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| 1 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 2 | On the tuning of electrical and thermal transport in thermoelectrics: an integrated theory–experiment perspective显示文摘During the last two decades,we have witnessed great progress in research on thermoelectrics.There are two primary focuses.One is the fundamental understanding of electrical and thermal transport,enabled by the interplay of theory and experiment;the other is the substantial enhancement of the performance of various thermoelectric materials,through synergistic optimisation of those intercorrelated transport parameters.Here we review some of the successful strategies for tuning electrical and thermal transport.For electrical transport,we start from the classical but still very active strategy of tuning band degeneracy(or band convergence),then discuss the engineering of carrier scattering,and finally address the concept of conduction channels and conductive networks that emerge in complex thermoelectric materials.For thermal transport,we summarise the approaches for studying thermal transport based on phonon–phonon interactions valid for conventional solids,as well as some quantitative efforts for nanostructures.We also discuss the thermal transport in complex materials with chemical-bond hierarchy,in which a portion of the atoms(or subunits)are weakly bonded to the rest of the structure,leading to an intrinsic manifestation of part-crystalline part-liquid state at elevated temperatures.In this review,we provide a summary of achievements made in recent studies of thermoelectric transport properties,and demonstrate how they have led to improvements in thermoelectric performance by the integration of modern theory and experiment,and point out some challenges and possible directions. | Jiong Yang Lili Xi Wujie Qiu Lihua Wu Xun Shi Lidong Chen Jihui Yang Wenqing Zhang Ctirad Uher David J Singh | 2016 | npj Computational Materials2016，，1： | 24 |
| 3 | Improving the accuracy of image-based forest fire recognition and spatial positioning显示文摘Forest fires are frequent natural disasters.It is necessary to explore advanced means to monitor,recognize and locate forest fires so as to establish a scientific system for the early detection,real-time positioning and quick fighting of forest fires.This paper mainly expounds methods and algorithms for improving accuracy and removing uncertainty in image-based forest fire recognition and spatial positioning.Firstly,we discuss a method of forest fire recognition in visible-light imagery.There are four aspects to improve accuracy and remove uncertainty in fire recognition:(1)eliminating factors of interference such as road and sky with high brightness,red leaves,other colored objects and objects that are lit up at night,(2)excluding imaging for specific periods and azimuth angles for which interference phenomena repeatedly occur,(3)improving the thresholding method for determining the flame border in image processing by adjusting the threshold to the season,weather and region,and (4)integrating the visible-light image method with infrared image technology.Secondly,we examine infrared-image-based methods and approaches of improving the accuracy of forest fire recognition by combining the spectrum threshold with an object feature value such as the normalized difference vegetation index and excluding factors of disturbance such as interference signals,extreme weather and high-temperature animals.Thirdly,a method of visible analysis to enhance the accuracy of forest fire positioning is examined and realized;the method includes decreasing the visual angle,selecting central points,selecting the largest spots,and judging the selection of fire spots according to the central distance.Case studies are examined and the results are found to be satisfactory. | JIANG LiLi 1,QI QingWen 1,ZHANG An 1,GUO ChaoHui 2 & CHENG Xi 1,3 1 Institute of Geographical Sciences and Natural Resources Research,Chinese Academy of Sciences,Beijing 100101,China 2 China Center for Resources Satellite Data and Applications,Beijing 100094,China 3Graduate University of Chinese Academy of Sciences,Beijing 100049,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 9 |
| 4 | Breeding strategy of Acrossocheilus fasciatus in the Puxi Stream of the Huangshan Mountain显示文摘Breeding strategies of Acrossocheilus fasciatus were studied from 592 specimens collected monthly during May 2007 and April 2008 in the Puxi Stream of the Huangshan Mountain.Sex ratio of the studied population was 0.90∶1(♀∶♂),not significantly different from 1∶1.Both sexes reached their first sexual maturity at age 2(the second calendar year of their birth).Fifty percent of females and males reached maturity at a total length of 69.75 mm and 69.36 mm respectively,and the minimum total length was 61.54 mm and 58.96 mm,respectively.Based on the monthly changes in gonado-somatic index and egg-development process,the breeding season of the population was from May to August,with one obvious interval(in June)occurring in the breeding activity for the females.The nonsynchronous development of oocytes observed in mature ovaries indicated that A.fasciatus is a batch spawner.Absolute fecundity of A.fasciatus ranged from 308 to 2002 eggs with a mean of 857 eggs,increased significantly with total length,and was significantly different among three age groups.Relative fecundity ranged from 38.63 to 71.70 egg/g with a mean of 53.29 egg/g,and was not significantly different among the three age groups.It was suggested that these reproductive characteristics were adaptive strategies for A.fasciatus to acclimatize to lotic water where environmental factors were unstable but predictable. | Yunzhi YAN Lili GUO Xiuying XIANG Yilong XI Yifeng CHEN | 2009 | Current Zoology2009，55，5： | 9 |
| 5 | Fe5C2 nanoparticles as low-cost HER electrocatalyst:the importance of Co substitution显示文摘Constructing and understanding the doping effect of secondary metal in transition metal carbide(TMC)catalysts is pivotal for the design of low-cost hydrogen evolution reaction(HER) electrocatalysts. In this work, we developed a wet-chemistry strategy for synthesizing Co-modified Fe_5C_2 nanoparticles((Fe_(1-x)Cox)_5C_2 NPs) as highly active HER electrocatalysts in basic solution. The structure of(Fe_(1-x)Cox)_5C_2 NPs was characterized by X-ray diffraction(XRD), extended X-ray absorption fine structure spectra(EXAFS) and scanning/transmission electron microscopy(S/TEM), indicating that the isomorphous substitution of cobalt in the lattice of Fe_5C_2.(Fe_(0.75) Co_(0.25))_5C_2 exhibited the best HER activity(174 mV for j = -10 mA/cm^2). Computational calculation results indicate that Co provides the most active site for HER. X-ray adsorption spectra(XAS) studies further suggested that the electron transfer in Fe–C bonds are enhanced by the substitution of Co, which modulates the hydrogen adsorption on the adjacent electronic-enriched carbon, and therefore promotes HER activity. Our results affirm the design of lowcost bimetallic TMCs based HER catalysts. | Siwei Li Pengju Ren Ce Yang Xi Liu Zhen Yin Weizhen Li Hanjun Yang Jian Li Xiaoping Wang Yi Wang Ruochen Cao Lili Lin Siyu Yao Xiaodong Wen Ding Ma | 2018 | Science Bulletin2018，63，20： | 6 |
| 6 | Atomically Smooth Ultrathin Films of Topological Insulator Sb_(2)Te_(3)显示文摘The growth and characterization of single-crystalline thin films of topological insulators(TIs)is an important step towards their possible applications.Using in situ scanning tunneling microscopy(STM)and angle-resolved photoemission spectroscopy(ARPES),we show that moderately thick Sb_(2)Te_(3)films grown layer-by-layer by molecular beam epitaxy(MBE)on Si(111)are atomically smooth,single-crystalline,and intrinsically insulating.Furthermore,these films were found to exhibit a robust TI electronic structure with their Fermi energy lying within the energy gap of the bulk that intersects only the Dirac cone of the surface states.Depositing Cs in situ moves the Fermi energy of the Sb_(2)Te_(3)films without changing the electronic band structure,as predicted by theory.We found that the TI behavior is preserved in Sb_(2)Te_(3)films down to five quintuple layers(QLs). | Guang Wang Xiegang Zhu Jing Wen Xi Chen Ke He Lili Wang Xucun Ma Ying Liu Xi Dai Zhong Fang Jinfeng Jia Qikun Xue | 2010 | Nano Research2010，3，12： | 5 |
| 7 | XerR, a negative regulator of XccR in Xanthomonas campestris pv. campestris, relieves its repressor function in planta显示文摘我们以前报导了那 XccR, Xanthomonas campestris pv 的一个 LuxR 类型管理者。campestris (Xcc ) ,响应某些主人植物因素激活下游的脯氨酸 iminopeptidase 毒力基因(果仁) 。在这份报告,我们进一步证明 xccR 基因的表示被一个 NtrC 类型反应管理者在文化媒介镇压,我们把它称为 XerR (XccR 表示相关,抑压者) ,并且当细菌是时,这压抑被减轻,这在 planta 成长。如此的规章的机制被 XerR 直接绑了在 xccR 倡导者的观察增强在里面 vitro,和那在 XerR 的 phosphorylation 相关的残余的变化导致了它的抑压者功能的损失。而且,当他们是渗入进卷心菜植物的真空时, xccR 的表示水平甚至在 XerR-overexpressing Xcc 房间增加了。我们 preliminarily 也描绘了涉及在 Xcc 和主人植物之间的上述提及的相互作用的主人因素,显示出那有不到 1 kDa 废除了的分子的重量的植物材料到 xccR 倡导者的 XerR 的绑定,当一样的材料在果仁倡导者提高了 XccR 的绑定到 luxXc 框时。一起拿,我们的结果含有在控制毒力相关的 xccR/pip 地点的表示的规章的机制的新层的 XerR 并且提供线索给与 XerR 和 XccR 交往提高 Xcc 的毒力的植物信号分子的鉴定。 | Li Wang Lili Zhang Yunfeng Geng Wei Xi Rongxiang Fang Yantao Jia | 2011 | Cell Research2011，21，7： | 5 |
| 8 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 9 | Efficacy compared between entecavir and adefovir dipivoxil on HBeAg-positive nucleos(t)ide-naive patients with chronic hepatitis B at week 12 and week 48显示文摘Objective:To evaluate the efficacy of entecavir and adefovir dipivoxil on HBeAg-positive nucleos(t)ide-naive patients with chronic hepatitis B with the method of Meta analysis.Methods:We searched PUBMED,EMBASE,CNKI (China National Knowledge Infrastructure),the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews with reference to all data documented before May 2010.The dosage of entecavir and adefovir dipivoxil was 0.5 mg/d and 10 mg/d,respectively.Heterogeneity was examined by Chi-square test,the relative risk calculated and forest plot drawn.Rates of undetected serum HBV DNA,serum alanine aminotransferase (ALT) normalization,HBeAg clearance,HBeAg seroconversion and adverse effect occurrence were analyzed.Results:Six articles were included,which fit well in with this study.Meta analysis showed that the rate of undetected serum HBV DNA(P=0.000 2 at week 12,P=0.002 at week 48)and that of serum ALT normalization(P=0.04 at week 12,P=0.008 at week 48)in the entecavir group were higher than those in the adefovir dipivoxil group.However,no statistic significance existed between the two groups in the rate of HBeAg clearance (P=0.17),the rate of HBeAg seroconversion(P=0.53)or the rate of adverse effect occurrence(P=0.92)at week 48.Conclusion:Entecavir was superior to adefovir dipivoxil in decreasing serum HBV DNA and normalizing serum ALT in the HBeAg-positive nucleos(t)ide-naive patients with chronic hepatitis B. | Zhao Pan Xu Dongping Wang Xi Duan Guangfeng Huang Lili | 2010 | Journal of Medical Colleges of PLA(China)2010，25，5： | 2 |
| 10 | Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial显示文摘We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial (NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4%with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8%by one course;it increased to 59.3%after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1%,95%confidence interval(CI)-19.4%to 9.2%,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3%)was similar to that of the control(95.2%,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7%by one course,which increased to 89.1%after subsequent multi-course,with non-inferiority(difference 24.7%,95%CI 12.8%-36.6%,P<0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1%vs.95.2%,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN. | Lili Chen Ling Xi Jie Jiang Rutie Yin Pengpeng Qu Xiuqin Li Xiaoyun Wan Yaxia Chen Dongxiao Hu Yuyan Mao Zimin Pan Xiaodong Cheng Xinyu Wang Qingli Li Danhui Weng Xi Zhang Hong Zhang Quanhong Ping Xiaomei Liu Xing Xie Beihua Kong Ding Ma Weiguo Lu | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 11 | Ternary compound CuInTe2:a promising thermoelectric material with diamond-like structure显示文摘 | Liu Ruiheng Xi Lili Liu Huili | | 0，，32： | 1 |
| 12 | Bifunctional photocatalysis of TiO 2 /Cu 2 O composite under visible light: Ti 3+ in organic pollutant degradation and water splitting显示文摘 | Liangbin Xiong Fan Yang Lili Yan Nannan Yan Xi Yang Mingqiang Qiu Ying Yu | 2011 | Journal of Physics and Chemistry of Solids2011，，： | 1 |
| 13 | Integrating biological knowledge with gene expression profiles for survival prediction of cancer 显示文摘 | Xi Chen Lily Wang | 2009 | J Comput Biol2009，16，2： | 1 |
| 14 | Intrinsic defects and the influences on electrical transport properties in quaternary diamond-like compounds:Cd_(2)Cu_(3)In_(3)Te_(8)as an example显示文摘Over the years,the fact that the quaternary diamond-like thermoelectric materials show much lower carrier mobilities than ternary compounds remains mysterious.In this work,by adopting first-principles defect chemistry and electrical transport calculations,the fundamental origin of the difference on carrier mobility between quaternary and ternary diamond-like compounds is addressed,exemplified by Cd_(2)Cu_(3)In_(3)Te_(8).The results of defect chemistry show that the main intrinsic defects in quaternary compound Cd_(2)Cu_(3)In_(3)Te_(8) are substitutional defects,i.e.,CdIn and CdCu,differing from the copper vacancy defect in ternary Cu-based compound such as CuInTe_(2).The low defect formation energies in Cd_(2)Cu_(3)In_(3)Te_(8) result in high defect concentrations,which is caused by the similar atomic radii and electronegativities between CdeIn and CdeCu.Further calculations show that the low-energy defects are mainly located around the valence band maximum in Cd_(2)Cu_(3)In_(3)Te_(8).The electrical transport calculations,considering both the acoustic phonon scattering and ionized impurity scattering,demonstrate that mainly due to the higher concentration of the ionized defects,the mobility of the quaternary Cd_(2)Cu_(3)In_(3)Te_(8) is much lower than that of ternary CuInTe2.Our work sheds light on the intrinsic defects in quaternary diamond-like compounds and their influence on charge transport. | Jianxin Zhang Zhou Zhang Lili Xi Jinyang Xi Jiong Yang | 2022 | Journal of Materiomics2022，8，6： | 1 |
| 15 | Flowers: precious food and medicine resources显示文摘Flower plants are popular all over the world and important sources of ornamental plants,bioactive molecules and nutrients.Flowers have a wide range of biological activities and beneficial pharmacological effects.Flowers and their active ingredients are becoming more and more popular in the preparation of food,drugs and industrial products.This paper summarizes the active ingredients,pharmacological activities and applications in the pharmaceutical and food industries of flower plants in recent years.In addition,the possible molecular mechanism of pharmacological effects of flower plants were also discussed.302 active constituents from 55 species of flower plants were summarized,including flavonoids(115),terpenoids(90),phenylpropanoids(20),alkaloids(13),organic acids(27)and others(37).The pharmacological effects of flower plants are very extensive,mainly including antioxidant,anti-inflammatory,anti-tumor,anti-virus,and hypoglycemic.The mechanisms of anti-inflammatory,anti-tumor and hypoglycemic activities present the characteristics of multi-way and multi-target.Because of its rich nutrients,bioactive ingredients and plant essential oils,and its wide sources,flower plants are widely used in food,beverage,cosmetics and drug research.Flower plants also play an important role in pharmaceutical industry,food industry and other fields. | Xuqiang Liu Senye Wang Lili Cui Huihui Zhou Yuhang Liu Lijun Meng Sitan Chen Xuefeng Xi Yan Zhang Wenyi Kang | 2023 | Food Science and Human Wellness2023，12，4： | 1 |
| 16 | Inhibitory effects of thioredoxin reductase antisense RNA on the growth of human hepatocellular carcinoma cells显示文摘 | Gan L Yang XI Lili Q | 2005 | J Cell Biochem2005，96，3： | 1 |
| 17 | Superconductivity in One-atomic-layer Metal Films显示文摘Superconductivity is a peculiar quantum phenomenon which originates from the pairing of conduction electrons, followed by phase coherent condensation. Since the discovery by K. Onnes in 1911, superconductivity has been one of the hottest topics in physics for an entire century, and still attracts people's great interest. One of the intriguing issues is | ZHANG Tong CHENG Peng LI Wenjuan SUN Yujie WANG Guang ZHU Xiegang HE Ke WANG Lili MA Xucun CHEN Xi WANG Yayu LIU Ying LIN Haiqing JIA Jinfeng XUE Qikun | 2011 | Bulletin of the Chinese Academy of Sciences2011，25，4： | 1 |
| 18 | The sequential processing of visual feature conjunction mismatches in the human brain显示文摘 | WANG Yuping CUI Lili WANG Huijun TIAN Shujuan ZHANG Xi | 2004 | Psychophysiology2004，41，1： | 1 |
| 19 | Graphene/MoS2 hybrid technology for large-scale two-dimensional elec- tronics显示文摘 | YU Lili LEE Y H LING Xi | 2014 | Nano Lett2014，14，6： | 1 |
| 20 | Preparation and characterization of Ca-P coating on AZ31 magnesium alloy 显示文摘 | TAN Lili WANG Qiang GENG Fang XI Xiaosong QIU Jian-hong YANG Ke | 2010 | Transactions of Nonferrous Metals Society of China2010，20，： | 1 |
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