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| 1 | Small molecules for fat combustion: targeting obesity显示文摘Obesity is increasing in an alarming rate worldwide, which causes higher risks of some diseases, such as type 2 diabetes, cardiovascular diseases, and cancer. Current therapeutic approaches,either pancreatic lipase inhibitors or appetite suppressors, are generally of limited effectiveness. Brown adipose tissue(BAT) and beige cells dissipate fatty acids as heat to maintain body temperature, termed non-shivering thermogenesis; the activity and mass of BAT and beige cells are negatively correlated with overweight and obesity. The existence of BAT and beige cells in human adults provides an effective weight reduction therapy, a process likely to be amenable to pharmacological intervention. Herein, we combed through the physiology of thermogenesis and the role of BAT and beige cells in combating with obesity. We summarized the thermogenic regulators identified in the past decades, targeting G proteincoupled receptors, transient receptor potential channels, nuclear receptors and miscellaneous pathways.Advances in clinical trials were also presented. The main purpose of this review is to provide a comprehensive and up-to-date knowledge from the biological importance of thermogenesis in energy homeostasis to the representative thermogenic regulators for treating obesity. Thermogenic regulatorsmight have a large potential for further investigations to be developed as lead compounds in fighting obesity. | Jingxin Liu Yitao Wang Ligen Lin | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 2 | Single-atom Sn-Zn pairs in CuO catalyst promote dimethyldichlorosilane synthesis显示文摘Single-atom catalysts are of great interest because they can maximize the atom-utilization efficiency and generate unique catalytic properties;however,much attention has been paid to single-site active components,rarely to catalyst promoters.Promoters can significantly affect the activity and selectivity of a catalyst,even at their low concentrations in catalysts.In this work,we designed and synthesized CuO catalysts with atomically dispersed co-promoters of Sn and Zn.When used as the catalyst in the Rochow reaction for the synthesis of dimethyldichlorosilane,this catalyst exhibited much-enhanced activity,selectivity and stability compared with the conventional CuO catalysts with promoters in the form of nanoparticles.Density functional theory calculations demonstrate that single-atomic Sn substitution in the CuO surface can enrich surface Cu vacancies and promote dispersion of Zn to its atomic levels.Sn and Zn single sites as the co-promoters cooperatively generate electronic interaction with the CuO support,which further facilitates the adsorption of the reactant molecules on the surface,thereby leading to the superior catalytic performance. | Qi Shi Yongjun Ji Wenxin Chen Yongxia Zhu Jing Li Hezhi Liu Zhi Li Shubo Tian Ligen Wang Ziyi Zhong Limin Wang Jianmin Ma Yadong Li Fabing Su | 2020 | National Science Review2020，7，3： | 2 |
| 3 | Deployment and Exploration of a Gas Storage Well Pattern Based on the Threshold Radius显示文摘To tackle the problem that wells that are deployed in a specific pattern based on the requirements of gas reservoir development are not suitable for gas storage,we have conducted concentrically circular injection and production simulation experiments for gas storage,discovered the existence of a threshold radius,denoted by Rt,and derived the expression for Rt.Based on the analysis and discussion results,we propose a strategy for deploying gas storage wells in specific patterns.The expression for Rt shows that it is affected by factors such as the gas storage gas production/injection time,the upper pressure limit,the lower pressure limit,the bottomhole flow pressure at the ends of injection and production,the and permeability.The analysis and discussion results show that the Rt of a gas storage facility is much smaller than the Rt for gas reservoir development.In the gas storage facilities in China,the Rt for gas production is less than the Rt for the gas injection,and Rt increases with the difference in the operating pressure and with permeability K.Based on the characteristics of Rt,we propose three suggestions for gas storage well pattern deployment:(1)calculate Rt according to the designed functions of the gas storage facility and deploy the well pattern according to Rt;(2)deploy sparser,large-wellbore patterns in high-permeability areas and denser,small-wellbore patterns in high-permeability areas;and(3)achieve the gas injection well pattern by new drilling,and the gas production well pattern through a combination of the gas injection well pattern and old wells.By assessing a gas storage facility with a perfect well pattern after a number of adjustments,we found that the Rt of the 12 wells calculated in this paper is basically close to the corresponding actual radius,which validates our method.The results of this study provide a methodological basis for well pattern deployment in new gas storage construction. | TANG Ligen ZHU Weiyao ZHU Huayin SUN Chunhui YANG Fenglai WANG Yan Li Xiaorui Li Haiming CHU Guangzhen WANG Jieming KONG Debin YUE Ming LIU Yuwei HUANG Kun | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 1 |
| 4 | Study on Preparation Process of Effervescent Tablets Made from EGCG of Tea显示文摘[Objective] The study aimed to discuss the preparation process of Epigallocatechin-3-gallate (EGCG) effervescent tablets. [Method] Various raw materials were dried for different time at 50 ℃, and then the sticking degree of EGCG effervescent tablets was reviewed. Hereafter, the formula of EGCG effervescent tablets was optimized by orthogonal test. [Result] Effervescent tablets without sticking were smooth after being dried for 150 min. The optimal formula of EGCG effervescent tablets was composed of 4% EGCG, 45% citric acid and sodium carbonate (Citric acid∶Sodium carbonate = 1.6∶1), 20% lactose, 4% L-leucine, 4% sodium cyclamate and 23% orange powder. [Conclusion] The prepared EGCG effervescent tablets without sticking has a good effervescence effect and taste. | WANG Xianbo ZOU Ligen QIAN Lihua ZHAO Yun | 2012 | Chinese Food Science2012，1，4： | 1 |
| 5 | Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production显示文摘 | Ligen Lin Weijun Pang Keyun Chen Fei Wang Jon Gengler Yuxiang Sun Qiang Tong | 2012 | AJP: Endocrinology and Metabolism2012，，12： | 1 |
| 6 | A novel phenotype of B cells associated with enhanced phagocytic capability and chemotactic function after ischemic stroke显示文摘Accumulating evidence has demonstrated the involvement of B cells in neuroinflammation and neuroregeneration.However,the role of B cells in ischemic stroke remains unclear.In this study,we identified a novel phenotype of macrophage-like B cells in brain-infiltrating immune cells expressing a high level of CD45.Macrophage-like B cells chara cterized by co-expression of B-cell and macrophage markers,showed stronger phagocytic and chemotactic functions compared with other B cells and showed upregulated expression of phagocytosis-related genes.Gene Ontology analysis found that the expression of genes associated with phagocytosis,including phagosome-and lysosome-related genes,was upregulated in macrophage-like B cells.The phagocytic activity of macrophage-like B cells was ve rified by immunostaining and three-dimensional reconstruction,in which TREM2-labeled macrophage-like B cells enwrapped and internalized myelin debris after cerebral ischemia.Cell-cell interaction analysis revealed that macrophage-like B cells released multiple chemokines to recruit peripheral immune cells mainly via CCL pathways.Single-cell RNA sequencing showed that the transdiffe rentiation to macrophage-like B cells may be induced by specific upregulation of the transcription factor CEBP fa mily to the myeloid lineage and/or by downregulation of the transcription factor Pax5 to the lymphoid lineage.Furthermore,this distinct B cell phenotype was detected in brain tissues from mice or patients with traumatic brain injury,Alzheimer’s disease,and glioblastoma.Overall,these results provide a new perspective on the phagocytic capability and chemotactic function of B cells in the ischemic brain.These cells may serve as an immunotherapeutic target for regulating the immune response of ischemic stroke. | Rui Wang Huaming Li Chenhan Ling Xiaotao Zhang Jianan Lu Weimin Luan Jianmin Zhang Ligen Shi | 2023 | Neural Regeneration Research2023，18，11： | 1 |
| 7 | Artificial intelligence-aided discovery of prolyl hydroxylase 2 inhibitors to stabilize hypoxia inducible factor-1α and promote angiogenesis显示文摘From ZINC database with a total of 1.8 million small molecules, four compounds are identified as prolyl hydroxylase 2 inhibitors through a virtual screening workflow that sequentially incorporates machine learning, molecular docking, and molecular dynamics. Among them, compound 103,(E)-5-(5-((2-(1Htetrazol-5-yl)hydrazineylidene)methyl)furan-2-yl)isoindoline-1,3-dione, promotes the migration and capillary tube formation capacity of human umbilical vein endothelial cells through enhancing the stability of hypoxia inducible factor-1α and increasing the level of vascular endothelial growth factor. | Jianzhong Zhu Cheng Chen Jie Dong Shasha Cheng Guodong Li Chunming Wang Defang Ouyang Chung-Hang Leung Ligen Lin | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 8 | An analysis method of injection and production dynamic transient flow in a gas field storage facility显示文摘A dynamic transient flow analysis method considering complex factors such as the cyclic injection and production history in a gas field storage facility was established in view of the limitations of the existing methods for transient flow analysis and the characteristics of the injection-production operation of strongly heterogeneous gas reservoirs, and the corresponding theoretical charts were drawn. In addition, an injection-production dynamic transient flow analysis model named 'three points and two stages' suitable for an underground gas storage(UGS) well with alternate working conditions was proposed. The 'three points' refer to three time points during cyclic injection and production, namely, the starting point of gas injection for UGS construction, the beginning and ending points of the injection-production analysis stage;and the 'two stages' refer to historical flow stage and injection-production analysis stage. The study shows that the dimensionless pseudo-pressure and dimensionless pseudo-pressure integral curves of UGS well flex downward in the early stage of the injection and production process, and the dimensionless pseudo-pressure integral derivative curve is convex during the gas production period and concave during the gas injection period, and the curves under different flow histories have atypical features. The new method present in this paper can analyze transient flow of UGS accurately. The application of this method to typical wells in Hutubi gas storage shows that the new method can fit the pressure history accurately, and obtain reliable parameters and results. | WANG Jieming LI Chun SUN Junchang TANG Ligen ZHONG Rong LIU Xianshan ZHENG Shaojing | 2022 | Petroleum Exploration and Development2022，49，1： | 0 |
| 9 | Atomistic mechanism of high ionic conductivity in lithium ytterbium-based halide solid electrolytes:A first-principles study显示文摘As the next generation of commercial automotive power batteries begins replacing liquid lithium batteries,many look towards all-solid-state batteries to pioneer the future.All-so lid-state batteries have attracted the attention of countless researchers around the world because of their high safety and high energy density.In recent times,halide solid-state electrolytes have become a research hotspot within solid-state electrolytes because of their potentially superior properties.In this paper,in the framework of DFT,we investigated the atomic mechanisms of improving the ionic conductivity and stability of Li_(3)YbCl_(6).Our calculations show that both trigonal and orthorhombic Li_(3)YbCl_(6) exhibit wide electrochemical windows and metastable properties(100 meV/atom>Ehull>0 meV/atom).However,the orthorhombic Li_(3)YbCl_(6) can be stabilized at high temperatures by taking the vibrational entropy into account,which is supported by the experimental results.Moreover,it is expected that because of the Yb/Li synergistic interactions that,due to their strong mutual coulomb repulsion,influence the Li^(+)transport behavior,the orthorhombic Li_(3)YbCl_(6) might have superior ionic conductivities with appropriate Li+migration paths determined by the Yb^(3+) distribution.Also,higher ionic conductivities can be obtained by regulating the random distribution of Li^(+) ions.Further Li^(+)-deficiency can also largely increase the ionic conductivity by invoking vacancies.This study helps gain a deeper understanding of the laws that govern ionic conductivities and stabilities and provides a certain theoretical reference for the experimental development and design of halide solid-state electrolytes. | Limin Wang Wei Xiao Lu Sun Rong Yang Jinqiu Yu Ligen Wang | 2024 | Journal of Rare Earths2024，42，1： | 0 |
| 10 | Engineering oxygen vacancies and localized amorphous regions in CuO-ZnO separately boost catalytic reactivity and selectivity显示文摘Generating different types of defects in heterogeneous catalysts for synergetic promotion of the reactivity and selectivity in catalytic reactions is highly challenging due to the lack of effective theoretical guidance.Herein,we demonstrate a facile strategy to introduce two types of defects into the CuO-ZnO model catalyst,namely oxygen vacancies(OVs)induced by H2 partial reduction and localized amorphous regions(LARs)generated via the ball milling process.Using industrially important Rochow–Müller reaction as a representative,we found OVs predominantly improved the target product selectivity of dimethyldichlorosilane,while LARs significantly increased the conversion of reactant Si.The CuO-ZnO catalyst with optimized OVs and LARs contents achieved the best catalytic property.Theoretical calculation further revealed that LARs promote the generation of the Cu3Si active phase,and OVs impact the electronic structure of the Cu3Si active phase.This work provides a new understanding of the roles of different catalyst defects and a feasible way of engineering the catalyst structure for better catalytic performances. | Yongjun Ji Xiaoli Chen Shaomian Liu Liwen Xing Xingyu Jiang Bin Zhang Huifang Li Wenxing Chen Ziyi Zhong Ligen Wang Guangwen Xu Fabing Su | 2023 | Nano Research2023，16，2： | 0 |
| 11 | 日粮nano-ZnOs对断奶仔猪生长、腹泻、矿物质沉积、肠道形态和屏障的影响显示文摘本研究旨在研究日粮纳米ZnOs(nano-ZnOs)对断奶仔猪生长性能、腹泻率、矿物质沉积(锌、铁和锰)、肠道形态和屏障的影响。将384只断奶仔猪(Duroc×Landrace×Yorkshire)分为4组,饲喂添加0、400和800 mg/kg的nano-ZnOs或3000 mg/kg的ZnO的基础日粮14天。与对照组相比,800 mg/kg的nano-ZnOs和3000 mg/kg ZnO显著提高了断奶仔猪的平均日增重,降低腹泻率。ZnO和nano-ZnO组之间没有显著差异。ZnO和nano-ZnOs未影响血清谷草转氨酶、谷丙转氨酶和和乳酸脱氢酶的活性。然而,ZnO和800 mg/kg nano-ZnOs显著增加了血浆、肝脏、胰腺和胫骨中的锌浓度,未影响铁和锰的浓度。与对照组相比,800 mg/kg的nano-ZnOs显著降低血浆二胺氧化酶活性,减少肠系膜淋巴结中总需氧菌群,提高回肠粘膜occludin、ZO-1、IL-1β、IL-10、TNF-α和ki67的mRNA表达水平,同时提高绒毛高度、宽度、隐窝深度和表面积。与ZnO组相比,800 mg/kg的nano-ZnOs显著降低好氧菌数量,提高occludin、IL-1β、IL-10和TNF-α的mRNA表达,降低粪便锌浓度。这些结果表明,800 mg/kg的nano-ZnOs可能是断奶仔猪日粮中3000 mg/kg ZnO的潜在替代品。 | 张济福 解玉怀(译) Chao Wang Ligen Zhang Zhixiong Ying | 2019 | 中国饲料添加剂2019，0，9： | 0 |
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