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| 1 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 2 | Colometer:A real-time quality feedback system for screening colonoscopy显示文摘AIM:To investigate the performance of a new software-based colonoscopy quality assessment system.METHODS:The software-based system employs a novel image processing algorithm which detects the levels of image clarity,withdrawal velocity,and level of the bowel preparation in a real-time fashion from live video signal.Threshold levels of image blurriness and the withdrawal velocity below which the visualization could be considered adequate have initially been determined arbitrarily by review of sample colonoscopy videos by two experienced endoscopists.Subsequently,an overall colonoscopy quality rating was computed based on the percentage of the withdrawal time with adequate visualization(scored 1-5;1,when the percentage was 1%-20%;2,when the percentage was 21%-40%,etc.).In order to test the proposed velocity and blurriness thresholds,screening colonoscopy withdrawal videos from a specialized ambulatory colon cancer screening center were collected,automatically processed and rated.Quality ratings on the withdrawal were compared to the insertion in the same patients.Then,3 experienced endoscopists reviewed the collected videos in a blinded fashion and rated the overall quality of each withdrawal(scored 1-5;1,poor;3,average;5,excellent) based on 3 major aspects:image quality,colon preparation,and withdrawal velocity.The automated quality ratings were compared to the averaged endoscopist quality ratings using Spearman correlation coefficient.RESULTS:Fourteen screening colonoscopies were assessed.Adenomatous polyps were detected in 4/14(29%) of the collected colonoscopy video samples.As a proof of concept,the Colometer software rated colonoscope withdrawal as having better visualization than the insertion in the 10 videos which did not have any polyps(average percent time with adequate visualization:79% ± 5% for withdrawal and 50% ± 14% for insertion,P < 0.01).Withdrawal times during which no polyps were removed ranged from 4-12 min.The median quality rating from the automated system and the reviewers was 3.45 [interquartile range(IQR),3.1-3.68] and 3.00(IQR,2.33-3.67) respectively for all colonoscopy video samples.The automated rating revealed a strong correlation with the reviewer's rating(ρ coefficient= 0.65,P = 0.01).There was good correlation of the automated overall quality rating and the mean endoscopist withdrawal speed rating(Spearman r coefficient= 0.59,P = 0.03).There was no correlation of automated overall quality rating with mean endoscopists image quality rating(Spearman r coefficient= 0.41,P = 0.15).CONCLUSION:The results from a novel automated real-time colonoscopy quality feedback system strongly agreed with the endoscopists' quality assessments.Further study is required to validate this approach. | Dobromir Filip Xuexin Gao Leticia Angulo-Rodriguez Martin P Mintchev Shane M Devlin Alaa Rostom Wayne Rosen Christopher N Andrews | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 3 | Silent diabetic nephropathy显示文摘AIM: To examine the risk of renal events in patients with biopsy-proven diabetic nephropathy(DN) and its possible associated factors.METHODS: Clinical and histological data of 60 patients diagnosed with diabetic nephropathy were retrospectively collected. Patients with evidence or suspicion of other nephropathies were excluded from the study. The final event was defined as renal replacement therapy(RRT) initiation or progression of chronic kidney disease(CKD), according to the KDIGO 2012 definition of a decrease in CKD category and a decrease in GFR of 25% or more. RESULTS: A total of 45 patients with a follow-up of at least 3 mo were included. Most of the patients presented type 2 DM, with a median age of 58.3 years old. The time of evolution of DM was 9.6 ± 7.8 years, although in 13 patients, it was less than 5 years. A total of 62% of patients reached the final event in a mean period of 3.4 years(95%CI: 2.1-4.7), with 21 of them requiring dialysis. The factors that were independently associated with renal survival were estimated glomerular filtration rate(e GFR) at the time of biopsy, cardiovascular disease(CVD) history and Hb A1 c less than 7%. Therefore, for each 10 m L/min per 1.73 m2 reduction in e GFR, we obtained a DN progression risk of HR = 2(1.3-3.0)(P = 0.001); patients with CVD were at greater risk for DN progression(HR = 2.8, 1.1-7.1, P = 0.032), and CKD patients with Hb A1 c < 7% demonstrated greater renal risk than patients with Hb A1 c ≥ 7%, with an HR of 2.9(1.0-8.4)(P = 0.054).CONCLUSION: A past history of CVD is a risk factor for DN progression. Levels of Hb A1 c less than 7% could favor an e GFR decrease in these patients. | Katia López-Revuelta Patricia Pea Galdo Ramona Stanescu Leticia Parejo Carmen Guerrero Elia Pérez-Fernández | 2014 | World Journal of Nephrology2014，3，1： | 2 |
| 4 | Release of multifunctional peptides by gastrointestinal digestion of sea cucumber ( Isostichopus badionotus )显示文摘 | Juan Antonio Pérez-Vega Leticia Olivera-Castillo José ángel Gómez-Ruiz Blanca Hernández-Ledesma | 2013 | Journal of Functional Foods2013，，： | 2 |
| 5 | Antioxidant and antimicrobial effects of phenolic compounds extracts of Northeast Portugal honey 显示文摘 | LETICIA E ANA P P LEANDRO M | 2008 | Food and Chemical Toxicology2008，46，： | 1 |
| 6 | Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-depend- ent kinase cdkl显示文摘 | ANNE FL LETICIA P VINCENT G | 2006 | Cell2006，17，3： | 1 |
| 7 | Histopathological Study of Delayed Regraft After Corneal Graft Failure显示文摘 | Leonardo N Santos Leticia Rielo de Moura Bruno F Fernandes Devinder P Cheema Miguel N Burnier | 2011 | Cornea2011，，2： | 1 |
| 8 | Trypanosoma cruzi : Molecular characterization of an RNA binding protein differentially expressed in the parasite life cycle显示文摘 | Leticia Pérez-Díaz María Ana Duhagon Pablo Smircich José Sotelo-Silveira Carlos Robello Marco Aurelio Krieger Samuel Goldenberg Noreen Williams Bruno Dallagiovanna Beatriz Garat | 2007 | Experimental Parasitology2007，，： | 1 |
| 9 | A short synthesis of astemizole 显示文摘 | Cecilia A P Leticia Q C Jesus S R | 1996 | Synthetic Communication1996，26，17： | 1 |
| 10 | Effects of larval-juvenile treatment with perchlorate and co-treatment with thyroxine on zebrafish sex ratios 显示文摘 | Sandeep M Leticia T Reynaldo P | 2007 | General and Comparative Endocrinology2007，150，3： | 1 |
| 11 | Evidence for a negative feedback control mediated by the 3′ untranslated region assuring the low expression level of the RNA binding protein TcRBP19 in T. cruzi epimastigotes显示文摘 | Leticia Pérez-Díaz Lucía Pastro Pablo Smircich Bruno Dallagiovanna Beatriz Garat | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 12 | Germination of fours species of the genus Mimosa(Leguminosae) in a semi-arid zone of Central Mexico 显示文摘 | Maria S O Leticia P L G Rosaura G | 2003 | J Arid Environ2003，55，1： | 1 |
| 13 | Caking and stickiness of diary- based food powders as related to glass transition显示文摘 | LETICIA E C LABUZA T P | 1994 | J Food Sci1994，59，1： | 1 |
| 14 | Effects of soil and foliar application of soluble silicon on mineral nutrition,gas exchange,and growth of potato plants显示文摘 | PILON CRISTIANE SORATTO ROGERIO P MORENO LETICIA A | 2013 | Crop Science2013，53，4： | 1 |
| 15 | Hypoxia/fatigue- induced degredation of troponin I and troponin C: new insights into physiologic muscle fatigue显示文摘 | Marco P B Shelia A V L Leticia S B | 2001 | Pfltigers Arch- Ettr Physiol2001，442，： | 1 |
| 16 | Effect of a size-based selection program on blood metabolites and immune response of Litopenaeus vaaaamei juveniles fed different dietary carbohydrate levels 显示文摘 | Cristina P Leticia A Gerard C | 2004 | Aquaculture2004，230，： | 1 |
| 17 | Sleep stage classification using fuzzy sets and machine learning techniques 显示文摘 | Pedro P Pavel G Leticia A | 2004 | Neurocomputing2004，，58： | 1 |
| 18 | Conservative management of retained trophoblastic tissue and placental polyp with diagnostic ambulatory hysteroscopy显示文摘 | Jesús S. Jiménez Cristina Gonzalez Carmen Alvarez Leticia Mu?oz Concha Pérez José L. Mu?oz | 2009 | European Journal of Obstetrics and Gynecology2009，，1： | 1 |
| 19 | Epigenetic markers of exposure to polycyclic aromatic hydrocarbons in Mexican brickmakers: A pilot study显示文摘 | Jorge Alejandro Alegría-Torres Francesco Barretta Lilia E. Batres-Esquivel Leticia Carrizales-Yá?ez Iván N. Pérez-Maldonado Andrea Baccarelli Pier Alberto Bertazzi | 2012 | Chemosphere2012，，： | 1 |
| 20 | Development and validation of a TaqMan-MGB real-time RT-PCR assay for simultaneous detection and characterization of infectious bursal disease virus显示文摘 | Gonzalo Tomás Martín Hernández Ana Marandino Yanina Panzera Leticia Maya Diego Hernández Ariel Pereda Alejandro Banda Pedro Villegas Sebastián Aguirre Ruben Pérez | 2012 | Journal of Virological Methods2012，，1： | 1 |
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