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	题名	作者	年代	出处	被引量
1	Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy.	Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf	2012	World Journal of Gastroenterology2012，18，6：	16
2	Role of circulating microRNAs in liver diseases显示文摘MicroRNAs(miRNAs) are small RNAs regulate gene expression by inhibiting the turnover of their target mRNAs. In the last years, it became apparent that miRNAs are released into the circulation and circulating miRNAs emerged as a new class of biomarkers for various diseases. In this review we summarize available data on the role of circulating miRNAs in the context of acute and chronic liver diseases including hepatocellular and cholangiocellular carcinoma. Data from animal models are compared to human data and current challenges in the field of miRNAs research are discussed.	Sven H Loosen Florian Schueller Christian Trautwein Sanchari Roy Christoph Roderburg	2017	World Journal of Hepatology2017，9，12：	7
3	Inflammatory Pathways in Liver Homeostasis and Liver Injury显示文摘	Frank Tacke Tom Luedde Christian Trautwein	2009	Clinical Reviews in Allergy & Immunology2009，，1：	3
4	Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis显示文摘	Christoph Roderburg Gerd‐Willem Urban Kira Bettermann Mihael Vucur Henning Zimmermann Sabine Schmidt J?rn Janssen Christiane Koppe Percy Knolle Mirco Castoldi Frank Tacke Christian Trautwein Tom Luedde	2011	Hepatology2011，，1：	3
5	Value of magnifying chromoendoscopy and narrow band imaging (NBI) in classifying colorectal polyps: a prospective controlled study显示文摘	J. Tischendorf H. Wasmuth A. Koch H. Hecker C. Trautwein R. Winograd	2007	Endoscopy2007，，12：	2
6	CA6NM: New developmentsbased on 20 years experience 显示文摘	Gysel W Gerber E Trautwein A	1982	Stainless Steel Castings1982，，3：	2
7	Cholangioscopic Characterization of Dominant Bile Duct Stenoses in Patients with Primary Sclerosing Cholangitis显示文摘	J. Tischendorf M. Krüger C. Trautwein N. Duckstein A. Schneider M. Manns P. Meier	2006	Endoscopy2006，，07：	2
8	Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis显示文摘	Yulia A. Nevzorova Wei Hu Francisco J. Cubero Ute Haas Julia Freimuth Frank Tacke Christian Trautwein Christian Liedtke	2013	BBA - Molecular Basis of Disease2013，，10：	2
9	Stimulation of collagen atpha 1 (I)gene expression is associated with lipid peroxidation in hepatocellular injury:a link to tissue fibrosis?显示文摘	Bedossa P Houglum K Trautwein c	1994	Hcpatology1994，19，5：	1
10	CBlcannabinoid receptor antag- onism :a new strategy for the treatment of liver fibrosis 显示文摘	Wasmuth HE Trautwein C	2007	Hepatology2007，45，2：	1
11	Biological effects of oxidized phytosterols: A review of the cur- rent knowledge显示文摘	Egbert Hovenkamp Isabelle Demonty Elke A Trautwein	2008	Progress in Lipid Research2008，，47：	1
12	Intracellular survival pathways in the liver显示文摘	Luedde T Trautwein C	2006	Liver Int2006，26，：	1
13	Der aktionsstrom yrokardfaser im sauerstoffmangel 显示文摘	Gottstein U Dudel J	1954	Pfuegers Arch1954，260，：	1
14	Cumulative effects of land use on fish metrics in different types of running waters in Austria显示文摘	TRAUTWEIN C SCHINEGGER R SCHMUTZ S	2012	Aquatic Sciences2012，74，2：	1
15	Cholangioscopic characterization of dominant bile duct stenoses in patients with primary sclerosing cholangitis 显示文摘	Tischendorf JJ Kruger M Trautwein C	2006	Endoscopy2006，38，7：	1
16	Dietary inulin lowers plasma cholesterol and alters biliary bile acid profile in hamsters显示文摘	TRAUTWEIN E A RIECKHOFF D ERRBERSDOBLER H F	1998	J Nutr1998，128，11：	1
17	Plasma concentrations of plant ste-rols:physiology and relationship with coronary heart disease显示文摘	Chan Y M Varady K A Lin Y Trautwein E Mensink R P Plat J	2006	Nutr Rev2006，64，：	1
18	Interrater reliabili- ty of the extended ICF core set for stroke applied by phys- ical therapists显示文摘	Starrost K Geyh S Trautwein A	2008	Phys Ther2008，88，7：	1
19	In situ stress variations at the Variscan deformation front -Results from the deep Aachen geo- thermal well显示文摘	Ute Trautwein - Bruns	2010	Tectonophysics2010，493，：	1
20	Inflammatory Pathways in Liver Homeostasis and Liver Injury显示文摘	Frank Tacke Tom Luedde Christian Trautwein	2009	Clinical Reviews in Allergy & Immunology2009，，1：	1

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