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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 脱脂糯小米米糠粉对面团流变学性质及馒头品质的影响显示文摘对比两种不同目数脱脂糯小米米糠粉(简称米糠粉)对面团流变学性质的影响;采用感官评价和质构分析相结合评价其对馒头品质的影响,确定其最适添加量。结果表明:两种粒度米糠粉在添加量为6%(质量分数,下同)以下时,对面团的粉质特性均有一定的改良作用。两种米糠粉的添加对面团的拉伸特性都有一定的恶化作用,但100~200目米糠粉添加量为4%~6%和过400目米糠粉添加量为6%~8%时,面团的拉伸特性恶化不明显。随着100~200目米糠粉添加量的增加,馒头的白度值逐渐减小;添加量为4%~6%时馒头的硬度、弹性、咀嚼性和回复性都较好,且感官评价得分较高。过400目米糠粉的添加对馒头的白度值影响相对较小,其添加量小于6%时馒头质构性质较好,且感官评价得分高于100~200目米糠粉。综上所述,添加适量的米糠粉可以在一定程度上延缓馒头老化,100~200目米糠粉的添加量应控制在4%~6%,过400目米糠粉添加量应控制在6%~8%。 | 邓利 Kizzy Nerissa Kira Ereia RENNIE 梁叶星 钟耕 | 2015 | 食品科学2015，36，7： | 13 |
| 3 | 俄罗斯国立艾尔米塔什博物馆藏克孜尔石窟壁画显示文摘新疆克孜尔石窟流失海外的壁画中,部分现藏于俄罗斯圣彼得堡国立艾尔米塔什博物馆。藏品来源包括两部分,少量为20世纪初俄国探险队从新疆直接揭走的壁画,其余为第二次世界大战后苏联红军从柏林运回的由德国考察队从新疆揭走的壁画。作者先后两次赴俄罗斯国立艾尔米塔什博物馆协助调查,工作主要围绕俄藏编号、德藏编号以及石窟壁画原位的对应来进行。本文就是这批壁画及整理的成果。 | 赵莉 Kira Samasyk Nicolas Pchelin | 2018 | 文物2018，，4： | 6 |
| 4 | Kaempferia parviflora ethanol extract improves self-assessed sexual health in men:a pilot study显示文摘Background: Sexual health positively correlates with overall wellbeing. Existing therapeutics to enhance male sexual health are limited by factors that include responsiveness, adherence and adverse effects. As the population ages, safe and effective interventions that preserve male sexual function are needed.Published research suggests that various preparations of Kaempferia parviflora, a plant in the Zingiberaceae(ginger) family, support cardiovascular health and may ameliorate erectile function.Objective: The aim of this study was to examine the effects of KaempMax^(TM), an ethanol extract of the K. parviflora rhizome, on erectile function in healthy middle-aged and older men.Design, setting, participants and interventions: We conducted an open-label, one-arm study on 14 generally healthy males aged 50–68 years with self-reported mild erectile dysfunction, who were not using prescription treatments. Participants took 100 mg KaempMax^(TM)daily for 30 days.Main outcome measures: Evaluations were conducted at baseline and on the final study assessment.Primary efficacy analyses included the International Index of Erectile Function(IIEF); secondary efficacy analyses included the Global Assessment Question about erectile function.Results: Thirteen participants completed the 30-day study. Supplementation with KaempMax^(TM)resulted in statistically significant improvements in erectile function, intercourse satisfaction and total scores on the IIEF questionnaire. KaempMax^(TM)was well tolerated and exhibited an excellent safety profile.Conclusion: Our results suggest that KaempMax^(TM)may improve erectile function in healthy middle-aged and older men. While the effects were not as pronounced as what might be seen with prescription medication, most participants found them satisfactory. Additional, longer and placebo-controlled clinical trials will be needed.Trial registration: Clinicaltrials.gov identifier NCT03389867. | Richard A.Stein Kira Schmid Jowell Bolivar Andrew G.Swick Steven V.Joyal Steven P.Hirsh | 2018 | Journal of Integrative Medicine2018，16，4： | 4 |
| 5 | 高性能发动机活塞销衬套材料的研制显示文摘近年来,柴油机要求更高的性能和更长的寿命。由于气缸爆发压力高,活塞销衬套的工作负荷和温度变得更高。因此要求活塞销衬套具有高承载能力、耐磨性和耐腐蚀性。为了改善铜衬套材料的耐腐蚀性,研究了铜合金中添加元素的效果。研究发现,在铜中加入镍可降低铜合金的硫腐蚀。此外,还得知可以通过传统的烧结方法来生产铜镍合金。尝试在铜基体中加入硬颗粒来提高耐磨性。研究的首要目标是确定硬颗粒对耐磨性和切削加工工艺性的影响。研究发现,在铜基体中加入一种硬颗粒时耐磨性有所提高,但切削加工性却变差。为了解决这个问题,试验同时添加两种硬颗粒,细的AIN和Fe3P颗粒。结果是成功地提高了耐磨性,又不使切削加工性变差。在本研究的基础上成功地开发了活塞销衬套新材料,有效地提高了高性能柴油机活塞销衬套的耐磨性和耐腐蚀性。 | Kira T Yokota H Kamiya S 顾如龙 | 2000 | 国外内燃机2000，32，4： | 3 |
| 6 | Phylogenomics,biogeography,and evolution of the blue-or white-fruited dogwoods(Cornus)-Insights into morphological and ecological niche divergence following intercontinental geographic isolation显示文摘The eastern Asian(EA)-eastem North American(ENA)floristic disjunction represents a major pattern of phytogeography of the Northern Hemisphere.Despite 20 years of studies dedicated to identification of taxa that display this disjunct pattern,its origin and evolution remain an open question,especially regarding postisolation evolution.The blue-or white-fruited dogwoods(BW)are the most species-rich among the four major clades of Cornus L.,consisting of-35 species divided into three subgenera(subg.Yinquania,subg.Mesomora,and subg.Kraniopsis).The BW group provides an excellent example of the EA-ENA floristic disjunction for biogeographic study due to its diversity distribution centered in eastern Asia and eastern North America,yet its species relationships and delineation have remained poorly understood.In this study,we combined genome-wide markers from RAD-seq,morphology,fossils,and climate data to understand species relationships,biogeographic history,and ecological niche and morphological evolution.Our phylogenomic analyses with RAxML and MrBayes recovered a strongly supported and well-resolved phylogeny of the BW group with three intercontinental disjunct clades in EA and ENA or Eurasia and North America,of which two are newly identified within subg.Kraniopsis.These analyses also recovered a potential new species but failed to resolve relationships within the C.hemsleyi-C.schindleri complex.In an effort to develop an approach to reduce computation time,analysis of different nodal age settings in treePL suggests setting a node's minimum age constraint to the lower bound of a fossil's age range to obtain similar ages to that of BEAST.Divergence time analyses with BEAST and treePL dated the BW stem back to the very Late Cretaceous and the divergence of the three subgenera in the Paleogene.By integrating fossil ages and morphology,a total evidence-based dating approach was used in conjunction with time-slice probabilities of dispersal under a DEC model to resolve ancestral ranges of each disjunct in the Miocene:Eurasia and ENA(disjunct 1),EA and western North America(disjunct 2),and EA(disjunct 3).The dated biogeographic history supports dispersal via the North Atlantic Land Bridge in the late Paleogene in disjunct 1 and dispersal via the Bering Land Bridge in the Miocene for disjuncts 2 and 3.Character mapping with a stochastic model in phytools and comparison of ecological niche,morphospace,and rate of evolution indicated differential divergence patterns in morphology,ecological niche,and molecules between disjunct sisters.Although morphological stasis was observed in most of the characters,evolutionary changes in growth habit and some features of leaf,flower,and fruit morphology occurred in one or both sister clades.A significant differentiation of ecological habitats in temperature,precipitation,and elevation between disjunct sisters was observed,suggesting a role of niche divergence in morphological evolution post-isolation.The patterns of evolutionary rate between morphology and molecules varied among disjunct clades and were not always congruent between morphology and molecules,suggesting cases of non-neutral morphological evolution driven by ecological selection.Our phylogenetic evidence and comparisons of evolutionary rate among disjunct lineages lend new insights into the formation of the diversity anomaly between EA and ENA,with particular support of an early diversification in EA.These findings,in conjunction with previous studies,again suggest that the EA-ENA disjunct floras are an assembly of lineages descended from the Mesophytic Forests that evolved from the early Paleogene“boreotropical flora”through varied evolutionary pathways across lineages. | Kira Lindelof Julieta ALindo Wenbin Zhou Xiang Ji Qiu-Yun(Jenny)Xiang | 2020 | Journal of Systematics and Evolution2020，58，5： | 3 |
| 7 | Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis显示文摘 | Christoph Roderburg Gerd‐Willem Urban Kira Bettermann Mihael Vucur Henning Zimmermann Sabine Schmidt J?rn Janssen Christiane Koppe Percy Knolle Mirco Castoldi Frank Tacke Christian Trautwein Tom Luedde | 2011 | Hepatology2011，，1： | 3 |
| 8 | Scintigraphic evaluation of gallbladder motor functions in H pylori positive and negative patients in the stomach with dyspepsia显示文摘AIM:To evaluate the relationship between gallbladder (GB) motor function and H pylori infection in the stomach. METHODS: All cases (86) underwent the 14C urea breath test (UBT). 14C-UBT was found as positive in 58 and negative in 28 dyspeptic patients. 14C- UBT was accepted as a gold standard test. Clo test and histopathologic examination were compared with the results of 14C-UBT in cases who tolerated upper gastrointestinal endoscopy procedure. Cholescintigraphy with 99mTc-mebrofenin was used to determine the parameters of GB motor function (GB filling and emptying time, half of the emptying time, ejection fraction at 30th and 60th min) in all patients. RESULTS: We found the sensitivity and specificity as 88% and 86% for Clo test and as 89% and 80% for histologic evaluation, respectively. The parameters of GB function were not significantly different in H pylori positive and negative patients. The GB emptying was normal in both groups. Minimum GB filling time was 30 min in 34 of 86 cases (39.5%), filling was not observed in 2 cases. The GB ultrasonography (USG) results were normal for all cases and bile composition abnormality was not determined.CONCLUSION: Our study showed that 14C-UBT is highly reliable method to detect the presence of H pylori. The presence of H pylori infection does not directly affect the GB function. | Olga Taskaya Yaylali Mustafa Yilmaz Fatma Suna Kira Serkan Degirmencioglu Metin Akbulut | 2008 | World Journal of Gastroenterology2008，14，9： | 3 |
| 9 | Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-Like Receptor-2显示文摘 | Thimoteus Speer Lucia Rohrer Przemyslaw Blyszczuk Rukshana Shroff Kira Kuschnerus Nicolle Kr?nkel Gabriela Kania Stephen Zewinger Alexander Akhmedov Yi Shi Tina Martin Damir Perisa Stephan Winnik Maja F. Müller Urban Sester Gabriel Wernicke Andreas Jung U | 2013 | Immunity2013，，： | 2 |
| 10 | On 2-Site Voronoi Diagrams Under Geometric Distance Functions显示文摘We revisit a new type of Voronoi diagram, in which distance is measured from a point to a pair of points. We consider a few more such distance functions, based on geometric primitives, namely, circles and triangles, and analyze the structure and complexity of the nearest- and furthest-neighbor 2-site Voronoi diagrams of a point set in the plane with respect to these distance functions. In addition, we bring to notice that 2-point site Voronoi diagrams can be alternatively interpreted as 1-site Voronoi diagrams of segments, and thus, our results also enhance the knowledge on the latter. | Gill Barequet Matthew Dickerson David Eppstein David Hodorkovsky Kira Vyatkina | 2013 | Journal of Computer Science & Technology2013，28，2： | 2 |
| 11 | Health damages from air pollution in China显示文摘 | Kira Matus Kyung-Min Nam Noelle E. Selin Lok N. Lamsal John M. Reilly Sergey Paltsev | 2011 | Global Environmental Change2011，，1： | 2 |
| 12 | Baseline carcinoembryonic antigen (CEA) serum levels predict bevacizumab‐based treatment response in metastatic colorectal cancer显示文摘 | Gerald W. Prager Kira H. Braemswig Alexandra Martel Matthias Unseld Georg Heinze Thomas Brodowicz Werner Scheithauer Gabriela Kornek Christoph C. Zielinski | 2014 | Cancer Sci2014，，8： | 2 |
| 13 | NDM-1:ein neuer sieg fur muStlresistente bakterien显示文摘 | KIRA W | | Chemie In Unserer Zeit0，，： | 2 |
| 14 | Bone regeneration with osteogenic matrix cell sheet and tricalcium phosphate:An experimental study in sheep显示文摘AIM To determine the effects of a cell sheet created from sheep bone marrow and tricalcium phosphate(TCP) on osteogenesis.METHODS Bone marrow cells were harvested from a sheep and cultured in a minimal essential medium(MEM) containing ascorbic acid phosphate(AscP) and dexamethasone(Dex). After 2 wk, the formed osteogenic matrix cell sheet was lifted from the culture dish using a scraper. Additionally, harvested bone marrow cells were cultured in MEM only as a negative control group, and in MEM with AscP, Dex, and β-glycerophosphate as a positive control group. For in vitro evaluation, we measured the alkaline phosphatase(ALP) activity and osteocalcin(OC) content in the media of the cultured cells from each group. For in vivo analysis, a porous TCP ceramic was used as a scaffold. We prepared an experimental group comprising TCP scaffolds wrapped with the osteogenic matrix cell sheets and a control group consisting of the TCP scaffold only. The constructs wereimplanted subcutaneously into athymic rats and the cell donor sheep, and bone formation was confirmed by histology after 4 wk.RESULTS In the in vitro part, the mean ALP activity was 0.39 ± 0.03 mg/well in the negative control group, 0.67 ± 0.04 mg/well in the sheet group, and 0.65 ± 0.07 mg/well in the positive control group. The mean OC levels were 1.46 ± 0.33 ng/well in the negative control group, 3.92 ± 0.16 ng/well in the sheet group, and 4.4 ± 0.47 ng/well in the positive control group, respectively. The ALP activity and OC levels were significantly higher in the cell sheet and positive control groups than in the negative control group(P < 0.05). There was no significant difference in ALP activity or OC levels between the cell sheet group and the positive control group(P > 0.05). TCP constructs wrapped with cell sheets prior to implantation showed bone formation, in contrast to TCP scaffolds alone, which exhibited poor bone formation when implanted, in the subcutaneous layer both in athymic rats and in the sheep. CONCLUSION This technique for preparing highly osteoinductive TCP may promote regeneration in large bone defects. | Tsutomu Kira Manabu Akahane Shohei Omokawa Takamasa Shimizu Kenji Kawate Tadanobu Onishi Yasuhito Tanaka | 2017 | World Journal of Orthopedics2017，8，10： | 2 |
| 15 | Juvenile muscular atrophy of the distal upper limb ( Hirayama disease) associated atropy 显示文摘 | Kira J Ochi H | 2001 | J Neurol Neurosurg Psy- chiatry2001，70，： | 1 |
| 16 | Primary bipolar hemiprosthesis for unstable intertrochanteric fractures显示文摘 | Rodop O Kira A Kaplan H | 2002 | Int Orthop2002，26，4： | 1 |
| 17 | Juvenile muscular atrophy of the distal upper limb (Hirayama disease) associated with atopy 显示文摘 | Kira J Ochi H | 2001 | Neurol Neurosurg Psychiatry2001，70，： | 1 |
| 18 | Tree allometry and improved estimation of carbon stocks and balance in tropical forests显示文摘 | Chave J Andalo C Brown S Cairns M A Chambers J Q Eamus D Folster H Fromard F Higuchi N Kira T Lescure J P Nelson B W Ogawa H Puig H Riera B Yamakura T | | 0，，： | 1 |
| 19 | Diagnostic usefulness diffusion- weighted of magnetic resonance imaging in influenza-associated acute encephalopathy or encephalitis显示文摘 | Tokunaga Y Kira R Takemoto M | 2000 | Brain Dev2000，22，7： | 1 |
| 20 | Western versus Asian types of multiple sclerosis:immunogenetically and clinically distinct disorders显示文摘 | Kira J Kanai T Nishimura Y | 1996 | Ann Neurol1996，40，4： | 1 |
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