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| 1 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 2 | Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes显示文摘 | Kangmin He Xiaohua Yan Nan Li Song Dang Li Xu Bing Zhao Zijian Li Zhizhen Lv Xiaohong Fang Youyi Zhang Ye-Guang Chen | 2015 | Cell Research2015，25，6： | 7 |
| 3 | A consensus linkage map of common carp (Cyprinus carpio L.) to compare the distribution and variation of QTLs associated with growth traits显示文摘The ability to detect and identify quantitative trait loci (QTLs) in a single population is often limited. Analyzing multiple populations in QTL analysis improves the power of detecting QTLs and provides a better understanding of their functional allelic variation and distribution. In this study, a consensus map of the common carp was constructed, based on four populations, to compare the distribution and variation of QTLs. The consensus map spans 2371.6 cM across the 42 linkage groups and comprises 257 microsatellites and 421 SNPs, with a mean marker interval of 3.7 cM/marker. Sixty-seven QTLs affecting four growth traits from the four populations were mapped to the consensus map. Only one QTL was common to three populations, and nine QTLs were detected in two populations. However, no QTL was common to all four populations. The results of the QTL comparison suggest that the QTLs are responsible for the phenotypic variability observed for these traits in a broad array of common carp germplasms. The study also reveals the different genetic performances between major and minor genes in different populations. | ZHENG XianHu KUANG YouYi LV WeiHua CAO DingChen ZHANG XiaoFeng LI Chao LU CuiYun SUN XiaoWen | 2013 | Science China(Life Sciences)2013，56，4： | 4 |
| 4 | Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway显示文摘Cardiac fibroblast(CF)differentiation into myofibroblasts is a crucial cause of cardiac fibrosis,which increases in the extracellular matrix(ECM)stiffness.The increased stiffness further promotes CF differentiation and fibrosis.However,the molecular mechanism is still unclear.We used bioinformatics analysis to find new candidates that regulate the genes involved in stiffnessinduced CF differentiation,and found that there were binding sites for the POU-domain transcription factor,POU2F1(also known as Oct-1),in the promoters of 50 differentially expressed genes(DEGs)in CFs on the stiffer substrate.Immunofluorescent staining and Western blotting revealed that pathological stiffness upregulated POU2F1 expression and increased CF differentiation on polyacrylamide hydrogel substrates and in mouse myocardial infarction tissue.A chromatin immunoprecipitation assay showed that POU2F1 bound to the promoters of fibrosis repressors IL1R2,CD69,and TGIF2.The expression of these fibrosis repressors was inhibited on pathological substrate stiffness.Knockdown of POU2F1 upregulated these repressors and attenuated CF differentiation on pathological substrate stiffness(35 kPa).Whereas,overexpression of POU2F1 downregulated these repressors and enhanced CF differentiation.In conclusion,pathological stiffness upregulates the transcription factor POU2F1 to promote CF differentiation by inhibiting fibrosis repressors.Our work elucidated the crosstalk between CF differentiation and the ECM and provided a potential target for cardiac fibrosis treatment. | Mingzhe Li Jimin Wu Guomin Hu Yao Song Jing Shen Junzhou Xin Zijian Li Wei Liu Erdan Dong Ming Xu Youyi Zhang Han Xiao | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 5 | Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics显示文摘Objective:The high expression of cell division cycle 42 protein(CDC42)may be involved in the occurrence and progression of several tumors.However,the expression and function of CDC42 in cervical squamous cell carcinoma remains unclear.This study aimed to investigate the expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.Methods:The expression of CDC42 in 162 cervical squamous cell carcinoma tissue samples and 33 normal cervical tissue samples was investigated by immunohistochemistry.The CDC42 mRNA expression was detected by reverse transcription-polymerase chain reaction(RT-PCR).Results:ThecervicalsquamouscellcarcinomagroupshowedasignificantlyhigherCDC42positiverate,compared to the normal cervical tissues(P<0.05).Furthermore,the tissues of stage II-IV carcinoma patients showed higher CDC42 expression levels compared to stage I patients(P=0.05).In addition,the expression of CDC42 was not correlated to age of patients,differentiation degree of cancer cells,or lymph node metastasis(P>0.05).Furthermore,compare with normal cervical tissues,the CDC42 mRNAexpressionincervicalcancerhadnosignificantdifference.Conclusions:CDC42 was up-regulated at protein level,but not mRNA level,in cervical squamous cell carcinoma.The high expression of CDC42 was correlated to the clinical stage of the patients,indicating that CDC42 might contribute to the progression of cervical squamous cell carcinoma. | Ding Ma Yuan Cheng Youyi Zhang Yanli Guo Zijian Li Geng Li | 2013 | Chinese Journal of Cancer Research2013，25，6： | 3 |
| 6 | Does Security of Land Operational Rights Matter for the Improvement of Agricultural Production Efficiency under the Collective Ownership in China?显示文摘Under the'separation of three rights'policy,the impact of security of land operationalrights on agricultural production efficiency has attracted much attention in recentyears.Data envelopment analysis and mediation effect analysis were applied to 888family farms run by new-type agricultural operators from Songjiang to identify themechanism of the effect of land operational rights security on agricultural productionefficiency through long-term investment.The results show that greater security of landoperational rights generally increased agricultural production efficiency.Approximately37.94 percent of the impact could be explained by long-term investment.The resultsalso indicate that significant heterogeneity exists in the effect of land operational rightssecurity on agricultural production efficiency at various levels of the family farms'efficiency distributions.lt is suggested that government should legalize land operationalrights and give them a status equal to those of households'contractual rights and landownership rights in China's future land tenure reform. | Xianqing Ji Shouying Liu Jianan Yan Youyi Li | 2021 | China & World Economy2021，29，1： | 2 |
| 7 | Cryoprotective effects of D-allose on mammalian ceils 显示文摘 | Sui Li Nomura R Dong Youyi | 2007 | Cryobiology2007，55，2： | 1 |
| 8 | A novel positively charged nanofiltration membrane prepared from N,N-dime- thylaminoethyl methacrylate by quaternization cross-linking显示文摘 | Li Xiaolin Zhu Liping Xu Youyi | 2011 | Journal of Membrane Science2011，374，12： | 1 |
| 9 | Experimental flow field characteristics of OFA for large-angle counter flow of fuel-rich jet combustion technology显示文摘 | FAN Weidong LIN Zhengchun LI Youyi | 2010 | Applied Energy2010，87，8： | 1 |
| 10 | Single-molecule imaging reveals the stoichiometry change of epidermal growth factor receptor during transactivation by β_2-adrenergic receptor显示文摘Stimulation of G protein-coupled receptors(GPCRs) can lead to the transactivation of the epidermal growth factor receptors(EGFR). The cross-communication between the two signaling pathways regulates several important physiological or pathological processes. However, the molecule mechanism underlying EGFR transactivation remains poorly understood. Here, we aim to study the GPCR-mediated EGFR transactivation process using the single-molecule fluorescence imaging and tracking approach.We found that although EGFR existed as monomers at the plasma membrane of resting cells, they became dimers and thus diffused slower following the activation of β2-adrenergic receptor(β2-AR) by isoproterenol(ISO). We further proved thatβ2-AR-mediated changes of EGFR in stoichiometry and dynamics were mediated by Src kinase. Thus, the observations obtained via the single-molecule imaging and tracking methods shed new insights into the molecular mechanism of EGFR transactivation at single molecule level. | Mingliang Zhang Kangmin He Jimin Wu Nan Li Jinghe Yuan Wei Zhou Zi Ye Zijian Li Han Xiao Zhizhen Lv Youyi Zhang Xiaohong Fang | 2017 | Science China Chemistry2017，60，10： | 1 |
| 11 | Effect of temperature on NO release during the combustion of coals with different ranks显示文摘 | Fan Weidong Lin Zhengchun Li Youyi | 2010 | Energy and Fuels2010，24，： | 1 |
| 12 | 2010, Structure and meaning in Chinese: an ERP study of idioms 显示文摘 | Liu Youyi Ping Li Hua Shu Qirui Zhang & Lang Chen | 2010 | Journal of Neurolinguistics2010，23，： | 1 |
| 13 | Fabrication andcharacterization of a novel TiO2 nanoparticle self-assemblymembrane with improved fouling resistance显示文摘 | LI Jianhua XU Youyi ZHU Liping | 2009 | J Membr Sci2009，326，： | 1 |
| 14 | Implication of malignancy and prognosis of p27^kip1, CyclinE and Cdk2 expression in epithelial ovarian tumors 显示文摘 | Li Sui Youyi Dong Masayuki Ohno | 2001 | Gynecologic Oncology2001，83，1： | 1 |
| 15 | Fabrication andcharacterization of a novel TiO2 nanoparticle self -assemblymembrane with improved fouling resistance显示文摘 | LI Jianhua XU Youyi ZHU Liping | 2009 | J Membr Sci2009，326，： | 1 |
| 16 | Inverse Expression of CDK4and p16 in epithelial ovarian tumors显示文摘 | Li Sui MD YouYi Dong Masayuki ohno | 2000 | Gynecologic oncology2000，79，： | 1 |
| 17 | Effect of air-staging on anthraeim combustion and NOx forma-tion显示文摘 | Fan Weidong Lin Zhengchun Li Youyi | 2009 | Energy & Fuels2009，23，1： | 1 |
| 18 | Clinical significance of Skp2 expression, alone and combined with Jab1and p27 in epithelial ovarian tumors显示文摘 | Li Sui Youyi Dong Yasuo Watanabe Fuminori Yamaguchi Katsuyoshi Sugimoto Masaaki Tokuda | 2006 | Oncology Reports2006，，4： | 1 |
| 19 | Stable carbon isotope stratigraphy across the Permian -Triassic boundary in shallow marine carbonate platforms, Nanpanjiang Basin, South China 显示文摘 | Krull E S Lehrmann D J P Drake D Kessel B P Yu Youyi Li Rongxi | 2004 | Palaeogeography Palaeoclimatology Palaeoecolo- gy2004，，34： | 1 |
| 20 | Effect of Air-Staging on Anthracite Combustion and NOx Formation 显示文摘 | FAN Weidong LIN Zhenchun LI Youyi | 2009 | Energy & Fuels2009，23，1： | 1 |
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