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| 1 | Pre-and intraoperative predictors of acute kidney injury after liver transplantation显示文摘BACKGROUND Acute kidney injury(AKI)after liver transplantation(LT)is a frequent and multifactorial event related to increased morbidity and mortality.Risk factors for AKI after LT still need to be clarified.AIM To identify the predictors of acute kidney injury after liver transplantation.METHODS The frequency and pre-and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in Croatia.AKI was defined according to the Kidney Disease:Improving Global Outcomes criteria.RESULTS Out of 205 patients(mean age 57±10 years;73.7%males,52.7%with alcoholrelated liver disease)93(45.36%)developed AKI,and the majority of them(58.06%)had stage 1.Only 5.38%of patients required renal replacement therapy after LT.The majority of patients(82.8%)developed AKI within the first two days after the procedure.Multivariate logistic regression identified pre-LT body mass index(OR=1.1,95%CI:1.05-1.24)and red blood cell transfusion(OR=1.66,95%CI:1.09-2.53)as independent predictors of early post-LT AKI occurrence.30-d survival after LT was significantly better for patients without AKI(P=0.01).CONCLUSION Early AKI after LT is a frequent event that negatively impacts short-term survival.The pathogenesis of AKI is multifactorial,but pre-LT BMI and intraoperative volume shifts are major contributors. | Anna Mrzljak Lucija Franusic Jadranka Pavicic-Saric Tomislav Kelava Zeljka Jurekovic Branislav Kocman Danko Mikulic Ivan Budimir-Bekan Mladen Knotek | 2020 | World Journal of Clinical Cases2020，8，18： | 4 |
| 2 | Importance of genetic polymorphisms in liver transplantation outcomes显示文摘Although,liver transplantation serves as the only curative treatment for patients with end-stage liver diseases,it is burdened with complications,which affect survival rates.In addition to clinical risk factors,contribution of recipient and donor genetic prognostic markers has been extensively studied in order to reduce the burden and improve the outcomes.Determination of single nucleotide polymorphisms(SNPs)is one of the most important tools in development of personalized transplant approach.To provide a better insight in recent developments,we review the studies published in the last three years that investigated an association of recipient or donor SNPs with most common issues in liver transplantation:Acute cellular rejection,development of new-onset diabetes mellitus and non-alcoholic fatty liver disease,hepatocellular carcinoma recurrence,and tacrolimus concentration variability.Reviewed studies confirmed previously established SNP prognostic factors,such as PNPLA3 rs738409 for nonalcoholic fatty liver disease development,or the role of CYP3A5 rs776746 in tacrolimus concentration variability.They also identified several novel SNPs,with a reasonably strong association,which have the potential to become useful predictors of post-transplant complications.However,as the studies were typically conducted in one center on relatively low-to-moderate number of patients,verification of the results in other centers is warranted to resolve these limitations.Furthermore,of 29 reviewed studies,28 used gene candidate approach and only one implemented a genome wide association approach.Genome wide association multicentric studies are needed to facilitate the development of personalized transplant medicine. | Tomislav Kelava Petra Turcic Antonio Markotic Ana Ostojic Dino Sisl Anna Mrzljak | 2020 | World Journal of Gastroenterology2020，26，12： | 2 |
| 3 | Advances in temporary mechanical support for treatment of cardiogenic shock显示文摘 | Koprivanac M Kelava M Soltesz E | 2015 | Expert Rev Med Devices2015，12，6： | 1 |
| 4 | Hepatoprotective action of panaxatriol saponins against acetaminophen-induced liver injury: what is the mechanism?显示文摘 | Kelava T Cavar I | 2014 | Liver Int2014，34，： | 1 |
| 5 | Induction of osteoclast progeni- tors in inflammatory conditions:key to bone destruction in arthritis 显示文摘 | u6ur A Katavi V Kelava T | 2014 | International Orthopaedics2014，38，9： | 1 |
| 6 | Risk for permanent pacemaker after transcatheter aortic valve implantation : a comprehensive analysis of the literature 显示文摘 | Erkapic D De Rosa S Kelava A el al | 2012 | J Cardiovasc Electrophysiol2012，23，4： | 1 |
| 7 | The role ofprostaglandin E2 in acute acetaminophen hepatotoxicity in mice 显示文摘 | Cavar I Kelava T Vukojevi6 K | 2010 | Histol Histopathol2010，25，7： | 1 |
| 8 | Influence of small doses of various drug vehicles on acetaminophen-induced liver injury显示文摘 | Kelava T Cavar i Culo F | 2010 | Can J Physiol Pharmacol2010，88，10： | 1 |
| 9 | Risk for permanent pacemaker after transcatheter aortic valve implantation:a comprehensive analysis of the literature显示文摘 | Erkapic D De Rosa S Kelava A | 2012 | J Cardiovasc Electrophysiol2012，23，4： | 1 |
| 10 | Risk for permanent pacemaker after transcatheter aortic valve implantation:a comprehensive analysis of the literature显示文摘 | Erkapic D De Rosa S Kelava A | 2012 | J Cardiovasc Electrophysiol2012，23，4： | 1 |
| 11 | Value of robotically assisted surgery for mitral valve disease 显示文摘 | Mihaljevic T Koprivanac M Kelava M | 2014 | JAMA Surg2014，149，7： | 1 |
| 12 | OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling显示文摘 | Fietz S A Kelava I Vogt J Wilsch-Br(a)uninger M Stenzel D Fish J L Corbeil D Riehn A Distler W Nitsch R Huttner W B | | 0，，06： | 1 |
| 13 | Risk for permanentpacemaker after transcatheter aortic valve implantation: a com-prehensive analysis of the literature 显示文摘 | Erkapic D De Rosa S Kelava A | 2012 | J Cardiovasc Electro-physiol2012，23，4： | 1 |
| 14 | Risk for permanentpacemaker after transcatheter aortic valve implantation : a com-prehensive analysis of the literature 显示文摘 | Erkapic D De Rosa S Kelava A | 2012 | J Cardiovasc Electro-physiol2012，23，4： | 1 |
| 15 | Breast and gynecological cancers in Croatia, 1988-2008显示文摘 | Kelava I | 2012 | Croat Med J2012，53，2： | 1 |
| 16 | Hospitalization before surgery increases risk for postoperative infections显示文摘 | Kelava M Robich M Houghtaling PL | 2014 | J Thorac Cardiovasc Surg2014，148，4： | 1 |
| 17 | Flooding as a cause of ungulate mortality in floodplain forests in Croatia显示文摘Floodplain forests with regular flooding regimes are the largest natural retentions areas in Croatia and are important as natural habitats for ungulates.The aim of this study was to determine the scale of mortality caused by flooding within these forests.Over a 10-year period,data on ungulate mortality(red deer,roe deer and wild boar),flood duration and flooded surface area were recorded.The study was conducted in primary(Posavske Sume—RET I)and secondary(Opeke II—RET II)retention areas within Lonjsko Polje Nature Park(Sava River region,Croatia).The longest flood period and the largest flooded surface area were recorded in RET I.Total ungulate mortality was749 individuals,with 482 individuals in RET I and 267 individuals in RET II,predominantly wild boar.Flood mortality did not differ by gender.The highest mortality of wild boar was recorded for the juvenile and yearling ageclasses.Low mortality of red and roe deer can be attributed to their body size and ecological niches.Differences in mortality between the primary and secondary retention areas corresponded to differences in flood regimes,flood column heights and micro relief structures.In both retention areas,wild boar mortality and flood duration,i.e.flooded surface area,were positively correlated.Because the growth rate of the analysed ungulate populations was higher than the recorded mortality,no long-term effect of floods is expected on species abundance in these areas. | Damir Ugarkovic Nikica Sprem Nikolina Kelava Ugarkovic Milan Orsanic | 2020 | Journal of Forestry Research2020，31，3： | 0 |
| 18 | Immunology demystified: A guide for transplant hepatologists显示文摘Liver transplantation has become standard practice for treating end-stage liver disease.The success of the procedure relies on effective immunosuppressive medications to control the host's immune response.Despite the liver's inherent capacity to foster tolerance,the early post-transplant period is marked by significant immune reactivity.To ensure favorable outcomes,it is imperative to identify and manage various rejection types,encompassing T-cell-mediated,antibody-mediated,and chronic rejection.However,the approach to prescribing immunosuppressants relies heavily on clinical judgment rather than evidencebased criteria.Given that the majority of patients will require lifelong immunosuppression as the mechanisms underlying operational tolerance are still being investigated,healthcare providers must possess an understanding of immune responses,rejection mechanisms,and the pathways targeted by immunosuppressive drugs.This knowledge enables customization of treatments and improved patient care,even though a consensus on an optimal immunosuppressive regimen remains elusive. | Iva Kosuta Tomislav Kelava Ana Ostojic Vibor Sesa Anna Mrzljak Hrvoje Lalic | 2024 | World Journal of Transplantation2024，14，1： | 0 |
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