文摘Single incision laparoscopic surgery(SILS) is a minimally invasive platform with specific benefits over traditional multiport laparoscopic surgery. The safety and feasibility of SILS has been proven, and the applications continue to grow with experience. After 500 cases at a high-volume, single-institution, we were able to standardize instrumentation and operative steps, as well as develop adaptations in technique to help overcome technical and ergonomic challenges. These technical adaptations have allowed the successful application of SILS to technically difficult patient populations, such as pelvic cases, inflammatory bowel disease cases, and high body mass index patients. This review is a frame of reference for the application and wider integration of the single incision laparoscopic platform in colorectal surgery. | Deborah S Keller Juan R Flores-Gonzalez Sergio Ibarra Eric M Haas | 2016 | World Journal of Gastroenterology2016，22，2： | 8 |
| 4 | Review of single incision laparoscopic surgery in colorectal surgery显示文摘As surgical techniques continue to move towards less invasive techniques,single incision laparoscopic surgery(SILS),a hybrid between traditional multiport laparoscopy and natural orifice transluminal endoscopic surgery,was introduced to further the enhanced outcomes of multiport laparoscopy. The safety and feasibility of SILS for both benign and malignant colorectal disease has been proven. SILS provides the potential for improved cosmesis,postoperative pain,recovery time,and quality of life at the drawback of higher technical skill required. In this article,we review the history,describe the available technology and techniques,and evaluate the benefits and limitations of SILS for colorectal surgery in the published literature. | Nisreen Madhoun Deborah S Keller Eric M Haas | 2015 | World Journal of Gastroenterology2015，21，38： | 8 |
| 5 | 初级保健中的过度诊断:分析问题,寻找答案显示文摘如果某种病症即使未被诊断出来也不会在患者的有生之年引起症状或伤害,而恰恰它却被诊断出来了,那么这就算是过度诊断。人们越来越认识到,过度诊断是癌症筛查和其他疾病筛查的负面产物。预防是初级保健的重要组成部分,这种保健服务面向广大人群,因此,从公共卫生的角度来看,初级保健中的过度诊断是一个重要的问题,具有深远的影响。在初级保健服务过程中产生的过度治疗,其范围大小尚不清楚,尽管无症状的乳腺癌、前列腺癌、甲状腺癌和肺癌常常有文献描述,但关于慢性肾脏疾病、抑郁症和注意力缺陷/多动障碍的过度诊断也有报道。然而,过度诊断在任何筛查项目中都难以避免,并且可能在很多临床场景下发生。过度诊断可以通过其导致的过度治疗(伴有相关的潜在毒性)、诊断相关的焦虑或抑郁、标签化或通过过度诊断带来的经济负担,对患者造成伤害。许多根深蒂固的因素促进过度诊断,包括越来越多地使用先进的诊断技术、经济激励措施、鼓励更多使用测试和治疗的医学文化、证据中的局限性所导致的诊断效用的模糊、使用无益的筛查、扩大疾病定义等。由于医生和患者之间缺乏对问题的认识以及术语混淆(过度诊断常常与相关概念相混淆),减少过度诊断的努力由此受到阻碍。理清术语概念将有助于医生对过度诊断问题的理解,有助于为描述其在初级保健中的流行情况及其带来的后果进一步积累证据。希望国际上在疾病定义和诊断标准上能够统一,这也将有助于减少未来的过度诊断。 | Minal S Kale Deborah Korenstein 李俊(译) | 2018 | 英国医学杂志中文版2018，21，12： | 3 |
| 6 | The role of serotonin receptor alleles and environmental stressors in the development of post‐concussive symptoms after pediatric mild traumatic brain injury显示文摘 | Kim Smyth Sandeep S Sandhu Susan Crawford Deborah Dewey Jillian Parboosingh Karen M Barlow | 2014 | Dev Med Child Neurol2014，，1： | 2 |
| 7 | Adverse events of upper GI endoscopy显示文摘 | Tamir Ben-Menachem G. Anton Decker Dayna S. Early Jerry Evans Robert D. Fanelli Deborah A. Fisher Laurel Fisher Norio Fukami Joo Ha Hwang Steven O. Ikenberry Rajeev Jain Terry L. Jue Khalid M. Khan Mary L. Krinsky Phyllis M. Malpas John T. Maple Ravi N. S | 2012 | Gastrointestinal Endoscopy2012，，4： | 2 |
| 8 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 9 | P53 and RPA are sequestered in viral replication centers in the nuclei of cells infected with human cytomegalovirus 显示文摘 | Elizabech A F Deborah H S | 1998 | J Virol1998，72，3： | 1 |
| 10 | Identification of △^5-desaturase from mortierella alpina by heterologous extrusion in bakers' yeast and canola显示文摘 | Deborah S K Jennifer M T Huang Y S | 1998 | J Biol Chem1998，273，29： | 1 |
| 11 | Therapeutic outcome according to histologic subtype in 121 patients with malignant pleural mesothelioma显示文摘 | Giovanni Luca Ceresoli Laura Deborah Locati Andrés José Mar??a Ferreri Cesare Cozzarini Paolo Passoni Giulio Melloni Piero Zannini Angelo Bolognesi Eugenio Villa | 2001 | Lung Cancer2001，，2： | 1 |
| 12 | Evaluation of C-reac tive protein, procalcitonin, tumor necrosis factor alpha, interleukin-6, and interleukin-8 as diagnostic parameters in sepsis-related fatalities显示文摘 | Bettina S Pascale R L Deborah S | 2012 | J Legal Med2012，126，5： | 1 |
| 13 | Primary care residents self assessment skills in dementia 显示文摘 | Kathy B Deborah S Edmend D | 2003 | Advances in Health Sciences Education2003，，8： | 1 |
| 14 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 15 | Illegitimate Cre dependent chromosome rearrangements in transgenic mouse spermatics显示文摘 | EDWARD E S DEBORAH S T JUSTIN R P | 2000 | PNAS2000，97，13： | 1 |
| 16 | The Prevalence of Depression in a Cohort of the very Dlderly显示文摘 | Deborah M G Claire B Eugene S P | 1995 | Journal of Affective Disorders1995，34，： | 1 |
| 17 | Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellar DNA replication 显示文摘 | Nilma B Veronica S Deborah H | 2003 | J Virol2003，77，4： | 1 |
| 18 | The endotheliaI cell protein C receptor显示文摘 | Fukudome K Kurosawa S Deborah J | 1996 | J Biol Chem1996，271，17： | 1 |
| 19 | The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin - binding protein but facilitates its loading onto DNA 显示文摘 | KELLY S YALI ZHU DEBORAH S | 2005 | Nucleic Acids Research2005，33，2： | 1 |
| 20 | Improving teenagers'knowledge of emergency contraception: cluster randomized controlled trial of a teacher led intervention 显示文摘 | Anna G Laurence M Deborah S | 2002 | BMJ2002，324，： | 1 |
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