|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular basis of the irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a functional disorder characterized by abdominal pain,discomfort and bloating.The pathophysiology of IBS is poorly understood,but the presence of psychosocial basis is now known.There is an increasing number of publications supporting the role of genetics in IBS.Most of the variations are found in genes associated with the brain-gut axis,revealing the strong correlation of brain-gut axis and IBS.miRNAs,which play critical roles in physiological processes,are not well studied in IBS.However,so far there is found an involvement of alterations in miRNA expression or sequence,in IBS symptoms.IBS phenotype is affected by epigenetic alteration and environment.Changes in DNA and histone methylation are observed in patients who suffered childhood trauma or abuse,resulting in altered gene expression,such as the glucocorticoid receptor gene.Finally,diet is another factor associated with IBS,which may contribute to symptom onset.Certain foods may affect on bacterial metabolism and epigenetic modifications,predisposing to IBS. | Anna Vaiopoulou Georgios Karamanolis Theodora Psaltopoulou George Karatzias Maria Gazouli | 2014 | World Journal of Gastroenterology2014，20，2： | 21 |
| 2 | Risk factors for gastroesophageal reflux disease and analysis of genetic contributors显示文摘Gastroesophageal reflux disease(GERD) is a common gastrointestinal disorder with an increasing prevalence. GERD develops when the reflux of stomach contents causes troublesome typical and atypical symptoms and/or complications. Several risk factors of GERD have been identified and evaluated over the years, including a considerable amount of genetic factors. Multiple mechanisms are involved in the pathogenesis of GERD including:(1) motor abnormalities, such as impaired lower esophageal sphincter(LES) resting tone, transient LES relaxations, impaired esophageal acid clearance and delayed gastric emptying; and(2) anatomical factors, such as hiatal hernia and obesity. Genetic contribution seems to play a major role in GERD and GERD-related disorders development such Barrett's esophagus and esophageal adenocarcinoma. Twin and family studies have revealed an about 31% heritability of the disease. Numerous single-nucleotide polymorphisms in various genes like FOXF1, MHC, CCND1, anti-inflammatory cytokine and DNA repair genes have been strongly associated with increased GERD risk. GERD, Barrett'sesophagus and esophageal adenocarcinoma share several genetic loci. Despite GERD polygenic basis,specific genetic loci such as rs10419226 on chromosome 19, rs2687201 on chromosome 3, rs10852151 on chromosome 15 and rs520525 on the paired related homeobox 1 gene have been mentioned as potential risk factors. Further investigation on the risk genes may elucidate their exact function and role and demonstrate new therapeutic approaches to this increasingly common disease. | Alexandra Argyrou Evangelia Legaki Christos Koutserimpas Maria Gazouli Ioannis Papaconstantinou George Gkiokas George Karamanolis | 2018 | World Journal of Clinical Cases2018，6，8： | 14 |
| 3 | Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis显示文摘Functional gastrointestinal disorders(FGID) are heterogeneous disorders with a variety of clinical manifestations, primarily defined by signs and symptoms rather than a definite underlying cause. Their pathophysiology remains obscure and, although it is expected to differ according to the specific FGID, disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis. The hormone ghrelin is an important component of this axis,exerting a wide repertoire of physiological actions, including regulation of gastrointestinal motility and protection of mucosal tissue. Ghrelin's gene shows genetic polymorphism, while its protein product undergoes complex regulation and metabolism in the human body. Numerous studies have studied ghrelin's relation to the emergence of FGIDs, its potential value as an index of disease severity and as a predictive marker for symptom relief during attempted treatment. Despite the mixed results currently available in scientific literature, the plethora of statistically significant findings shows that disruptions in ghrelin genetics and expression are plausibly related to FGID pathogenesis. The aim of this paper is to review current literature studying these associations, in an effort to uncover certain patterns of alterations in both genetics and expression, which could delineate its true contribution to FGID emergence, either as a causative agent or as a pathogenetic intermediate. | Tilemachos Koutouratsas Theodora Kalli Georgios Karamanolis Maria Gazouli | 2019 | World Journal of Gastroenterology2019，25，5： | 14 |
| 4 | Gene polymorphisms associated with functional dyspepsia显示文摘Functional dyspepsia(FD) is a constellation of functional upper abdominal complaints with poorly elucidated pathophysiology. However, there is increasing evidence that susceptibility to FD is influenced by hereditary factors. Genetic association studies in FD have examined genotypes related to gastrointestinal motility or sensation, as well as those related to inflammation or immune response. G-protein b3 subunit gene polymorphisms were first reported as being associated with FD. Thereafter, several gene polymorphisms including serotonin transporter promoter, interlukin-17 F, migration inhibitory factor, cholecystocynine-1 intron 1, cyclooxygenase-1, catechol-o-methyltransferase, transient receptor potential vanilloid 1 receptor, regulated upon activation normal T cell expressed and secreted, p22 PHOX, Toll like receptor 2, SCN10 A, CD14 and adrenoreceptors have been investigated in relation to FD; however, the results are contradictory. Several limitations underscore the value of current studies. Among others, inconsistencies in the definitions of FD and controls, subject composition differences regarding FD subtypes, inadequate samples, geographical and ethnical differences, as well as unadjusted environmental factors. Further well-designed studies are necessary to determine how targeted genes polymorphisms, influence the clinical manifestations and potentially the therapeutic response in FD. | Anastasia Kourikou George P Karamanolis George D Dimitriadis Konstantinos Triantafyllou | 2015 | World Journal of Gastroenterology2015，21，25： | 8 |
| 5 | Endoscopic treatments for chronic radiation proctitis显示文摘Chronic radiation proctitis is a complication that occurs in patients who receive radiation therapy for pelvic malignancies. The common presentation is with rectal bleeding, but also rectal pain, diarrhea, tenesmus and even passage of mucus can occur. The optimal treatment of bleeding due to radiation proctitis remains unclear. Among various therapeutic options, medical management is generally ineffective and surgical intervention has a high incidence of morbidity. Promising advances have been made in endoscopic therapy, including argon plasma coagulation (APC), formalin application as well as new techniques such as radio-frequency ablation and cryoablation. APC is a safe, highly effective and long-lasting therapy in patients with rectal bleeding associated with radiation proctitis. It has been shown that several sessions of APC reduce the rate of bleeding and therefore the blood transfusion requirements. Moreover, the effect of treatment is long lasting. However, best results are achieved in patients with mild to moderate radiation proctitis, leaving space for alternative treatments for patients with more severe disease. In patients with severe or refractoryradiation proctitis intra rectal formalin application is an appropriate treatment option. Radiofrequency ablation and cryoablation have shown efficacy as alternative methods in a limited number of patients with refractory chronic radiation proctitis. | George Karamanolis Panagiota Psatha Konstantinos Triantafyllou | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 7 |
| 6 | Colonic gas explosion during therapeutic colonoscopy with electrocautery显示文摘有电镀物品烙术的治疗学的结肠镜检查广泛地在全世界被使用。足够的结肠的清洁为这个过程的安全被认为一个关键因素。结肠的煤气的爆炸稀罕,在有电镀物品的结肠镜检查期间是最令人恐惧的因医生之治疗而引的复杂并发症之一烙术。这复杂并发症是到爆炸集中的结肠的气体的累积的结果,但是可以被过细的肠准备阻止。这评论的目的是为治疗学的结肠镜检查讨论指示和肠准备的类型,并且与电镀物品烙术为结肠镜检查为足够的肠准备贡献建议。 | Spiros D Ladas George Karamanolis Emmanuel Ben-Soussan | 2007 | World Journal of Gastroenterology2007，13，40： | 5 |
| 7 | Long‐term administration of rifaximin improves the prognosis of patients with decompensated alcoholic cirrhosis显示文摘 | Jiannis Vlachogiannakos Nikos Viazis Panagiota Vasianopoulou Irene Vafiadis Dimitrios G Karamanolis Spiros D Ladas | 2013 | J Gastroenterol Hepatol2013，，3： | 4 |
| 8 | A prospective cross-over study using a sphincterotome and a guidewire to increase the success rate of common bile duct cannulation显示文摘AIM: During endoscopic retrograde cholangiopancreatography (ERCP), selective cannulation of the common bile duct (CBD) is required in most of the cases.METHODS: From June 2001 till December 2002, all patients referred to our unit for ERCP were considered for entry into the study. Selective CBD cannulation was first attempted with a standard catheter with or without the use of a guidewire. In cases, where CBD cannulation was considered unsuccessful, patients were crossed over to a double-lumen sphincterotome and a guidewire. All patients were hospitalized for 24 h after the procedure in order to assess the incidence of post-ERCP complications.RESULTS: The study sample consisted of 158 patients.Selective CBD cannulation using a standard ERCP catheter with or without the assistance of a guidewire, was accomplished in 129 patients (success rate: 81.65%).From the 29 patients who were crossed over to a sphincterotome and a guidewire, selective CBD cannulation was achieved in 24; the overall success rate rising to 96.8%. Meanwhile, the use of this technique did not increase the incidence of post-ERCP complications.CONCLUSION: The use of a sphincterotome and a guidewire increases the success rate of selective bile duct cannulation in cases that this has not been accomplished with a standard catheter. | Georgios Karamanolis Aikaterini Katsikani Nikos Viazis Gerasimos Stefanidis Spilios Manolakopoulos Spiros Sgouros Efthimia Papadopoulou Apostolos Mantides | 2005 | World Journal of Gastroenterology2005，11，11： | 3 |
| 9 | Colon capsule endoscopy is feasible to perform after incomplete colonoscopy and guides further workup in clinical practice显示文摘 | Konstantinos Triantafyllou Nikos Viazis Panagiotis Tsibouris Georgios Zacharakis Chryssostomos Kalantzis Demetrios G. Karamanolis Spiros D. Ladas | 2014 | Gastrointestinal Endoscopy2014，，2： | 3 |
| 10 | Changes in the esophageal mucosa of patients with non erosive reflux disease:How far have we gone?显示文摘The normal esophageal mucosa creates a protective epithelial barrier that constrains the acidic reflux in the esophageal lumen. Microscopic findings and functional studies indicate that this barrier might be impaired in patients with non erosive reflux disease(NERD) but not in patients with functional heartburn(FH). Whereas endoscopy and pH monitoring are the most important diagnostic tools in the diagnosis of NERD, recent studies suggest that esophageal biopsies might have a complementary role. Particularly in the differential diagnosis between NERD and FH, the application of histological severity scores showed very promising results. Further evaluation of the scores could lead to routine application of histology in specific NERD populations. | Christos Triantos Nikolaos Koukias Georgios Karamanolis Konstantinos Thomopoulos | 2015 | World Journal of Gastroenterology2015，21，19： | 3 |
| 11 | Serum zonulin levels in patients with liver cirrhosis:Prognostic implications显示文摘BACKGROUND Increased gut permeability and bacterial translocation play an important role in liver cirrhosis.Zonulin is a recently recognized protein involved in the disintegration of the intestinal barrier.AIM To investigate possible differences in serum zonulin levels among patients with different cirrhosis stages and their potential prognostic implications.METHODS Consecutive cirrhotic patients who attended our liver clinic were included in the study.Serum zonulin levels,clinical,radiological and biochemical data were collected at baseline.Patients who accepted participation in a regular surveillance program were followed-up for at least 12 mo.RESULTS We enrolled 116 cirrhotics[mean Child-Turcotte-Pugh(CTP)score:6.2±1.6;model for end-stage liver disease score:11±3.9].The causes of cirrhosis were viral hepatitis(39%),alcohol(30%),non-alcoholic fatty liver disease(17%),and other(14%).At baseline,53% had decompensated cirrhosis,48% had ascites,and 32% had history of hepatic encephalopathy.Mean zonulin levels were significantly higher in patients with CTP-B class than CTP-A class(4.2±2.4 ng/dL vs 3.5±0.9 ng/dL,P=0.038),with than without ascites(P=0.006),and with than without history of encephalopathy(P=0.011).Baseline serum zonulin levels were independently associated with the probability of decompensation at 1 year(P=0.039),with an area under the receiving operating characteristic of 0.723 for predicting hepatic decompensation.Higher CTP score(P=0.021)and portal vein diameter(P=0.022)were independent predictors of mortality.CONCLUSION Serum zonulin levels are higher in patients with more advanced chronic liver disease and have significant prognostic value in identifying patients who will develop decompensation. | Theodoros A Voulgaris Dimitrios Karagiannakis E Hadziyannis Spilios Manolakopoulos Georgios P Karamanolis George Papatheodoridis John Vlachogiannakos | 2021 | World Journal of Hepatology2021，13，10： | 2 |
| 12 | Systematic review: Coca‐Cola can effectively dissolve gastric phytobezoars as a first‐line treatment显示文摘 | S. D. Ladas D. Kamberoglou G. Karamanolis J. Vlachogiannakos I. Zouboulis‐Vafiadis | 2012 | Aliment Pharmacol Ther2012，，2： | 2 |
| 13 | Is there a role for second-look capsule endoscopy in patients with obscure GI bleeding after a nondiagnostic first test?显示文摘 | Nikos Viazis Kostis Papaxoinis John Vlachogiannakos Alkiviadis Efthymiou Ioannis Theodoropoulos Dimitrios G. Karamanolis | 2009 | Gastrointestinal Endoscopy2009，，4： | 2 |
| 14 | Solitary colonic neurofibroma in a patient with transient segmental colitis: Case report显示文摘Neurofibromas of the large bowel are very rare and usually are part of the colonic involvement in neurofibromatosis type 1 (Nf1, von Recklinghausen's disease). Solitary neurofibromas of the colon are extremely rare. We describe a case of an isolated neurofibroma that was found in the large bowel of a patient who suffered from segmental colitis and presented with bloody diarrhea. A review of the literature is also included, concerning the disclosure of isolated neurofibromas in the gut and other body parts and the type of gastrointestinal involvement in von Recklinghausen's disease. | Vasilios Panteris Thivi Vassilakaki Nikos Vaitsis Ioannis Elemenoglou Irini Mylonakou Dimitrios Georgios Karamanolis | 2005 | World Journal of Gastroenterology2005，11，35： | 2 |
| 15 | Association of miR-146 rs2910164,miR-196a rs11614913,miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn's disease显示文摘AIM To investigate the correlation between rs2910164, rs11 614913, rs113054794, and rs188519172 polymorphisms and response to anti-TNF treatment in patients with Crohn's disease(CD). METHODS One hundred seven patients with CD based on standardclinical, endoscopic, radiological, and pathological criteria were included in the study. They all received infliximab or adalimumab intravenously or subcutaneously at standard induction doses as per international guidelines. Clinical and biochemical response was assessed using the HarveyBradshaw index and CRP levels respectively. Endoscopic response was evaluated by ileocolonoscopy at week 12-20 of therapy. The changes in endoscopic appearance compared to baseline were classified into four categories, and patients were classified as responders and nonresponders. Whole peripheral blood was extracted and genotyping was performed by PCR.RESULTS One hundred and seven patients were included in the study. Seventy two(67.3%) patients were classified as complete responders, 22(20.5%) as partial while 13(12.1%) were primary non-responders. No correlation was detected between response to anti-TNF agents and patients' characteristics such as gender, age and disease duration while clinical and biochemical indexes used were associated with endoscopic response. Concerning prevalence of rs2910164, rs11614913, and rs188519172 polymorphisms of miR-146, miR-196a and miR-224 respectively no statistically important difference was found between complete, partial, and non-responders to antiTNF treatment. Actually CC genotype of rs2910164 was not detected in any patient. Regarding rs113054794 of miR-221, normal CC genotype was the only one detected in all studied patients, suggesting this polymorphism is highly rare in the studied population.CONCLUSION No correlation is detected between studied polymorphisms and patients' response to anti-TNF treatment. Polymorphism rs113054794 is not detected in our population. | Ioannis Papaconstantinou Christina Kapizioni Evangelia Legaki Elena Xourgia George Karamanolis Antonios Gklavas Maria Gazouli | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，4： | 2 |
| 16 | A comparative audy of postendoscopic sphincterotomy complications with various types of electrosurgical current in patients with choledocholithiasis显示文摘 | Karamanolis G Viazis N | 2003 | Gastrointest Endosc2003，57，： | 1 |
| 17 | Triage: performance differentiation for storage systems using adaptive control显示文摘 | Karlsson M Karamanolis K Zhu Xiaoyun | 2005 | ACM Transactions on Storage2005，1，4： | 1 |
| 18 | The role of NSAIDs in colon cancer prevention显示文摘 | Antonakopoulos N Karamanolis DG | 2007 | Hepatogastroenterology2007，54，78： | 1 |
| 19 | 功能性消化不良的突出症状与临床特征及病理生理学机制的关系显示文摘Background & Aims: Functional dyspepsia (FD) is considered a heterogeneous disorder with different pathophysiological mechanisms contributing to the symptom pattern. The Rome II committee proposed that subdividing patients with FD into groups with predominant pain versus discomfort might identify subgroups with homogeneous pathophysiological and clinical properties. The aim of this study was to analyze the relationship of predominant pain or discomfort with pathophysiological mechanisms and to evaluate whether considering individual predominant symptoms yields better results. Methods: Consecutive FD patients (n = 720; 489 women; mean age, 41.3 ± 0.6 years) filled out a dyspepsia questionnaire and identified a single most bothersome symptom. We analyzed the association of this predominant symptom with demographic, clinical, and pathophysiological features (Helicobacter pylori status, gastric emptying in 592 patients, and gastric sensitivity and accommodation testing in 332 patients). Results: According to Rome II criteria, 22% were pain predominant and 78% discomfort predominant. Patients with predominant pain had a higher prevalence of hypersensitivity (44% vs 25% ) and delayed gastric emptying was observed less frequently in these patients (16% vs 26% ), but there was major overlap. Detailed analysis showed that any of 8 dyspeptic symptoms could be predominant. Predominant early satiety or vomiting was associated with significantly higher prevalences of weight loss (89% and 75% , respectively) and of acute onset (61% and 60% , respectively). Impaired accommodation was found in 79% of patients with predominant early satiety. The highest prevalence of delayed emptying was found in predominant fullness (38% ) and of hypersensitivity in predominant pain (44% ). Conclusions: Subdividing FD patient groups according to the predominant symptom does not reliably identify subgroups with a homogeneous underlying pathophysiological mechanism. | Karamanolis G. Caenepeel P. Arts J. Tack J. 赵天智(译) 张欣(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 1 |
| 20 | P447 Long term benefit of one year infliximab administration for the treatment of chronic refractory pouchitis显示文摘 | N. Viazis M. Giakoumis J. Anastasiou K. Katopodi G. Kechagias G. Tribonias D. Karamanolis | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员