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| 1 | Diagnostic value for extrahepatic metastases of hepatocellular carcinoma in positron emission tomography/computed tomography scan显示文摘AIM: To evaluated the value of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) scan in diagnosis of hepatocellular carcinoma (HCC) and extrahepatic metastases. METHODS: A total of 138 patients with HCC who had both conventional imaging modalities and 18F-FDG PET/CT scan done between November 2006 and March 2011 were enrolled. Diagnostic value of each imaging modality for detection of extrahepatic metastases was evaluated. Clinical factors and tumor characteristics including PET imaging were analyzed as indicative factors for metastases by univariate and multivariate methods. RESULTS: The accuracy of chest CT was significantly superior compared with the accuracy of PET imaging for detecting lung metastases. The detection rate of metastatic pulmonary nodule ≥ 1 cm was 12/13 (92.3%), when < 1 cm was 2/10 (20%) in PET imaging. The accuracy of PET imaging was significantly superior compared with the accuracy of bone scan for detecting bone metastases. In multivariate analy- sis, increased tumor size (≥ 5 cm) (P = 0.042) and increased average standardized uptake value (SUV) uptake (P = 0.028) were predictive factors for extrahepatic metastases. Isometabolic HCC in PET imaging was inversely correlated in multivariate analysis (P = 0.035). According to the receiver operating characteristic curve, the optimal cutoff of average SUV to predict extrahepatic metastases was 3.4. CONCLUSION: 18F-FDG PET/CT scan is invaluable for detection of lung metastases larger than 1 cm and bone metastases. Primary HCC having larger than 5 cm and increased average SUV uptake more than 3.4 should be considered for extrahepatic metastases. | Ji Eun Lee Jae Young Jang Soung Won Jeong Sae Hwan Lee Sang Gyune Kim Sang-Woo Cha Young Seok Kim Young Deok Cho Hong Soo Kim Boo Sung Kim So Young Jin Deuk Lin Choi | 2012 | World Journal of Gastroenterology2012，18，23： | 10 |
| 2 | Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive stimuli-induced depression显示文摘Previous studies have shown that Lycium barbarum polysaccharide,the main active component of Lycium barbarum,exhibits antiinflammatory and antioxidant effects in treating neurological diseases.However,the therapeutic action of Lycium barbarum polysaccharide on depression has not been studied.In this investigation,we established mouse models of depression using aversive stimuli including exposure to fox urine,air puff and foot shock and physical restraint.Concurrently,we administered 5 mg/kg per day Lycium barbarum polysaccharide-glycoprotein to each mouse intragastrically for the 28 days.Our results showed that long-term exposure to aversive stimuli significantly enhanced depressive-like behavior evaluated by the sucrose preference test and the forced swimming test and increased anxietylike behaviors evaluated using the open field test.In addition,aversive stimuli-induced depressed mice exhibited aberrant neuronal activity in the lateral habenula.Importantly,concurrent Lycium barbarum polysaccharide-glycoprotein treatment significantly reduced these changes.These findings suggest that Lycium barbarum polysaccharide-glycoprotein is a potential preventative intervention for depression and may act by preventing aberrant neuronal activity and microglial activation in the lateral habenula.The study was approved by the Jinan University Institutional Animal Care and Use Committee(approval No.20170301003)on March 1,2017. | Yun-Wei Fu Yan-Fang Peng Xiao-Dan Huang Yan Yang Lu Huang Yue Xi Zheng-Fang Hu Song Lin Kwok-Fai So Chao-Ran Ren | 2021 | Neural Regeneration Research2021，16，3： | 8 |
| 3 | Efficacy of Lycium barbarum polysaccharide in adolescents with subthreshold depression: interim analysis of a randomized controlled study显示文摘Subthreshold depression is a highly prevalent condition in adolescents who are at high risk for developing major depressive disorder.In preclinical models of neurological and psychiatric diseases,Lycium barbarum polysaccharide(LBP)extracted from Goji berries had antidepressant effects including but not limited to anti-oxidative and anti-inflammatory properties.However,the effect of LBP on subthreshold depression is unclear.To investigate the clinical efficacy and safety of LBP for treating subthreshold depression in adolescents,we conducted a randomized,double-blind,placebo-controlled trial(RCT)with 29 adolescents with subthreshold depression recruited at The Fifth Affiliated Hospital of Guangzhou Medical University.The participants were randomly assigned to groups where they received either 300 mg LBP(LBP group,n=15,3 boys and 12 girls aged 15.13±2.17 years)or a placebo(placebo group,n=14,2 boys and 12 girls aged 15±1.71 years)for 6 successive weeks.Interim analyses revealed that the LBP group exhibited a greater change in Hamilton Depression Scale(HAMD-24)scores relative to the baseline and a higher remission rate(HAMD-24 total score≤7)at 6 weeks compared with the placebo group.Scores on the Beck Depression Inventory-II(BDI-II),Pittsburgh Sleep Quality Index(PSQI),Kessler Psychological Distress Scale(Kessler),and Screen for Child Anxiety-Related Emotional Disorders(SCARED)were similar between the LBP and placebo groups.No side effects related to the intervention were reported in either group.These results indicate that LBP administration reduced depressive symptoms in adolescents with subthreshold depression.Furthermore,LBP was well tolerated with no treatment-limiting adverse events.Clinical trials involving a larger sample size are needed to further confirm the anti-depressive effects of LBP in adolescents with subthreshold depression.This study was approved by the Medical Ethics Committee of the Fifth Affiliated Hospital of Guangzhou Medical University(Guangzhou,China;approval No.L2019-08)on April 4,2019 and was registered on ClinicalTrials.gov(identifier:NCT04032795)on July 25,2019. | Xiaoyue Li Xuan Mo Tao Liu Robin Shao Kayla Teopiz Roger S.McIntyre Kwok-Fai So Kangguang Lin | 2022 | Neural Regeneration Research2022，17，7： | 6 |
| 4 | Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy显示文摘Diabetic neuropathy is a prevalent microvascular complication of diabetes mellitus,affecting nerves in all parts of the body including corneal nerves and peripheral nervous system,leading to diabetic corneal neuropathy and diabetic peripheral neuropathy,respectively.Diabetic peripheral neuropathy is diagnosed in clinical practice using electrophysiological nerve conduction studies,clinical scoring,and skin biopsies.However,these diagnostic methods have limited sensitivity in detecting small-fiber disease,hence they do not accurately reflect the status of diabetic neuropathy.More recently,analysis of alterations in the corneal nerves has emerged as a promising surrogate marker for diabetic peripheral neuropathy.In this review,we will discuss the relationship between diabetic corneal neuropathy and diabetic peripheral neuropathy,elaborating on the foundational aspects of each:pathogenesis,clinical presentation,evaluation,and management.We will further discuss the relevance of diabetic corneal neuropathy in detecting the presence of diabetic peripheral neuropathy,particularly early diabetic peripheral neuropathy;the correlation between the severity of diabetic corneal neuropathy and that of diabetic peripheral neuropathy;and the role of diabetic corneal neuropathy in the stratification of complications of diabetic peripheral neuropathy. | Wei Zheng So Natalie Shi Qi Wong Hong Chang Tan Molly Tzu Yu Lin Isabelle Xin Yu Lee Jodhbir S.Mehta Yu-Chi Liu | 2022 | Neural Regeneration Research2022，17，10： | 3 |
| 5 | Laparoscopic appendecto-my by residents: evaluating outcomes and learning curve显示文摘 | LIN Y Y SHABBIR A SO J B | 2010 | Surg Endosc2010，24，1： | 1 |
| 6 | Ci2 -adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5显示文摘 | Hsing CH Lin CF So E | 2012 | AmJ Physiol Renal Physiol2012，303，10： | 1 |
| 7 | Reduction of hospital stay and cost after the implementation of a clinical pathway for radical gas-trectomy for gastric cancer显示文摘 | SO J B LIM Z L LIN H A | 2008 | Gastric Cancer2008，11，： | 1 |
| 8 | Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias显示文摘 | So C W Lin M Ayton P M | 2003 | Cancer Cell2003，4，2： | 1 |
| 9 | A new constrained weighted least squares algorithm for TDOA-based localization显示文摘 | Lin L X So H C Chan F K W | 2013 | Signal Processing2013，93，11： | 1 |
| 10 | A new constrained weigh- ted least squares algorithm for TI)OA-based localization 显示文摘 | Lin L So HC Chan FKW | 2013 | Signal Processing2013，93，11： | 1 |
| 11 | α2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5显示文摘 | Hsing CH Lin CF So E | 2012 | Am J Physiol Renal Physiol2012，303，10： | 1 |
| 12 | Linear least squares approach for accurate received signal strength based sourcelocalization显示文摘 | SO H C LIN L | 2011 | IEEE Transactions on Signal Processing2011，59，8： | 1 |
| 13 | A New Constrained Weighted Least Squares Algorithm for TDOA-Based Localization 显示文摘 | LIN Lan-xin SO H C FRANKIE K W | 2013 | Signal Processing2013，93，3： | 1 |
| 14 | alpha2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through in- creasing BMP-7 and inhibiting HDAC2 and HDAC5 显示文摘 | Hsing CH Lin CF So E | 2012 | Arn J Physiol Renal Physiol2012，303，10： | 1 |
| 15 | A synthetic triterpenoid CDDO-Im inhibits tumorspherc formation by regulating stem cellsignaling pathways in trlple-negative breast canc- er显示文摘 | So J Y Lin J J Wahler J | 2014 | PLoS One2014，9，10： | 1 |
| 16 | Pulmonary scar cancer: A pathologic reappraisal显示文摘 | Ignatius Tak Min Kung Irene Oi Lin Lui Shee Loong Loke M. Aung Khin Che Keung Mok Wah Kit Lam Shun Yang So | 1985 | The American Journal of Surgical Pathology1985，，6： | 1 |
| 17 | Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias显示文摘 | So CW Lin M Ayton PM | 2003 | Cancer Cell2003，4，2： | 1 |
| 18 | Linear Least Squares Approach for Accurate Re- ceived Signal Strength Based Source Localization显示文摘 | So H C Lin L | 2011 | IEEE Trans-actions on Signal Processing2011，59，8： | 1 |
| 19 | The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients显示文摘 | Lin SO Chen KH Lin CH | 2007 | Eur J Olin Invest2007，37，12： | 1 |
| 20 | Antiwear mechanism of zinc dialkyl dithiophates added to a paraffinic oil in boundary lubrication condition 显示文摘 | So H Lin Y C | 1993 | Wear1993，166，： | 1 |
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