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| 1 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 2 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 3 | Intestinal stem cells and the colorectal cancer microenvironment显示文摘Colorectal cancer(CRC)remains a highly fatal condition in part due to its resilience to treatment and its propensity to spread beyond the site of primary occurrence.One possible avenue for cancer to escape eradication is via stem-like cancer cells that,through phenotypic heterogeneity,are more resilient than other tumor constituents and are key contributors to cancer growth and metastasis.These proliferative tumor cells are theorized to possess many properties akin to normal intestinal stem cells.Not only do these CRC'stem'cells demonstrate similar restorative ability,they also share many cell pathways and surface markers in common,as well as respond to the same key niche stimuli.With the improvement of techniques for epithelial stem cell identification,our understanding of CRC behavior is also evolving.Emerging evidence about cellular plasticity and epithelial mesenchymal transition are shedding light onto metastatic CRC processes and are also challenging fundamental concepts about unidirectional epithelial proliferation.This review aims to reappraise evidence supporting the existence and behavior of CRC stem cells,their relationship to normal stem cells,and their possible dependence on the stem cell niche. | Bryan A Ong Kenneth J Vega Courtney W Houchen | 2014 | World Journal of Gastroenterology2014，20，8： | 2 |
| 4 | Direct dating of sulfides by Rb-Sr:Acritical test using the Polaris Mississippi Valley-type Zn-Pb deposit显示文摘 | Christensen J N Halliday A N Kenneth E L Roderick N R and Stephen E K | | 0，，： | 1 |
| 5 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 1 |
| 6 | Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial显示文摘 | George L Bakris Pantelis A Sarafidis Matthew R Weir Bj?rn Dahl?f Bertram Pitt Kenneth Jamerson Eric J Velazquez Linda Staikos-Byrne Roxzana Y Kelly Victor Shi Yann-Tong Chiang Michael A Weber | 2010 | The Lancet2010，，9721： | 1 |
| 7 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 8 | 前列腺癌骨髓小生境:不仅仅是“沃土”显示文摘骨髓中的造血干细胞小生境在过去的几十年中已被广泛地研究了,然而支持转移性前列腺癌生长的骨髓微环境,最近才被认为是一种特殊的“小生境”。新研究表明前列腺癌的播散肿瘤细胞事实上以造血千细胞小生境为目标,替换原有“居住者”的造血干细胞,并占据其已有的小生境空间。这篇综述描述了播散肿瘤细胞作为造血干细胞小生境的分子寄生虫的一些证据和机制。再者,播散肿瘤细胞、造血干细胞和小生境的相互作用可能会为小生境导向的疗法提供新的目标,也可进一步解读复杂的转移性前列腺癌疾病的临床表现。 | Elisabeth A Pedersen Yusuke Shiozawa Kenneth J Pienta Russell S Taichman | 2012 | Asian Journal of Andrology2012，14，3： | 1 |
| 9 | 显示文摘 | Lu W J Kenneth A D Andrew R | 2002 | J Appl Polym Sci2002，40，： | 1 |
| 10 | Manganesedependent cleavage of nonphenolic lignin structures byceriporiopsis subvermispora in the absence of ligninperox idase显示文摘 | Kenneth A Jensen J R Bao W L | 1996 | Applied and Environmental Microbiology1996，62，10： | 1 |
| 11 | Sensor measurement scheduling an enhanced dynamic, preemptive algorithm 显示文摘 | Mclntyre Gregory A Hintz Kenneth J | 1998 | Optical Engineering1998，7，23： | 1 |
| 12 | Multisection CT:scanning techniques and clinical applications显示文摘 | Rydberg J Kenneth A Karen S et a | 2000 | Radiolographi cs2000，20，6： | 1 |
| 13 | Schmittgen Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2^-△△Ct Method显示文摘 | Kenneth J Livak A Thomas D | 2001 | METHODS2001，25，4： | 1 |
| 14 | Significant levels of extracellular reactive oxygen species produced by brown rot basidiomycetes on cellulose显示文摘 | Roni Cohen Kenneth A Jensen Jr Carl J Houtman | 2002 | FEBS Letters November2002，531，3： | 1 |
| 15 | Antigen detection in bronchoalveolar lavage fluid for diagnosis of fungal pneumonia显示文摘 | Chadi A Hage Kenneth S Knox Thomas E Davis Lawrence J Wheat | 2011 | Current Opinion in Pulmonary Medicine2011，，3： | 1 |
| 16 | Ligand design and metal-ion recognition interaction of nikel ( Ⅱ ) with 17- to 19-membered macrocycles containing O2N3 donor and O3N2 donor sets and X-ray structure of the parent 17-membered macrocyclic ligand显示文摘 | KENNETH R A ATHONY J L LEONARD F L | 1983 | J Amer Chem Soc1983，105，4： | 1 |
| 17 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 18 | The impact of herpes zoster and postherpetic neuralgia on health-related quality of life: a prospective study显示文摘 | Drolet Mélanie Brisson Marc Schmader Kenneth E Levin Myron J Johnson Robert Oxman Michael N Patrick David Blanchette Caty Mansi James A | 2010 | Canadian Medical Association. Journal2010，，： | 1 |
| 19 | Sequence stratigraphy of upper Mississipian artata in the central Appalachians: A record of glacioeustasy and teetonoeeustasy in a foreland basin setting显示文摘 | Daniel J M and Kenneth A E | 2000 | AAPG2000，84，2： | 1 |
| 20 | A CMOS integrated power detector for UWB 显示文摘 | KENNETH A TOWNSEND J W HASLETT J N | 2007 | IEEE Microwave and Wireless Components Letters2007，47，1： | 1 |
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