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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 3 | Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study显示文摘 | Timothy J Price Marc Peeters Tae Won Kim Jin Li Stefano Cascinu Paul Ruff Atilli Satya Suresh Anne Thomas Sergei Tjulandin Kathy Zhang Swaminathan Murugappan Roger Sidhu | 2014 | Lancet Oncology2014，，6： | 2 |
| 4 | Infection with virulent strains of helicobacter pylori is not associated with ischaemic heart disease:evidence from a population-based case-control study of myocardial infarction显示文摘 | Liam J Kathy B Bamford F K | 2000 | Atherosclerosis2000，149，： | 2 |
| 5 | Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care显示文摘 | Katharine Bushby Richard Finkel David J Birnkrant Laura E Case Paula R Clemens Linda Cripe Ajay Kaul Kathi Kinnett Craig McDonald Shree Pandya James Poysky Frederic Shapiro Jean Tomezsko Carolyn Constantin | 2010 | Lancet Neurology2010，，2： | 1 |
| 6 | Surface modifiction of multi - walled carbon nanotubes using 3 - aminopropyltriethoxysilane 显示文摘 | KATHI J RHEE K Y | 2008 | J Mater Sci2008，43，： | 1 |
| 7 | Nonirtherited risk factors and congenital cardiovascular defects 显示文摘 | Kathy J J Adolfo C Jeffrey A F | 2007 | Circulation2007，115，： | 1 |
| 8 | Effect of chemical functiona- ]ization of multi -walled carbon nanotubes with 3-amino- propyltriethoxysilane on mechanical and morphological prop- erties of epoxy nanocomposites显示文摘 | Kathi J Rhee K Y Lee J H | 2009 | Compos(Part A) : Appl Sci Manuf2009，40，67： | 1 |
| 9 | Effect of chemical functionaliza- tion of multi - walled carbon nanotubes with 3 - aminopropyhriethox- ysilane on mechanical and morphological properties of epoxy nano- composites显示文摘 | KATHI J RHEE K Y LEE J H | 2009 | Composites2009，40，： | 1 |
| 10 | Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial显示文摘 | Stephen J Allen Kathie Wareham Duolao Wang Caroline Bradley Hayley Hutchings Wyn Harris Anjan Dhar Helga Brown Alwyn Foden Michael B Gravenor Dietrich Mack | 2013 | The Lancet . 2013 (9900)2013，，9900： | 1 |
| 11 | Toxicity of selenium and other elements in food organisms to razorback sucker larvae显示文摘 | Steven J H Kathy M H Kevin J B | 2002 | Aquatic Toxicology2002，59，34： | 1 |
| 12 | Mulfigenerafion study of 1, 2,4-trichlorobenzene in rats 显示文摘 | KathyS Robinson Robert J | 1981 | Journal of Toxicology and Environmental Health1981，8，： | 1 |
| 13 | Dietary Nucleotides and Early Growth in Formula-Fed Infants: A Randomized Con- trolled Trial显示文摘 | Atul Singhal Kathy Kennedy J Lanigan | 2010 | Pediatrics2010，126，： | 1 |
| 14 | Negative pressure therapy is effective to manage a variety of wounds in infants and children显示文摘 | Shannon S Bindi J Kathy M | 2007 | Wound Repair Rege2007，15，3： | 1 |
| 15 | The impact of implantable cardioverter-defibrillator therapy on survival in autosomal-dominant arrhythmogenic right ventricular cardiomyopathy (ARVD5)显示文摘 | Kathy A. Hodgkinson Patrick S. Parfrey Anne S. Bassett Christine Kupprion J?rg Drenckhahn Mark W. Norman Ludwig Thierfelder Susan N. Stuckless Elizabeth L. Dicks William J. McKenna Sean P. Connors | 2005 | Journal of the American College of Cardiology2005，，3： | 1 |
| 16 | Application of methods for identifying broiler chicken gut bacterial species linked with increased energy metabolism显示文摘 | Valeria A T Kathy O K Maylene Loo Robert J H | 2008 | Applied and Environmental Microbiology2008，74，3： | 1 |
| 17 | Effect of chemical functionalization of multi-walled carbon nanotubos with 3-aminopropyhriethoxysilane on mechanical andmorphological properties of epoxy nanocomposites显示文摘 | Kathi J Rhee K Y Lee J H | 2009 | Composites (Part A): Applied Science and Manufacturing2009，40，67： | 1 |
| 18 | From raw materials to customers: supply chain manage- ment in the service industry 显示文摘 | Cook J S Kathy Debree Amie Feroleto | 2001 | SAM Advanced Management Journal2001，66，4： | 1 |
| 19 | Music as Therapy 显示文摘 | KEMPER KATHI J DANHAUER | 2005 | Southern Medical Journal2005，98，3： | 1 |
| 20 | Neighborhood school characteristics:what signals quality to homebuyers显示文摘 | KATHY J HAYES LORI L TAYLOR | 1996 | Federal Reserve Bank of Dallas Economic Review1996，，3： | 1 |
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