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| 1 | The Human Microbiota in Health and Disease显示文摘Trillions of microbes have evolved with and continue to live on and within human beings. A variety of environmental factors can affect intestinal microbial imbalance, which has a close relationship with human health and disease. Here, we focus on the interactions between the human microbiota and the host in order to provide an overview of the microbial role in basic biological processes and in the development and progression of major human diseases such as infectious diseases, liver diseases, gastrointestinal cancers, metabolic diseases, respiratory diseases, mental or psychological diseases, and autoimmune diseases. We also review important advances in techniques associated with microbial research, such as DNA sequencing, metabonomics, and proteomics combined with computation-based bioinformatics.Current research on the human microbiota has become much more sophisticated and more comprehensive.Therefore, we propose that research should focus on the host-microbe interaction and on causeeffect mechanisms, which could pave the way to an understanding of the role of gut microbiota in health and disease, and provide new therapeutic targets and treatment approaches in clinical practice. | Baohong Wang Mingfei Yao Longxian Lv Zongxin Ling Lanjuan Li | 2017 | Engineering2017，3，1： | 24 |
| 2 | Petrogenesis and tectonic implications of early Paleozoic granitoids in East Kunlun belt: Evidences from geochronology, geochemistry and isotopes显示文摘The East Kunlun Orogenic Belt(EKOB) provides an important link to reconstruct the evolution of the Proto-Tethys and Paleo-Tethys realm. The EKOB is marked by widespread Early Paleozoic magmatism.Here we report the petrology, bulk geochemistry, zircon Ue Pb dating and, Lue Hf and SreN d isotopic data of the Early Paleozoic granitic rocks in Zhiyu area of the southern EKOB. Based on the zircon U-Pb dating, these granitoids, consisting of diorite, granodiorite and monzogranite, were formed during 450 -430 Ma the Late Ordovician to Middle Silurian. The diorite and granodiorite are high Sr/Y ratio as adakitic affinities, and the monzogranite belongs to highly fractionated I-type. Their(^(87)Sr/^(86)Sr)ivalues range from 0.7059 to 0.7085, εNd(t) values from -1.6 to -6.0 and the zircon εHf(t) values show large variations from +9.1 to -8.6 with Hf model ages(T_(DM2)) about 848 Ma and 1970 Ma. The large variations of whole-rock Nd and zircon Hf isotopes demonstrate strong isotopic heterogeneity of the source regions which probably resulted from multi-phase underplating of mantle-derived magmas. Geochemical and isotopic studies proved that the diorite and granodiorite had been derived from partial melting of heterogeneous crustal source with variable contributions from ancient continental crust and juvenile components, and the monzogranites were representing fractional crystallization and crustal contamination for arc magma. The Early Paleozoic adakitic rocks and high-K calc-alkaline granitoids in the southern EKOB were likely emplaced in a continental marginal arc setting possibly linked to the southwards subduction of the Paleo Kunlun Ocean and the magma generation is linked to partial melting of thickened continental crust induced by underplating of mantle-derived magmas. | Guochen Dong Mingfei Luo Xuanxue Mo Zhidan Zhao Liangqiong Dong Xuehui Yu Xin Wang Xiaowei Li Xiongfei Huang Yanbin Liu | 2018 | Geoscience Frontiers2018，9，5： | 10 |
| 3 | Layered double hydroxide-based core-shell nanoarrays for efficient electrochemical water splitting显示文摘 | Wenfu Xie Zhenhua Li Mingfei Shao Min Wei | 2018 | Frontiers of Chemical Science and Engineering2018，12，3： | 9 |
| 4 | Structural Changes of Wheat Straw Lignin during Formic Acid Treatment显示文摘The aromatic nature of lignin makes it a potential renewable source of chemicals and other valuable products.Isolation of lignin from lignocellulosic biomass using organic solvents enables the production of high-purity lignin.The use of formic acid in the organosolv pulping and fractionation process has been widely studied.Characterization of lignin is necessary to achieve valueadded applications of lignin.To simplify the isolation of formic acid-treated lignin,herein,milled wheat straw lignin(MWSL) was employed as an archetype for characterization of the structural changes of lignin during formic acid treatment.The results showed that the MWSL was GSH-type(comprising p-hydroxyphenyl(H),guaiacyl(G),and syringyl(S) monolignols) and underwent structural changes during formic acid treatment.Lignin was esterified during the formic acid treatment.The content of alkyl hydroxyl groups in lignin decreased upon formic acid treatment,corresponding to an increase of the number of double bond equivalents(DBE).Lignin units with active reaction sites were liable to slight condensation,which resulted in a moderate increase of the molecular weight.The molecular weight distribution of formic acid-treated MWSL(FMWSL) was wider than that of the MWSL,although the molecular weight of both species did not differ significantly.The β-O-4 linkage in lignin was partially cleaved during formic acid treatment,resulting in the production of new phenolic structures.This improved the solubility of lignin in the cooking liquor and its reactivity for downstream applications. | RuiXue Dong XiuWen Mei Chang Ma MingFei Li YongMing Fan | 2016 | Paper And Biomaterials2016，1，2： | 5 |
| 5 | Aerosol-assisted submicronγ-Fe2O3/C spheres as a promising heterogeneous Fenton-like catalyst for soil and groundwater remediation:Transport,adsorption and catalytic ability显示文摘This research reports a novel heterogeneous Fenton-like catalyst which could freely move through the model sediments and easily seize the pollutants in addition to efficiently catalyze H2O2,well suitable for soil and groundwater remediation.Herein,submicron y-Fe2O3/C spheres were synthesized through a facile one-step aerosol-based process.In a series of column tests,these spheres exhibit better transport ability due to their optimal size,conforming to the prediction by the Tufenkji-Elimelech filtration theo ry.Meanwhile,y-Fe2O3/C spheres could act as a strong adsorbent for organic pollutants owing to the presence of carbon,thereby providing a driving force to gather contaminants into their vicinity and facilitating the reaction.In addition,immobilization of y-Fe2O3 nanoparticles into carbon spheres protects iron oxides from aggregation,and thus retains the number of active sites for catalytic decomposition of H2O2.Hence,the system containing the as-prepared y-Fe2O3/C spheres and H2O2 shows the high removal efficiency and degradation efficiency in the remediation of recalcitrant organic contaminants such as methylene blue and sulfamethoxazole. | Jingjing Zhan Mingfei Li Xiujuan Zhang Yu An Weiqi Sun Aixia Peng Hao Zhou | 2020 | Chinese Chemical Letters2020，31，3： | 3 |
| 6 | Hierarchical Carbon Microtube@Nanotube Core-Shell Structure for High-Performance Oxygen Electrocatalysis and Zn-Air Battery显示文摘Zinc-air batteries(ZABs)hold tremendous promise for clean and efficient energy storage with the merits of high theoretical energy density and environmental friendliness.However,the performance of practical ZABs is still unsatisfactory because of the inevitably decreased activity of electrocatalysts when assembly into a thick electrode with high mass loading.Herein,we report a hierarchical electrocatalyst based on carbon microtube@nanotube core-shell nanostructure(CMT@CNT),which demonstrates superior electrocatalytic activity for oxygen reduction reaction and oxygen evolution reaction with a small potential gap of 0.678 V.Remarkably,when being employed as air-cathode in ZAB,the CMT@CNT presents an excellent performance with a high power density(160.6 mW cm^−2),specific capacity(781.7 mAhgZn^−1)as well as long cycle stability(117 h,351 cycles).Moreover,the ZAB performance of CMT@CNT is maintained well even under high mass loading(3 mg cm−2,three times as much as traditional usage),which could afford high power density and energy density for advanced electronic equipment.We believe that this work is promising for the rational design of hierarchical structured electrocatalysts for advanced metal-air batteries. | Wenfu Xie Jianming Li Yuke Song Shijin Li Jianbo Li Mingfei Shao | 2020 | Nano-Micro Letters2020，12，8： | 3 |
| 7 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 8 | On the oxidation states of metal elements in MO-3(M=V,Nb,Ta,Db,Pr,Gd,Pa)anions显示文摘Relativistic quantum chemistry investigations are carried out to tackle the puzzling oxidation state problem in a series of MO_3^- trioxide anions of all d- and f-block elements with five valence electrons. We have shown here that while the oxidation states of V, Nb, Ta, Db, Pa are, as usual, all +V with divalent oxygen O(-II) in MO_3^- anions, the lanthanide elements Pr and Gd cannot adopt such high +V oxidation state in similar trioxide anions. Instead, lanthanide element Gd retains its usual +III oxidation state, while Pr retains a +IV oxidation state, thus forcing oxygen into a non-innocent ligand with an uncommon monovalent radical(O~·) of oxidation state -I. A unique Pr·- ·(O)_3 biradical with highly delocalized unpairing electron density on Pr(IV) and three O atoms is found to be responsible for stabilizing the monovalent-oxygen species in PrO_3^- ion, while GdO_3^- ion is in fact an OGd^+(O_2^(2-)) complex with Gd(III). These results show that a na?ve assignment of oxidation state of a chemical element without electronic structure analysis can lead to erroneous conclusions. | Jing Su Shuxian Hu Wei Huang Mingfei Zhou Jun Li | 2016 | Science China Chemistry2016，59，4： | 2 |
| 9 | Characterization and electrochemical properties of LiMn2O4 thin films prepared by solution deposition显示文摘 | Wu Xianming Ph D He Zeqiang Xu Mingfei Li Xinhai Xiao Zhuobing | 2006 | Journal of Wuhan University of Technology - Mater Sci Ed2006，，3： | 1 |
| 10 | High Prevalence of Eimeria Infection in Domestic Pigeons(Columba Livia Domestica) in Guangdong Province, Southern China显示文摘[Objective] This study aimed to make a survey of domestic pigeons for infection with Eimeria species of coccidia was conducted in Guangdong Province, southern China. [Method] A total of 244 fecal samples(102 from Huizhou, 83 from Jiangmen, 35 from Chaozhou and 24 from Guangzhou, respectively) in four pigeon breeding farms between June 2012 and March2013 were collected and examined microscopically. [Results] Eimeria oocysts were seen in 223(91.4%) fecal samples, with three species, namely E. labbeana, E.columbae and E. kapotei. E. labbeana was the most common species in Guangdong provinces with an overall prevalence of 91.4%, while a slightly lower incidence of E. columbae and E. kapotei species was detected with11.1% and 6.6%, representatively. The prevalence in different months varied ranging from 83.3% to 91.7%, with the highest prevalence in summer. Nestling groups showed obviously high infection than adult pigeons. [Conclusion] The present survey indicated the wide and severe prevalence of Eimeria infection in Guangdong domestic pigeons, which suggested that integrated measures should be taken to control and prevent coccidiosis of pigeons in this province. | Juan LI Xuhui LIN Caiyan WU Shenquan LIAO Nanshan QI Minna LV Mingfei SUN | 2016 | Agricultural Science & Technology2016，17，1： | 1 |
| 11 | Experimental studies on the properties of constructional steel at elevated temperatures 显示文摘 | Li Guoqiang Jiang Shouchao Yin Yingzhi Chen Kai Li Mingfei | 2003 | Journal of Structural Engineering2003，129，12： | 1 |
| 12 | Experimental studies on the properties of constructional steel at elevated temperatures 显示文摘 | LI Guoqiang JIANG Shouchao YIN Yingzhi CHEN Kai LI Mingfei | 2003 | Journal of Structural Engineering2003，129，12： | 1 |
| 13 | The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of Ligilactobacillus salivarius Liol and Resveratrol in Ameliorating Colitis in Mice显示文摘Currently approved therapeutical strategies for inflammatory bowel diseases(IBD)suffer from variable efficacy and association with risk of serious side effects.Therefore,efforts have been made in searching for alternative therapeutics strategies utilizing gut microbiota manipulation.In this study,we show that the probiotic strain Ligilactobacillus salivarius Li01(Li01)and the phytochemical prebiotic resveratrol(RSV)have synergistic effect in ameliorating colitis in mice.Oral coadministration of Li01(109 CFU/d)and RSV(1.5 g/kg/d)promoted restoration of various inflammatory injuries and gut microbiota composition,exhibiting a favorable anti-inflammatory effect in DSS-induced colitis mice.The combination treatment was associated with reductions in the levels of proinflammatory cytokines IL-1βand IL-6 and increases in the levels of the anti-inflammatory cytokine IL-17A in mouse serum.Moreover,the combination treatment was found to alter the composition and metabolism of the gut microbiota,especially influencing the production of short chain fatty acids and anti-inflammatory related molecules.The mechanism underlying the improved anti-inflammatory effect from the RSV and Li01 combination treatment was found to be associated with the environmental sensor mammalian aryl hydrocarbon receptor(AHR)and tryptophan metabolism pathway.Administration of RSV in combination with Li01 in different mouse model led to enhanced conversion of RSV into metabolites,including dihydroresveratrol(DHR),resveratrol-sulfate,and resveratrol-glucuronide.DHR was found to be the dominant metabolite of RSV in conventional and colitis mice.An increased DHR/RSV ratio was confirmed to activate AHR and contribute to an enhanced anti-inflammatory effect.DHR is considered as a potential AHR ligand.The DHR/RSV ratio also affected the serotonin pathway by controlling the expression of Tph1,SERT,and 5-HT7R leading to amelioration of colitis in mice.Our data suggest that treatment with a combination of Li01 and RSV has potential as a therapeutic strategy for IBD;further investigation of this combination in clinical settings is warranted. | Yiqiu Fei Shuobo Zhang Shengyi Han Bo Qiu Yanmeng Lu Weixing Huang Fang Li Deying Chen Bjorn Berglund Hang Xiao Lanjuan Li Mingfei Yao | 2022 | Research2022，，4： | 1 |
| 14 | Targeting RAS phosphorylation in cancer therapy:Mechanisms and modulators显示文摘RAS,a member of the small GTPase family,functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state.RAS gain-of-function mutations are one of the leading causes in human oncogenesis,accounting for w19%of the global cancer burden.As a well-recognized target in malignancy,RAS has been intensively studied in the past decades.Despite the sustained efforts,many failures occurred in the earlier exploration and resulted in an‘undruggable’feature of RAS proteins.Phosphorylation at several residues has been recently determined as regulators for wild-type and mutated RAS proteins.Therefore,the development of RAS inhibitors directly targeting the RAS mutants or towards upstream regulatory kinases supplies a novel direction for tackling the anti-RAS difficulties.A better understanding of RAS phosphorylation can contribute to future therapeutic strategies.In this review,we comprehensively summarized the current advances in RAS phosphorylation and provided mechanistic insights into the signaling transduction of associated pathways.Importantly,the preclinical and clinical success in developing anti-RAS drugs targeting the upstream kinases and potential directions of harnessing allostery to target RAS phosphorylation sites were also discussed. | Yuran Qiu Yuanhao Wang Zongtao Chai Duan Ni Xinyi Li Jun Pu Jie Chen Jian Zhang Shaoyong Lu Chuan Lv Mingfei Ji | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
| 15 | Characterization of extracted lignin of bamboo (Neosinocalamus Affinis) pretreated with sodium hydroxide/urea solution at low temperature显示文摘 | Li Mingfei Fan Yingmin Sun Runcang | 2010 | Bioresource2010，5，3： | 1 |
| 16 | Cold sodium hydroxide/urea based pretreatment of bamboo for bioethanol production: characterization of the cellulose rich fraction显示文摘 | Li Mingfei Fan Yongming Xu Feng | 2010 | Ind Crops Prod2010，32，： | 1 |
| 17 | Characterization of anti-endothelial cell antibodies in the patients with Systemic Lupus Erythematosus: a potential marker for disease activity显示文摘 | Li Jiann-Shyong Liu Mingfei Lei Huanyao | 1996 | Clin Immunol Immunopathol1996，79，： | 1 |
| 18 | Leadrecovery and glass microspheres synthesis from wasteCRT funnel glasses through carbon thermal reductionenhanced acid leaching process 显示文摘 | XING Mingfei WANG Yaping LI Jun | 2016 | Journal ofHazardous Materials2016，305，： | 1 |
| 19 | Cold sodium hydroxide/urea based pretreatment of bamboo for bioethanol production:characterization of the cellulose rich fraction显示文摘 | Li Mingfei Fan Yongming Xu Feng | | 0，，03： | 1 |
| 20 | Engineering of Push‐Pull Thiophene Dyes to Enhance Light Absorption and Modulate Charge Recombination in Mesoscopic Solar Cells显示文摘 | Ning Cai Yinglin Wang Mingfei Xu Ye Fan Renzhi Li Min Zhang Peng Wang | 2012 | Adv Funct Mater2012，，14： | 1 |
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