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| 1 | Cloning, expression, and protective immunity in mice of a gene encoding the diagnostic antigen P-29 of Echinococcus granulosus显示文摘Taeniid 绦虫包虫 granulosus 是包虫病的原因的代理人,有世界范围的分发的重要动物病。在这研究,诊断抗原 P-29 从 E 被克隆。granulosus 并且在 Escherichia 表示了 coli。顺序分析证明 EgP-29 包含 717-bp 开的读框架并且与 27.1 kDa 的预言的分子的重量编码 238 氨基酸残余的蛋白质。recombinant EgP-29 (rEgP-29 ) 能在西方的弄污与反老鼠 sera 被认出。特定的抗体被连接酶的 immunosorbent 试金检测。老鼠与 rEgP-29 种牛痘并且与 E intraperitoneally 质问了。granulosus protoscoleces 揭示了 96.6% 的重要保护的免疫(P < 0.05 ) ,与控制组相比。因此, rEgP-29 蛋白质是一个有希望的候选人让一支有效疫苗阻止第二等的包虫病。 | Zhiyun Shi Yana Wang Zongji Li Zhaoyu Li Yang Bo Rui Ma Wei Zhao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 19 |
| 2 | Effect of Sb-site nonstoichiometry on the structure and microwave dielectric properties of Li_(3)Mg_(2)Sb_(1-x)O_(6) ceramics显示文摘The non-stoichiometric Li_(3)Mg_(2)Sb_(1-x)O_(6)(0.05≤x≤0.125)compounds have been prepared via the mixed oxide method.The influences of Sb nonstoichiometry on the sintering behavior,microstructure,phase composition along with microwave dielectric performances for Li_(3)Mg_(2)Sb_(1-x)O_(6) ceramics were studied.Combined with X-ray diffraction(XRD)and Raman spectra,it was confirmed that phase composition could not be affected by the Sb nonstoichiometry and almost pure phase Li_(3)Mg_(2)SbO_(6) was formed in all compositions.Appropriate Sb-deficiency in Li_(3)Mg_(2)SbO_(6) not only lowered its sintering temperature but also remarkably improved its Q×f value.In particular,non-stoichiometric Li_(3)Mg_(2)Sb_(0.9)O_(6) ceramics sintered at 1250℃/5 h owned seldom low dielectric constant ε_(r)=10.8,near-zero resonant frequency temperature coefficient τ_(f)=-8.0 ppm/℃,and high quality factor Q×f=86,300 GHz(at 10.4 GHz).This study provides an alternative approach to ameliorate its dielectric performances for Li_(3)Mg_(2)SbO_(6)-based compounds through defect-engineering. | Cuijin PEI Jingjing TAN Yang LI Guoguang YAO Yanmin JIA Zhaoyu REN Peng LIU Huaiwu ZHANG | 2020 | Journal of Advanced Ceramics2020，9，5： | 6 |
| 3 | Settling behavior of non-spherical particles in power-law fluids:Experimental study and model development显示文摘Solid-particle settling occurs in many natural and industrial processes, such as in the transportation of drilling cuttings and fracturing proppant. Knowledge of the drag coefficient and settling velocity of cuttings and proppant is of significance to hydraulics design, wellbore cleanout, and fracture optimization. We conducted 553 tests to investigate the settling characteristics of spherical and non-spherical particles in power-law fluids. Three major particle shapes (spherical, cubic, and cylindrical) and eight different particle sphericities were used to simulate cuttings and proppant, and power-law fluids were applied to simulate drilling and fracturing fluids. Based on the data analysis, a new drag coefficient-particle Reynolds number correlation was developed to determine the drag coefficient in a power-law fluid for spherical and non-spherical particles. The drag coefficient increases as the sphericity decreases for the same particle Reynolds number. For a specific particle shape, the drag coefficient decreases as the particle Reynolds number increases, but the decreasing trend is reduced at high particle Reynolds number conditions. An explicit settling-velocity equation was proposed to calculate the settling velocity of spherical and non-spherical particles in power-law fluids by considering the effect of sphericity. A suitable range for the proposed model is 0.0001 < Re <200, 0.471 <φ< 1, and 0.505 < n < 1. An illustrative example is presented to show how to calculate the drag coefficient and settling velocity in power-law fluids with given particle and fluid properties. | Zhengming Xu Xianzhi Song Gensheng Li Zhaoyu Pang Zhaopeng Zhu | 2019 | Particuology2019，17，5： | 6 |
| 4 | Novel trichromatic phosphor Co-doped with Eu, Tb in SiO_2 gel matrix显示文摘The Eu, Tb co-doped SiO2 matrix tricolor fluorescence system was prepared by sol-gel technique. Red emission at 618 nm, green emission at 543 nm and blue emission at 350―500 nm were observed in the PL spectra of the sample, indicating that Eu3+, Eu2+ and Tb3+ ions coexisted in the matrix. In the co-doped sample, the blue emission of Eu2+ was much stronger than that of the sample single doped with Eu, which implied that the electron transfer between Eu3+ and Tb3+ maybe happened in the SiO2 matrix. The influences of the annealing temperature and Tb concentration on the PL spectra of the samples were investigated. The optimal doped concentration of Tb was determined to be 0.2% and the optimal annealing temperature 850℃. Annealed at 600℃, Tb3+ had a sensitizing effect on Eu3+ in the SiO2 matrix, and the emission intensity of Eu3+ in the Eu, Tb co-doped sample was more than four times that of the single doped sample, which could be attributed to the energy transfer from Tb3+ to Eu3+. | HU XiaoYun FAN Jun LI Ting ZHANG DeKai BAI Jinmao REN ZhaoYu HOU Xun | 2007 | Chinese Science Bulletin2007，52，4： | 5 |
| 5 | New method for determining central axial orientation of flux rope embedded within current sheet using multipoint measurements显示文摘A new method for determining the central axial orientation of a two-dimensional coherent magnetic flux rope(MFR)via multipoint analysis of the magnetic-field structure is developed. The method is devised under the following geometrical assumptions:(1) on its cross section, the structure is left-right symmetric;(2) the projected structure velocity is vertical to the line of symmetry. The two conditions can be naturally satisfied for cylindrical MFRs and are expected to be satisfied for MFRs that are flattened within current sheets. The model test demonstrates that, for determining the axial orientation of such structures, the new method is more efficient and reliable than traditional techniques such as minimum-variance analysis of the magnetic field,Grad-Shafranov(GS) reconstruction, and the more recent method based on the cylindrically symmetric assumption. A total of five flux transfer events observed by Cluster are studied using the proposed approach, and the application results indicate that the observed structures, regardless of their actual physical properties, fit the assumed geometrical model well. For these events, the inferred axial orientations are all in excellent agreement with those obtained using the multi-GS reconstruction technique. | LI ZhaoYu CHEN Tao YAN GuangQing | 2016 | Science China Earth Sciences2016，59，10： | 4 |
| 6 | Online single particle measurement of fireworks pollution during Chinese New Year in Nanning显示文摘Time-resolved single-particle measurements were conducted during Chinese New Year in Nanning, China. Firework displays resulted in a burst of SO_2, coarse mode, and accumulation mode(100–500 nm) particles. Through single particle mass spectrometry analysis, five different types of particles(fireworks-metal, ash, dust, organic carbon-sulfate(OC-sulfate), biomass burning) with different size distributions were identified as primary emissions from firework displays. The fireworks-related particles accounted for more than70% of the total analyzed particles during severe firework detonations. The formation of secondary particulate sulfate and nitrate during firework events was investigated on single particle level. An increase of sulfite peak(80SO_3^-) followed by an increase of sulfate peaks(97HSO_4^-+ 96SO_4^-) in the mass spectra during firework displays indicated the aqueous uptake and oxidation of SO_2 on particles. High concentration of gaseous SO_2, high relative humidity and high particle loading likely promoted SO_2 oxidation. Secondary nitrate formed through gas-phase oxidation of NO_2 to nitric acid, followed by the condensation into particles as ammonium nitrate. This study shows that under worm, humid conditions, both primary and secondary aerosols contribute to the particulate air pollution during firework displays. | Jingyan Li Tingting Xu Xiaohui Lu Hong Chen Sergey A.Nizkorodov Jianmin Chen Xin Yang Zhaoyu Mo Zhiming Chen Huilin Liu Jingying Mao Guiyun Liang | 2017 | Journal of Environmental Sciences2017，29，3： | 3 |
| 7 | A shear-thinning,ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis显示文摘Spinal cord injury(SCI)is a serious clinical disease.Due to the deformability and fragility of the spinal cord,overly rigid hydrogels cannot be used to treat SCI.Hence,we used TPA and Laponite to develop a hydrogel with shear-thinning ability.This hydrogel exhibits good deformation,allowing it to match the physical properties of the spinal cord;additionally,this hydrogel scavenges ROS well,allowing it to inhibit the lipid peroxidation caused by ferroptosis.According to the in vivo studies,the TPA@Laponite hydrogel could synergistically inhibit ferroptosis by improving vascular function and regulating iron metabolism.In addition,dental pulp stem cells(DPSCs)were introduced into the TPA@Laponite hydrogel to regulate the ratios of excitatory and inhibitory synapses.It was shown that this combination biomaterial effectively reduced muscle spasms and promoted recovery from SCI. | Yibo Ying Zhiyang Huang Yurong Tu Qiuji Wu Zhaoyu Li Yifan Zhang Huilei Yu Annian Zeng Hanzhi Huang Jiahui Ye Weiyang Ying Min Chen Zhiyi Feng Ziyue Xiang Qingsong Ye Sipin Zhu Zhouguang Wang | 2023 | Bioactive Materials2023，，4： | 2 |
| 8 | Rock magnetic properties and palaeomagnetic results of sediments from a stone implement layer in the Bose Basin, Guangxi显示文摘Directional samples were taken to study rock magnetism and palaeomagnetic records from the Dong- sheng profile, which is 5 m thick and on the northwest edge of the Bose Basin. Mineralogy and rock magnetism of typical samples indicate that coarse granular titanomagnetite, and fine-grained hematite, superparamagnetic maghemite formed by pedogenesis are in the sediment, which has undergone many transformative processes during different stages of pedogenesis. Parallel samples were taken for thermal demagnetization (TH) (0 to 680℃) and alternating field (AF) demagnetization (0 to 80 mT) respectively. Experimental results of these two kinds of demagnetization illustrate that there are two or more magnetic components in the samples. Intensity of NRM decreases by almost 60% to 90% rapidly when the temperature ranges from 100℃ to 350℃, with a steady magnetic component. It is impossible to analyze the magnetic components at high temperature because those fluctuate widely when the temperature is higher than 400℃. Steady magnetic components from 100℃ to 350℃ indicate that the remanence was mainly carried by fine-grained hematite formed by pedogenesis, reflecting a change in the geomagnetic field while the magnetite was being oxidized into hematite by chemical weathering after deposition. The formative age of the sediments cannot be obtained by magnetic methods in this profile. | YANG XiaoQiang ZHU ZhaoYu ZHANG YiNan LI HuaMei ZHOU WenJuan YANG Jie | 2008 | Science China Earth Sciences2008，51，3： | 2 |
| 9 | Geometry-based distributed arc-consistency method formultiagent planning and scheduling显示文摘This research focuses on building a distributed algorithm for planning and scheduling multiple agents to help people deal with events beyond their cognitive capacity, such as car assembly, factory management, spacecraft constellation, etc. We address not only the efficiency of the algorithm but also communication and the individual privacy. As to reason over the problems with multiple agents which are distributed but interconnected, a formal account of the Action-centric Multiagent Simple Temporal Problem(AMSTP) is put forward using the representation of geometries. The key technique we build on is a novel distributed arc-consistency algorithm centered by the geometric method called GDAC, which pays attention to how an agent's local subproblem affects other agents' subproblems. The GDAC is based on geometries taking the action rather than the timepoint as a variable, which can deal with continuous intervals and decrease the number of variables. Comprehensive experiments are run and the proposed technique outperforms the competitor and shows considerable merit compared to the centralized algorithm. | XU Rui LI ZhaoYu CUI PingYuan | 2019 | Science China(Technological Sciences)2019，62，1： | 2 |
| 10 | Unmanned aerial vehicle positioning based on multi-sensor information fusion显示文摘Unmanned aerial vehicle(UAV)positioning is one of the key techniques in the field of UAV navigation.Although the high positioning precision of UAV can be achieved through global positioning system(GPS),the frequency of updating signal in GPS is low and the energy consumption of GPS module is huge,which does not satisfy the real-time demand of UAV positioning.In this paper,a multi-sensor information fusion method based on GPS,inertial navigation system(INS),and the visible light sensors is proposed for UAV positioning.The Kalman filter combining with simulated annealing algorithm is used to estimate the position error between GPS or INS and the visible light sensors,and then the motion trajectory is corrected according to this position error information.Therefore,the positioning accuracy of UAV can be improved in case of only INS being available.Experimental results demonstrate that the proposed method can remarkably improve the positioning accuracy and greatly reduce the energy consumption. | Wenjun Li Zhaoyu Fu | 2018 | Geo-Spatial Information Science2018，21，4： | 2 |
| 11 | Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis显示文摘While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS), there is an unmet need for treatments that slow neurodegeneration resulting from secondary disease progression. The mechanism of neurodegeneration in MS has not yet been established. Here, we discovered a potential pathogenetic role of ferroptosis, an iron-dependent regulated cell death mechanism, in MS. We found that critical ferroptosis proteins (acyl-CoA synthetase long-chain family member 4, ACSL4) were altered in an existing genomic database of MS patients, and biochemical features of ferroptosis, including lipid reactive oxygen species (ROS) accumulation and mitochondrial shrinkage, were observed in the experimental autoimmune encephalitis (EAE) mouse model. Targeting ferroptosis with ferroptosis inhibitors or reducing ACSL4 expression improved the behavioral phenotypes of EAE mice, reduced neuroinflammation, and prevented neuronal death. We found that ferroptosis was an early event in EAE, which may promote T-cell activation through T-cell receptor (TCR) signaling in vitro and in vivo. These data indicate that ferroptosis may be a potential target for treating MS. | Jinyuan Luoqian Wenyong Yang Xulong Ding Qing-zhang Tuo Zheng Xiang Zhaoyue Zheng Yu-jie Guo Li Li Pengbo Guan Scott Ayton Biao Dong Huiyuan Zhang Hongbo Hu Peng Lei | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 12 | Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer显示文摘 | Zhaoyu Li Geetu Tuteja Jonathan Schug Klaus H. Kaestner | 2012 | Cell2012，，1： | 2 |
| 13 | Influence of fading on characteristics of thermal analysis curve of compacted graphite iron显示文摘In general, during the production of compacted graphite iron (CGI), the active residual magnesium reduces and the effect of inoculation fades after magnesium treatment. In this paper, characteristics of the thermal analysis curve of CGI are compared with those of ductile iron and grey cast iron. The fading effect on the compacted graphite percentage and thermal analysis curve were also studied. Results indicate that the undercooling of CGI is as low as that of ductile iron, but CGI shows evident recalescence. In fading process, the magnesium element acts with oxygen. For a decrease in magnesium content, both the compacted graphite percentage and the austenitic liquidus temperature increase. The temperature of eutectic undercooling (TEU) decreases before the flake graphite appears. After that, TEU increases quickly, up to as high as 20℃, and then gradually decreases. The evolution of recalescence degree is opposite to that of TEU. | Liu Jinhai Yi Litao Li Guolu Liu Changqi Li Yinguo Yang Zhaoyu | 2011 | China Foundry2011，8，3： | 2 |
| 14 | Social insights on the implementation of One Health in zoonosis prevention and control: a scoping review显示文摘Background:The One Health (OH) concept has been promoted widely around the globe. OH framework is expected to be applied as an integrated approach to support addressing zoonotic diseases as a significant global health issue and to improve the efficiency and effectiveness of zoonosis prevention and control. This review is intended to overview the social impact of the implementation of OH on zoonosis prevention and control.Methods:A scoping review of studies in the past 10 years was performed to overview the integration feature of OH in zoonosis prevention and control and the social impacts of OH. PubMed and Web of Science were searched for studies published in English between January 2011 and June 2021. The included studies were selected based on predefined criteria.Results:Thirty-two studies were included in this review, and most of them adopted qualitative and semi-qualitative methods. More than 50% of the studies focused on zoonosis prevention and control. Most studies were conducted in low- and middle-income countries in Africa and Asia. Applying OH approach in diseases control integrates policymakers, stakeholders, and academics from various backgrounds. The impact of OH on economic is estimated that it may alleviate the burden of diseases and poverty in the long term, even though more financial support might be needed at the initial stage of OH implementation. OH implementation considers social and ecological factors related to zoonosis transmission and provides comprehensive strategies to assess and address related risks in different communities according to regions and customs.Conclusions:Based on reviewed literature, although there seems to be a lack of guidelines for assessing and visualizing the outcomes of OH implementation, which may limit the large-scale adoption of it, evidence on the contributions of implementing OH concepts on zoonosis prevention and control indicates long-term benefits to society, including a better integration of politics, stakeholders and academics to improve their cooperation, a potential to address economic issues caused by zoonosis, and a comprehensive consideration on social determinants of health during zoonosis prevention and control. | Junyi He Zhaoyu Guo Pin Yang Chunli Cao Jing Xu Xiaonong Zhou Shizhu Li | 2022 | Infectious Diseases of Poverty2022，11，3： | 1 |
| 15 | Clinical features and risk factors for post-partum depression in a large cohort of Chinese women with recurrent major depressive disorder显示文摘 | Tian Tian Yihan Li Dong Xie Yifeng Shen Jianer Ren Wenyuan Wu Chengbin Guan Zhen Zhang Danning Zhang Chengge Gao Xiaoming Zhang Jinbo Wu Hong Deng Gang Wang Yunshu Zhang Yun Shao Han Rong Zhaoyu Gan Yan Sun Bin Hu Jiyang Pan Yi Li Shufan Sun Libo Song Xue | 2011 | Journal of Affective Disorders2011，，3： | 1 |
| 16 | Experimental Study on Frost heave of Silty Clay in Seasonally Frost Soil Regions显示文摘 | ZHAO Huixin WU Zhiqin LI Zhaoyu | 2012 | Procedia Engineering2012，，28： | 1 |
| 17 | Phosphatidylcholine and choline homeostasis 显示文摘 | Li Zhaoyu Vance DE | 2008 | Journal of Lipid Re- search2008，49，6： | 1 |
| 18 | Highly time-resolved aerosol characteristics during springtime in Weizhou Island显示文摘A single particle aerosol mass spectrometer was deployed to measure the changes of single particle species and sizes during March 2015 in Weizhou Island of the Beibu Gulf, Guangxi province, South China. In this campaign, a total of 3,100,597 particles were sized, and 25.8%particles with both positive and negative mass spectrum were collected and 24.8%characterized in combination with the ART-2 a neural network algorithm. The distribution of sized particles was mainly in from 520 to 600 nm, and the diameters ranging from 340 to1000 nm accounted for above 90%. Eight types of particles were classified: Elemental Carbon containing(EC), Organic Carbon containing(OC), EC and OC combined containing particles,Na containing particles, K containing particles(K), Levoglucosan containing particles,mineral containing particles, and Heavy Metal containing particles(HM). EC, OC and K were the major containing particles, which accounted for 84.3% in the eight types particles. The relative ratio and size distribution of the three types were EC(48.1%, 620 nm), OC(12.7%,440 nm), and K(23.5%, 600 nm), respectively. The three types of particles were a bit increasing ratios compared with those in clean periods during haze pollution periods.Combined with the back-trajectory results from the Hysplit-4 model and local pollution sources revealed that the ambient air quality on the Weizhou Island may be influenced by biomass burning in the Indochina Peninsula(biomass burning in the Indochina Peninsula)from the transportation on higher level atmospheric layer and by mainland of south China located northeast of Weizhou Island on the ground. | Jingying Mao Zhiming Chen Zhaoyu Mo Xiaoyang Yang Hong Li Yonglin Liu Huilin Liu Jiongli Huang Junchao Yang Hongjiao Li | 2018 | Journal of Environmental Sciences2018，30，10： | 1 |
| 19 | Regulation of the macrophage-related inflammatory microenvironment for atherosclerosis treatment and angiogenesis via anti-cytokine agents显示文摘Macrophages-mediated atherosclerosis(AS)is an inflammatory disease and the most common cause of ischemia.With the progress of basic and clinical research,anti-cytokine therapy has garnered considerable attention of the research community for the regulation of the inflammatory microenvironment for AS treatment.Despite of their promising potential,primary clinical trials have revealed that anti-cytokine drugs exhibit poor selectivity and thus affect other parts of the immune system,especially during long-term management.To circumvent these limitations,herein we exploited mesoporous silica nanoparticles(MSNs)with a pore size of 15.5 nm as carriers for the anti-interleukin-1β(anti-IL-1β)delivery to be the anti-cytokine agents.In vitro mechanistic studies indicated that the MSNs@anti-IL-1βcan regulate the macrophage-related inflammatory microenvironment,promote the viability of vascular endothelial cells(vECs),and reduce proliferation and phenotypic switching of vascular smooth muscle cells(vSMCs).In vivo evaluation further revealed that the MSNs@anti-IL-1βwere preferentially accumulated in macrophages,impeding the AS progress by maintaining the endothelium integrity and inhibiting the vSMCs proliferation.Besides,MSNs@antiIL-1βinduced neovascularization and improved hindlimb ischemia regeneration.Taken together,these MSNs affording the sustained release of anti-cytokine agents may have broad implications for the clinical management of the AS,including the reduction of the AS progression and alleviation of the ischemia. | Hongji Pu Minghua Yao Zhaoyu Wu Zhijue Xu Chaoyi Cui Renhua Huang Muhammad Shafiq Weimin Li Xinwu Lu Bo Li | 2022 | Nano Research2022，15，8： | 1 |
| 20 | The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis显示文摘 | Zhaoyu Li Luis B. Agellon Theresa M. Allen Masato Umeda Larry Jewell Andrew Mason Dennis E. Vance | 2006 | Cell Metabolism2006，，5： | 1 |
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