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| 1 | Condyloma acuminatum of the anal canal,treated with endoscopic submucosal dissection显示文摘Condyloma acuminatum(CA) is a common sexually transmitted disease caused by human papilloma virus infection. Not all individuals develop persistent, progressive disease, but careful follow up is required with moderate-to-severe dysplasia to prevent progression to malignancy. Standard therapies include surgical treatments(trans-anal resection and transanal endoscopic microsurgery) and immunotherapeutic and topical methods(topical imiquimod); however, local recurrence remains a considerable problem. Here, we report a case with superficial CA of the anal canal, treated with endoscopic submucosal dissection(ESD). A 28-year-old man presented with a chief complaint of hematochezia. Digital exam did not detect a tumor. Screening colonoscopy revealed 10-mm long, whitish condyles extending from the anal canal to the lower rectum. The lesion covered almost the whole circumference, and only a small amount of normal mucosa remained. Magnifying endoscopy with narrow band imaging showed brownish hairpin-shaped, coiled capillaries. Although histopathological diagnosis by biopsy revealed CA, accurate histological differentiation between CA, papilloma, and squamous cell carcinoma can be difficult with a small specimen. Therefore, weperformed diagnostic ESD, which provides a complete specimen for precise histopathological evaluation. The pathological diagnosis was CA, with moderate dysplasia(anal intraepithelial neoplasia 2). There was no recurrence at 16 mo after the initial ESD. Compared to surgical treatment, endoscopic diagnosis and resection could be performed simultaneously and the tumor margin observed clearly with a magnifying chromocolonoscopy, resulting in less recurrence. These findings suggest that endoscopic resection may be an alternative method for CA that prevents recurrence. | Akiko Sasaki Takeshi Nakajima Hideto Egashira Kotaro Takeda Shinnosuke Tokoro Chikamasa Ichita Sakue Masuda Haruki Uojima Kazuya Koizumi Takeshi Kinbara Taku Sakamoto Yutaka Saito Makoto Kako | 2016 | World Journal of Gastroenterology2016，22，8： | 11 |
| 2 | Efficacy of combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients: A randomized study显示文摘AIM To assess the effects of a combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients.METHODS A two-center,randomized,open-label,prospective study was conducted. Japanese patients who met the criteria were randomized to trial group and the combination diuretic group(received 7.5 mg of tolvaptan) or the conventional diuretic group(received 40 mg of furosemide) for 7 d in addition to the natriuretic drug which was used prior to enrolment in this study. The primary endpoint was the change in body weight from the baseline. Vital signs,fluid intake,and laboratory and urinary data were assessed to determine the pharmacological effects after administration of aquaretic and natriuretic drugs.RESULTS A total of 56 patients were randomized to receive either tolvaptan(n = 28) or furosemide(n = 28). In the combination and conventional diuretic groups,the average decrease in body weight from the baseline was 3.21 ± 3.17 kg(P < 0.0001) and 1.75 ± 2.36 kg(P = 0.0006),respectively,when measured on the final dosing day. Following 1 wk of treatment,a significantly greater reduction in body weight was observed in the combination diuretic group compared to that in the conventional diuretic group(P = 0.0412).CONCLUSION Compared to a conventional diuretic therapy with only a natriuretic drug,a combination diuretic therapy with natriuretic and aquaretic drugs is more effective for patients with cirrhotic ascites. | Haruki Uojima Hisashi Hidaka Tsuyoshi Nakayama Ji Hyun Sung Chikamasa Ichita Shinnosuke Tokoro Sakue Masuda Akiko Sasaki Kazuya Koizumi Hideto Egashira Makoto Kako | 2017 | World Journal of Gastroenterology2017，23，45： | 2 |
| 3 | Dynamical model of HEV with two planetary gear units and its application to optimization of energy consumption显示文摘A hybrid electric vehicle(HEV) that uses multiple planetary gear units with clutches as transmission system is advanced for the powertrain performance, because the operation of the clutches can lead to distinct operating modes, and the induced possible operating modes provide additional freedom to deal with the energy optimal control problem. Under each operating mode, the powertrain mechanical system has specific dynamical behavior. In order to develop model-based optimization schemes that can tackle the transient operations of the vehicle, exact dynamical modeling is investigated focusing on a hybrid powertrain system that uses a two-planetary-gear transmission box with two clutches. It shows that according to the states of the two clutches, the powertrain system has the power-split mode, parallel mode and the electric vehicle(EV) mode. Finally, an analysis for the calculation of the desired driving torque and its application to the dynamic programming(DP)-based energy management indicate the significance of the developed exact dynamical models. | Jiangyan ZHANG Shota INUZUKA Takafumi KOJIMA Tielong SHEN Junichi KAKO | 2019 | Science China(Information Sciences)2019，62，12： | 2 |
| 4 | Real-time energy optimization of HEVs under-connected environment: a benchmark problem and receding horizon-based solution显示文摘In this paper,we propose a benchmark problem for the challengers aiming to energy efficiency control of hybrid electric vehicles(HEVs)on a road with slope.Moreover,it is assumed that the targeted HEVs are in the connected environment with the obtainment of real-time information of vehicle-to-everything(V2X),including geographic information,vehicle-to-infrastructure(V2I)information and vehicle-to-vehicle(V2V)information.The provided simulator consists of an industrial-level HEV model and a traffic scenario database obtained through a commercial traffic simulator,where the running route is generated based on real-world data with slope and intersection position.The benchmark problem to be solved is the HEVs powertrain control using traffic information to fulfill fuel economy improvement while satisfying the constraints of driving safety and travel time.To show the HEV powertrain characteristics,a case study is given with the speed planning and energy management strategy. | Fuguo Xu Hiroki Tsunogawa Junichi Kako Xiaosong Hu Shengbo Eben Li Tielong Shen Lars Eriksson Carlos Guardiola | 2022 | Control Theory and Technology2022，20，2： | 2 |
| 5 | Sharp Decline in the Food Self-sufficiency Ratio in Japan and Its Future Prospects显示文摘 | T. Kako | 2010 | Journal of Agricultural Science and Technology2010，4，3： | 2 |
| 6 | Hypoglyce- mic activity of some triterpenoid glycosides 显示文摘 | Mami Kako Toshihiro Miura Yumi Nishiyama | 1997 | Nat prod1997，60，： | 1 |
| 7 | Inhibitory action of gemfibrozil on cholesterol absorption in rat intestine 显示文摘 | Umeda Y Kako Y Mizutani K | 2001 | J Lipid Res2001，42，8： | 1 |
| 8 | Photophysical and photocatalytic properties of SrTiO3 doped with Cr cations on different sites 显示文摘 | Wang D Ye J Kako T | 2006 | The Journal of Physical Chemistry B2006，110，15： | 1 |
| 9 | Antiviral effects of the interferon‐induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein显示文摘 | Yasuhiro Itsui Naoya Sakamoto Sei Kakinuma Mina Nakagawa Yuko Sekine‐Osajima Megumi Tasaka‐Fujita Yuki Nishimura‐Sakurai Gouki Suda Yuko Karakama Kako Mishima Machi Yamamoto Takako Watanabe Mayumi Ueyama Yusuke Funaoka Seishin Azuma Mamoru Watanabe | 2009 | Hepatology2009，，6： | 1 |
| 10 | Intracoronary verapamil rapidly terminates reperfusion tachyarrhythmias in acute myocardial infarction显示文摘 | KAKO M DOTE K SASAKI S | 2004 | Chest2004，126，3： | 1 |
| 11 | In vivo T-cell depletion withalemtuzumab in allogeneic hematopoietic stem celltransplantation: Combined results of two studies on aplasticanemia and HLA-mismatched haploidentical transplantation显示文摘 | Kanda Y Oshima K’Kako S | 2013 | AmJ Hematol2013，88，4： | 1 |
| 12 | Structural features and hypoglycemic activity of a polysaccharide( CS F10) from the cultured mycellum of Cordyceps sinensis 显示文摘 | Tadashi K Kako Q Shigdyuki U | 1999 | Biod pharm Bull1999，22，9： | 1 |
| 13 | High-dose (9MU) long-term (60 weeks) alfa-interferon therapy for chronic hepatitis patients infected with HCV genotype 1b显示文摘 | Kanai K Kako M Kumada T | 1998 | Arch Virol1998，143，8： | 1 |
| 14 | Advances in quantum dots for classical and non-classical light sources Invited Paper显示文摘Recent advances in quantum dots(QDs)for classical and non-classical light sources are presented.We have established metal organic chemical vapor deposition(MOCVD)technology for InAs-based QD lasers at 1.3μm and achieved ultralow threshold in QD lasers with photonic crystal(PhC)nanocavity.In addition, single photon emitters at 1.55μm,GaN-based single photon sources operating at 200 K,and high-Q PhC nanocavity have been demonstrated. | Yasuhiko Arakawa Satoshi Iwamoto Satoshi Kako Masahiro Nomura Denis Guimard | 2008 | Chinese Optics Letters2008，6，10： | 1 |
| 15 | Enhanced Photocatalytic Activity of La-doped AgNbO3 under Visible Light Irradiation显示文摘 | Li G Q Kako T Wang D | 2009 | Dalton Trans2009，13，： | 1 |
| 16 | Hypoglycemic effect of the rhizomes of ophiopogonis tuber in normal and diabetic mice 显示文摘 | Kako M Miura T Usami M | 1995 | Biol Pharm Bull1995，18，5： | 1 |
| 17 | Clinical outcome in patients with small intestinal non-Hodgkin lymphoma 显示文摘 | Kako S Oshima K Sato M | 2009 | Leuk Lympho- ma2009，50，10： | 1 |
| 18 | A protective role for kidney apolipoprotein E :Regulation of mesangial cell proliferation and matrixs expansion显示文摘 | Paka L Kako Y | 2001 | J Biol Chem2001，276，49： | 1 |
| 19 | Strong adsorption and effective photo- catalytic activities of one-dimensionalnano-structured silver ti- tanates显示文摘 | Li Q Y Kako T Ye J H | 2010 | Appl Catal A2010，375，1： | 1 |
| 20 | Coupling between a point-defect cavity and a line-defect wave guide in three-dimen- sional photonic crystal 显示文摘 | Okano M Kako S Noda S | 2003 | Physical Reviews B2003，68，23： | 1 |
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