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| 1 | Heavy metal distribution of natural and reclaimed tidal riparian wetlands in south estuary, China显示文摘We evaluated the distribution and accumulation of Cd, Cr, Cu, Ni, Pb and Zn in two plant species (Scirpus tripueter Linn. and Cyperus malaccensis Lam.), in water and soils sampled from the reclaimed tidal riparian wetlands (RTRWs) and the natural riparian wetlands (NRWs) in the Pearl River Estuary (PRE). The results showed that the concentrations of studied heavy metals in soils exceeded theeco-toxic threshold recommended by US EPA. The concentrations of Cd, Cr and Zn in plants may lead to toxic effects. The heavy metalconcentrations were high in water and low in soils of RTRWs compared with that in the NRWs. The accumulation of heavy metalsin the roots of plants was higher in NRWs than those in RTRWs while the opposite result was found for heavy metal accumulation inshoots. Based on the bioaccumulation and translocation factors, the plants in NRWs had a higher capacity to accumulate heavy metalswhile higher abilities to transport heavy metals from roots to shoots were observed in RTRWs. Heavy metal contaminations in RTRWswere dominated by anthropogenic sources from both side uplands and river water, whereas in NRWs, the metal accumulations weresimultaneously affected by anthropogenic and natural | Honggang Zhang Baoshan Cui Kejiang Zhang | 2011 | Journal of Environmental Sciences2011，23，12： | 7 |
| 2 | Investigation of non-isothermal and isothermal gasification process of coal char using different kinetic model显示文摘Isothermal and non-isothermal gasification kinetics of coal char were investigated by using thermogravimetric analysis(TGA) in CO2 atmosphere, and the experimental data were interpreted with the aids of random pore model(RPM), unreacted shrinking core model(URCM) and volume model(VM). With the increase of heating rate, gasification curve moves into high temperature zone and peak rate of gasification increases; with the increase of gasification temperature, gasification rate increases and the total time of gasification is shortened. The increase of both heating rate and gasification temperature could improve gasification process of coal char. Kinetics analysis indicates that experimental data agree better with the RPM than with the other two models. The apparent activation energy of non-isothermal and isothermal gasification of coal char using RPM is 193.9 k J/mol and 212.6 k J/mol respectively, which are in accordance with reported data. Gasification process of coal char under different heating rates and different temperatures are predicted by the RPM derived in this study, and it is found that the RPM predicts the reaction process satisfactorily. | Wang Guangwei Zhang Jianliang Shao Jiugang Li Kejiang Zuo Haibin | 2015 | International Journal of Mining Science and Technology2015，25，1： | 6 |
| 3 | Predictors of post coronary artery bypass grafting atrial fibrillation显示文摘Objective: To investigate the incidence and relative risk factors of post coronary artery bypass grafting(post-CABG) atrial fibrillation(AF). Methods: 312 patients with CABG were reviewed and divided into an AF group and a non-AF group. Statistical analysis was used to compare the data between the two groups and screen for risk factors of post-CABG AF. Results: 103/312 (33.01%) patients developed post-CABG AF. Univariate analysis showed that patients in AF group compared with those in non-AF group were more likely to have advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm), a history of AF, prolonged p-wave duration (≥120 ms) and increased number of grafts (≥3). Multivariate logistic regression analysis showed that advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm) and a history of AF were highly related to post-CABG AF. Conclusion: The incidence of AF in patients following CABG was 33.01% in this study. Advanced age, early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement and a history of AF were independent risk factors of post-CABG AF. | Tongtong Shen Qijun Shan Biao Yuan Bing Yang Chun Chen Dongjie Xu Minglong Chen Jiangang Zou Kejiang Cao | 2007 | Journal of Nanjing Medical University2007，21，3： | 5 |
| 4 | Effect of burden and origin sites of premature ventricular contractions on left ventricular function by 7-day Holter monitor显示文摘Recent studies have shown that premature ventricular contractions(PVCs) could enlarge the heart,but its risk factors are incompletely understood as a single 24-hour recording cannot reflect the true PVC burden due to day-to-day variability.Our purpose was to investigate the effect of burden and origin sites on left ventricular(LV) function in patients with PVCs by 7-day Holter electrocardiography(ECG).From May 2012 to August2013,112 consecutive patients with PVCs were recruited from the authors' affiliated hospital.All patients received2-dimensional transthoracic echocardiography,12-lead routing ECG and 7-days Holter ECG.Serum N-terminal probrain natriuretic peptide(NT-proBNP) levels were measured.A total of 102 participants with PVCs were included in the final analysis.Origin of PVCs from the tricuspid annulus had the highest burden and NT-proBNP level.LV papillary muscle had a higher LV ejection fraction(EF) level and a lower LV end-systolic dimension(ESD) than other PVC foci(P<0.05).The high burden group had a higher LV end-diastolic dimension(EDD) and LVESD but lower LVEF than the other two groups(P<0.05).Female,older age,physical work,and history of PVCs had a significantly positive correlation with symptoms.Male,older age,physical work,and high burden were positive predictors of enlarged LVEDD,LVESD and higher serum NT-proBNP level,but lower LVEF.Seven-day dynamic ECG Holter monitor showed the true PVC burden on patients with PVCs.PVCs with a lower burden or origin from the LV papillary muscle and the fascicle were relatively benign,while PVCs with a higher burden or origin from the tricuspid annulus may lead to cardiac dysfunction. | Wenhua Xu Mingfang Li Minglong Chen Bing Yang Daowu Wang Xiangqing Kong Hongwu Chen Weizhu Ju Kai Gu Kejiang Cao Hailei Liu Qi Jiang Jiaojiao Shi Yan Cui Hong Wang | 2015 | The Journal of Biomedical Research2015，29，6： | 4 |
| 5 | HGF percutaneous endocardial injection induces cardiomyocyte proliferation and rescues cardiac function in pigs显示文摘Objective:To investigate the effect of cardiomyocyte proliferation induced by human hepatocyte growth factor(HGF)in pigs with chronic myocardial infarction(CMI).Methods:A steerable,deflectable 7F catheter incorporating a 27-guage needle was advanced percutaneously to the left ventricular myocardium of 18 pigs with CMI.Pigs were randomized(1:1:1)to receive adenoviral vector HGF(total dose,1×1010 genome copies),which was administered as five injections into the infarcted myocardium(total,1.0 mL),or saline,or Ad-null(control groups).Injections were guided by Ensite NavX left ventricular electroanatomical mapping.HGF and cyclin proteins were detected by western blot and immunoprecipitation analysis.Histological and immunohistochemical analysis determined proliferating cardiomyocytes.Myocardial perfusion and cardiac function were estimated by Gated-Single Photon Emission Computed Tomography(G-SPECT).Results:Western blot analyses showed that HGF were predominantly expressed in the infarct core and border in the myocardium of the infarcted heart.G-SPECT analysis indicated that the HGF group had better cardiac function and myocardial perfusion four weeks after the injection of Ad-HGF than before the injection of Ad-HGF.After treatment there were more proliferating cardiomyocytes in the HGF group compared to either of the control groups.Furthermore,the HGF group myocardial samples expressed higher levels of p-Akt,cyclin A,cyclin E,cyclin D1,cdk2,cdk4 than those in the control groups.Conclusion:The over-expression of HGF activates pro-survival pathways,induces cardiomyocyte proliferation,and improves the perfusion and function of the porcine CMI heart. | Zhengxian Tao Bo Chen Yingming Zhao Hongwu Chen Liansheng Wang Yonghong Yong Kejiang Cao Qifeng Yu Danian Ke` Hua Wang Zuze Wu Zhijian Yang | 2010 | The Journal of Biomedical Research2010，24，3： | 3 |
| 6 | Mechanical and corrosion properties of Al/Ti film on magnesium alloy AZ31B显示文摘 | Rong-Chang ZENG KeJIANG Shuo-Qi LI Fen ZHANG Hong-Zhi CUI En-Hou HAN | 2015 | Frontiers of Materials Science2015，9，1： | 3 |
| 7 | Spatial distribution and ecological risk assessment of heavy metals in surface sediments from a typical plateau lake wetland, China显示文摘 | Junhong Bai Baoshan Cui Bin Chen Kejiang Zhang Wei Deng Haifeng Gao Rong Xiao | 2009 | Ecological Modelling2009，，2： | 3 |
| 8 | The clinical application of clopidogrel in current coronary artery surgery显示文摘The article presents an overview of the current clinical application of clopidogrel in coronary artery surgery. The viewpoint is that clopidogrel can reduce preoperative and postoperative ischemic events of coronary artery bypass grafting (CABG). With the development of standardized medication and the corresponding preventive technique, it will be of great value to reduce hemorrhage complications and obtain the maximum benefit from clopidogrel's anti-platelet properties. | Yangyang Zhang Kejiang Cao | 2008 | Journal of Nanjing Medical University2008，22，6： | 3 |
| 9 | Assessment of heavy metal pollution in wetland soils from the young and old reclaimed regions in the Pearl River Estuary, South China显示文摘 | Junhong Bai Rong Xiao Baoshan Cui Kejiang Zhang Qinggai Wang Xinhui Liu Haifeng Gao Laibin Huang | 2010 | Environmental Pollution2010，，3： | 3 |
| 10 | Pediatric restrictive cardiomyopathy due to a heterozygous mutation of the TNNI3 gene显示文摘Pediatric restrictive cardiomyopathy is rare and most commonly idiopathic in origin.Here,we applied a candidate gene approach and identified a missense mutation in the cardiac troponin I gene in a 12-year-old Chinese girl with restrictive cardiomyopathy.This study indicates that mutation in sarcomere protein genes may play an important role in idiopathic pediatric restrictive cardiomyopathy. | Yan Chen Shiwei Yang Jun Li Gannan Wang Yuming Qin Daowu Wang Kejiang Cao | 2014 | The Journal of Biomedical Research2014，28，1： | 3 |
| 11 | Soil Nutrient Distribution in Two Typical Paddy Terrace Wetlands Along an Elevation Gradient During the Fallow Period显示文摘Soil nutrient concentrations in the top soils from two paddy terraces were determined in order to investigate spatial distributions of soil nutrients along the elevations on the Yunnan plateau of China during the fallow period.Results showed that soil nutrients in both terraces were higher than the reference concentrations except for SOC,TN,TP and Fe.Soil macronutrients didn't show significant differences in both terraces except for Mg and Ca,so did soil micronutrients except for Mn.Spatial distribution patterns of soil nutrients along the increasing elevations were different in both terraces.However,soil nutrients in both terraces were generally not significantly influenced by the elevations and soil pH values.The findings of this study can contribute to soil fertility management and ecological protection of Hani terraces. | WANG Qinggai BAI Junhong HUANG Laibin DENG Wei XIAO Rong ZHANG Kejiang | 2011 | Journal of Mountain Science2011，8，3： | 2 |
| 12 | Tpeak-Tend interval as a new risk factor for arrhythmic event in pa-tient with Brugada syndrome显示文摘Objective: To evaluate Tpeak- Tend ( Tp- e) interval in surface standard ECG as a new risk factor for arrhythmic event inpatient with Brugada syndrome. Methods: 23 male patients with Brugada syndrome and 20 male patients with paroxysmalsupraventricular tachycardia ( PSVT) as the control group were investigated in this study. Tp- e interval in surface standardECG was compared between BrS and PSVT patients. Results: Tp- e interval in BrS patients was significantly longer thanthat in PSVT patients ( 109.57±22.86 ms vs. 88.50±13.08ms, P<0.05) . There was significant difference in Tp- e interval be-tween 16 BrS patients with arrhythmic events ( including syncope, clinical ventricular fibrillation [ VF] and programmed elec-trical stimulation [ PES] - induced VF) and 7 BrS patients without arrhythmic events and PSVT patients ( 118.12±20.40ms vs.90.00±15.27ms, P<0.05; 118.12±20.40ms vs. 88.50±13.08ms, P<0.05). However, Tp- e interval was similar in BrS patients with-out arrhythmic events and PSVT patients (90.00±15.27ms vs 88.50±13.08ms, P>0.05). Conclusion: The prolongation of Tp- einterval could serve as a new noninvasive event predictor for arrhythmic events in patients with Brugada syndrome. | Jinfeng Wang Qijun Shan Bing Yang Minglong Chen Jiangang Zou Dongjie Xu Chun Chen Kejiang Cao | 2007 | Journal of Nanjing Medical University2007，21，4： | 2 |
| 13 | Assessment of atrial electromechanical interval using echocardiography after catheter ablation in patients with persistent atrial fibrillation显示文摘We sought to investigate variation of atrial electromechanical interval after catheter ablation procedure in patients with persistent atrial fibrillation using pulse Doppler(PW) and pulse tissue Doppler imaging(PW-TDI).A total of 25 consecutive in-patients with persistent atrial fibrillation,who restored sinus rhythm after ablation procedure,were recruited in our cardiac center.Echocardiography was performed on each patient at 2 hours,1 day,5 days,1 month and 3 months after the ablation therapy,and atrial electromechanical delay was measured simultaneously by PW and PW-TDI.There was no significant difference between PW and TDI in measuring atrial electromechanical delay.However,at postoperative 2 hours,peak A detection rates were mathematically but nonsignificantly greater by PWTDI than by PW.Second,there was a significant decreasing trend in atrial electromechanical interval from postoperative 2 hours to 3 months,but only postoperative 2-hour atrial electromechanical interval was significantly greater than atrial electromechanical interval at other time.Lastly,patients without postoperative 2-hour atrial electromechanical interval had a significantly longer duration of atrial fibrillation as compared to those with postoperative 2-hour atrial electromechanical interval,by the PW or by PW-TDI,respectively.In patients with persistent atrial fibrillation,atrial electromechanical interval may decrease significantly within the first 24 hours after ablation but remain consistent later,and was significantly related to patients' duration of atrial fibrillation.Atrial electromechanical interval,as a potential predicted factor,is recommended to be measured by either PW or TDI after24 hours,when patients had recovered sinus rhythm by radiofrequency ablation. | Xiaodong Chen Minglong Chen Yingying Wang Bing Yang Weizhu Ju Fengxiang Zhang Kejiang Cao | 2016 | The Journal of Biomedical Research2016，30，6： | 2 |
| 14 | Distinct effects of Cu^2+-binding on oligomerization of human and rabbit prion proteins显示文摘 | Kejiang Lin Ziyao Yu Yuanhui Yu Xinli Liao Pei Huang Chenyun Guo Donghai Lin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 2 |
| 15 | Improvement of cardiac function by hepatocyte growth factor via intracoronary transfection in the swine myocardial infarction model显示文摘Objective:To study the amelioration effect of Adenovirus5-mediated human hepatocyte growth factor(Ad5-HGF)on postinfarction heart failure in the swine myocardial infarction model.Methods:Twelve SuZhong young swine were randomly divided into 2 groups with 6 swine in each group:Ad5-HGF-treated group and null-Ad5 group.Four weeks after ligation at left anterior descending coronary artery in swine hearts,Ad5-HGF was transferred to the swine myocardium.Simultaneously,Gated myocardial perfusion imaging was performed to evaluate cardiac perfusion and heart function.After three weeks,Gated myocardial perfusion imaging was performed again,then the hearts were harvested and sectioned to examine the expression of HGF through ELISA.Results:High expression of human HGF was observed in the myocardium of Ad5-HGF-treated group.From 4 weeks to 7 weeks after operation,Left ventricular ejection fraction was increased in Ad5-HGF-treated group.The improvement in LVEF was greater in Ad5-HGF-treated group than that in null-Ad5 group at 7 weeks after operation.Cardiac perfusion was significantly improved in the Ad5-HGF-treated group.Conclusion:High expression of human HGF was observed in the myocardium through intracoronary transfection,which suggests that HGF can ameliorate heart function in swine with postinfarction heart failure. | Wei Wang Zhijian Yang Dongchao Ma Shunlin Xu Yourong Zhang Yuqing Zhang Liansheng Wang Bo Chen Kejiang Cao Wenzhu Ma | 2006 | Journal of Nanjing Medical University2006，20，4： | 2 |
| 16 | Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells显示文摘Our previous studies showed that resveratrol could inhibit the proliferation of vascular smooth muscle cells (VSMCs) and repress mRNA and protein expression of quinone reductase 2 (NQO2).This study further explored the potential mechanisms whereby resveratrol inhibits the proliferation of rat VSMCs.Lentiviral vectors that incorporated NQO2 small interfering RNA (siRNA) were constructed and transduced into rat VSMCs.The cell proliferation was detected using the bromodeoxyuridine (BrdU) assay.Cultured rat VSMCs were stimulated with angiotensin II and the level of reactive oxygen species (ROS) was measured using a ROS assay kit.A realtime quantitative PCR was used to detect NQO2 mRNA levels.Extracellular signal-regulated kinase (ERK1/2) and NQO2 protein expression were determined by Western blotting analysis.The inhibitory effect of resveratrol (10 and 50 μmol/L) on the proliferation of rat VSMCs in the NQO2 siRNA group was significantly weaker than that in the normal and scrambled siRNA group (P < 0.01).The ROS level in the NQO2 siRNA and resveratrol (50 μmol/L) treatment groups were lower than that in the normal and scrambled siRNA groups (P < 0.01 in both).Compared with the normal and scrambled siRNA group,the phosphorylation of ERK1/2 was significantly decreased in the NQO2 siRNA and resveratrol (50 μmol/L) treatment group (P < 0.01 in both).In conclusion,high concentration of resveratrol inhibits angiotensin II-induced ERK1/2 phosphorylation and subsequent proliferation by down-regulation of NQO2 in cultured rat VSMCs. | Xiwen Zhang Yao Wang Weiwei Yang Xiaofeng Hou Jiangang Zou Kejiang Cao | 2012 | The Journal of Biomedical Research2012，26，2： | 2 |
| 17 | Activation of calcium-sensing receptors is associated with apoptosis in a model of simulated cardiomyocytes ischemia/reperfusion显示文摘Objective:Calcium-sensing receptors(CaSRs)are G-protein coupled receptors which maintain systemic calcium homeostasis and participate in hormone secretion,activation of ion channels,cell apoptosis,proliferation,and differentiation.Previous studies have shown that CaSRs induce apoptosis in isolated adult rat heart and in normal neonatal rat cardiomyocytes by G-protein-PLC-IP 3 signaling transduction.However,little knowledge is presently available concerning the role of CaSRs in the apoptosis induced by ischemia and reperfusion in neonatal cardiomyocytes.Methods:Primary neonatal rat ventricular cardiomyocytes were incubated in ischemiamimetic solution for 2 h,and then re-incubated in normal culture medium for 24 h to establish a model of simu- lated ischemia/reperfusion(I/R).Cardiomyocyte apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL).The expression of CaSRs mRNA was detected by real-time reverse transcription polymerase chain reaction(RT-PCR).In addition,the expressions of caspase-3 and Bcl-2 were analyzed by western blot.Results:The simulated I/R enhanced the expression of CaSRs and cardiomyocyte apopto- sis.GdCl 3 ,a specific activator of CaSRs,further increased the expression of CaSRs and cardiomyocyte apoptosis, along with up-regulation of caspase-3 and down-regulation of Bcl-2.Conclusion:CaSRs are associated with I/R injury and apoptosis in neonatal rat ventricular cardiomyocytes via suppressing Bcl-2 and promoting caspase-3 expression. | Ling Yan Tlebing Zhu Tingting Sun Liansheng Wang Shiyang Pan Zhengxlan Tao Zhijian Yang Kejiang Cao | 2010 | The Journal of Biomedical Research2010，24，4： | 2 |
| 18 | Effect of ecdysterone on heteroptopic heart transplantation in rats显示文摘Objective:To investigate the protective effects of ecdysterone(EDS)on the allograft heart transplant model of rats.Methods:Fifty healthy Sprayue-Dawley(SD)rats were divided into donors and recipients randomly.Hearts were harvested and placed heterotopically into allogenic recipients.All animals were divided into three groups:sham-operation group(only opening and closing the abdomen, n=10),EDS group(injected intraperitoneally with 20 mg/(kg·day)of EDS,n=10),and control group(injected intraperitoneally with normal saline,n=10).The pathological changes of myocardial tissue were analyzed by light microscopy and transmission electron microscopy and the levels of myocardial enzymes(GOT,LDH,CPK),SOD,ET-1,NO,MDA in serum were measured.Tissue samples underwent the detection of apoptotic cell death by in situ terminal deoxyribonucleotide transferase-mediated dUTP nick end labeling for apoptotic index(AI)and also by immunohistochemistry method to study the expressions of Bcl-2 and Bax.Results:Pathological examination and transmission electron microscope observation showed greater myocardium damage in the control group.EDS group showed a decrease in the amount of myocardial enzymes,MDA,ET-1 and an increase in the levels of SOD,NO,compared to the control group.The AI of EDS group became lower than that of control group,meanwhile the EDS group increased the expression of Bcl-2 and decreased the expression of Bax.Conclusion:EDS has protective effects on heteroptopic heart transplantation,which provides a new idea for myocardial protection in heart transplantation.However,the mechanism of its protective effect needs further research. | Zhong Zhao Yangyang Zhang Wen Ge Gaofeng Zhang Biao Yuan Kejiang Cao | 2008 | Journal of Nanjing Medical University2008，22，5： | 2 |
| 19 | Arsenic and heavy metal pollution in wetland soils from tidal freshwater and salt marshes before and after the flow-sediment regulation regime in the Yellow River Delta, China显示文摘 | Junhong Bai Rong Xiao Kejiang Zhang Haifeng Gao | 2012 | Journal of Hydrology2012，，： | 2 |
| 20 | Isothermal kinetic analysis on reduction of solid/liquid wustite by hydrogen显示文摘Isothermal thermogravimetric analysis was used to study the reduction process of solid/liquid wustite by hydrogen.Results show that wustite in both states can be reduced entirely at all temperatures.The thermal and kinetic conditions for the hydrogen reduction of molten phases are better than those when the reactants and products are in the solid state,with a higher reaction rate.The hydrogen reduction of different wustite phases fits the Mampel Power model(power exponent n=1/2)well,and this model is independent of the phase state.The average apparent activation energies of the reduction process calculated by the iso-conversional method are 5.85 kJ·mol^(−1) and 104.74 kJ·mol^(−1),when both reactants and products are in the solid state and the molten state,respectively.These values generally agree with those calculated by the model fitting method. | Jianliang Zhang Yang Li Zhengjian Liu Tengfei Wang Yaozu Wang Kejiang Li Guilin Wang Tao Xu Yong Zhang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，10： | 2 |
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