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| 1 | Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase显示文摘genomic DNA 的 Cytosine methylation 控制基因表示并且维持染色体稳定性。一个特定的 DNA 序列怎么被 methyltransferase 为 methylation 指向,大部分是未知的。这里,我们证明 histone H3 跟踪缺乏离氨酸 4 (K4 ) methylation 功能作为为由到它的植物 homeodomain (哲学博士) 的绑定的 methyltransferase Dnmt3a 的 allosteric 使活跃之物。在 vitro, histone H3 肽相对地刺激了 Dnmt3a 的 methylation 活动直到 8 褶层,以一种方式与 K4 methylation 的水平相关。allosteric 规定的生物意义被在 PHD 和其变化由 H3 肽然而并非 H3 肽的绑定损害了 methylation 活动的刺激的 Dnmt3a 的催化领域的分子的建模和关键残余的鉴定表明。显著地,这些变异的 Dnmt3a 蛋白质在 DNA methylation 是几乎不活跃的当他们到 genomic 的招募指向时,什么时候在老鼠表示了胚胎的干细胞,是未改变的。我们因此为 de novo DNA methylation 建议二拍子的圆舞机制 - 染色质绑定或 DNA 有约束力的因素可能帮助的 methyltransferase 的第一招募,然后取决于在 Dnmt3a 和 histone 之间的相互作用的 allosteric 激活跟踪 - 后者可能为 methylation 活动用作一个检查点。 | Bin-Zhong Li Zheng Huang Qing-Yan Cui Xue-Hui Song Lin Du Albert Jeltsch Ping Chen Guohong Li En Li Guo-Liang Xu | 2011 | Cell Research2011，21，8： | 17 |
| 2 | In situ stabilization remediation of cadmium contaminated soils of wastewater irrigation region using sepiolite显示文摘The effects of immobilization remediation of Cd-contaminated soils using sepiolite on soil pH,enzyme activities and microbial communities,TCLP-Cd(toxicity characteristic leaching procedure-Cd) concentration,and spinach(Spinacia oleracea) growth and Cd uptake and accumulation were investigated.Results showed that the addition of sepiolite could increase soil pH,while the TCLP-Cd concentration in soil was decreased with increasing sepiolite.The changes of soil enzyme activities and bacteria number indicated that a certain metabolic recovery occurred after the sepiolite treatments,and spinach shoot biomass increased by 58.5%-65.5% in comparison with the control group when the concentration of sepiolite was 10 g/kg.However,the Cd concentrations in the shoots and roots of spinach decreased with an increase in the rate of sepiolite,experiencing 38.4%-59.1% and 12.6%-43.6% reduction,respectively,in contrast to the control.The results indicated that sepiolite has the potential for success on a field scale in reducing Cd entry into the food chain. | Yuebing Sun Guohong Sun Yingming Xu Lin Wang Dasong Lin Xuefeng Liang Xin Shi | 2012 | Journal of Environmental Sciences2012，24，10： | 11 |
| 3 | A hypersonic target coherent integration detection algorithm based on Doppler feedback显示文摘The traversal search of multi-dimensional parameter during the process of hypersonic target echo signal coherent integration,leads to the problem of large amounts of calculation and poor real-time performance.In view of these problems,a modified polynomial Radon-polynomial Fourier transform(MPRPFT)hypersonic target coherent integration detection algorithm based on Doppler feedback is proposed in this paper.Firstly,the Doppler estimation value of the target is obtained by using the target point information obtained by subsequent non-coherent integration detection.Then,the feedback adjustment of the coherent integration process is performed by using the acquired target Doppler estimation value.Finally,the coherent integration is completed after adjusting the search interval of compensation.The simulation results show that the algorithm can effectively reduce the computational complexity and improve the real-time performance on the basis of the effective coherent integration of hypersonic target echo signals. | LI Lin WANG Guohong SUN Dianxing ZHANG Xiangyu | 2020 | Journal of Systems Engineering and Electronics2020，31，1： | 6 |
| 4 | Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: A randomized phase III trial显示文摘 | Masatoshi Kudo Guohong Han Richard S. Finn Ronnie T.P. Poon Jean‐Frederic Blanc Lunan Yan Jijin Yang Ligong Lu Won‐Young Tak Xiaoping Yu Joon‐Hyeok Lee Shi‐Ming Lin Changping Wu Tawesak Tanwandee Guoliang Shao Ian B. Walters Christine Dela Cruz Valerie Po | 2014 | Hepatology2014，，5： | 1 |
| 5 | Sorption of lead ion by layered double hydroxide intercalated with diethylenetriaminepentaacetic acid显示文摘 | Xuefeng Liang Wanguo Hou Yingming Xu Guohong Sun Lin Wang Yang Sun Xu Qin | 2010 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2010，，1： | 1 |
| 6 | Assessment of natural sepiolite on cadmium stabilization, microbial communities, and enzyme activities in acidic soil显示文摘 | Yuebing Sun Guohong Sun Yingming Xu Lin Wang Xuefeng Liang Dasong Lin Fazhi Hu | 2013 | Environmental Science and Pollution Research2013，，5： | 1 |
| 7 | Assessment of sepiolite for immobilization of cadmium-contaminated soils显示文摘 | Yuebing Sun Guohong Sun Yingming Xu Lin Wang Xuefeng Liang Dasong Lin | 2013 | Geoderma2013，，： | 1 |
| 8 | 新型可遗传编码的荧光探针实现在果蝇、斑马鱼和小鼠中快速特异地示踪多巴胺显示文摘文章简介多巴胺是神经系统中一种重要的单胺类神经递质,它介导了一系列重要的生理、病理过程。如何在自由活动的动物脑中特异、精准地示踪特定时间、区域的多巴胺释放是长期以来困扰神经科学家的技术难题。 | 孙芳妙 曾健智 井淼 Jingheng Zhou 冯杰思 Scott F.Owen 骆奕辰 Funing Li 王欢 Takashi Yamaguchi 雍自昊 Yijing Gao Wanling Peng Lizhao Wang Siyu Zhang Jiulin Du Dayu Lin Min Xu Anatol C.Kreitzer Guohong Cui 李毓龙 | 2019 | 科学新闻2019，0，2： | 1 |
| 9 | Role of Inflammation and Its Mediators in Acute Ischemic Stroke显示文摘 | Rong Jin Lin Liu Shihao Zhang Anil Nanda Guohong Li | 2013 | Journal of Cardiovascular Translational Research2013，，5： | 1 |
| 10 | Assessment of sepiolite for immobilization of cadmium-contaminated soils显示文摘 | Yuebing Sun Guohong Sun Yingming Xu Lin Wang Xuefeng Liang Dasong Lin | 2013 | Geoderma2013，，： | 1 |
| 11 | Erratum to:Borates as a new direction in the design of oxide ion conductors(vol 65,issue 10,page 2737,2022)显示文摘In the version of the article originally published in the volume 62,issue 10,2022 of Sci.china Mater.(page 2737-2745,http://gffzzd3cc09b8251d45dfsvuw55bxw5ppf66oo.ffgz.tsg.suse.edu.cn/10.1007/s40843-022-2044-3).The chemical shift reported in Figure 5f for the^(11)B solid-state NMR spectra is incorrect because no parameter correction was performed during data processing. | Xiaohui Li Li Yang Zhenyu Zhu Xiaoge Wang Bohua Chen Senchuan Huang Xianyi Wei Guohong Cai Pascal Manuel Sihai Yang Jianhua Lin Xiaojun Kuang Junliang Sun | 2022 | Science China Materials2022，65，11： | 0 |
| 12 | SARS-CoV-2-specific immune response in COVID-19 convalescent individuals显示文摘We collected blood from coronavirus disease 2019(COVID-19)convalescent individuals and investigated SARS-CoV-2-specific humoral and cellular immunity in these discharged patients.Follow-up analysis in a cohort of 171 patients at 4-11 months after the onset revealed high levels of IgG antibodies.A total of 78.1%(164/210)of the specimens tested positive for neutralizing antibody(NAb).SARS-CoV-2 antigen peptide pools-stimulated-IL-2 and-IFN-y response can distinguish COVID-19 convalescent individuals from healthy donors.Interestingly,NAb survival was significantly affected by the antigen peptide pools-stimulated-IL-2 response,-IL-8 response,and-IFN-y response.The antigen peptide pools-activated CD8+T cell counts were correlated with NAb.The antigen peptide pools-activated natural killer(NK)cell counts in convalescent individuals were correlated with NAb and disease severity.Our data suggested that the development of NAb is associated with the activation of T cells and NK cells.Our work provides a basis for further analysis of the protective immunity to SARS-CoV-2 and for understanding the pathogenesis of COVID-19.It also has implications for the development of an effective vaccine for SARS-CoV-2 infection. | Yunbao Pan Xianghu Jiang Liu Yang Liangjun Chen Xiaojiao Zeng Guohong Liu Yueting Tang Chungen Qian Xinming Wang Fangming Cheng Jun Lin Xinghuan Wang Yirong Li | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 13 | Correction:SARS-CoV-2-specific immune response in COYID-19 convalescent individuals显示文摘After online publication of the article1 the authors noticed an error in the figure legends of Fig.1 and Supplementary Materials Fig.S2,where the'*P<0.05,0.05<**P<0.001,***P<0.001W.should be replaced by n*P<0.05,**P<0.01,***P<0.001M.The original article has been corrected. | Yunbao Pan Xianghu Jiang Liu Yang Liangjun Chen Xiaojiao Zeng Guohong Liu Yueting Tang Chungen Qian Xinming Wang Fangming Cheng Jun Lin Xinghuan Wang Yirong Li | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 14 | Total Maximum Allocated Loads on Stoichiometry of Nitrogen and Identification of Critical Form in Jiaozhou Bay, China显示文摘Total pollutant load control management for total dissolved nitrogen(TDN) is an urgent task required to gain a good water quality status in Jiaozhou Bay(JZB), China. In this paper, the stoichiometry of multiform TDN on land-ocean interactions associated with marine biogeochemical reaction(LOIMBR) was studied by modeling the load-response relationship based on a three-dimensional water quality model of nitrogen in JZB. The results showed that the stoichiometry on LOIMBR of dissolved organic nitrogen(DON), NO3-N and NH4-N was 3:1:1, with one-third of the contribution on the concentration of dissolved inorganic nitrogen(DIN) in JZB for the land-based DON loads to DIN loads. Based on the stoichiometric relationship of nitrogen forms, the total maximum allocated load(TMAL) of equivalent TDN(ETDN) was approximately 5300 t a^-1 in JZB, equivalent to the TMAL of 5700, 5800 and 15600 t a^-1 for NH4-N, NO3-N and DON, respectively. According to the loads of ETDN, there were four outfalls overloaded in JZB in 2015, which lie in the head of the bay. In the four overloaded outfalls, besides NO3-N, NH4-N was the critical nitrogen control form for Moshui River, while DON for Dagu River and Haibo River. The results of numerical experiments further showed that JZB will achieve good water quality after 7 years by implementation of the 'different emission reduction' based on TMAL of ETDN, which is significantly better than 'equal percent removal'. | LIN Guohong SONG Xianli LU Dongliang LI Keqiang LIANG Shengkang WANG Xiulin | 2020 | Journal of Ocean University of China2020，19，3： | 0 |
| 15 | Achieving ultrahigh electrochemical performance by surface design and nanoconfined water manipulation显示文摘The effects of nanoconfined water and the charge storage mechanism are crucial to achieving the ultrahigh electrochemical performance of two-dimensional transition metal carbides(MXenes). We propose a facile method to manipulate nanoconfined water through surface chemistry modification. By introducing oxygen and nitrogen surface groups, more active sites were created for TiCMXene, and the interlayer spacing was significantly increased by accommodating three-layer nanoconfined water. Exceptionally high capacitance of 550 F g(2000 F cm) was obtained with outstanding high-rate performance. The atomic scale elucidation of the layer-dependent properties of nanoconfined water and pseudocapacitive charge storage was deeply probed through a combination of ‘computational and experimental microscopy’. We believe that an understanding of, and a manipulation strategy for, nanoconfined water will shed light on ways to improve the electrochemical performance of MXene and other two-dimensional materials. | Haisheng Li Kui Xu Pohua Chen Youyou Yuan Yi Qiu Ligang Wang Liu Zhu Xiaoge Wang Guohong Cai Liming Zheng Chun Dai Deng Zhou Nian Zhang Jixin Zhu Jinglin Xie Fuhui Liao Hailin Peng Yong Peng Jing Ju Zifeng Lin Junliang Sun | 2022 | National Science Review2022，9，6： | 0 |
| 16 | 可遗传编码的荧光探针用于在体快速特异地检测去甲肾上腺素显示文摘文章简介在人的神经系统中有数十亿个神经元,这些细胞主要通过神经递质的释放和感知完成相互之间的通讯。去甲肾上腺素(Norepinephrine,NE)是一种单胺类的神经递质,它作用于多种肾上腺素受体。在中枢神经系统和交感神经系统中都参与诸多必要的生理过程,如感觉信号的调节、注意力的调控、清醒与睡眠、学习与记忆等。 | 冯杰思 Changmei Zhang Julieta E.Lischinsky Miao Jing Jingheng Zhou Huan Wang Yajun Zhang Ao Dong Zhaofa Wu Hao Wu Weiyu Chen Peng Zhang Jing Zou S.Andrew Hires J.Julius Zhu Guohong Cui Dayu Lin Jiulin Du 李毓龙 | 2020 | 科学新闻2020，，2： | 0 |
| 17 | Ultrafast photocarrier and coherent phonon dynamics in type-II Dirac semimetal PtTe2 thin films probed by optical spectroscopy显示文摘We report the ultrafast photocarrier dynamics and coherent phonon excitation in type-II Dirac semimetal platinum ditelluride(PtTe2)thin films via femtosecond(fs)pump-probe spectroscopy at room temperature.Quantitative analysis revealed that the incoherent electronic relaxation consists of two components:a subpicosecond fast relaxation process and a slow component with a time constant of hundreds of picoseconds(ps).Furthermore,the launch of a coherent acoustic phonon(CAP)in the 20 nm film but absence in the 6.8 nm film uncovers the dominant role of temperature gradient in producing a strain wave.The sound velocity and Young’s modulus in the thick PtTe_(2) are determined to be 1.736 km/s and 29.5 GPa,respectively.In addition,the coherent optical phonon(COP)with a frequency of 4.7 THz corresponding to Te atoms out-of-plane A1g vibration has been well resolved in all films,which is ascribed to displacive excitation of coherent phonon(DECP).The observation of a strong probe-wavelength dependent COP amplitude reveals the resonant feature of the optical excitation-induced atomic displacement in PtTe2.Our findings provide deep insight into the excitation and dynamics of CAP and COP as well as the photocarriers’recovery pathway and lifetimes in PtTe_(2).Our study also demonstrates that the COP spectroscopy is a powerful tool to reveal the modulation of frequency-dependent optical constants induced by atomic vibrations,which may find applications in the fields of optoelectronics and ultrafast photonics. | Peng Suo Shengnan Yan Ruihua Pu Wenjie Zhang Di Li Jiaming Chen Jibo Fu Xian Lin Feng Miao Shi-Jun Liang Weimin Liu Guohong Ma | 2022 | Photonics Research2022，10，3： | 0 |
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