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| 1 | Antibiotic resistance and cagA gene correlation:A looming crisis of Helicobacter pylori显示文摘AIM:To determine antibiotic resistance of Helicobacter pylori(H.pylori) in Pakistan and its correlation with host and pathogen associated factors.METHODS:A total of 178 strains of H.pylori were isolated from gastric biopsies of dyspeptic patients.Susceptibility patterns against first and second-line antibiotics were determined and trends of resistance were analyzed in relation to the sampling period,gastric conditions and cagA gene carriage.The effect of cagA gene on the acquisition of resistance was investigated by mutant selection assay.RESULTS:The observations showed that monoresistant strains were prevalent with rates of 89% for metronidazole,36% for clarithromycin,37% for amoxicillin,18.5% for ofloxacin and 12% for tetracycline.Furthermore,clarithromycin resistance was on the rise from 2005 to 2008(32% vs 38%,P = 0.004) and it is significantly observed in non ulcerative dyspeptic patients compared to gastritis,gastric ulcer and duodenal ulcer cases(53% vs 20%,18% and 19%,P = 0.000).On the contrary,metronidazole and ofloxacin resistance were more common in gastritis and gastric ulcer cases.Distribution analysis and frequencies of resistant mutants in vitro correlated with the absence of cagA gene with metronidazole and ofloxacin resistance.CONCLUSION:The study confirms the alarming levels of antibiotic resistance associated with the degree of gastric inflammation and cagA gene carriage in H.pylori strains. | Adnan Khan Amber Farooqui Hamid Manzoor Syed Shakeel Akhtar Muhammad Saeed Quraishy Shahana Urooj Kazmi | 2012 | World Journal of Gastroenterology2012，18，18： | 15 |
| 2 | 芋病毒病田间调查及毒氟磷对芋病毒病的防治效果显示文摘对芋病毒病及类似病害症状进行调查,其症状表现主要分为羽状花叶、叶片向上卷曲并伴有黄化或花叶、脉间黄化、明亮褪绿黄斑、褪绿斑点(斑驳)及叶片皱缩和叶缘黄化。采用RT-PCR和PCR技术对随机采集的32份表现症状的鄂芋一号样品进行了芋花叶病毒(DsMV)和芋杆状病毒(TaBV)2种病毒的检测,检出率均为68.8%。同时,利用30%毒氟磷可湿性粉剂500倍液和1 000倍液对芋病毒病进行田间药效试验,第一次施药后10 d调查,毒氟磷可湿性粉剂500倍液和1 000倍液的防治效果分别为30.9%和24.9%;第二次施药后15 d调查,500倍液和1 000倍液防治效果分别为72.8%和59.4%。田间药剂试验结果表明,毒氟磷可湿性粉剂500倍液比1 000倍的防治效果好,从田间芋头长势可看出,毒氟磷对芋头生长有明显的促进作用。 | 王彦芬 Syeda Amber Kazmi 曲林宁 王国平 刘玉平 洪霓 | 2012 | 长江蔬菜2012，，16： | 7 |
| 3 | 血脂、脂蛋白和载脂蛋白作为心肌梗死风险标志物(INTER-HEART研究):在52个国家进行的一项病例对照研究显示文摘背景载脂蛋白作为冠心痛的标志物是否优于血脂和脂蛋白,目前存在广泛争议。本研究旨在对载脂蛋白和胆固醇作为急性心肌梗死风险指标进行比较.
方法在52个国家的12461例急性心肌梗死患者和14637例年龄(±5岁)、性别匹配的对照者中进行了一项有关急性心肌梗死的大型、标准化病例对照研究。获得了9345例急性心肌梗死患者和12120例对照者的非空腹血液样本。测定了血脂、脂蛋白和载脂蛋白浓度,并计算了胆固醇和栽脂蛋白比值通过比较五分位数的上四位与最低位,计算每一总体测值和每一种族组的优势比(0R)及其95%CI以及人群归因危险度(PAR)。
结果载脂蛋白B100(ApoB)/载脂蛋白A1(ApoA1)比值的PAR最高(54%),其每一标准差差别的OR最高(1.59,95%CI1.53~1.64)。LDL胆固醇/HDL-胆固醇比值的PAR为37%;总胆固醇/HDL-胆固醇的PAR为32%,其显著低于ApoB/A1比值的PAR(P〈0.0001)。这些结果在所有种族组、男女两性组及所有年龄组均一致。
结论在所有种族组、男女两性组及所有年龄组,非空腹ApoB/A1比值在评估急性心肌梗死风险方面优于任何胆固醇比值,其应当被引入全世界的临床实践中。 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mahammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf 郭战宏(译) | 2008 | 世界临床医学2008，2，6： | 3 |
| 4 | 直觉线性μ-演算(英文)显示文摘线性mu-演算(μTL)是线性时序逻辑(LTL)的不动点扩展.LTL是一个便于规范和论证反应式系统的方法.μTL作为比LTL表达能力更强的逻辑,用LTL表示的性质度可由μTL表示.类似于LTL的直觉线性时序逻辑(ILTL),提出一种基于直觉解释的μTL,称为直觉μTL(IμTL).确立了IμTL和ILTL的关系,比较了它们之间的表达能力.讨论了使用IμTL与安全性质和活性描述的关系以及描述'假设-保证'规范的问题. | KAZMI Syed Asad Raza 张文辉 | 2008 | 软件学报2008，19，12： | 2 |
| 5 | Anxiolytic potential of ursolic acid derivative-a stearoyl glucoside isolated from Lantana camara L.(verbanaceae)显示文摘Objective:To investigate the anxiolytic activity of newly isolated compound by our lab called ursolic acid stearoyl glucoside(UASG) from the leaves of Lantana camam(L camam).Methods: Column chromatography was used to isolate UASG.Anxiolytic potential was experimentally proved and demonstrated through Elevated plus-maze,Open field and light and dark test. Results:The UASG showed marked increased in time spent(%) and number of frequent movements made by animals in open arm of elevated plus-maze apparatus.In light and dark model,UASG produced marked increase in time spent by animal,number of crossing and reduced duration of immobility in light box.Conclusions:UASG showed significant increase in number of rearing,assisted rearing and number of square crossed in open field established test model.UASG showed its anxiolytic effect in dose dependent manner. | Imran Kazmi Muhammad Afzal Babar Ali Zoheir A.Damanhouri Aftab Ahmaol Firoz Anwar | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 2 |
| 6 | On nonlinear variational inequalities显示文摘 | Ansari Q H Kazmi K R | 1994 | Indian J Pure Appl Math1994，25，4： | 1 |
| 7 | Anemia:an early complication of chronic renal insufficiency显示文摘 | Kazmi W H Kausz A T Khan S | 2001 | Am J Kidney Dis2001，38，4： | 1 |
| 8 | Iterative approximation of a solution of a general variational-like inclusion in Banach spaces显示文摘 | Chidume C E Kazmi K R Zegeye H | 2004 | Int J Math Math Sci2004，22，： | 1 |
| 9 | Quasi-static and dynamic loading responses and constitutive modeling of titanium alloys显示文摘 | Akhtar S. Khan Yeong Sung Suh Rehan Kazmi | 2004 | International Journal of Plasticity2004，，12： | 1 |
| 10 | Iterative approximation of a solution of multi-valued variational-like inclusion in Banach spaces:A P-proximal-point mapping approach显示文摘 | Kazmi K R Khan F A | 2007 | J Math Anall Appl2007，325，： | 1 |
| 11 | Platelet function in pre - ec- lampsia显示文摘 | Kazmi RS Cooper AJ Lwaleed BA | 2011 | Semin Thromb Hemost2011，37，2： | 1 |
| 12 | Antiulcer and antioxidant activities of a new steroid from Morus alba显示文摘 | Aftab Ahmad Gaurav Gupta Muhammad Afzal Imran Kazmi Firoz Anwar | 2012 | Life Sciences2012，，： | 1 |
| 13 | Novel al- gorithm for fast and efficient speed-sensorless maximum power point tracking in wind energy conversion systems 显示文摘 | KAZMI S M R GOTO H GUO Haijiao | 2011 | IEEE Transactions on Industrial Electronics2011，58，1： | 1 |
| 14 | Chondrogenic potential of progenitor ceils derived from human bone marrow and adipose tissue: a patient-matched comparison显示文摘 | Huang JI Kazmi N Durbhakula MM etal | 2005 | J Orthop Res2005，23，6： | 1 |
| 15 | Iterative approximation of a unique solution of Variational-like inclusions in real q-uniformly smooth Banach spaces显示文摘 | Kazmi K R Khan F A | 2007 | Nonlinear Analysis2007，67，3： | 1 |
| 16 | New anticoagulants: how to deal with treatment failure and bleeding compli- cations显示文摘 | Kazmi RS Lwaleed BA | 2011 | Br J Clin Pharmacol2011，72，4： | 1 |
| 17 | The emerging role of multidetector row CT angiography in the diagnosis of cervical arterial dessection:preliminary study显示文摘 | Elijovich L Kazmi K Gauvrit JY | | 0，，02： | 1 |
| 18 | Auxiliary problems and algorithm for a system generalized Variational-like inequality problem显示文摘 | KAZMI K R FHAN F A | 2007 | Appl Math Comput2007，187，2： | 1 |
| 19 | Asian earthquake:report from the first volunteer British hospital team in Pakistan显示文摘 | Laverick S Kazmi S Ahktar S | 2007 | Emerg Med J2007，24，： | 1 |
| 20 | Ectopic pregnancy:a review显示文摘 | Rana P Kazmi I Singh R | | 0，，4： | 1 |
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