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| 1 | Functional Gastroduodenal Disorders显示文摘 | Jan Tack Nicholas J. Talley Michael Camilleri Gerald Holtmann Pinjin Hu Juan-R. Malagelada Vincenzo Stanghellini | 2006 | Gastroenterology2006，，5： | 3 |
| 2 | Randomised clinical trials: linaclotide phase 3 studies in IBS ‐C – a prespecified further analysis based on European Medicines Agency‐specified endpoints显示文摘 | E. M. M. Quigley J. Tack W. D. Chey S. S. Rao J. Fortea M. Falques C. Diaz S. J. Shiff M. G. Currie J. M. Johnston | 2012 | Aliment Pharmacol Ther2012，，1： | 3 |
| 3 | Trace metal behaviour in estuarine and riverine floodplain soils and sediments: A review显示文摘 | G. Du Laing J. Rinklebe B. Vandecasteele E. Meers F.M.G. Tack | 2008 | Science of the Total Environment2008，，13： | 2 |
| 4 | Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis显示文摘 | Yulia A. Nevzorova Wei Hu Francisco J. Cubero Ute Haas Julia Freimuth Frank Tacke Christian Trautwein Christian Liedtke | 2013 | BBA - Molecular Basis of Disease2013，，10： | 2 |
| 5 | In Situ Localization of the Putative Movement Protein (pr17) from Potato Leafroll Luteovirus (PLRV) in Infected and Transgenic Potato Plants显示文摘 | J. Schmitz C. Stussi-Garaud E. Tacke D. Prüfer W. Rohde O. Rohfritsch | 1997 | Virology1997，，2： | 1 |
| 6 | Postprandial symptoms originating from the stomach in functional dyspepsia显示文摘 | H. Vanheel T. Vanuytsel L. Oudenhove R. Farré K. Verbeke J. Tack | 2013 | Neurogastroenterol. Motil2013，，11： | 1 |
| 7 | A Single-Base Mutation in the Peroxisome Proliferator-Activated Receptor γ4 Promoter Associated with Altered in Vitro Expression and Partial Lipodystrophy显示文摘 | Khalid Al-Shali Henian Cao Nine Knoers Ad R. Hermus Cees J. Tack Robert A. Hegele | 2004 | The Journal of Clinical Endocrinology & Metabolism2004，，11： | 1 |
| 8 | Plant-induced changes in soil chemistry do not explain differences in uranium transfer显示文摘 | L. Duquène H. Vandenhove F. Tack E. Van der Avoort M. Van Hees J. Wannijn | 2006 | Journal of Environmental Radioactivity2006，，1： | 1 |
| 9 | Development and psychometric evaluation of the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) in patients with upper gastrointestinal disorders显示文摘 | A.M. Rentz P. Kahrilas V. Stanghellini J. Tack N.J. Talley C. De la loge E. Trudeau D. Dubois D.A. Revicki | 2004 | Quality of Life Research2004，，10： | 1 |
| 10 | 功能性消化不良的突出症状与临床特征及病理生理学机制的关系显示文摘Background & Aims: Functional dyspepsia (FD) is considered a heterogeneous disorder with different pathophysiological mechanisms contributing to the symptom pattern. The Rome II committee proposed that subdividing patients with FD into groups with predominant pain versus discomfort might identify subgroups with homogeneous pathophysiological and clinical properties. The aim of this study was to analyze the relationship of predominant pain or discomfort with pathophysiological mechanisms and to evaluate whether considering individual predominant symptoms yields better results. Methods: Consecutive FD patients (n = 720; 489 women; mean age, 41.3 ± 0.6 years) filled out a dyspepsia questionnaire and identified a single most bothersome symptom. We analyzed the association of this predominant symptom with demographic, clinical, and pathophysiological features (Helicobacter pylori status, gastric emptying in 592 patients, and gastric sensitivity and accommodation testing in 332 patients). Results: According to Rome II criteria, 22% were pain predominant and 78% discomfort predominant. Patients with predominant pain had a higher prevalence of hypersensitivity (44% vs 25% ) and delayed gastric emptying was observed less frequently in these patients (16% vs 26% ), but there was major overlap. Detailed analysis showed that any of 8 dyspeptic symptoms could be predominant. Predominant early satiety or vomiting was associated with significantly higher prevalences of weight loss (89% and 75% , respectively) and of acute onset (61% and 60% , respectively). Impaired accommodation was found in 79% of patients with predominant early satiety. The highest prevalence of delayed emptying was found in predominant fullness (38% ) and of hypersensitivity in predominant pain (44% ). Conclusions: Subdividing FD patient groups according to the predominant symptom does not reliably identify subgroups with a homogeneous underlying pathophysiological mechanism. | Karamanolis G. Caenepeel P. Arts J. Tack J. 赵天智(译) 张欣(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 1 |
| 11 | Functional Dyspepsia Symptoms, Gastric Emptying and Satiety Provocative Test: Analysis of Relationships显示文摘 | R. Cuomo G. Sarnelli R. Grasso D. Bruzzese R. Pumpo M. Salomone E. Nicolai J. Tack G. Budillon | 2001 | Scandinavian Journal of Gastroenterology2001，，10： | 1 |
| 12 | Randomised clinical trials: linaclotide phase 3 studies in IBS ‐C – a prespecified further analysis based on European Medicines Agency‐specified endpoints显示文摘 | E. M. M. Quigley J. Tack W. D. Chey S. S. Rao J. Fortea M. Falques C. Diaz S. J. Shiff M. G. Currie J. M. Johnston | 2012 | Aliment Pharmacol Ther2012，，1： | 1 |
| 13 | Enhanced phytoextraction of uranium and selected heavy metals by Indian mustard and ryegrass using biodegradable soil amendments显示文摘 | L. Duquène H. Vandenhove F. Tack E. Meers J. Baeten J. Wannijn | 2008 | Science of the Total Environment2008，，5： | 1 |
| 14 | A One-Year Follow-up Study of Endoluminal Gastroplication (Endocinch) in GERD Patients Refractory to Proton Pump Inhibitor Therapy显示文摘 | J. Arts MD T. Lerut MD PhD P. Rutgeerts MD PhD D. Sifrim MD PhD J. Janssens MD PhD J. Tack MD PhD | 2005 | Digestive Diseases and Sciences2005，，2： | 1 |
| 15 | Trace metal behaviour in estuarine and riverine floodplain soils and sediments: A review显示文摘 | G. Du Laing J. Rinklebe B. Vandecasteele E. Meers F.M.G. Tack | 2008 | Science of the Total Environment2008，，13： | 1 |
| 16 | 决定胃食管反流相关性耳鼻喉症状的远期预后因素显示文摘Gastroesophageal reflux disease(GERD)is present in up to 75%of patients with chronic refractory ear,nose,and throat(ENT)symptoms,and proton pump inhibitor(PPI)therapy induces symptom relief in the majority of these patients.It has been suggested that endoscopic findings and quantification of esophageal acid exposure may help to predict the long-term outcome of medical therapy,but prospective studies that confirm this hypothesis are lacking.The aim of the present study was to investigate the relationship of endoscopic findings and quantification of reflux with long-term outcome in patients with reflux-related ENT symptoms.One hundred six consecutive patients with chronic refractory unexplained ENT symptoms underwent upper GI endoscopy,24-hr dual-channel esophageal pH and Bilitec(n = 35)monitoring,and esophageal manometry.Subsequently,all were treated with omeprazole,20 mg b.i.d.,and patients were followed at 2-week intervals until symptom relief.Four weeks later,omeprazole therapy was gradually decreased and the lowest effective omeprazole maintenance dose,if any,was determined.Eighty-one patients(49 men;mean age,50)experienced a clear or excellent therapeutic response after,on average,4 weeks of omeprazole,20 mg b.i.d.In 36 patients(44%;group A),PPI treatment could be stopped completely,27 patients(33%;group B)required a maintenance dose of omeprazole,20 mg/day,and 18 patients(22%;group C)required maintenance with omeprazole,40 mg/day.The prevalence of reflux esophagitis was significantly lower in group A patients,who also had significantly lower distal esophageal acid exposure,proximal esophageal acid exposure,and esophageal duodenogastroesophageal reflux exposure compared to groups B and C.Multivariate analysis identified the presence of esophagitis and pathological distal esophageal acid exposure as risk factors for the need of maintenance therapy.In patients with reflux-related ENT symptoms,initial findings on upper GI endoscopy and 24-hr pH-metry help to predict the need for maintenance therapy. | Poelmans J. Feenstra L. Tack J. 张红凯(译) 陈云茹(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，9： | 1 |
| 17 | Prevalence and Socioeconomic Impact of Upper Gastrointestinal Disorders in the United States: Results of the US Upper Gastrointestinal Study显示文摘 | Michael Camilleri Dominique Dubois Bernard Coulie Michael Jones Peter J. Kahrilas Anne M. Rentz Amnon Sonnenberg Vincenzo Stanghellini Walter F. Stewart Jan Tack Nicholas J. Talley William Whitehead Dennis A. Revicki | 2005 | Clinical Gastroenterology and Hepatology2005，，6： | 1 |
| 18 | Prevalence and Socioeconomic Impact of Upper Gastrointestinal Disorders in the United States: Results of the US Upper Gastrointestinal Study显示文摘 | Michael Camilleri Dominique Dubois Bernard Coulie Michael Jones Peter J. Kahrilas Anne M. Rentz Amnon Sonnenberg Vincenzo Stanghellini Walter F. Stewart Jan Tack Nicholas J. Talley William Whitehead Dennis A. Revicki | 2005 | Clinical Gastroenterology and Hepatology2005，，6： | 1 |
| 19 | Effect of prucalopride on symptoms of chronic constipation显示文摘 | J. Tack V. Stanghellini D. Dubois A. Joseph L. Vandeplassche R. Kerstens | 2014 | Neurogastroenterol Motil2014，，1： | 1 |
| 20 | Impact of fluid intake in the prevention of urinary system diseases: a brief review显示文摘 | Yair Lotan Michel Daudon Franck Bruyère Glenn Talaska Giovanni Strippoli Richard J. Johnson Ivan Tack | 2013 | Current Opinion in Nephrology and Hypertension2013，，： | 1 |
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