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| 1 | Mesenteric ischemia:Pathogenesis and challengingdiagnostic and therapeutic modalities显示文摘Mesenteric ischemia(MI) is an uncommon medical condition with high mortality rates. ΜΙ includes inadequate blood supply, inflammatory injury and eventually necrosis of the bowel wall. The disease can be divided into acute and chronic MI(CMI), with the first being subdivided into four categories. Therefore, acute MI(AMI) can occur as a result of arterial embolism, arterial thrombosis, mesenteric venous thrombosis and nonocclusive causes. Bowel damage is in proportion to the mesenteric blood flow decrease and may vary from minimum lesions, due to reversible ischemia, to transmural injury, with subsequent necrosis and perforation. CMI is associated to diffuse atherosclerotic disease in more than 95% of cases, with all major mesenteric arteries presenting stenosis or occlusion. Because of a lack of specific signs or due to its sometime quiet presentation, this condition is frequently diagnosed only at an advanced stage. Computed tomography(CT) imaging and CT angiography contribute to differential diagnosis and management of AMI. Angiography is also the criterion standard for CMI, with mesenteric duplex ultrasonography and magnetic resonance angiography also being of great importance. Therapeutic approach of MI includes both medical and surgical treatment. Surgical procedures include restoration of the blood flow with arteriotomy, endarterectomy or anterograde bypass, while resection of necrotic bowel is always implemented. The aim of this review was to evaluate the results of surgical treatment for MI and to present the recent literature in order to provide an update on the current concepts of surgical management of the disease. Mesh words selected include MI, diagnostic approach and therapeutic management. | Aikaterini Mastoraki Sotiria Mastoraki Evgenia Tziava Stavroula Touloumi Nikolaos Krinos Nikolaos Danias Andreas Lazaris Nikolaos Arkadopoulos | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 23 |
| 2 | Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer显示文摘瞄准:在象 interleukin ( IL )那样的煽动性的反应相关的基因调查在普通单个核苷酸多型性( SNP )之间的协会-6, IL-8 ,肿瘤坏死因素高山哈( TNFalpha ), peroxisome 激活proliferators 的受体鲸鱼群妈( PPARgamma ),细胞间的粘附 molecule-1 ( ICAM-1 )和颜色的风险在一组希腊病人的表面的癌症( CRC )。方法:学习组由 222 个 CRC 病人和 200 健康控制组成了。Genotyping 用 PRC-RFLP 的等位基因特定的 PCR 被执行,结果被定序证实。我们在 IL-6 学习了 SNP 的协会(-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G 和 K469E ) ,和 PPARgamma (Pro12Ala ) 基因和 CRC 的风险。结果:ICAM-1 的 IL-6 -174G, R241 和 K469 等位基因与 CRC 的增加的风险被联系(或 = 1.77, 95% CI:1.34-2.34;或 = 1.83, 95% CI:1.23-2.72;并且或 = 1.35, 95% CI:1.03-1.77 分别地) 。IL-8 和 TNFalpha 多型性没有效果。而 PPARgamma Pro12 遗传型与疾病的增加的风险被联系(或 = 1.78, 95% CI:1.25-2.49 ) 。结论:在在免疫逻辑的普通 SNP 之间的协会反应相关的基因和 CRC 在现在的学习被报导。除了使恶意开始和前进的机制清楚些, SNP 可以改进在风险的为亚人口的适当屏蔽。 | George Theodoropoulos Ioannis Papaconstantinou Evangelos Felekouras Nikolaos Nikiteas Petros Karakitsos Dimitris Panoussopoulos Andreas Ch Lazaris Efstratios Patsouris John Bramis Maria Gazouli | 2006 | World Journal of Gastroenterology2006，12，31： | 16 |
| 3 | Facing the challenge of venous thromboembolism prevention in patients undergoing major abdominal surgical procedures for gastrointestinal cancer显示文摘Venous thromboembolism(VTE)refers to a hypercoa-gulable state that remains an important and preven-table factor in the surgical treatment of malignancies.VTE includes two identical entities with regards to deep vein thrombosis and pulmonary embolism.The incidence of VTE after major abdominal interventions for gastro-intestinal,hepato-biliary and pancreatic neoplastic disor-ders is as high as 25%without prophylaxis.Prophylactic use of classic or low-molecular-weight heparin,anti-Xa factors,antithrombotic stocking,intermittent pneumatic compression devices and early mobilization have been described.Nevertheless,thromboprophylaxis is often dis-continued after discharge,although a serious risk may persist long after the initial triggering event,as the coagu-lation system remains active for at least 14 d post-opera-tively.The aim of this review is to evaluate the results of the current practice of VTE prevention in cancer patients undergoing major abdominal surgical operations,with special attention to adequately elucidated guidelinesand widely accepted protocols.In addition,the recent literature is presented in order to provide an update on the current concepts concerning the surgical manage-ment of the disease. | Aikaterini Mastoraki Sotiria Mastoraki Dimitrios Schizas Raphael Patras Nikolaos Krinos Ioannis S Papanikolaou Andreas Lazaris Theodore Liakakos Nikolaos Arkadopoulos | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 7 |
| 4 | Histologic features and genomic alterations of primary colorectal adenocarcinoma predict growth patterns of liver metastasis显示文摘BACKGROUND Different histological growth patterns(HGPs)of colorectal carcinoma(CRC)liver metastasis are associated with patients’prognosis and response to antiangiogenic therapy.However,the relationship between HGPs of liver metastasis and clinicopathological and genomic characteristics of primary cancer has not been well established.AIM To assess whether certain clinicopathological and genomic features of primary CRC could predict the HGPs of liver metastasis.METHODS A total of 29 patients with paired resections of both primary CRC and liver metastasis were divided into two groups:A(15 cases with desmoplastic liver metastasis)and B(14 cases with replacement liver metastasis).Clinical information was obtained from patients’charts.Mismatch repair proteins,BRAFV600E,and PD-L1 were evaluated by immunohistochemistry.Five cases were selected randomly from each group for whole exome sequencing(WES)analysis.RESULTS In the primary tumor,expanding growth pattern,low tumor budding score(TBS),and Crohn’s disease-like response(CDR)were associated with desmoplastic liver metastasis and better overall survival,whereas infiltrating growth pattern alone of primary carcinoma could predict the replacement liver metastasis and worse overall survival(P<0.05).On WES analysis,primary carcinoma with desmoplastic liver metastasis showed mutations in APC(4/5);TP53(3/5);KRAS,PIK3CA,and FAT4(2/5);BRCA-1,BRCA2,BRAF,and DNAH5(1/5),whereas primary carcinoma with replacement liver metastasis showed mutations in APC and TP53(3/5);KRAS,FAT4,DNH5,SMAD,ERBB2,ERBB3,LRP1,and SDK1(1/5).CONCLUSION The HGPs,TBS,and CDR of primary CRC as well as the presence of specific genetic mutations such as those in PIK3CA could be used to predict the HGPs of liver metastasis,response to therapy,and patients’prognosis. | Jing-Bo Wu Ali Lopez Sarmiento Pierre-Olivier Fiset Anthula Lazaris Peter Metrakos Stephanie Petrillo Zu-Hua Gao | 2019 | World Journal of Gastroenterology2019，25，26： | 5 |
| 5 | Comparison of Monopolar Electrocoagulation, Bipolar Electrocoagulation, Ultracision, and Ligasure显示文摘 | Theodore Diamantis Michael Kontos Antonios Arvelakis Spiridon Syroukis Dimitris Koronarchis Apostolos Papalois Emmanuel Agapitos Elias Bastounis Andreas C. Lazaris | 2006 | Surgery Today2006，，10： | 2 |
| 6 | Nematode acetylcholinesterases are encoded by multiple genes and perform non-overlapping functions显示文摘 | SELKIRK M E LAZARI O HUSSEIN A S | 2005 | Chem Biol Interact2005，，： | 1 |
| 7 | Effect of dental surface treatment with Nd:YAG and Er:YAG lasers on bond strength of resin composite to recently bleached enamel显示文摘 | Rocha Gomes Torres C Caneppele TM Del Moral de Lazari R | 2012 | Laser Med Sci2012，27，4： | 1 |
| 8 | Chordoma of the sacrum:'en bloc' total sacrectomy and lumbopelvic reconstraction显示文摘 | Varga PP Lazary A | 2010 | Eur Spine J2010，19，6： | 1 |
| 9 | Immunohistochemical expression of C-rays oncogene, heat shock protein 70 and HLA-DR molecules in malignant cutaneous melanoma显示文摘 | Lazaris AC Theodoropoulos GE Aroni K | 1995 | Vfiehous Arch1995，426，6： | 1 |
| 10 | Spider silk fibers spun from soluble recombinant silk produced in mammalian cells 显示文摘 | Lazaris A Arcidiacono S Huang Y | 2002 | Science2002，295，： | 1 |
| 11 | Atrial septal pacing to synchonize atrial deplorization in patients with delayed interatrial conduction显示文摘 | Katsivas A Manolis AG Lazaris E | 1998 | PACE1998，21，： | 1 |
| 12 | Chemical constituents from ecballium elaterium and their effects on a non-small-cell bronxhial carcinoma line显示文摘 | Lazaris D Chinou I Roussis V | 1998 | Pharm PharmacoI Lett1998，8，1： | 1 |
| 13 | Flow-divert- ing multilayer stents:a promising but questionable solution for aor- tic pathologies显示文摘 | Lazaris AM Charalampopoulos A Maheras AN | 2013 | J Endovasc Ther2013，20，3： | 1 |
| 14 | Evaluation of hypoxiainducible factor la overexpressionas a predictor of tumour recurrence and progression in superficial urothelial bladder carcinoma显示文摘 | Vasilios E Theodompoulos C Lazaris I K | 2005 | BJU International2005，95，3： | 1 |
| 15 | The favourable prognostic value of oestrogen receptor beta immunohistochemical expression in breast cancer 显示文摘 | Nakopoulou L Lazaris AC Panayotopoulou EC | 2004 | J Clin Pathol2004，57，： | 1 |
| 16 | Evaluation of hypoxia-indueible factor lalpha overexpression as a predictor of tumour recurrence and progression in superficial urothelial bladder carcinoma 显示文摘 | Theodoropoulos VE Lazaris AC Kastriotis I | 2005 | BJU Int2005，95，3： | 1 |
| 17 | The expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and angiogenesis markers in hyperplastic and malignant prostate tissue显示文摘 | Lekas A Lazaris AC Deliveliotis C | 2006 | Anticancer Res2006，26，4： | 1 |
| 18 | The role of the gypsum in bonesubstitution: molecular biological approach?based on own researchresults显示文摘 | Lazary A BaIla B Kosa Ko | 2007 | Orv Heti2007，148，51： | 1 |
| 19 | Origins and perspectives of the schizo- phrenia research 显示文摘 | Faludi G Dome P Lazary J | 2011 | Neuropsychopharmacol Hung2011，13，4： | 1 |
| 20 | Malignant transformation a eulcaryotic initiation factor subunit that binds to mRNA 5'cap显示文摘 | Lazaris Karatzas A Montine K S Sonenberg N | | 0，，： | 1 |
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