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| 1 | Efficacy and advantages of modified Traditional Chinese Medicine treatments based on'kidney reinforcing'for chronic aplastic ane-mia:a randomized controlled clinical trial显示文摘OBJECTIVE:To compare the efficacy of modified treatments based on 'kidney reinforcing' in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and eleven patients with CAA were randomly divided into three groups:kidney reinforcing alone(KA),'kidney reinforcing and Qi tonifying'(KQ),and 'kidney reinforcing and blood circulation invigorating'(KC).Normal and positive control groups were also formed.All patients were treated for 6 months(two courses).Hemograms,Traditional Chinese Medicine(TCM) syndrome scores,and therapeutic effects were assessed,and changes in T-lymphocyte subsets,regulatory T cells and cytokines were detected.RESULTS:The KQ and KC groups had lower TCM syndrome scores than the positive control group after 6 months(P < 0.05).The KQ group had a higher overall efficacy than the positive control group after 3 months(P < 0.05),while platelet counts increased in the KC group after 6 months(P < 0.05).CD3+ T-lymphocyte ratios decreased only in the KQ group,while CD3 + CD4 + CD8-Tlymphocytes increased only in the KC group after 6 months(P <0.05).Levels of interferon-γ,tumor necrosis fac-tor-α,interleukin(IL)-2 and IL-6 decreased and levels of IL-4 and IL-10 increased in all treated groups after 6 months.Levels of IL-6 in the KQ and KC groups were lower than those in the positive control group(P < 0.05).CONCLUSION:Treatments based on kidney reinforcing have a rebalancing effect on cytotoxic and T helper cells,and regulate expression of interferon-γ,IL-2,IL-6 and IL-4.KQ may be more effective in treating CAA,and KC may have an advantage in platelet recovery. | Wu Dijiong Shen Yiping Ye Baodong Fang Bingmu Lin Shengyun Chen Zhilu Jiang Huifang Feng Changwei He Lüyuan Gao Yanting Liu Yonglin Liu Yonghua Zhu Jiajia Wu Liqiang Shao Keding Zhou Yuhong | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 6 |
| 2 | Sequential maneuvering decisions based on multi-stage influence diagram in air combat显示文摘A multi-stage influence diagram is used to model the pilot's sequential decision making in one on one air combat.The model based on the multi-stage influence diagram graphically describes the elements of decision process,and contains a point-mass model for the dynamics of an aircraft and takes into account the decision maker's preferences under uncertain conditions.Considering an active opponent,the opponent's maneuvers can be modeled stochastically.The solution of multistage influence diagram can be obtained by converting the multistage influence diagram into a two-level optimization problem.The simulation results show the model is effective. | Zhong Lin Tong Ming'an Zhong Wei Zhang Shengyun | 2007 | Journal of Systems Engineering and Electronics2007，18，3： | 6 |
| 3 | Composition and ecological distribution of ichthyoplankton in eastern Beibu Gulf显示文摘Surveys were conducted in four seasons in the eastern Beibu Gulf from July 2006 to November 2007,to determine the ichthyoplankton composition,abundance,as well as environmental factors impacted on their spatiotemporal distributions.The fish eggs and larvae were sorted from 303 zooplankton quantitative samples,in which at least 1 order,60 families,31 genera and 61 species of fish eggs and larvae were identified.The species number was highest in summer whereas lowest in winter.With the most abundant fish egg (the average density was 2.41 ind./m 3),spring was the main spawning season,while the greatest mean density of fish larva was 1.35 ind./m 3 in summer.In the whole year around,fish eggs had the trends to aggregate in the nearshore of Guangxi coast,fish larvae were more abundant in the northern water.Relationships between fish eggs and larvae abundance and environmental factors were analyzed by using the Yield-Density model.The spatiotemporal distribution of ichthyoplankton in eastern Beibu Gulf was closely related to the Chl a concentration,and the optimal temperature,salinity and Chl a were 19.4-21.7 C,31.8-33.1 and 1.5-4.8 mg/m 3,respectively.Additionally,the distribution of fish larvae could be effected by ocean currents in summer and autumn. | ZHOU Meiyu LIN Yuanshao YANG Shengyun CAO Wenqing ZHENG Lianming | 2011 | Acta Oceanologica Sinica2011，30，1： | 3 |
| 4 | Engineered exosomes from different sources for cancertargeted therapy显示文摘Exosome is a subgroup of extracellular vesicles,which has been serving as an efficient therapeutic tool for various diseases.Engineered exosomes are the sort of exosomes modified with surface decoration and internal therapeutic molecules.After appropriate modification,engineered exosomes are able to deliver antitumor drugs to tumor sites efficiently and precisely with fewer treatment-related adverse effects.However,there still exist many challenges for the clinical translation of engineered exosomes.For instance,what sources and modification strategies could endow exosomes with the most efficient antitumor activity is still poorly understood.Additionally,how to choose appropriately engineered exosomes in different antitumor therapies is another unresolved problem.In this review,we summarized the characteristics of engineered exosomes,especially the spatial and temporal properties.Additionally,we concluded the recent advances in engineered exosomes in the cancer fields,including the sources,isolation technologies,modification strategies,and labeling and imaging methods of engineered exosomes.Furthermore,the applications of engineered exosomes in different antitumor therapies were summarized,such as photodynamic therapy,gene therapy,and immunotherapy.Consequently,the above provides the cancer researchers in this community with the latest ideas on engineered exosome modification and new direction of new drug development,which is prospective to accelerate the clinical translation of engineered exosomes for cancer-targeted therapy. | Menghui Zhang Shengyun Hu Lin Liu Pengyuan Dang Yang Liu Zhenqiang Sun Bingbing Qiao Chengzeng Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 5 | The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway显示文摘Polyphyllin I(PPI)and polyphyllin II(PII)are the main active substances in the Paris polyphylla.However,liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated.In this work,we found that PPI and PII exposure could induce significant hepatotoxicity in human liver cell line L-02 and zebrafish in a dose-dependent manner.The results of the proteomic analysis in L-02 cells and transcriptome in zebrafish indicated that the hepatotoxicity of PPI and PII was associated with the cholesterol biosynthetic pathway disorders,which were alleviated by the cholesterol biosynthesis inhibitor lovastatin.Additionally,3-hydroxy-3-methy-lglutaryl CoA reductase(HMGCR)and squalene epoxidase(SQLE),the two rate-limiting enzymes in the cholesterol synthesis,selected as the potential targets,were confirmed by the molecular docking,the overexpression,and knockdown of HMGCR or SQLE with siRNA.Finally,the pull-down and surface plasmon resonance technology revealed that PPI could directly bind with SQLE but not with HMGCR.Collectively,these data demonstrated that PPI-induced hepatotoxicity resulted from the direct binding with SQLE protein and impaired the sterol-regulatory element binding protein 2/HMGCR/SQLE/lanosterol synthase pathways,thus disturbing the cholesterol biosynthesis pathway.The findings of this research can contribute to a better understanding of the key role of SQLE as a potential target in drug-induced hepatotoxicity and provide a therapeutic strategy for the prevention of drug toxic effects with similar structures in the future. | Zhiqi Li Qiqi Fan Meilin Chen Ying Dong Farong Li Mingshuang Wang Yulin Gu Simin Guo Xianwen Ye Jiarui Wu Shengyun Dai Ruichao Lin Chongjun Zhao | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 2 |
| 6 | The complete mitochondrial genome of the grey bamboo shark (Chiloscyllium griseum) (Orectolobiformes: Hemiscylliidae): genomic characterization and phylogenetic application显示文摘The complete mitochondrial genome of the grey bamboo shark, Chiloscyllium griseum (Orectolobiformes: Hemiscylliidae) was obtained, with a total of 16 755 base pairs (bp). The mitogenome encoded 13 proteincoding genes, two ribosomal RNAs, 22 transfer RNAs and a noncoding control region, a gene arrangement identical to the most common type found in vertebrates. All tRNA sequences were folded into typical cloverleaf secondary structure with the exception of tRNA-Ser2, in which the DHU arm stem was replaced with 12 unpaired nucleotides and formed a simple loop. In the control region, the putative termination-associated sequences (TAS) with hairpin-loop structure and the conserved sequence blocks (CSB) Ⅰ-Ⅲ were identified and considered to be associated with the replication and transcription of mtDNA. No repeat motifs were found in the mitogenome of C. griseum. On the basis of the mitogenomic data available in the Class Chondrichthyes from both Genbank and this study, and the phylogenetic analyses using maximum likelihood (ML) and Bayesian inference (BI) methods, the results strongly support the basal division between batoids and sharks and the monophyly of the Superorder Galeomorphii, and confirm the phylogenetic position of C. griseum in the Subclass Elasmobranchii. This study suggests that the mitogenomic data are more robust for reconstructing phylogenetic relationships than individual genes in the Elasmobranchii. | CHEN Xiao AI Weiming YE Le WANG Xuehui LIN Chongwen YANG Shengyun | 2013 | Acta Oceanologica Sinica2013，32，4： | 0 |
| 7 | Bound states in the continuum in all-dielectric metasurfaces with scaled lattice constants显示文摘Bound states in the continuum(BICs)have emerged as an efficient tool for trapping light at the nanoscale,promising several exciting applications in photonics.Breaking the structural symmetry has been proposed as an effective way of exciting quasiBICs(QBICs)and generating high-Q resonances.Herein,we demonstrate that QBICs can be excited in an all-dielectric metasurface by scaling the lattice of the metasurface,causing translational symmetry breaking.The corresponding BICs arise from band folding from the band edge to the Γ point in the first Brillouin zone.Multipole analysis reveals that the toroidal dipole dominates these QBICs.Furthermore,scaling the lattice along different directions provides additional freedom for tailoring QBICs,enabling polarization-dependent or-independent QBICs.In addition,this allows the realization of two QBICs at different wavelengths using plane-wave illumination with different polarizations on the metasurface.We experimentally demonstrated the existence of these BICs by fabricating silicon metasurfaces with scaled lattices and measuring their transmission spectra.The vanished resonant linewidth identifies BICs in the transmission spectrum,and the QBICs are characterized by highQ Fano resonances with the Q-factor reaching 2000.Our results have potential applications in enhancing light-matter interaction,such as laser,nonlinear harmonic generation,and strong coupling. | Mimi Zhou Shaojun You Lei Xu Menghui Fan Jing Huang Wenbin Ma Mingzhe Hu Shengyun Luo Mohsen Rahmani Ya Cheng Lin Li Chaobiao Zhou Lujun Huang Andrey E.Miroshnichenko | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，12： | 0 |
| 8 | A self-powered ultraviolet photodetector with van der Waals Schottky junction based on TiO_(2) nanorod arrays/Au-modulated V2CTx MXene显示文摘A self-powered ultraviolet photodetector(UV PD)with van der Waals(vdW)Schottky junction based on TiO_(2) nanorod arrays/Au-modulated V2 CTx MXene is reported.The Schottky junction enables the device to operate in self-powered mode.The dangling bond-free surface of V2 CTx MXene reduces the charge recombination at the junction interface.Meanwhile,V2 CTx MXene,with the work function(WF)increasing to 5.35 eV,forms a hole transport layer by contacting with Au electrode,which facilitates the carrier extraction.The electron lifetime in the device has prolonged to 8.95μs.As a result,the responsivity and detectivity of the PD have achieved 28 mA/W and 1.2×10^(11) cm Hz1/2/W(340 nm,65 mW/cm2,0 V),respectively.In addition,the presence of the Au electrode prevents the vanadium from coming into contact with oxygen and oxidizing,preserving the properties of the V2 CTx films.After 180 days of exposure to the atmosphere,the device performance remained at a particularly high level,indicating enhanced durability.This work points out an effective approach to modulate the properties of V2 CTx to obtain the high performance and stability of the UV PD. | Guangcan Luo Ziling Zhang Yabing Wang Qun Deng Shengtao Pan Tengfei Wang Qinghong Li Kaixiang Liu Pengfei Kong Jing Zhang Shengyun Luo Hong Lin | 2023 | Journal of Materials Science & Technology2023，，25： | 0 |
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