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| 1 | Platelet-to-lymphocyte ratio in the setting of liver transplantation for hepatocellular cancer: A systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on platelet-to-lymphocyte ratio(PLR) as a risk factor for post-transplant hepatocellular cancer(HCC) recurrence. METHODS A systematic literature search was performed using PubM ed. Participants of any age and sex, who underwent liver transplantation for HCC were considered following these criteria:(1) studies comparing pre-transplant low vs high PLR values;(2) studies reporting post-transplant recurrence rates; and(3) if more than one study was reported by the same institute, only the most recent was included. The primary outcome measure was set for HCC recurrence after transplantation. RESULTS A total of 5 articles, published between 2014 and 2017, fulfilled the selection criteria. As for the quality of the reported studies, all the investigated articles presented an overall high quality. A total of 899 cases were investigated: 718 cases(80.0%) were males. Three studies coming from European countries and one from Japan presented HCV as the main cause of cirrhosis. On the opposite, one Chinese study presented a greater incidence of HBV-related cirrhotic cases. In all the studies apart one, the PLR cut-off value of 150 was reported. At meta-analysis, high PLR value was associated with a significant increase in recurrence after transplantation(OR = 3.33; 95%CI: 1.78-6.25; P < 0.001). A moderate heterogeneity was observed among the identified studies according to the Higgins I^2 statistic value.CONCLUSION Pre-transplant high PLR values are connected with an increased risk of post-operative recurrence of hepatocellular cancer. More studies are needed for better clarify the biological mechanisms of this results. | Quirino Lai Fabio Melandro Zoe Larghi Laureiro Francesco Giovanardi Stefano Ginanni Corradini Flaminia Ferri Redan Hassan Massimo Rossi Gianluca Mennini | 2018 | World Journal of Gastroenterology2018，24，15： | 19 |
| 2 | Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy显示文摘Some authors have suggested that intraductal papillary mucinous neoplasms of the bile duct(IPMN-B) could be the the biliary counterpart of IPMN of the pancreas(IPMN-P) since they share several clinical-pathological features.These include prominent intraductal papil-lary proliferation pattern,a gastrointestinal phenotype,frequent mucin hyper-secretion and progression to mu-cinous carcinoma.To date there are just four reported cases of patients with synchronous IPMN-B and IPMN-P all of which were treated surgically.We hereby report the case of a 76-year-old woman who was incidentally diagnosed with both an asymptomatic 3 cm bulky uid lesion obstructing the bile duct lumen,diagnosed as a malignant IPMN-B,and synchronous multiple pancreatic cystic lesions(10-13 mm) communicating with an irreg-ular Wirsung,diagnosed as branch duct IPMN-P.Since surgery was ruled-out because of the patient's age and preferences,she underwent a conservative manage-ment regimen comprising both chemotherapy and radio-therapy.This was effective in decreasing the mass size and in resolving subsequent jaundice.This is also the f irst reported case of IPMN-B successfully treated with chemoradiotherapy.Clinicians should consider medical treatment as an option in this clinical scenario,in pa-tients who may be unf it for surgery. | Roberto Valente Gabriele Capurso Paola Pierantognetti Elsa Iannicelli Matteo Piciucchi Adriana Romiti Paolo Mercantini Alberto Larghi Giulia Francesca Federici Viola Barucca Maria Falchetto Osti Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，2： | 13 |
| 3 | Hypothermic oxygenated perfusion for a steatotic liver graft显示文摘To the Editor:Donor steatosis represents a well-known risk factor for primary non-function,early allograft dysfunction,and biliary complications after liver transplantation(LT)[1,2].Recently,machine perfusion(MP)technology has been implemented in the clinical practice,with the primary intent to assess the graft quality and to optimize the organ selection process[3].A limited number of articles has been published specifically investigated the role of MP in steatotic livers[4–10],with few of them looking at the role of hypothermic MP. | Quirino Lai Franco Ruberto Fabio Melandro Zoe Larghi Laureiro Massimo Rossi Gianluca Mennini | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 7 |
| 4 | The role of K- ras gene mutation analysis in EUS-guided FNA cytology specimens for the differential diagnosis of pancreatic solid masses: a meta-analysis of prospective studies显示文摘 | Lorenzo Fuccio Cesare Hassan Liboria Laterza Loredana Correale Nico Pagano Paolo Bocus Carlo Fabbri Antonella Maimone Vincenzo Cennamo Alessandro Repici Guido Costamagna Franco Bazzoli Alberto Larghi | 2013 | Gastrointestinal Endoscopy2013，，： | 4 |
| 5 | Uncommon indications for associating liver partition and portal vein ligation for staged hepatectomy:a systematic review显示文摘Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)represents an innovative surgical technique used for the treatment of large hepatic lesions at high risk for post-resection liver failure due to a small future liver remnant.The most significant amount of literature concerns the use of ALPPS for the treatment of hepatocellular carcinoma(HCC),cholangiocarcinoma(CCC),and colorectal liver metastases(CRLM).On the opposite,few is known about the role of ALPPS for the treatment of uncommon liver pathologies.The objective of the present study was to evaluate the current literature on this topic.A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines.Eligible articles published up to February 2020 were included using the MEDLINE,Scopus,and Cochrane databases.Among the 486 articles screened,45 papers met the inclusion criteria,with 136 described cases of ALPPS for rare indications.These 136 cases were reported in 18 different countries.Only in two countries,namely Germany and Brazil,more than ten cases were observed.As for the ALPPS indications,we reported 41(30.1%)cases of neuroendocrine tumor(NET)metastases,followed by 27(19.9%)cases of gallbladder cancer(GBC),nine(6.6%)pediatric cases,six(4.4%)gastrointestinal stromal tumors,six(4.4%)adult cases of benign primary liver disease,four(2.9%)adult cases of malignant primary liver disease,and 43(31.6%)adult cases of malignant secondary liver disease.According to the International ALPPS Registry data,less than 10%of the ALPPS procedures have been performed for the treatment of uncommon liver pathologies.NET and GBC are the unique pathologies with acceptable numerosity.ALPPS for NET appears to be a safe procedure,with satisfactory long-term results.On the opposite,the results observed for the treatment of GBC are poor.However,these data should be considered with caution.The rationale for treating benign pathologies with ALPPS appears to be weak.No definitive response should be given for all the other pathologies.Multicenter studies are needed with the intent to clarify the potentially beneficial effect of ALPPS for their treatment. | Quirino Lai Gianluca Mennini Zoe Larghi Laureiro Massimo Rossi | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 4 |
| 6 | Feasibility and yield of a novel 22-gauge histology EUS needle in patients with pancreatic masses: a multicenter prospective cohort study显示文摘 | Alberto Larghi Julio Iglesias-Garcia Jan-Werner Poley Geneviève Monges Maria Chiara Petrone Guido Rindi Ihab Abdulkader Paolo Giorgio Arcidiacono Guido Costamagna Katharina Biermann Erwan Bories Claudio Doglioni J. Enrique Dominguez-Mu?oz Cesare Hassan Ma | 2013 | Surgical Endoscopy2013，，10： | 3 |
| 7 | Successful endoscopic closure of a lateral duodenal perforation at ERCP with fibrin glue显示文摘 | Massimiliano Mutignani Federico Iacopini Stefanos Dokas Alberto Larghi Pietro Familiari Andrea Tringali Guido Costamagna | 2006 | Gastrointestinal Endoscopy2006，，4： | 2 |
| 8 | Endoscopic direct cholangioscopy by using an ultra-slim upper endoscope: a feasibility study显示文摘 | Alberto Larghi Irving Waxman | 2006 | Gastrointestinal Endoscopy2006，，6： | 2 |
| 9 | Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline显示文摘 | J.-M. Dumonceau M. Polkowski A. Larghi P. Vilmann M. Giovannini J.-L. Frossard D. Heresbach B. Pujol G. Fernández-Esparrach E. Vazquez-Sequeiros A. Ginès | 2011 | Endoscopy2011，，10： | 2 |
| 10 | Endoscopic ultrasound fine needle aspiration:Technique and applications in clinical practice显示文摘Since its initial report in 1992,endoscopic ultrasoundguided fine needle aspiration(EUS-FNA) has now been incorporated into the diagnostic and staging algorithm for the evaluation of benign and malignant diseases of the gastrointestinal tract and of adjacent organs.Its introduction constitutes a major breakthrough in the endoscopic field and has gradually transformed EUS from a pure imaging modality into a more interventional procedure.In addition,the possibility of collecting samples,providing a definitive cytological and/or histological evidence of the presence of malignancy,has strongly contributed to changing EUS from a subjective,highly operator dependant procedure into a more objective one.This article will review the instrumentation,technique and the most important clinical applications of EUS-FNA. | Benjamin Tharian Fotios Tsiopoulos Nayana George Salvatore Di Pietro Fabia Attili Alberto Larghi | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，12： | 2 |
| 11 | Outcome of an outbreak of acute hepatitis C among healthy volunteers participating in pharmacokinetics studies显示文摘 | Alberto Larghi Massimo Zuin Andrea Crosignani Maria Lisa Ribero Cristina Pipia Pier Maria Battezzati Giorgio Binelli Francesco Donato Alessandro Remo Zanetti Mauro Podda Alessandro Tagger | 2002 | Hepatology2002，，4： | 1 |
| 12 | State of the art on endoscopic mucosal resection and endoscopic submucosal dissection 显示文摘 | Larghi A Waxman I | 2007 | Gastrointest Endosc Clin N Am2007，17，3： | 1 |
| 13 | Divergent effects of hy- poxia on dendritic cell functions 显示文摘 | Mancino A Schioppa T Larghi P | 2008 | Blood2008，112，9： | 1 |
| 14 | Modulators of complement activation: a patent review (2008-2013) 显示文摘 | Larghi EL Kaufman TS | 2014 | Expert Opin Ther Pat2014，24，6： | 1 |
| 15 | Screening for Pancreatic cancer in high-risk individuals: A call for endoscopic ultrasound显示文摘 | larghi A Vema EC Lecca PG | 2009 | Clin Cancer Re''s2009，15，6： | 1 |
| 16 | Macrophage polarization in tumour progression显示文摘 | Sica A Larghi P Mancino A | 2008 | Semin Cancer Biol2008，18，5： | 1 |
| 17 | Tumor promotion by tumor-associated macrophages显示文摘 | Porta C Subhra Kumar B Larghi P | 2007 | Adv Exp Med Biol2007，604，： | 1 |
| 18 | Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline显示文摘 | J.-M. Dumonceau M. Polkowski A. Larghi P. Vilmann M. Giovannini J.-L. Frossard D. Heresbach B. Pujol G. Fernández-Esparrach E. Vazquez-Sequeiros A. Ginès | 2011 | Endoscopy2011，，10： | 1 |
| 19 | Macrophage polarization in tumor progression显示文摘 | Sica A Larghi P Mancino A | 2008 | Semin Cancer Biol2008，18，5： | 1 |
| 20 | Macrophage polarization in tumour progression显示文摘 | Sica A Larghi P Mancino A | 2008 | Semin Cancer Biol2008，18，5： | 1 |
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